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Literature citations Results

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

Meerang M., Ritz D., Paliwal S., Garajova Z., Bosshard M., Mailand N., Janscak P., Hubscher U., Meyer H., Ramadan K.

Nat. Cell Biol. 13:1376-1382(2011) · UniProtKB (1)

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

Baranes-Bachar K., Levy-Barda A., Oehler J., Reid D.A., Soria-Bretones I., Voss T.C., Chung D., Park Y., Liu C., Yoon J.B. et al.

Mol. Cell 69:866-878.e7(2018) · Mapped (5)

The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.

Maga G., Blanca G., Shevelev I., Frouin I., Ramadan K., Spadari S., Villani G., Huebscher U.

FASEB J. 18:1743-1745(2004) · UniProtKB (1) · Mapped (12)

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Zimmer J., Tacconi E.M.C., Folio C., Badie S., Porru M., Klare K., Tumiati M., Markkanen E., Halder S., Ryan A. et al.

Mol. Cell 61:449-460(2016) · Mapped (125)

Novel and Mediterranean beta thalassemia mutations in the indigenous Northern Ireland population.

Knott M., Ramadan K.M., Savage G., Jones F.G., El-Agnaf M., McMullin M.F., Percy M.J.

Blood Cells Mol. Dis. 36:265-268(2006) · Mapped (64)

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.

Lessel D., Vaz B., Halder S., Lockhart P.J., Marinovic-Terzic I., Lopez-Mosqueda J., Philipp M., Sim J.C., Smith K.R., Oehler J. et al.

Nat. Genet. 46:1239-1244(2014) · UniProtKB (1) · Mapped (4)

Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.

Shevelev I., Blanca G., Villani G., Ramadan K., Spadari S., Huebscher U., Maga G.

Nucleic Acids Res. 31:6916-6925(2003) · UniProtKB (1) · Mapped (12)

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.

Vaz B., Popovic M., Newman J.A., Fielden J., Aitkenhead H., Halder S., Singh A.N., Vendrell I., Fischer R., Torrecilla I. et al.

Mol. Cell 64:704-719(2016) · Mapped (4)

Immunoglobulin heavy chain (IGH@) translocations negatively impact treatment-free survival for chronic lymphocytic leukemia patients who have an isolated deletion 13q abnormality.

Gerrie A.S., Bruyere H., Chan M.J., Dalal C.B., Ramadan K.M., Huang S.J., Toze C.L., Gillan T.L.

Cancer Genet 205:523-527(2012) · Mapped (5)

Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.

Blanca G., Villani G., Shevelev I., Ramadan K., Spadari S., Hubscher U., Maga G.

Biochemistry 43:11605-11615(2004) · Mapped (13)

Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions.

Ramadan K., Maga G., Shevelev I.V., Villani G., Blanco L., Hubscher U.

J. Mol. Biol. 328:63-72(2003) · Mapped (13)

Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.

Maga G., Villani G., Ramadan K., Shevelev I., Tanguy Le Gac N., Blanco L., Blanca G., Spadari S., Hubscher U.

J. Biol. Chem. 277:48434-48440(2002) · Mapped (13)

Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study.

Blanca G., Shevelev I., Ramadan K., Villani G., Spadari S., Huebscher U., Maga G.

Biochemistry 42:7467-7476(2003) · UniProtKB (1)

DNA polymerase theta purified from human cells is a high-fidelity enzyme.

Maga G., Shevelev I., Ramadan K., Spadari S., Hubscher U.

J. Mol. Biol. 319:359-369(2002) · Mapped (7)

DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.

Maga G., Ramadan K., Locatelli G.A., Shevelev I., Spadari S., Hubscher U.

J. Biol. Chem. 280:1971-1981(2005) · UniProtKB (1) · Mapped (12)

Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy.

Ramadan K., Meerang M.

FEBS Lett. 585:2868-2875(2011) · Mapped (16)

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.

Franz A., Pirson P.A., Pilger D., Halder S., Achuthankutty D., Kashkar H., Ramadan K., Hoppe T.

Nat. Commun. 7:10612-10612(2016) · UniProtKB (9) · Mapped (2)

Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity.

Puumalainen M.R., Lessel D., Ruthemann P., Kaczmarek N., Bachmann K., Ramadan K., Naegeli H.

Nat Commun 5:3695-3695(2014) · Mapped (1)

Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin.

Ramadan K., Bruderer R., Spiga F.M., Popp O., Baur T., Gotta M., Meyer H.H.

Nature 450:1258-1262(2007) · UniProtKB (2)

A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition.

Gill M.R., Harun S.N., Halder S., Boghozian R.A., Ramadan K., Ahmad H., Vallis K.A.

Sci Rep 6:31973-31973(2016) · Mapped (1)

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