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Literature citations Results

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export.

Vohhodina J., Barros E.M., Savage A.L., Liberante F.G., Manti L., Bankhead P., Cosgrove N., Madden A.F., Harkin D.P., Savage K.I.

Nucleic Acids Res. 45:12816-12833(2017) · Mapped (9)

The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma.

Smith P.G., Wang F., Wilkinson K.N., Savage K.J., Klein U., Neuberg D.S., Bollag G., Shipp M.A., Aguiar R.C.

Blood 105:308-316(2005) · Mapped (16)

The nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin.

Kalousi A., Hoffbeck A.S., Selemenakis P.N., Pinder J., Savage K.I., Khanna K.K., Brino L., Dellaire G., Gorgoulis V.G., Soutoglou E.

Cell Rep 11:149-163(2015) · Mapped (10)

The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo.

Wienke D., Davies G.C., Johnson D.A., Sturge J., Lambros M.B., Savage K., Elsheikh S.E., Green A.R., Ellis I.O., Robertson D. et al.

Cancer Res. 67:10230-10240(2007) · Mapped (3)

Targeting of cholecystokinin B/gastrin receptor in colonic, pancreatic and hepatocellular carcinoma cell lines.

Savage K., Waller H.A., Stubbs M., Khan K., Watson S.A., Clarke P.A., Grimes S., Michaeli D., Dhillon A.P., Caplin M.E.

Int. J. Oncol. 29:1429-1435(2006) · Mapped (3)

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.

Richard D.J., Bolderson E., Cubeddu L., Wadsworth R.I.M., Savage K., Sharma G.G., Nicolette M.L., Tsvetanov S., McIlwraith M.J., Pandita R.K. et al.

Nature 453:677-681(2008) · UniProtKB (3) · Mapped (2)

Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism.

Case L.K., Petell L., Yurkovetskiy L., Purdy A., Savage K.J., Golovkina T.V.

J. Virol. 82:1438-1447(2008) · Mapped (21)

Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma.

Gunawardana J., Chan F.C., Telenius A., Woolcock B., Kridel R., Tan K.L., Ben-Neriah S., Mottok A., Lim R.S., Boyle M. et al.

Nat. Genet. 46:329-335(2014) · Mapped (4)

Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.

Deevi R.K., Javadi A., McClements J., Vohhodina J., Savage K., Loughrey M.B., Evergren E., Campbell F.C.

J. Pathol. 244:445-459(2018) · Mapped (3)

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study.

Lambros M.B., Natrajan R., Geyer F.C., Lopez-Garcia M.A., Dedes K.J., Savage K., Lacroix-Triki M., Jones R.L., Lord C.J., Linardopoulos S. et al.

Mod. Pathol. 23:1334-1345(2010) · Mapped (6)

Oncogenic Braf induces melanocyte senescence and melanoma in mice.

Dhomen N., Reis-Filho J.S., da Rocha Dias S., Hayward R., Savage K., Delmas V., Larue L., Pritchard C., Marais R.

Cancer Cell 15:294-303(2009) · Mapped (9)

Nivolumab in previously untreated melanoma without BRAF mutation.

Robert C., Long G.V., Brady B., Dutriaux C., Maio M., Mortier L., Hassel J.C., Rutkowski P., McNeil C., Kalinka-Warzocha E. et al.

N. Engl. J. Med. 372:320-330(2015) · UniProtKB (1)

NF-kappaB is a critical mediator of BRCA1-induced chemoresistance.

Harte M.T., Gorski J.J., Savage K.I., Purcell J.W., Barros E.M., Burn P.M., McFarlane C., Mullan P.B., Kennedy R.D., Perkins N.D. et al.

Oncogene 33:713-723(2014) · Mapped (2)

NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes.

Feuerhake F., Kutok J.L., Monti S., Chen W., LaCasce A.S., Cattoretti G., Kurtin P., Pinkus G.S., de Leval L., Harris N.L. et al.

Blood 106:1392-1399(2005) · Mapped (4)

Myostatin promotes the terminal differentiation of embryonic muscle progenitors.

Manceau M., Gros J., Savage K., Thome V., McPherron A., Paterson B., Marcelle C.

Genes Dev. 22:668-681(2008) · Mapped (6)

MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy.

Savage K.J., Johnson N.A., Ben-Neriah S., Connors J.M., Sehn L.H., Farinha P., Horsman D.E., Gascoyne R.D.

Blood 114:3533-3537(2009) · Mapped (61)

MYC amplification in breast cancer: a chromogenic in situ hybridisation study.

Rodriguez-Pinilla S.M., Jones R.L., Lambros M.B., Arriola E., Savage K., James M., Pinder S.E., Reis-Filho J.S.

J. Clin. Pathol. 60:1017-1023(2007) · Mapped (61)

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition.

Ennishi D., Takata K., Beguelin W., Duns G., Mottok A., Farinha P., Bashashati A., Saberi S., Boyle M., Meissner B. et al.

Cancer Discov 9:546-563(2019) · Mapped (18)

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers.

Steidl C., Shah S.P., Woolcock B.W., Rui L., Kawahara M., Farinha P., Johnson N.A., Zhao Y., Telenius A., Neriah S.B. et al.

Nature 471:377-381(2011) · Mapped (9)

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.

McCabe N., Hanna C., Walker S.M., Gonda D., Li J., Wikstrom K., Savage K.I., Butterworth K.T., Chen C., Harkin D.P. et al.

Cancer Res. 75:2159-2165(2015) · Mapped (12)

Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival.

Johnson N.A., Savage K.J., Ludkovski O., Ben-Neriah S., Woods R., Steidl C., Dyer M.J., Siebert R., Kuruvilla J., Klasa R. et al.

Blood 114:2273-2279(2009) · Mapped (70)

Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1beta (HP1-beta) mobilization and DNA repair in heterochromatin.

Bolderson E., Savage K.I., Mahen R., Pisupati V., Graham M.E., Richard D.J., Robinson P.J., Venkitaraman A.R., Khanna K.K.

J. Biol. Chem. 287:28122-28131(2012) · Mapped (5)

Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability.

Savage K.I., Gorski J.J., Barros E.M., Irwin G.W., Manti L., Powell A.J., Pellagatti A., Lukashchuk N., McCance D.J., McCluggage W.G. et al.

Mol. Cell 54:445-459(2014) · Mapped (1)

Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma.

Twa D.D., Chan F.C., Ben-Neriah S., Woolcock B.W., Mottok A., Tan K.L., Slack G.W., Gunawardana J., Lim R.S., McPherson A.W. et al.

Blood 123:2062-2065(2014) · Mapped (5)

Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin-specific clinical impact.

Ennishi D., Mottok A., Ben-Neriah S., Shulha H.P., Farinha P., Chan F.C., Meissner B., Boyle M., Hother C., Kridel R. et al.

Blood 129:2760-2770(2017) · Mapped (70)

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