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Keyword - Cushing syndrome (KW-1062)

Definition

Protein which, if defective, causes Cushing syndrome, a condition caused by prolonged exposure to excess levels of cortisol from endogenous or exogenous sources. Endogenous Cushing syndrome is due to excess production of cortisol by the adrenal glands. It may be caused by pituary hypersecretion of adrenocorticotropic hormone (ACTH), ectopic ACTH secretion by non-pituary tumors, or may result from cortisol hypersecretion by adrenal gland tumors (ACTH-independent Cushing syndrome). Cushing syndrome is clinically characterized by upper body obesity, osteoporosis, hypertension, diabetes mellitus, hirsutism, amenorrhea, and excess body fluid.

Synonyms

  • Cushing's syndrome
  • Hyperadrenocorticism
  • Hypercortisolism

Category

Disease

Graphical

Cushing syndromeDisease
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