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Overview

StatusReference proteome
Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 5,126
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000000265
Taxonomy272620 - Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
StrainATCC 700721 / MGH 78578
Last modifiedSeptember 28, 2019
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000016305.1 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) pan proteome (fasta)

Bacteria of the genus Klebsiella are widely distributed in nature, in the soil and in water. They are also part of the normal flora of the intestinal tract, but usually in low numbers compared with E. coli. Klebsiella, especially strains of the species K. pneumonia, are opportunistic pathogens that can cause pneumonia, urinary tract infections, and bacteremia. In recent years there has been an increase in Klebsiella infections, especially in hospitals and due to multiple-antibiotic resistant strains. The most striking difference between most strains of Klebsiella and its close relatives E. coli and Salmonella is that Klebsiella cells have a thick coat of slime or extracellular polysaccharide which is called a "capsule". The capsule protects the cells from dessication, and may also protect them from phagocytosis when they are in an animal host. Surprisingly, many strains of Klebsiella can fix nitrogen, i.e., they can reduce atmospheric nitrogen to ammonia and amino acids.

Klebsiella pneumoniae MGH 78578 (also known as ATCC 700721/SGSC4697) was isolated from the sputum of a 66-year-old ICU patient in 1994. Klebsiella was considered to have a role in his pneumonia. The strain is resistant to many antibiotics, including ampicillin, ticarcillin, trimethoprim-sulfamethoxazole, and gentamicin, but is susceptible to amikacin, ciprofloxacin, and imipenem (adapted from genome.wustl.edu/genomes/view/klebsiella_pneumoniae/).

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome4765
Plasmid pKPN3174
Plasmid pKPN4123
Plasmid pKPN591
Plasmid pKPN65
Plasmid pKPN75
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Main funding by: National Institutes of Health

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