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Overview

Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 1,580
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000000790
Taxonomy405566 - Lactobacillus helveticus (strain DPC 4571)
StrainDPC 4571
Last modifiedNovember 12, 2018
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000015385.1 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) pan proteome (fasta)

Lactobacilli are normal inhabitants of the gastrointestinal tract of man and animals where they are widely considered to exert a number of beneficial roles including immunomodulation, interference with enteric pathogens, and maintenance of a healthy intestinal microflora. The genus Lactobacillus presently comprises more than 50 recognized species of non pathogenic bacteria which in addition to their probiotic effects are useful to human as indispensable agents for the fermentation of foods and feed.

Lactobacillus helveticus DPC 4571 is a Swiss cheese isolate that has been thoroughly investigated as a starter and adjunct culture in cheese manufacture and demonstrates a number of highly desirable traits including rapid autolysis, reduced bitterness and increased flavor notes. It has two hundred and thirteen insertion sequence (IS) elements, ten times more than other fully sequenced lactobacilli. Genome alignments revealed an unprecedented level of genome stability between the Lactobacillus species considering the number of IS elements in the L. helveticus genome. Comparative analysis also indicated that the IS elements were not the primary agents of niche adaptation for the L. helveticus genome. A clear bias towards the loss of genes reported to be important for gut colonization was observed for the cheese culture but there was no clear evidence of IS associated gene deletion and decay for the majority of genes lost. An extraordinary level of sequence diversity exists between copies of certain IS elements in the DPC 4571 genome indicating they may represent an ancient component of the L. helveticus genome.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome1580

Publications

  1. "Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion."
    Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.
    J. Bacteriol. 2008:727-735(2008) [PubMed] [Europe PMC] [Abstract]
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