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Overview

StatusReference proteome
Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 3,590
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000001986
Taxonomy441771 - Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
StrainHall / ATCC 3502 / NCTC 13319 / Type A [Sanger]
Last modifiedJuly 15, 2019
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000063585.1 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) pan proteome (fasta)

Clostridium botulinum produces botulinum neurotoxin, one of deadliest toxins known. It inhibits acetylcholine release in neuromuscular junctions, causing paralysis by inhibiting muscle contraction. In most cases the affected person dies of asphyxiation or heart failure. Strains of C. botulinum are physiologically heterogeneous, and four distinct phenotypic groups (I to IV) are recognized. These four metabolically distinct groups do not, however, necessarily correlate with the serological specificities of the botulinum neurotoxin produced, which are classified into 7 serotypes, A-F. The type A toxin is used in minute doses to treat both painful muscle spasms and as a cosmetic treatment to temporarily remove frown lines between eyebrows.

Strain Hall, ATCC 3502, is a representative of the Group I (proteolytic) botulinum toxin producing bacteria. Group I strains produce one or two toxins of type A, B or F; strain Hall produces type A1 neurotoxin. Food-borne, infant and wound botulism can all be caused by Group I strains. Strain Hall, the most widely studied of the C.botulinum strains, has been found to have an active chitinolytic system, enabling it to colonize environments where chitin-containing organism such as fungi, insects and crustaceans are abundant. Additionally it produces several extracellular proteases, presumably helping it to soften and destroy rotting or decaying tissues to support its saprophytic lifestyle. Two representatives of this strain have been sequenced, one of which contains a plasmid that encodes a bacteriocin boticin-like synthetic and transport system which may enable the bacteria to compete against other microbes.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome3572
Plasmid pBOT350218
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Main funding by: National Institutes of Health

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