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Overview

Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 1,041
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000002305
Taxonomy347255 - Rickettsia africae (strain ESF-5)
StrainESF-5
Last modifiedJuly 25, 2019
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000023005.1 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Rickettsia prowazekii (strain Madrid E) pan proteome (fasta)

Rickettsiae are obligate intracellular Gram-negative bacteria mostly found in arthropods, some of which cause mild to severe diseases in humans. Over the last ten years, Rickettsia africae has emerged as the causative agent of African tick-bite fever, the most common spotted fever group (SFG) rickettsiosis. It's success as an infectious agent is probably due in part to increased tourism, and it is now found in the Caribbean, probably due to importation of infected cattle. It is highly prevalent in its host ticks (Amblyomma sp.), being present in up to 100%; in addition it does not seem to be detrimental to its hosts. By comparison with R. conorii, the second most prevalent SFG rickettsia in Africa (RICCN) R. africae exhibits a higher prevalence in ticks, a lower virulence in humans, and a greater genetic homogeneity. It may be a recently emerged species. Interestingly in the Rickettsia increased virulence results from gene inactivation. The ESF-5 strain, first isolated in from an Amblyomma variegatum tick collected from cattle in the Shulu province of Ethiopia in 1966, may have undergone loss or rearrangement of plasmid or chromosomal genes during multiple passages in cell culture. It also appears that depending on the geographic location, the plasmid of R. africae may be unstable (adapted from PubMed 19379498).

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome1030
Plasmid pRAF11

Publications

  1. "Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction."
    Fournier P.-E., El Karkouri K., Leroy Q., Robert C., Giumelli B., Renesto P., Socolovschi C., Parola P., Audic S., Raoult D.
    BMC Genomics 2009:166-166(2009) [PubMed] [Europe PMC] [Abstract]
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