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Entry version 56 (16 Oct 2019)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Alkylated DNA repair protein AlkB

Gene

alkB

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenaseImported, MethyltransferaseImported, Oxidoreductase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alkylated DNA repair protein AlkBImported
Submitted name:
Alpha-ketoglutarate-dependent dioxygenaseImported
Submitted name:
Alpha-ketoglutarate-dependent dioxygenase (Alkylated DNA repair protein)Imported (EC:1.14.11.-Imported)
Submitted name:
Alpha-ketoglutarate-dependent dioxygenase AlkBImported
Submitted name:
DNA oxidative demethylase AlkBImported (EC:1.14.11.33Imported)
Submitted name:
Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesionsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:alkBImported
ORF Names:ACU57_12965Imported, AM464_02395Imported, AUQ13_05145Imported, BANRA_00775Imported, BANRA_04849Imported, BON93_22730Imported, BUE81_13920Imported, BvCms2454_00819Imported, BvCmsKSP026_02025Imported, BvCmsKSP040_01645Imported, BW690_03385Imported, C4J69_21315Imported, CA593_16140Imported, D0X26_21250Imported, D3821_02010Imported, E2119_00870Imported, EAI52_06245Imported, EC3234A_43c00340Imported, EC3426_03292Imported, ECTO6_01718Imported, EEP23_14490Imported, EL75_1421Imported, EL79_1430Imported, EL80_1452Imported, NCTC13462_05379Imported, NCTC9062_01469Imported, RK56_005885Imported, SAMEA3472047_00739Imported, SAMEA3484427_01528Imported, SAMEA3484429_01333Imported, SAMEA3752559_01660Imported, SAMEA3753300_00164Imported, SK85_02462Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000237650 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000278449 Componenti: Unassembled WGS sequence
  • UP000236496 Componenti: Unassembled WGS sequence
  • UP000030018 Componenti: Unassembled WGS sequence
  • UP000294295 Componenti: Chromosome 1
  • UP000030000 Componenti: Unassembled WGS sequence
  • UP000188724 Componenti: Unassembled WGS sequence
  • UP000302965 Componenti: Unassembled WGS sequence
  • UP000070045 Componenti: Unassembled WGS sequence
  • UP000250448 Componenti: Unassembled WGS sequence
  • UP000297784 Componenti: Unassembled WGS sequence
  • UP000294318 Componenti: Chromosome 1
  • UP000250519 Componenti: Unassembled WGS sequence
  • UP000036012 Componenti: Unassembled WGS sequence
  • UP000301940 Componenti: Unassembled WGS sequence
  • UP000254480 Componenti: Unassembled WGS sequence
  • UP000186204 Componenti: Unassembled WGS sequence
  • UP000304027 Componenti: Unassembled WGS sequence
  • UP000258442 Componenti: Unassembled WGS sequence
  • UP000278742 Componenti: Unassembled WGS sequence
  • UP000050556 Componenti: Unassembled WGS sequence
  • UP000273648 Componenti: Unassembled WGS sequence
  • UP000250737 Componenti: Unassembled WGS sequence
  • UP000029988 Componenti: Unassembled WGS sequence
  • UP000259784 Componenti: Unassembled WGS sequence
  • UP000077380 Componenti: Unassembled WGS sequence
  • UP000194199 Componenti: Chromosome
  • UP000247477 Componenti: Chromosome
  • UP000279837 Componenti: Unassembled WGS sequence
  • UP000251336 Componenti: Unassembled WGS sequence
  • UP000268915 Componenti: Unassembled WGS sequence
  • UP000297636 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 213Fe2OG dioxygenaseInterPro annotationAdd BLAST101

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CF1 Bacteria
COG3145 LUCA

Database of Orthologous Groups

More...
OrthoDBi
1391445at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.590, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004574 Alkb
IPR027450 AlkB-like
IPR037151 AlkB-like_sf
IPR005123 Oxoglu/Fe-dep_dioxygenase

The PANTHER Classification System

More...
PANTHERi
PTHR16557 PTHR16557, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13532 2OG-FeII_Oxy_2, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00568 alkb, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51471 FE2OG_OXY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A037Y4V1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLDLFADAEP WQEPLAAGAV ILRRFAFNAA EQLIRDINDV ASQSPFRQMV
60 70 80 90 100
TPGGYTMSVA MTNCGHLGWT THRQGYLYSP IDPQTNKPWP AMPQSFHNLC
110 120 130 140 150
QRAATAAGYP DFQPDACLIN RYAPGAKLSL HQDKDEPDLR APIVSVSLGL
160 170 180 190 200
PAIFQFGGLK RNDPLKRLLL EHGDVVVWGG ESRLFYHGIQ PLKAGFHPLT
210
IDCRYNLTFR QAGKKE
Length:216
Mass (Da):24,076
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i494FE1E70EABD278
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP021175 Genomic DNA Translation: ARR34521.1
CP029741 Genomic DNA Translation: AWS61870.1
BFGA01000010 Genomic DNA Translation: GCO97907.1
BGAJ01000042 Genomic DNA Translation: GDK09284.1
BGAT01000054 Genomic DNA Translation: GDK83657.1
JPKH01000010 Genomic DNA Translation: KGM70468.1
JPKL01000027 Genomic DNA Translation: KGM82333.1
JPMZ01000010 Genomic DNA Translation: KGM83779.1
LEUM01000016 Genomic DNA Translation: KLX96048.1
LDYI01000093 Genomic DNA Translation: KPO11620.1
LOOZ01000009 Genomic DNA Translation: KXR92868.1
ROIZ01000044 Genomic DNA Translation: MGU40131.1
LCVH01000043 Genomic DNA Translation: OAC43621.1
MSEK01000091 Genomic DNA Translation: OLR86713.1
MTKH01000021 Genomic DNA Translation: ONG31386.1
JWSO02000009 Genomic DNA Translation: PNP00231.1
PSSV01000017 Genomic DNA Translation: PPI89833.1
QVOP01000026 Genomic DNA Translation: RFT86867.1
QZVZ01000002 Genomic DNA Translation: RJX96192.1
RDDG01000010 Genomic DNA Translation: RLX84608.1
UARY01000011 Genomic DNA Translation: SPW89395.1
UCZF01000001 Genomic DNA Translation: SQP83742.1
UDGC01000007 Genomic DNA Translation: SQY36302.1
UDGL01000006 Genomic DNA Translation: SQZ09962.1
UGBV01000003 Genomic DNA Translation: STH76259.1
UINO01000005 Genomic DNA Translation: SVF10959.1
UINP01000007 Genomic DNA Translation: SVF25417.1
LS992166 Genomic DNA Translation: SYX11558.1
LS992185 Genomic DNA Translation: SYX36616.1
SNTG01000001 Genomic DNA Translation: TEW35529.1
MTYA01000124 Genomic DNA Translation: TFA47431.1
UWVU01000001 Genomic DNA Translation: VCW51207.1
UWXQ01000001 Genomic DNA Translation: VCZ28568.1

NCBI Reference Sequences

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RefSeqi
WP_000884971.1, NZ_VIAN01000003.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AOT32126; AOT32126; FORC31_1663
KGM70468; KGM70468; EL75_1421
KGM82333; KGM82333; EL80_1452
KGM83779; KGM83779; EL79_1430
KLX96048; KLX96048; SK85_02462
KPO11620; KPO11620; ACU57_12965
KQJ17531; KQJ17531; AM266_05815
KXQ37504; KXQ37504; AUQ01_20260
OAC43621; OAC43621; EC3234A_43c00340

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|562.10493.peg.3434

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP021175 Genomic DNA Translation: ARR34521.1
CP029741 Genomic DNA Translation: AWS61870.1
BFGA01000010 Genomic DNA Translation: GCO97907.1
BGAJ01000042 Genomic DNA Translation: GDK09284.1
BGAT01000054 Genomic DNA Translation: GDK83657.1
JPKH01000010 Genomic DNA Translation: KGM70468.1
JPKL01000027 Genomic DNA Translation: KGM82333.1
JPMZ01000010 Genomic DNA Translation: KGM83779.1
LEUM01000016 Genomic DNA Translation: KLX96048.1
LDYI01000093 Genomic DNA Translation: KPO11620.1
LOOZ01000009 Genomic DNA Translation: KXR92868.1
ROIZ01000044 Genomic DNA Translation: MGU40131.1
LCVH01000043 Genomic DNA Translation: OAC43621.1
MSEK01000091 Genomic DNA Translation: OLR86713.1
MTKH01000021 Genomic DNA Translation: ONG31386.1
JWSO02000009 Genomic DNA Translation: PNP00231.1
PSSV01000017 Genomic DNA Translation: PPI89833.1
QVOP01000026 Genomic DNA Translation: RFT86867.1
QZVZ01000002 Genomic DNA Translation: RJX96192.1
RDDG01000010 Genomic DNA Translation: RLX84608.1
UARY01000011 Genomic DNA Translation: SPW89395.1
UCZF01000001 Genomic DNA Translation: SQP83742.1
UDGC01000007 Genomic DNA Translation: SQY36302.1
UDGL01000006 Genomic DNA Translation: SQZ09962.1
UGBV01000003 Genomic DNA Translation: STH76259.1
UINO01000005 Genomic DNA Translation: SVF10959.1
UINP01000007 Genomic DNA Translation: SVF25417.1
LS992166 Genomic DNA Translation: SYX11558.1
LS992185 Genomic DNA Translation: SYX36616.1
SNTG01000001 Genomic DNA Translation: TEW35529.1
MTYA01000124 Genomic DNA Translation: TFA47431.1
UWVU01000001 Genomic DNA Translation: VCW51207.1
UWXQ01000001 Genomic DNA Translation: VCZ28568.1
RefSeqiWP_000884971.1, NZ_VIAN01000003.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAOT32126; AOT32126; FORC31_1663
KGM70468; KGM70468; EL75_1421
KGM82333; KGM82333; EL80_1452
KGM83779; KGM83779; EL79_1430
KLX96048; KLX96048; SK85_02462
KPO11620; KPO11620; ACU57_12965
KQJ17531; KQJ17531; AM266_05815
KXQ37504; KXQ37504; AUQ01_20260
OAC43621; OAC43621; EC3234A_43c00340
PATRICifig|562.10493.peg.3434

Phylogenomic databases

eggNOGiENOG4105CF1 Bacteria
COG3145 LUCA
OrthoDBi1391445at2

Family and domain databases

Gene3Di2.60.120.590, 1 hit
InterProiView protein in InterPro
IPR004574 Alkb
IPR027450 AlkB-like
IPR037151 AlkB-like_sf
IPR005123 Oxoglu/Fe-dep_dioxygenase
PANTHERiPTHR16557 PTHR16557, 1 hit
PfamiView protein in Pfam
PF13532 2OG-FeII_Oxy_2, 1 hit
TIGRFAMsiTIGR00568 alkb, 1 hit
PROSITEiView protein in PROSITE
PS51471 FE2OG_OXY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A037Y4V1_ECOLX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A037Y4V1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 16, 2019
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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