Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 31 (16 Oct 2019)
Sequence version 1 (27 May 2015)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Collagen IV NC1 domain-containing protein

Gene

COL4A4

Organism
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen IV NC1 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL4A4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri60711 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000029965 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
60711.ENSCSAP00000003719

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1467 – 1692Collagen IV NC1InterPro annotationAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni61 – 173DisorderedSequence analysisAdd BLAST113
Regioni222 – 258DisorderedSequence analysisAdd BLAST37
Regioni367 – 390DisorderedSequence analysisAdd BLAST24
Regioni404 – 1459DisorderedSequence analysisAdd BLAST1056

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 79Pro-richSequence analysisAdd BLAST17
Compositional biasi531 – 545Pro-richSequence analysisAdd BLAST15
Compositional biasi614 – 644Pro-richSequence analysisAdd BLAST31
Compositional biasi877 – 911Pro-richSequence analysisAdd BLAST35
Compositional biasi1117 – 1131Pro-richSequence analysisAdd BLAST15
Compositional biasi1220 – 1243Pro-richSequence analysisAdd BLAST24
Compositional biasi1260 – 1280Pro-richSequence analysisAdd BLAST21
Compositional biasi1298 – 1314Pro-richSequence analysisAdd BLAST17
Compositional biasi1334 – 1377Pro-richSequence analysisAdd BLAST44

Keywords - Domaini

CollagenSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153991

KEGG Orthology (KO)

More...
KOi
K06237

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCNVTYP

Database of Orthologous Groups

More...
OrthoDBi
63831at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00111 C4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51403 NC1_IV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0D9R530-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLHVVLMR CSFRLTKSLA TGPWSLILIL FSVQYVYGSG KKYVGPCGGR
60 70 80 90 100
DCSVCHCVPE KGSRGPPGPP GPQGPIGPLG APGPTGLSGE KGMRGDRGPP
110 120 130 140 150
GAAGDKGDKG PTGVPGFPGL DGIPGHPGPP GPRGKPGKCG YNGSRGDPGF
160 170 180 190 200
PGGRGALGPG GPPGHPGEKG EKGNSVFILG AIKGIQGDRG DPGLPGLPGS
210 220 230 240 250
WGAGGPAGPA GYPGEPGLVG PPGQPGRPGL KGNPGVGVKG QMGDPGEVGQ
260 270 280 290 300
QGSPGPTLLV EPPDFCLYKG EKGIKGIPGM IGLPGPPGRK GESGIGAKGE
310 320 330 340 350
KGIPGFPGPW GDPGSYGSPG FPGLKGELGL VGDPGPFGFL GPKGDPGDRG
360 370 380 390 400
HPGPPGVLVT PPLPLKGPPG DPGFPGRYGE TGDVGPPGPP GLLGRPGEAC
410 420 430 440 450
AGMIGPPGPQ GFPGLPGLPG EAGIPGRPDS APGKPGKPGS PGLPGAPGLQ
460 470 480 490 500
GLPGSSVTYC SVGNPGPQGI KGKVGPPGGR GSKGEKGNEG LCACEPGPMG
510 520 530 540 550
PPGPPGLPGR QGSKGDLGLP GWLGTKGDPG PPGAEGPPGL PGKPGASGPP
560 570 580 590 600
GNKGAKGDVV ISRVKGHKGE RGPDGPPGFP GQPGSHGLDG RAGEKGDPGL
610 620 630 640 650
PGDHEDAIPG GKGFPGPLGP PGKAGPVGPP GLGFPGPPGE RGHPGVPGHP
660 670 680 690 700
GVRGPDGLKG QKGDTVSCNV TYPGRQGPPG FDGRPGPKGF PGPQGAPGLS
710 720 730 740 750
GSDGHKGRPG TPGTSEIPGP PGFRGDIGDP GFGGEKGSSP VGPPGPPGSP
760 770 780 790 800
GVNGQKGIPG DPAFGHLGPL GKRGLSGVPG IKGPRGDPGY PGAEGPAGIP
810 820 830 840 850
GFPGLKGPKG REGHAGFPGV PGPPGHSCER GAPGIPGQPG LPGDPGSPGA
860 870 880 890 900
PGGKGLPGDV GPPGPAGMKG LPGLPGRPGA HGPPGLPGIP GPFGDDGLPG
910 920 930 940 950
PPGPKGPRGL PGFPGFPGER GKPGAEGCPG TKGEPGEKGM SGFPGDRGVR
960 970 980 990 1000
GAKGAIGPPG DEGEMAIISK KGKPGEPGPP GDDGFPGERG DKGTPGMQGR
1010 1020 1030 1040 1050
RGEPGRYGPP GFHRGEPGEK GQPGPPGPPG PPGSTGLRGF IGFPGLPGDQ
1060 1070 1080 1090 1100
GEPGSPGPPG FSGIDGARGP KGNKGDPAPA SHFGPPGPKG EPGSSGCPGH
1110 1120 1130 1140 1150
FGASGEQGLP GVQGPRGSPG WPGPPGSSGP PGCPGDQGMP GLRGQPGEMG
1160 1170 1180 1190 1200
DPGPRGLQGD PGIPGPPGIK GPSGSPGLNG LHGLKGQKGT KGASGLHDVG
1210 1220 1230 1240 1250
PPGPVGMPGL KGERGDPGSP GISPPGPCGE QGLPGPPGRS GPPGPAGATG
1260 1270 1280 1290 1300
RAPKDIPDPG PSGDQGPPGP DGPRGAPGPP GLPGSVDLLR GEPGDCGLPG
1310 1320 1330 1340 1350
PPGLPGPPGP PGYKGFPGCD GKDGQKGPMG FPGPQGPHGF PGPPGEKGLP
1360 1370 1380 1390 1400
GPPGRKGPTG LPGPRGEPGP PADADDCPRI PGLPGVPGLR GPEGAMGLPG
1410 1420 1430 1440 1450
MRGPPGPGCK GEPGLDGRRG MDGIPGSPGP PGRKGDTGED GYPGGPGPPG
1460 1470 1480 1490 1500
PTGDPGPKGF GAGYLSGFLL VLHSQTDQEP TCPLGMPRLW TGYSLLYLEG
1510 1520 1530 1540 1550
QEKAHNQDLG LAGSCLPVFS TLPFAYCNIH QVCHYAQRND RSYWLASAAP
1560 1570 1580 1590 1600
LPMMPLSEEA IRPYVSRCAV CEAPAQAVAV HSQDQSIPPC PQTWRSLWIG
1610 1620 1630 1640 1650
YSFLMHTGAG DQGGGQALMS PGSCLEDFRA APFLECQGRQ GTCHFFANEY
1660 1670 1680 1690
SFWLTTVKAD LQFSPAPAPD TLKESQAQRQ KISRCQVCLK YS
Length:1,692
Mass (Da):164,310
Last modified:May 27, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FE91E8BEB08B19C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AQIB01002322 Genomic DNA No translation available.
AQIB01002323 Genomic DNA No translation available.
AQIB01002324 Genomic DNA No translation available.
AQIB01002325 Genomic DNA No translation available.
AQIB01002326 Genomic DNA No translation available.
AQIB01002327 Genomic DNA No translation available.
AQIB01002328 Genomic DNA No translation available.
AQIB01002329 Genomic DNA No translation available.
AQIB01002330 Genomic DNA No translation available.
AQIB01002331 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_007964687.1, XM_007966496.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCSAT00000005500; ENSCSAP00000003719; ENSCSAG00000007607

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103217992

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
csab:103217992

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIB01002322 Genomic DNA No translation available.
AQIB01002323 Genomic DNA No translation available.
AQIB01002324 Genomic DNA No translation available.
AQIB01002325 Genomic DNA No translation available.
AQIB01002326 Genomic DNA No translation available.
AQIB01002327 Genomic DNA No translation available.
AQIB01002328 Genomic DNA No translation available.
AQIB01002329 Genomic DNA No translation available.
AQIB01002330 Genomic DNA No translation available.
AQIB01002331 Genomic DNA No translation available.
RefSeqiXP_007964687.1, XM_007966496.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi60711.ENSCSAP00000003719

Genome annotation databases

EnsembliENSCSAT00000005500; ENSCSAP00000003719; ENSCSAG00000007607
GeneIDi103217992
KEGGicsab:103217992

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1286

Phylogenomic databases

GeneTreeiENSGT00940000153991
KOiK06237
OMAiSCNVTYP
OrthoDBi63831at2759

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 15 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0D9R530_CHLSB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0D9R530
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: October 16, 2019
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again