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Entry version 31 (18 Sep 2019)
Sequence version 1 (11 Nov 2015)
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Protein
Submitted name:

DiSHevelled related

Gene

dsh-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-201688 WNT mediated activation of DVL
R-CEL-2028269 Signaling by Hippo
R-CEL-4086400 PCP/CE pathway
R-CEL-4641258 Degradation of DVL
R-CEL-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-CEL-5099900 WNT5A-dependent internalization of FZD4
R-CEL-8856825 Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DiSHevelled relatedImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dsh-1Imported
ORF Names:C34F11.9Imported, CELE_C34F11.9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C34F11.9e ; CE50427 ; WBGene00001101 ; dsh-1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A0A0K3AUI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0K3AUI8 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0K3AUI8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini582 – 655PDZInterPro annotationAdd BLAST74
Domaini769 – 843DEPInterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 91DisorderedSequence analysisAdd BLAST91
Regioni104 – 193DisorderedSequence analysisAdd BLAST90
Regioni215 – 264DisorderedSequence analysisAdd BLAST50
Regioni287 – 327DisorderedSequence analysisAdd BLAST41
Regioni446 – 474DisorderedSequence analysisAdd BLAST29
Regioni516 – 566DisorderedSequence analysisAdd BLAST51
Regioni714 – 737DisorderedSequence analysisAdd BLAST24
Regioni910 – 961DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 75PolarSequence analysisAdd BLAST63
Compositional biasi122 – 153PolarSequence analysisAdd BLAST32
Compositional biasi160 – 174PolyampholyteSequence analysisAdd BLAST15
Compositional biasi177 – 193PolarSequence analysisAdd BLAST17
Compositional biasi222 – 238PolyampholyteSequence analysisAdd BLAST17
Compositional biasi249 – 264PolarSequence analysisAdd BLAST16
Compositional biasi287 – 314PolarSequence analysisAdd BLAST28
Compositional biasi455 – 469PolarSequence analysisAdd BLAST15
Compositional biasi516 – 535PolyampholyteSequence analysisAdd BLAST20
Compositional biasi547 – 561BasicSequence analysisAdd BLAST15
Compositional biasi914 – 936PolarSequence analysisAdd BLAST23

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182903

Database of Orthologous Groups

More...
OrthoDBi
1174829at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR008339 Dishevelled_fam
IPR015506 Dsh/Dvl-rel
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10878 PTHR10878, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 1 hit
PF00595 PDZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01760 DISHEVELLED

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A0K3AUI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIKLGARDR ALPSPSGSSN TPSTSSDMIR SLLFTSKERK VRSTYTAPPP
60 70 80 90 100
NRQHSPGVVS QLINKIELKT SPTNTSSRPK KKKKAPPLAK IDDLDLVDDE
110 120 130 140 150
KTIVSEVVKS PRRKKYTGNP LGNLKILNNI LPSSKASDDK ENSGSQQQPS
160 170 180 190 200
TGKKLKKSRS KSRVEPESEA PFRLKRTLTD LTNNHTPAGS TWRQMVSNAL
210 220 230 240 250
GGPLKKRLSE GALLFPGTSK ASDDCNDEEG DNTKTTTKRR FLQRRKQSEK
260 270 280 290 300
SAGGANGKES GGGSASSSFF GALIRLSHSA ASLTSLTSLG GSKSRSASPS
310 320 330 340 350
PSSSRSNTKE FKENLSPPQP PPPDLIAPAA ALARPTFSLA APDSPVSLAP
360 370 380 390 400
PSRELRKSKT CQITTDRPPI IPSITISESR SLNRIDRCRP VTVDGSGLSS
410 420 430 440 450
DCRPLVSRRS TMSRTMSLIP TSPSLPPLYE EETASTAAMV EEERADRAQK
460 470 480 490 500
RRMRRYGGSN TTSTYQGRKD VAPDASPRRH LIGFLHRTSH LSLTSELSAD
510 520 530 540 550
ASFYLIGHRR HLEESTIGSE SDARVFSDDD DRGSTTTDFT SVSRQHEKMA
560 570 580 590 600
KKKKNKRNFR KPSRASSFSS ITESSMSLDV ITVNLNMDTV NFLGISIVGQ
610 620 630 640 650
TSNCGDNGIY VANIMKGGAV ALDGRIEAGD MILQVNETSF ENFTNDQAVD
660 670 680 690 700
VLREAVSRRG PIKLTVAKSF ENGQSCFTIP RNSREEPVRP IDTQAWIQHT
710 720 730 740 750
NAMRGMPSIV EESAPTPIPG EWPHGRPPSS STVTSNGSNG QNTVVGGGAH
760 770 780 790 800
IILDIHTDKK KVVEIMAMPG SGLDIKNRTW LKIPIPMSFL GSDLVEWLLD
810 820 830 840 850
HVEGLRERKT ARNFAADLLK LKYIAHVVNK VTFTEQCYYV LGDECSDYAR
860 870 880 890 900
FRNEDGGPKY QWTIGMNGMS AGNGSSVMLP PPHLPGGMAG PPGAFKGMAP
910 920 930 940 950
SMVSGYASMP ASPFPPAQLQ QQRREGSTTS GSSGGGIRKQ RVVVLPRKPS
960 970 980
SSANVPFDDS STIYEESNNS FLMATGQRYE Y
Length:981
Mass (Da):106,469
Last modified:November 11, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6A7D5709959DDDA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2KZ17H2KZ17_CAEEL
DiSHevelled related
dsh-1 C34F11.9, CELE_C34F11.9
702Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1Q240B1Q240_CAEEL
DiSHevelled related
dsh-1 C34F11.9, CELE_C34F11.9
915Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7WN58B7WN58_CAEEL
DiSHevelled related
dsh-1 C34F11.9, CELE_C34F11.9
636Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AQZ1A0A0K3AQZ1_CAEEL
DiSHevelled related
dsh-1 C34F11.9, CELE_C34F11.9
506Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AWU4A0A0K3AWU4_CAEEL
DiSHevelled related
dsh-1 C34F11.9, CELE_C34F11.9
440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CTQ86460.1

NCBI Reference Sequences

More...
RefSeqi
NP_001300521.1, NM_001313592.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C34F11.9e.1; C34F11.9e.1; WBGene00001101

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
173894

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CTQ86460.1
RefSeqiNP_001300521.1, NM_001313592.1

3D structure databases

SMRiA0A0K3AUI8
ModBaseiSearch...

Proteomic databases

EPDiA0A0K3AUI8

Genome annotation databases

EnsemblMetazoaiC34F11.9e.1; C34F11.9e.1; WBGene00001101
GeneIDi173894

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
173894
WormBaseiC34F11.9e ; CE50427 ; WBGene00001101 ; dsh-1

Phylogenomic databases

GeneTreeiENSGT00950000182903
OrthoDBi1174829at2759

Enzyme and pathway databases

ReactomeiR-CEL-201688 WNT mediated activation of DVL
R-CEL-2028269 Signaling by Hippo
R-CEL-4086400 PCP/CE pathway
R-CEL-4641258 Degradation of DVL
R-CEL-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-CEL-5099900 WNT5A-dependent internalization of FZD4
R-CEL-8856825 Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828 Clathrin-mediated endocytosis

Gene expression databases

ExpressionAtlasiA0A0K3AUI8 baseline and differential

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR008339 Dishevelled_fam
IPR015506 Dsh/Dvl-rel
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR01760 DISHEVELLED
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0K3AUI8_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0K3AUI8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 11, 2015
Last sequence update: November 11, 2015
Last modified: September 18, 2019
This is version 31 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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