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Entry version 28 (16 Oct 2019)
Sequence version 1 (11 May 2016)
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Protein
Submitted name:

FERM and PDZ domain-containing 3

Gene

Frmpd3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FERM and PDZ domain-containing 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Frmpd3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3646547 Frmpd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A0A140LIW3, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A140LIW3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 98PDZInterPro annotationAdd BLAST78
Domaini147 – 461FERMInterPro annotationAdd BLAST315

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni490 – 519DisorderedSequence analysisAdd BLAST30
Regioni621 – 697DisorderedSequence analysisAdd BLAST77
Regioni832 – 870DisorderedSequence analysisAdd BLAST39
Regioni882 – 909DisorderedSequence analysisAdd BLAST28
Regioni971 – 1244DisorderedSequence analysisAdd BLAST274
Regioni1315 – 1350DisorderedSequence analysisAdd BLAST36
Regioni1718 – 1762DisorderedSequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1683 – 1703Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi502 – 519PolarSequence analysisAdd BLAST18
Compositional biasi675 – 692PolyampholyteSequence analysisAdd BLAST18
Compositional biasi833 – 847Pro-richSequence analysisAdd BLAST15
Compositional biasi1001 – 1015PolarSequence analysisAdd BLAST15
Compositional biasi1022 – 1051PolarSequence analysisAdd BLAST30
Compositional biasi1103 – 1127PolarSequence analysisAdd BLAST25
Compositional biasi1142 – 1197PolarSequence analysisAdd BLAST56
Compositional biasi1718 – 1736PolarSequence analysisAdd BLAST19
Compositional biasi1737 – 1751Pro-richSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183035

Identification of Orthologs from Complete Genome Data

More...
OMAi
QAYLLAH

Database of Orthologous Groups

More...
OrthoDBi
24326at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473 FERM_B-lobe, 1 hit
cd13183 FERM_C_FRMPD1_FRMPD3_FRMPD4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR041779 FRMPD1/3/4_FERM_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373 FERM_M, 1 hit
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295 B41, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A140LIW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEESANDME CVQLPAETLR QVTIHRDPIY GFGFVAGSER PVVVRSVRPG
60 70 80 90 100
GPSEDKLLAG DQIVAINEED VSEAPRERFI ELIRSAKESI VLTVLHTHQS
110 120 130 140 150
PKSAFISAAK KAKLRSNPVK VRFSEQVTIG ETDAKMMKKE ALLLIPNVLK
160 170 180 190 200
VFLENGQIKS FTFDGRTTVK DVMATLQDRL SLRSIEHFAL VLEYTGPEQN
210 220 230 240 250
HKFLILQDKQ PLAYVVQRTH YHGMKCLFRI SFFPKDPVEL LRRDPAAFEY
260 270 280 290 300
LYIQSRNDVI RERFGMEPKP EMLLGLAALH IYITVSATRP SQKITLKNVE
310 320 330 340 350
KEWGLEPFLP PSLLQGIKEK NLRKSLSQQL KAHQMHPSSS TKGSAIQAKL
360 370 380 390 400
QYLRILNELP TFTGVLFNTV GLDEKHSATT LLVGPRHGIS HVIDLKTNLT
410 420 430 440 450
TVLSEFSKIS KIQLFRENQG VARVETSIMD AKPLVLLMEW PEATNFACLI
460 470 480 490 500
AGYCRLLLDS RKMVFSRPAS QPLPPPMIKA DHMHSAHRPV TGGHLGKKES
510 520 530 540 550
SYVGSVGTSP RKSSRCTTPP ADSELVSFCY LHMREQRKEQ ESRTDVNENL
560 570 580 590 600
IFFEETRPRT KSDPTSKSSG QGYEVIPDDF DAASLDHEPC ASRARSYTLD
610 620 630 640 650
NSLGAEALNF YCDSCKVKLQ EQMGPRKGGR PGSSRDNMVD LMSLPPPGSE
660 670 680 690 700
EEEEEEDETT SLLPAIAAPP PGFRDNSSDE DDPKRRAVQS QEQGRHLRGL
710 720 730 740 750
LYDEIPVTLI DSVQTRTVRD HAQELDDALV STLQALEALA ASEDGPHPPP
760 770 780 790 800
PQTAGLIVLA TITPESSLDS GHETNSSELT DMSEMMSAMK QHQNTTYFLA
810 820 830 840 850
QHLNKDSLLA RKDLPFRIQS CAAQAVLTAP YALGPPDPNP SPQPAVTGQS
860 870 880 890 900
PAPTGARRKI PQSEVQVQGD RPYSLAVHPA LSPQLSEQKN LSLLPPVPED
910 920 930 940 950
RGPGHSRAGL EMSLRSATPS LSEEQVSELR ENLPKEVRLS PKLILDPKGN
960 970 980 990 1000
VTPAIISAAL QQVVHSKSLA TPGTALATPS NRGERRLEAS MGRPEVTMSR
1010 1020 1030 1040 1050
PEVSVMSSSV SKNLKFKMSP GAPETTRNSQ QQLGPEVSAS PRASTGSRAD
1060 1070 1080 1090 1100
NLHLSPPEDR FPVQSFPPKS YLSRVSRDSM GKQATGEVAG KGGPEGAKPP
1110 1120 1130 1140 1150
PNKQSVVSGQ GDKGQLESLS KSSKLEETSL VPRAGYPMAL QSPSCQPRSH
1160 1170 1180 1190 1200
SPSCQPRGPS PSSQSRGQSP SCQPRSQSPL RPLATSRQVS TMPSRKLETT
1210 1220 1230 1240 1250
LDGAHSASEG PTKPKSSRGP FRLRNLFSAT FPTRQKKETD ERQAQLQKVK
1260 1270 1280 1290 1300
QYELEFLEEL LKPPSQGELP GTEYLQPPAP GRCSCQLRSS PVQQGPGMSR
1310 1320 1330 1340 1350
EQRRSCDCKR ICRGGRPQAA QTPAPGLRER ERVPPTQRQP EAGPGLSLNS
1360 1370 1380 1390 1400
PINVQRIRST SLESRECRSD PESGVSCLTT CASGGECLGD PNYRKLMRHY
1410 1420 1430 1440 1450
SISELDQGDT VSLTSDVYPH PPLGMLPREV KEIESGFPVG LGPKSKCAES
1460 1470 1480 1490 1500
PTLGEPSYVQ VAPESKGPRQ MAVFSLPEEV YRRPADLDED SESSKCCSIR
1510 1520 1530 1540 1550
YCFYYRKCDM ADDASDGKDE LSYSIPMKIL PGMKLDEQVV PVVSRTLQVL
1560 1570 1580 1590 1600
DAATCSSSPE VPHTQEIDLR VSTFEGSLAK INALRAHAYG LPDGFLAARL
1610 1620 1630 1640 1650
DTNELLTVLR QCVASPEARA PKPYVSQISE YKLELALKFK ELRASCRRVA
1660 1670 1680 1690 1700
NVDKSPTHML AAITGSFQVL SSLIETFVRL VFIVRSEAQR QELLAKVEEV
1710 1720 1730 1740 1750
VRNYTFLLRA AEESTARNLN QQQQLQQQQQ QQQQQQQQPL PPPPLPAATG
1760 1770
HHPPDSPSST VMSTFTRSLK TLIK
Length:1,774
Mass (Da):195,349
Last modified:May 11, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43F49B3E1F17659F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL672297 Genomic DNA No translation available.
FQ790391 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001307875.1, NM_001320946.1
XP_017173990.1, XM_017318501.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000208130; ENSMUSP00000146983; ENSMUSG00000042425

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
245643

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:245643

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672297 Genomic DNA No translation available.
FQ790391 Genomic DNA No translation available.
RefSeqiNP_001307875.1, NM_001320946.1
XP_017173990.1, XM_017318501.1

3D structure databases

SMRiA0A140LIW3
ModBaseiSearch...

Protein-protein interaction databases

IntActiA0A140LIW3, 1 interactor

Genome annotation databases

EnsembliENSMUST00000208130; ENSMUSP00000146983; ENSMUSG00000042425
GeneIDi245643
KEGGimmu:245643

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84443
MGIiMGI:3646547 Frmpd3

Phylogenomic databases

GeneTreeiENSGT00950000183035
OMAiQAYLLAH
OrthoDBi24326at2759

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
cd13183 FERM_C_FRMPD1_FRMPD3_FRMPD4, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR041779 FRMPD1/3/4_FERM_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A140LIW3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A140LIW3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 11, 2016
Last sequence update: May 11, 2016
Last modified: October 16, 2019
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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