Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 27 (13 Nov 2019)
Sequence version 1 (30 Nov 2016)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Uncharacterized protein

Gene

TIAM2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorSAAS annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-193648 NRAGE signals death through JNK
R-GGA-194840 Rho GTPase cycle
R-GGA-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIAM2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini506 – 620PHInterPro annotationAdd BLAST115
Domaini811 – 884RBDInterPro annotationAdd BLAST74
Domaini893 – 979PDZInterPro annotationAdd BLAST87
Domaini1102 – 1296DHInterPro annotationAdd BLAST195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni210 – 247DisorderedSequence analysisAdd BLAST38
Regioni1022 – 1059DisorderedSequence analysisAdd BLAST38
Regioni1075 – 1098DisorderedSequence analysisAdd BLAST24
Regioni1503 – 1557DisorderedSequence analysisAdd BLAST55
Regioni1571 – 1590DisorderedSequence analysisAdd BLAST20
Regioni1597 – 1628DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili459 – 479Sequence analysisAdd BLAST21
Coiled coili670 – 690Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1022 – 1043PolarSequence analysisAdd BLAST22
Compositional biasi1044 – 1058PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1602 – 1628PolyampholyteSequence analysisAdd BLAST27

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157012

KEGG Orthology (KO)

More...
KOi
K16847

Database of Orthologous Groups

More...
OrthoDBi
34437at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR040655 TIAM1_CC-Ex

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF18385 Tiam_CC_Ex, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A1D5PML9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSESQYSL QGSKNHAAAS TGSKQKPCSL KIRSIHAKDE KSCSLHGWGH
60 70 80 90 100
TNSGSNYKSR SLARSCLSHF KSSQPYSARL SDTVVKASKS NVLAKHRTHT
110 120 130 140 150
SGDYCPGNNA VFLPDNGFHY IGLQAGSNHA APRDCNGHIL KCYGKNESLA
160 170 180 190 200
STSPSEDRRS PKVLIKTLGK LDGCLRVEFH NSSNSKVPTE ESSGPVQLLR
210 220 230 240 250
YSPTLESKSN NLLDVRRNSS ADCSSNHRLS PTDSRLRSSK GSSLSSESSW
260 270 280 290 300
YDSLWGNAGD ISELDGPYLT RSTPDTSIHA SFPASDKKSF NQSSSLSSLR
310 320 330 340 350
DLYKDTNLEG TPPPGIRLSD EYIDTHGSLS NRVSFASDID VPSRVEQGSP
360 370 380 390 400
AHYSSYTLPC RKSKPLAEDA SKKDTLKSRM RRISDWTGSL SRKKRKLQEP
410 420 430 440 450
KCKDGSEYFD SRMDNFSTDT LAPSQQSTLL WSPSSSHILS QRSESTNAVS
460 470 480 490 500
SDALRQNIYE NFMRELEMSR TNLENTETSS ETEDSSSESL SSLEQLDLLY
510 520 530 540 550
EKEQGVVRKA GWLFFKPLVT LQKEKKLELV TRRKWKQYWV TLKGCTLLFY
560 570 580 590 600
ETYGRNSMEQ SSLPRYALFA EDSIVQSVPE HPKKENVFCL SNSFGDVYLF
610 620 630 640 650
QATSQTDLEN WVTAIHSACA SLFAKKLGKE DTVRLLKNQT KSLFQKIDMD
660 670 680 690 700
SKMKKMAELQ LSIVSDPKNR KAIENQIQQW EQNLEKFNMD LFRMRCYLAS
710 720 730 740 750
LQGGELPNPK SLLAAASRPS KLALGRLGIF SVSSFHALIC SRDEAALRKR
760 770 780 790 800
TLSLSQRVRN KKGLFSSLKG LDTLARKGKE KRPSITQQVD EFLNVYCSVP
810 820 830 840 850
DSIQKENAWE TQTYVHFCDG QGVALTLKPD HRVEDVLSLA CKMKQLEPRN
860 870 880 890 900
YGLQLRRLVD ENTEYCAPEP YEYIVDQESV YDEIEICPLN VYHIHLTKTE
910 920 930 940 950
NITDFGFAVT AQVDENQHLT HIFVSDVLPD GLAYREGLRV GNEILSINGE
960 970 980 990 1000
SVSDLDLRQM ELLFSERSVM LTLRMSHCGN QQPLCASWSS DGDISRVPKS
1010 1020 1030 1040 1050
LLPPPNQSQL LEEFLDNFRK NTENDFNNVP DVTSSLKRSS TDGTLDQVPH
1060 1070 1080 1090 1100
REKTDPPFRS AEQISALCRN FQEVQTSSME GQKDNQDPPP RPLARHLSDA
1110 1120 1130 1140 1150
DRLRKVIQEL MDTEKSYVKD LSCLFELYLE PLQNETFLTQ DEMESLFGSL
1160 1170 1180 1190 1200
PEMLDFQKVF LETLEDGISS SSDFNTLETP SQFRKLLFSL GGSFLYYADH
1210 1220 1230 1240 1250
FKLYSGFCAN HIKVQKVLER AKTDSAFKAF LDARNPTKQH SSTLESYLIK
1260 1270 1280 1290 1300
PVQRVLKYPL LLKELVSLTD NESEEHYHLT EALKAMEKVA SHINEMQKIY
1310 1320 1330 1340 1350
EDYGTVFDQL VADQSGTEKE VTELSMGELL MHSTVSWLNP FPSLGKARKD
1360 1370 1380 1390 1400
LELTVFVFKR AVILVYKENY KLKKKMPTNV RAAHNYGDLD PFKFRWLIPL
1410 1420 1430 1440 1450
SALQVRLGNT AGTENSCIWE LIHTKSELEG RPETIFQLCS SDCENKTNIV
1460 1470 1480 1490 1500
KVIRSILREN FRRHIKCELP LDKTCKDRLI PLKNRVPATA KLASTRSLKV
1510 1520 1530 1540 1550
LKNSPSSEWN GDQGKGTFQD SDDCSLSSST QSSSCNTTES IQEPKTSSPD
1560 1570 1580 1590 1600
QHVQSCSSDF SNALVKESDI LSDDDDDDYQ SLKKGSPTKD IEIQFQRLKI
1610 1620 1630 1640 1650
SEEPSTDSER DQAAEKEEGD GFKMGEHPKL IRGHFCPVKR KVNSTKRNRG
1660 1670 1680 1690 1700
TLTAMQERHQ SLDSHSDAAN LDLNSILERE FSVQSLTSVV NEDCFYEAVE

RHGKS
Length:1,705
Mass (Da):192,314
Last modified:November 30, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95B8AB423036FA5A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000003 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001254464.1, NM_001267535.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000077643; ENSGALP00000054100; ENSGALG00000036005

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
421648

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:421648

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000003 Genomic DNA No translation available.
RefSeqiNP_001254464.1, NM_001267535.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSGALT00000077643; ENSGALP00000054100; ENSGALG00000036005
GeneIDi421648
KEGGigga:421648

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26230

Phylogenomic databases

GeneTreeiENSGT00940000157012
KOiK16847
OrthoDBi34437at2759

Enzyme and pathway databases

ReactomeiR-GGA-193648 NRAGE signals death through JNK
R-GGA-194840 Rho GTPase cycle
R-GGA-416482 G alpha (12/13) signalling events

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR003116 RBD_dom
IPR040655 TIAM1_CC-Ex
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF18385 Tiam_CC_Ex, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SM00455 RBD, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50898 RBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1D5PML9_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1D5PML9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 30, 2016
Last sequence update: November 30, 2016
Last modified: November 13, 2019
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again