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Entry version 18 (18 Sep 2019)
Sequence version 1 (18 Jan 2017)
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Protein

Agglutinin-like protein 9

Gene

ALS9

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections (PubMed:17510860, PubMed:22321066, PubMed:22429754). Allele ALS9-2 contributes to endothelial cell adhesion, whereas ALS9-1 does not (PubMed:17600078).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Virulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Agglutinin-like protein 9
Alternative name(s):
Adhesin 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ALS9
Synonyms:ALS11
Ordered Locus Names:CAALFM_C603710WA
ORF Names:orf19.13164, orf19.5742
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237561 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0000194750 ALS9

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:C6_03710W_A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043916818 – 1867Agglutinin-like protein 9Add BLAST1850
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00004391691868 – 1890Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi73 ↔ 150Combined sources1 Publication
Disulfide bondi96 ↔ 112Combined sources1 Publication
Disulfide bondi205 ↔ 297Combined sources1 Publication
Disulfide bondi226 ↔ 255Combined sources1 Publication
Glycosylationi1175N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1475N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1818N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1821N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1867GPI-anchor amidated aspartateSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated and O-glycosylated.
The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5476.C4YSD9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11890
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A1D8PQ86

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati400 – 431ALS 1Add BLAST32
Repeati437 – 468ALS 2Add BLAST32
Repeati473 – 504ALS 3Add BLAST32
Repeati509 – 540ALS 4Add BLAST32
Repeati545 – 576ALS 5Add BLAST32
Repeati581 – 612ALS 6Add BLAST32
Repeati617 – 648ALS 7Add BLAST32
Repeati653 – 684ALS 8Add BLAST32
Repeati689 – 720ALS 9Add BLAST32
Repeati725 – 756ALS 10Add BLAST32
Repeati761 – 792ALS 11Add BLAST32
Repeati797 – 828ALS 12Add BLAST32
Repeati833 – 864ALS 13Add BLAST32
Repeati869 – 900ALS 14Add BLAST32
Repeati905 – 936ALS 15Add BLAST32
Repeati941 – 972ALS 16Add BLAST32
Repeati977 – 1008ALS 17Add BLAST32
Repeati1013 – 1044ALS 18Add BLAST32
Repeati1049 – 1077ALS 19Add BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi329 – 1606Thr-richPROSITE-ProRule annotationAdd BLAST1278
Compositional biasi1092 – 1871Ser-richPROSITE-ProRule annotationAdd BLAST780

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each ALS protein has a similar three-domain structure, including a N-ter domain of 433-436 amino acids that is 55-90 percent identical across the family and which mediates adherence to various materials; a central domain of variable numbers of tandemly repeated copies of a 36 amino acid motif; and a C-ter; domain that is relatively variable in length and sequence across the family.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ALS family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K22493

Database of Orthologous Groups

More...
OrthoDBi
1428896at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1280, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008966 Adhesion_dom_sf
IPR008440 Agglutinin-like_ALS_rpt
IPR024672 Agglutinin-like_N
IPR033504 ALS
IPR011252 Fibrogen-bd_dom1

The PANTHER Classification System

More...
PANTHERi
PTHR33793 PTHR33793, 7 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05792 Candida_ALS, 19 hits
PF11766 Candida_ALS_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01056 Candida_ALS_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49401 SSF49401, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A0A1D8PQ86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPQFLLLLL YLTVSTAKTI TGVFNSFDSL TWTRSVEYVY KGPETPTWTA
60 70 80 90 100
VLGWSLNSTT ADAGDTFTLI MPCVFKFITS QTSVDLTADG VSYATCDFNA
110 120 130 140 150
GEEFTTFSSL SCTVNSVSVS YDKASGTVKL PITFNVGGTG SSVDLTDSKC
160 170 180 190 200
FTAGKNTVTF MDGDTKISTT VDFDASPVSP SGYITSSRII PSLNKASSLF
210 220 230 240 250
VSPQCENGYT SGIMGFVTSQ GATIDCSNIN IGISKGLNDW NFPVSSESFT
260 270 280 290 300
YTKTCSSSGI IVEYENVPAG YRPFVDAYIS SENVEQYTLT YANEYTCKNG
310 320 330 340 350
NTVVDPFTLT WWGYKNSEAD SNGDIIVVTT KTVTASTTAV TTLPFNPTVD
360 370 380 390 400
KTETIEVLQP IPTTTITTSY IGISTSYETF TATIGGTATV IVDTPYHITT
410 420 430 440 450
TVTTFWTGSV TTTTTYSNPT GSIDTVIVQI PSPDPTTTIT EFWSESFAST
460 470 480 490 500
TTVTNPPDGT NSVIIKEPYN PTVTTTEFWS ESFASTTTIT NPPDGTNSVI
510 520 530 540 550
VKEPYNPTVT TTEFWSESFA STTTVTNPPD GTNSVIIKEP YNPTVTTTEF
560 570 580 590 600
WSESFASTTT ITNPPDGTNS VIVKEPYNPT VTTTEFWSES FASTTTVTNP
610 620 630 640 650
PDGTNSVIIK EPYNPTVTTT EFWSESFAST TTITNPPDGT NSVIVKEPYN
660 670 680 690 700
PTVTTTEFWS ESFASTTTIT NPPDGTNSVI VKEPYNPTVT TTEFWSESFA
710 720 730 740 750
STTTITNPPD GTNSVIVKEP YNPTVTTTEF WSESFASTTT ITNPPDGTNS
760 770 780 790 800
VIVKEPYNPT VTTTEFWSES FASTTTVTNP PDGTNSVIVK EPYNPTVTTT
810 820 830 840 850
EFWSESFAST TTITNPPDGT NSVIVKEPYN PTVTTTEFWS ESFASTTTIT
860 870 880 890 900
NPPDGTNSVI VKEPYNPTVT TTEFWSESFA STTTITNPPD GTNSVIIKEP
910 920 930 940 950
YNPTVTTTEF WSESFASTTT ITNPPDGTNS VIIKEPYNPT VTTTEFWSES
960 970 980 990 1000
FASTTTVTNP PDGTNSVIIK EPYNPTVTTT EFWSESFAST TTVTNPPDGT
1010 1020 1030 1040 1050
NSVIIKEPYN PTVTTTEFWS ESFASTTTVT NPPDGTNSVI VKEPYNPTVT
1060 1070 1080 1090 1100
TTEFWSESFA STTTVTNPPD GTNSVIIKEP YNPTVTTTEF WSESFASTTP
1110 1120 1130 1140 1150
SVSSFESKTF YSSEAQSSLE IDSSNTFMTS ISVSTASSYD ESSTIVSSAF
1160 1170 1180 1190 1200
PTLHISSYSL STSFVPPVTL PRYVNTTISS SPSFESSSMY SSVTSAVTSI
1210 1220 1230 1240 1250
DNDREVPTST TTYLHSKLYS ESISTVIQTK SSDWSLSLGN SNKPESASTV
1260 1270 1280 1290 1300
SEESLHYLST PGPSSSEYSI SFTSEKEGHV SSYVPRVSYT SSVKVSISST
1310 1320 1330 1340 1350
MSSENGMSAT HTFGISTNTI PSSTETSIKS ATVTTPVSES TNTGMSIFMS
1360 1370 1380 1390 1400
TTTESKTTDI TTETSVSGEV NLGSATVKVS SSEFISKGTV TRIMPTELTN
1410 1420 1430 1440 1450
SESTFTASPS FVLTSTESSV IETPATIEMS SRSSSYSVPL SKLRSEGETT
1460 1470 1480 1490 1500
RVIPTSSTAT GSTVIGSPSS VSTSNESIIT GSSSFVSTTA ETISTRSIVT
1510 1520 1530 1540 1550
ESIVAGSPSL VLTTTVLDTT ETTITETSIV GESSSRSLTF KASSLSKGEI
1560 1570 1580 1590 1600
TGTVTPEMSV STSKATTGTT SEVSIKESLT TKVPTFTSTT IKPETSETQH
1610 1620 1630 1640 1650
SESRTTQIPY SETKGSQLST ANSQVSQTGS SKSSIFESAI SKDESTFVSA
1660 1670 1680 1690 1700
TVKSITTPAV TQYQTSLPNP AVSVSEESGK KSSIIESQTE NSATQHSIYF
1710 1720 1730 1740 1750
DSIETSTLSN TLANTLVSGA MKNSETTSEL TTSDKAIGFS TTTETSIPGA
1760 1770 1780 1790 1800
TNSALSPSVD SGKSSMLGWS GGIVSTVSTS TRLEDSTATS SSITAANQDS
1810 1820 1830 1840 1850
LNPSTVSKYP HGSETIDNGS NGSSHSSSAL ASTISASHSI KFSAHQTTLS
1860 1870 1880 1890
QSLISSSTKT VIASTYDGSG SVIKLHSWFY GLVTIFFLFI
Length:1,890
Mass (Da):201,290
Last modified:January 18, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E394E9A31CFF950
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti537I → V in AAP34370 (PubMed:14523127).Curated1
Sequence conflicti537I → V in AAP34371 (PubMed:14523127).Curated1
Sequence conflicti705I → V in AAP34370 (PubMed:14523127).Curated1
Sequence conflicti705I → V in AAP34371 (PubMed:14523127).Curated1
Sequence conflicti741I → V in AAP34370 (PubMed:14523127).Curated1
Sequence conflicti741I → V in AAP34371 (PubMed:14523127).Curated1
Sequence conflicti1886F → L in AAP34370 (PubMed:14523127).Curated1
Sequence conflicti1886F → L in AAP34371 (PubMed:14523127).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti6 – 11LLLLLY → ILLFIS in allele ALS9-2. 1 Publication6
Natural varianti28 – 42DSLTW…YVYKG → NSLTWANAANYGYQT in allele ALS9-1. 1 PublicationAdd BLAST15
Natural varianti39V → A in allele ALS9-2. 1 Publication1
Natural varianti49T → N in allele ALS9-2. 1 Publication1
Natural varianti63A → P in allele ALS9-2. 1 Publication1
Natural varianti71M → L in allele ALS9-2. 1 Publication1
Natural varianti80S → T in allele ALS9-2. 1 Publication1
Natural varianti122 – 124DKA → ARV in allele ALS9-2. 1 Publication3
Natural varianti132 – 133IT → FS in allele ALS9-1. 1 Publication2
Natural varianti146T → A in allele ALS9-2. 1 Publication1
Natural varianti161M → T in allele ALS9-1. 1 Publication1
Natural varianti166 – 190KISTT…SSRII → EISTSVDFQASPISSSGYIA SARVV in allele ALS9-1. 1 PublicationAdd BLAST25
Natural varianti196A → L in allele ALS9-2. 1 Publication1
Natural varianti202S → V in allele ALS9-2. 1 Publication1
Natural varianti218T → A in allele ALS9-2. 1 Publication1
Natural varianti220Q → N in allele ALS9-2. 1 Publication1
Natural varianti229I → V in allele ALS9-2. 1 Publication1
Natural varianti250T → S in allele ALS9-2. 1 Publication1
Natural varianti256 – 265SSSGIIVEYE → TSTSITVEFQ in allele ALS9-2. 1 Publication10
Natural varianti281 – 286SENVEQ → AENIDK in allele ALS9-2. 1 Publication6
Natural varianti298K → E in allele ALS9-2. 1 Publication1
Natural varianti312W → T in allele ALS9-1. 1 Publication1
Natural varianti322N → D in allele ALS9-2. 1 Publication1
Natural varianti325I → V in allele ALS9-2. 1 Publication1
Natural varianti331K → R in allele ALS9-2. 1 Publication1
Natural varianti335A → D in allele ALS9-2. 1 Publication1
Natural varianti348T → S in allele ALS9-2. 1 Publication1
Natural varianti357V → I in allele ALS9-2. 1 Publication1
Natural varianti371 – 374IGIS → VGVT in allele ALS9-1. 1 Publication4
Natural varianti380F → L in allele ALS9-2. 1 Publication1
Natural varianti382A → G in allele ALS9-2. 1 Publication1
Natural varianti400T → A in allele ALS9-2. 1 Publication1
Natural varianti404T → N in allele ALS9-2. 1 Publication1
Natural varianti410V → I in allele ALS9-2. 1 Publication1
Natural varianti417S → T in allele ALS9-2. 1 Publication1
Natural varianti423I → V in allele ALS9-1. 1 Publication1
Natural varianti429 – 470QIPSP…KEPYN → ELPSPA in allele ALS9-1. 1 PublicationAdd BLAST42
Natural varianti453V → I in allele ALS9-2. 1 Publication1
Natural varianti489I → V in allele ALS9-1. 1 Publication1
Natural varianti501V → I in allele ALS9-1. 1 Publication1
Natural varianti525V → I in allele ALS9-2. 1 Publication1
Natural varianti561I → V in allele ALS9-1. 1 Publication1
Natural varianti577Y → H in allele ALS9-2. 1 Publication1
Natural varianti607V → F in allele ALS9-1. 1 Publication1
Natural varianti609I → V in allele ALS9-1. 1 Publication1
Natural varianti633I → V in allele ALS9-1. 1 Publication1
Natural varianti645V → I in allele ALS9-1. 1 Publication1
Natural varianti669I → V in allele ALS9-1. 1 Publication1
Natural varianti679V → I in allele ALS9-1. 1 Publication1
Natural varianti682K → M in allele ALS9-1. 1 Publication1
Natural varianti685Y → F in allele ALS9-2. 1 Publication1
Natural varianti712T → R in allele ALS9-1. 1 Publication1
Natural varianti718K → M in allele ALS9-1. 1 Publication1
Natural varianti753V → I in allele ALS9-2. 1 Publication1
Natural varianti781P → L in allele ALS9-2. 1 Publication1
Natural varianti789 – 932Missing in allele ALS9-2. 1 PublicationAdd BLAST144
Natural varianti789V → I in allele ALS9-1. 1 Publication1
Natural varianti813I → V in allele ALS9-1. 1 Publication1
Natural varianti820T → R in allele ALS9-1. 1 Publication1
Natural varianti826K → M in allele ALS9-1. 1 Publication1
Natural varianti849I → V in allele ALS9-1. 1 Publication1
Natural varianti882T → S in allele ALS9-1. 1 Publication1
Natural varianti885I → V in allele ALS9-1. 1 Publication1
Natural varianti921I → V in allele ALS9-1. 1 Publication1
Natural varianti944T → N in allele ALS9-2. 1 Publication1
Natural varianti948S → Y in allele ALS9-2. 1 Publication1
Natural varianti993V → I in allele ALS9-2. 1 Publication1
Natural varianti1029V → I in allele ALS9-2. 1 Publication1
Natural varianti1045Y → H in allele ALS9-2. 1 Publication1
Natural varianti1065V → I in allele ALS9-2. 1 Publication1
Natural varianti1077I → V in allele ALS9-2. 1 Publication1
Natural varianti1081Y → H in allele ALS9-2. 1 Publication1
Natural varianti1108 – 1134KTFYS…SISVS → TIFHSSEPHYSSDFDSSDSF VTLISVT in allele ALS9-2. 1 PublicationAdd BLAST27
Natural varianti1149A → T in allele ALS9-2. 1 Publication1
Natural varianti1155 – 1164ISSYSLSTSF → LSSYTWSSGL in allele ALS9-2. 1 Publication10
Natural varianti1170L → F in allele ALS9-2. 1 Publication1
Natural varianti1180 – 1183SSPS → NLPT in allele ALS9-2. 1 Publication4
Natural varianti1189 – 1227MYSSV…ISTVI → VYSSTASAVASTDGDSVVPS STNLVTQSISSSETYCIDIS GCSSVRQSSSVMVTPSNSGR IIISDSAYLTTTYSHSESDL ESIVTVV in allele ALS9-2. 1 PublicationAdd BLAST39
Natural varianti1238L → S in allele ALS9-2. 1 Publication1
Natural varianti1242N → D in allele ALS9-2. 1 Publication1
Natural varianti1248 – 1257STVSEESLHY → TTVSDDNSYS in allele ALS9-2. 1 Publication10
Natural varianti1301M → V in allele ALS9-2. 1 Publication1
Natural varianti1308S → N in allele ALS9-2. 1 Publication1
Natural varianti1429M → L in allele ALS9-2. 1 Publication1
Natural varianti1488T → TTAESIATKTIVSETPVTKV LSSKSLAANASPSEPTSKKE in allele ALS9-2. 1 Publication1
Natural varianti1799D → G in allele ALS9-2. 1 Publication1
Natural varianti1859K → N in allele ALS9-2. 1 Publication1
Natural varianti1861V → I in allele ALS9-2. 1 Publication1
Natural varianti1875L → H in allele ALS9-2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY269422 Genomic DNA Translation: AAP34370.1
AY269423 Genomic DNA Translation: AAP34371.1
CP017628 Genomic DNA Translation: AOW30298.1

NCBI Reference Sequences

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RefSeqi
XP_718078.2, XM_712985.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
3640281

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cal:CAALFM_C603710WA

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY269422 Genomic DNA Translation: AAP34370.1
AY269423 Genomic DNA Translation: AAP34371.1
CP017628 Genomic DNA Translation: AOW30298.1
RefSeqiXP_718078.2, XM_712985.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y7LX-ray1.49A18-328[»]
2Y7MX-ray1.98A18-328[»]
2Y7NX-ray2.00A18-328[»]
2Y7OX-ray1.75A18-328[»]
2YLHX-ray1.70A18-328[»]
SMRiA0A1D8PQ86
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi5476.C4YSD9

Genome annotation databases

GeneIDi3640281
KEGGical:CAALFM_C603710WA

Organism-specific databases

CGDiCAL0000194750 ALS9
EuPathDBiFungiDB:C6_03710W_A

Phylogenomic databases

KOiK22493
OrthoDBi1428896at2759

Family and domain databases

Gene3Di2.60.40.1280, 1 hit
InterProiView protein in InterPro
IPR008966 Adhesion_dom_sf
IPR008440 Agglutinin-like_ALS_rpt
IPR024672 Agglutinin-like_N
IPR033504 ALS
IPR011252 Fibrogen-bd_dom1
PANTHERiPTHR33793 PTHR33793, 7 hits
PfamiView protein in Pfam
PF05792 Candida_ALS, 19 hits
PF11766 Candida_ALS_N, 1 hit
SMARTiView protein in SMART
SM01056 Candida_ALS_N, 1 hit
SUPFAMiSSF49401 SSF49401, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALS9_CANAL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1D8PQ86
Secondary accession number(s): Q7ZA78, Q7ZA79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: January 18, 2017
Last modified: September 18, 2019
This is version 18 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Candida albicans
    Candida albicans: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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