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Entry version 13 (31 Jul 2019)
Sequence version 1 (12 Apr 2017)
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Protein
Submitted name:

astrotactin-2 isoform X1

Gene

ASTN2

Organism
Erinaceus europaeus (Western European hedgehog)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
astrotactin-2 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASTN2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiErinaceus europaeus (Western European hedgehog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9365 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaEulipotyphlaErinaceidaeErinaceinaeErinaceus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000079721 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei220 – 245HelicalSequence analysisAdd BLAST26
Transmembranei445 – 464HelicalSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 48Sequence analysisAdd BLAST48
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501035650449 – 1353Sequence analysisAdd BLAST1305

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9365.XP_007521997.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini865 – 1049MACPFInterPro annotationAdd BLAST185

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni85 – 108DisorderedSequence analysisAdd BLAST24
Regioni312 – 360DisorderedSequence analysisAdd BLAST49
Regioni379 – 422DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi92 – 108PolarSequence analysisAdd BLAST17
Compositional biasi315 – 333PolyampholyteSequence analysisAdd BLAST19
Compositional biasi341 – 359PolyampholyteSequence analysisAdd BLAST19
Compositional biasi407 – 422PolarSequence analysisAdd BLAST16

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
39300at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040685 Annexin-like
IPR040510 ASTN_2_hairpin
IPR026995 Astrotactin
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR020864 MACPF

The PANTHER Classification System

More...
PANTHERi
PTHR16592 PTHR16592, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18411 Annexin_like, 1 hit
PF18577 ASTN_2_hairpin, 1 hit
PF01823 MACPF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00457 MACPF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A1S2ZN83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGARRCP GPSSGLGGRL RLGFHTAPPP PPPPLLLFLL LLPPPLLAGA
60 70 80 90 100
TAAAAASREP DSPCRLKTVT VSTLPALRES DIGWSGARAG AGTGTGTGTG
110 120 130 140 150
TGTGTGTAAG AAASAAAAAS PGSAGFAGTA AESRLLLFVR NELPGRIAVQ
160 170 180 190 200
DDLDNTELPF FTLEMSGTAA DISLVHWRQQ WLENGTLYFH VSMSSSGQLA
210 220 230 240 250
RATAPTLQEP SEIVEEQMHI LHISVMGGLI ALLLLMLVFT VALYAQRRWQ
260 270 280 290 300
KRRRIPQKSA STEATHEIHY IPSVLLGPQA RESFRSSRLQ AHNSVIGVPI
310 320 330 340 350
RETPILDDYD YEEDEEPPRR ANHVSREDEF GSQVTHTLDS LGRSGEDKGD
360 370 380 390 400
FEKKAAAEAT QETVESLMQK FKESFRANTP IEIGQLQPAP RSTLKRKRRS
410 420 430 440 450
KSRGGISFGR SKGTSGSEAD DETQLTFYTE QYRSRRRSKG LLKSPVNKTA
460 470 480 490 500
LTLIAVSSCI LAMVCGSQMS CPLTVKVTLH VPEHFIADGS SFVVSEGSYL
510 520 530 540 550
DISDWLNPAK LSLYYQINAT SPWVRDLCGQ RTTDACEQLC DPETGECSCH
560 570 580 590 600
EGFAPDPVHK HLCVRSDWGQ SEGPWPYTTL ERGYDLVTGE QAPEKILRST
610 620 630 640 650
FSLGQGLWLP VSKSFVVPPV ELSINPLASC KTDVLVTEDP ADVREEAMLS
660 670 680 690 700
TYFETINDLL SSFGPVRDCS RNNGGCTRNF KCVSDRQVDS SGCVCPEELR
710 720 730 740 750
PMKDGSGCYD HSKGIDCSDG FNGGCEQLCL QQTLPLPYDT TSSTIFMFCG
760 770 780 790 800
CVEEYKLASD GKSCLMLSDV CEGPKCLKSG SKFNDTLFGE MLHGYNNRTQ
810 820 830 840 850
HVNQGQVFQM TFRENNFIKD FPQLADGLLV IPLPVEEQCR GVLSEPLPDL
860 870 880 890 900
QLLTGDIRYD EAMGYPMVQQ WRVRSNLYRV KLSTITLSAA FTNVLKILTK
910 920 930 940 950
ESSREELLSF IQHYGSHYIA EALYGSELTC IIHFPSKKVQ QQLWLQYQKE
960 970 980 990 1000
TTELGSKKEL KSMPFITYLS GLLTAQMLSD DQLISGVEIR CEEKGRCPST
1010 1020 1030 1040 1050
CHLCRRPGKE QLSPTPVLLE INRVIPLYTL IQDNGTKQAF KNALMSSYWC
1060 1070 1080 1090 1100
SGKGDVIDDW CRCDLSAFDA SGLPNCSPLP QPVLRLSPTV EPSSTVVSLE
1110 1120 1130 1140 1150
WVDVQPAIGT KVSDYILQHK KVDEYTDTDL YTGEFLSFAD DLLSGLGTSC
1160 1170 1180 1190 1200
VAAGRSHGEV PEVSIYSVIF KCLEPDGLYK FTLYAVDTRG RHSELSTVTL
1210 1220 1230 1240 1250
RTACPLVDDN KAEEIADKIY NLYNGYTSGK EQQTAYNTLM EVSASMLFRV
1260 1270 1280 1290 1300
QHHYNSHYEK FGDFVWRSED ELGPRKAHLI LRRLERVSSH CSNLLRSAYI
1310 1320 1330 1340 1350
QSRVDTTPYL FCRSEEVRPA GMVWYSILKD TKITCEEKMV SMARNTYGES

KGR
Length:1,353
Mass (Da):149,323
Last modified:April 12, 2017 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EFF582FF9F8EE6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1S2ZNA4A0A1S2ZNA4_ERIEU
astrotactin-2 isoform X2
ASTN2
1,304Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1S3W9R8A0A1S3W9R8_ERIEU
astrotactin-2 isoform X3
ASTN2
1,349Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_007521997.1, XM_007521935.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103112502

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_007521997.1, XM_007521935.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9365.XP_007521997.1

Genome annotation databases

GeneIDi103112502

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23245

Phylogenomic databases

OrthoDBi39300at2759

Family and domain databases

CDDicd00063 FN3, 1 hit
InterProiView protein in InterPro
IPR040685 Annexin-like
IPR040510 ASTN_2_hairpin
IPR026995 Astrotactin
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR020864 MACPF
PANTHERiPTHR16592 PTHR16592, 1 hit
PfamiView protein in Pfam
PF18411 Annexin_like, 1 hit
PF18577 ASTN_2_hairpin, 1 hit
PF01823 MACPF, 1 hit
SMARTiView protein in SMART
SM00457 MACPF, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A1S2ZN83_ERIEU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A1S2ZN83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2017
Last sequence update: April 12, 2017
Last modified: July 31, 2019
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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