@base <http://purl.uniprot.org/uniprot/> .
@prefix annotation: <http://purl.uniprot.org/annotation/> .
@prefix citation: <http://purl.uniprot.org/citations/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix disease: <http://purl.uniprot.org/diseases/> .
@prefix ECO: <http://purl.obolibrary.org/obo/ECO_> .
@prefix enzyme: <http://purl.uniprot.org/enzyme/> .
@prefix faldo: <http://biohackathon.org/resource/faldo#> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix go: <http://purl.obolibrary.org/obo/GO_> .
@prefix isoform: <http://purl.uniprot.org/isoforms/> .
@prefix keyword: <http://purl.uniprot.org/keywords/> .
@prefix location: <http://purl.uniprot.org/locations/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix position: <http://purl.uniprot.org/position/> .
@prefix pubmed: <http://purl.uniprot.org/pubmed/> .
@prefix range: <http://purl.uniprot.org/range/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix taxon: <http://purl.uniprot.org/taxonomy/> .
@prefix tissue: <http://purl.uniprot.org/tissues/> .
@prefix up: <http://purl.uniprot.org/core/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
<A0A221KMD8> rdf:type up:Protein ;
  up:reviewed false ;
  up:created "2017-10-25"^^xsd:date ;
  up:modified "2024-01-24"^^xsd:date ;
  up:version 32 ;
  up:mnemonic "A0A221KMD8_9INFA" ;
  up:citation citation:SIPBD3AB8C6EF72E862 ;
  rdfs:seeAlso <http://purl.uniprot.org/embl-cds/ASM80232.1> ,
    <http://purl.uniprot.org/glycosmos/A0A221KMD8> ,
    <http://purl.uniprot.org/gene3d/6.10.250.1640> ,
    <http://purl.uniprot.org/hamap/MF_04069> ,
    <http://purl.uniprot.org/interpro/IPR002089> ,
    <http://purl.uniprot.org/pfam/PF00599> ;
  up:recommendedName <A0A221KMD8#SIP6AC56F8EB5A9FD70> ;
  up:alternativeName <A0A221KMD8#SIP957F0FF8D34DAF04> ;
  up:organism taxon:2018269 ;
  up:encodedBy <A0A221KMD8#gene-MD59E5B4AB0E705D30C37BC3AA71E767526> ;
  up:annotation <A0A221KMD8#SIP5FB62C9A71E12F10> ,
    <A0A221KMD8#SIPC8D13FA18A6F3C14> ,
    <A0A221KMD8#SIP471798C392B1AD7B> ,
    <A0A221KMD8#SIP32F0BC45B31C5C87> ,
    <A0A221KMD8#SIP6099C3B7A0F26F86> ,
    <A0A221KMD8#SIP56FD7E16888E8E14> ,
    <A0A221KMD8#SIP3A26B3018204A9DB> ,
    <A0A221KMD8#SIP7B3C65C3D846D8AC> ,
    <A0A221KMD8#SIP306245F4C453826A> ,
    <A0A221KMD8#SIP61FBA7C70E58DF76> ,
    <A0A221KMD8#SIPCEDB72E044171A37> ,
    <A0A221KMD8#SIP37136496028F9F0B> ,
    <A0A221KMD8#SIPC53BA8369A8ED3F9> ,
    <A0A221KMD8#SIP54F408E0BDA09DD9> ,
    <A0A221KMD8#SIP0EDBC825EF3318E8> ,
    <A0A221KMD8#SIPCA395F325904C5F7> ,
    <A0A221KMD8#SIPF1750740405DDAF6> ,
    <A0A221KMD8#SIP9D6E850A39DD3229> ,
    <A0A221KMD8#SIP4CAFFF132185FAAC> ,
    <A0A221KMD8#SIP99E0CD5C47F23C66> ,
    <A0A221KMD8#SIP86BC08437FB68363> ;
  up:existence up:Inferred_from_Homology_Existence ;
  up:classifiedWith keyword:1015 ,
    keyword:325 ,
    keyword:1032 ,
    keyword:375 ,
    keyword:1083 ,
    keyword:564 ,
    keyword:597 ,
    keyword:735 ,
    keyword:1133 ,
    keyword:1182 ,
    keyword:946 ,
    go:0020002 ,
    go:0016020 ,
    go:0055036 ,
    go:0005216 ,
    go:0015078 ,
    go:0051259 ,
    go:0039521 ,
    go:0039707 ;
  up:sequence isoform:A0A221KMD8-1 ;
  up:attribution <A0A221KMD8#attribution-0CACA73AD6FA5FC8FF131F2C26F5E326> ,
    <A0A221KMD8#attribution-8AEC0CC661531CFE2FAE4F290FCF9B78> ,
    <A0A221KMD8#attribution-5BBC0B62EE6EC5E156144B6F61C637A9> ,
    <A0A221KMD8#attribution-85DC3F584DAB97A5D185E2BCED91C893> ,
    <A0A221KMD8#attribution-5001A9F5DD25D4C5E0ACF9676EAEAF81> ,
    <A0A221KMD8#attribution-AD40D0414E09A087388C0ADFF0E35A84> ,
    <A0A221KMD8#attribution-E57DD1D8DBDB83C7A66A32FC16864DF1> ,
    <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> ,
    <A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> ,
    <A0A221KMD8#attribution-260F9275F08C92D1CF2D41553CB78263> ,
    <A0A221KMD8#attribution-E81E3CD13273E6C639C0CE448CF71E78> ,
    <A0A221KMD8#attribution-C6CCD48C8D266B9E80AAF5C54CBE2DDE> .
citation:SIPBD3AB8C6EF72E862 rdf:type up:Submission_Citation ;
  up:title "Characterization of influenza A/H3N2 viruses for pediatric inpatients in South Korea during winter 2011-2012." ;
  up:author "Kim J.-K." ,
    "Song E.-J." ;
  up:date "2017-07"^^xsd:gYearMonth ;
  up:submittedTo "EMBL/GenBank/DDBJ" .
<#_A0A221KMD8-citation-SIPBD3AB8C6EF72E862> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:citation ;
  rdf:object citation:SIPBD3AB8C6EF72E862 ;
  rdf:type up:Citation_Statement ;
  up:scope "NUCLEOTIDE SEQUENCE" ;
  up:context <A0A221KMD8#context-MD568EBD3311AD528B859A0F425563C41AA> ;
  up:attribution <A0A221KMD8#attribution-C6CCD48C8D266B9E80AAF5C54CBE2DDE> .
<A0A221KMD8#context-MD568EBD3311AD528B859A0F425563C41AA> rdf:type up:Strain ;
  rdfs:label "A/Korea/KUMC-GR121/2011" .
<#_2EA2DF1CD5BA9CFB_up.context_4A3686C847CFE95D> rdf:type rdf:Statement ;
  rdf:subject <#_A0A221KMD8-citation-SIPBD3AB8C6EF72E862> ;
  rdf:predicate up:context ;
  rdf:object <A0A221KMD8#context-MD568EBD3311AD528B859A0F425563C41AA> ;
  up:attribution <A0A221KMD8#attribution-C6CCD48C8D266B9E80AAF5C54CBE2DDE> .
<http://purl.uniprot.org/embl-cds/ASM80232.1> rdf:type up:Nucleotide_Resource ;
  up:database <http://purl.uniprot.org/database/EMBL> ;
  up:locatedOn <http://purl.uniprot.org/embl/MF441153> .
<http://purl.uniprot.org/embl/MF441153> rdf:type up:Viral_cRNA .
<http://purl.uniprot.org/glycosmos/A0A221KMD8> rdf:type up:Resource ;
  up:database <http://purl.uniprot.org/database/GlyCosmos> ;
  rdfs:comment "1 site, No reported glycans" .
<http://purl.uniprot.org/gene3d/6.10.250.1640> rdf:type up:Resource ;
  up:database <http://purl.uniprot.org/database/Gene3D> ;
  up:signatureSequenceMatch <http://purl.uniprot.org/isoforms/A0A221KMD8-1#Gene3D_6.10.250.1640_match_1> .
<http://purl.uniprot.org/hamap/MF_04069> rdf:type up:Resource ;
  up:database <http://purl.uniprot.org/database/HAMAP> ;
  rdfs:comment "INFV_M2" ;
  up:signatureSequenceMatch <http://purl.uniprot.org/isoforms/A0A221KMD8-1#HAMAP_MF_04069_match_1> .
<http://purl.uniprot.org/interpro/IPR002089> rdf:type up:Resource ;
  up:database <http://purl.uniprot.org/database/InterPro> ;
  rdfs:comment "Flu_M2" .
<http://purl.uniprot.org/pfam/PF00599> rdf:type up:Resource ;
  up:database <http://purl.uniprot.org/database/Pfam> ;
  rdfs:comment "Flu_M2" ;
  up:signatureSequenceMatch <http://purl.uniprot.org/isoforms/A0A221KMD8-1#Pfam_PF00599_match_1> .
<A0A221KMD8#SIP6AC56F8EB5A9FD70> rdf:type up:Structured_Name ;
  up:fullName "Matrix protein 2" .
<#_EFC6AECB69E54E0D_up.fullName_B6AAB8915966A7BC> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP6AC56F8EB5A9FD70> ;
  rdf:predicate up:fullName ;
  rdf:object "Matrix protein 2" ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> ,
    <A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> .
<A0A221KMD8#SIP957F0FF8D34DAF04> rdf:type up:Structured_Name ;
  up:fullName "Proton channel protein M2" .
<#_2626E79C6205C9F4_up.fullName_A6399CEAF9A36754> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP957F0FF8D34DAF04> ;
  rdf:predicate up:fullName ;
  rdf:object "Proton channel protein M2" ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.organism_49AE2CA834AFB3D9> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:organism ;
  rdf:object taxon:2018269 ;
  up:attribution <A0A221KMD8#attribution-C6CCD48C8D266B9E80AAF5C54CBE2DDE> .
<A0A221KMD8#gene-MD59E5B4AB0E705D30C37BC3AA71E767526> rdf:type up:Gene ;
  skos:prefLabel "M2" ;
  skos:altLabel "M" .
<#_1E5699EFB772B615_FFA56BCD0169E5A3_M2> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#gene-MD59E5B4AB0E705D30C37BC3AA71E767526> ;
  rdf:predicate skos:prefLabel ;
  rdf:object "M2" ;
  up:attribution <A0A221KMD8#attribution-C6CCD48C8D266B9E80AAF5C54CBE2DDE> .
<#_1E5699EFB772B615_6787AFEE56800A4A_M> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#gene-MD59E5B4AB0E705D30C37BC3AA71E767526> ;
  rdf:predicate skos:altLabel ;
  rdf:object "M" ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP5FB62C9A71E12F10> rdf:type up:Function_Annotation ;
  rdfs:comment "Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation." .
<#_2E3854661EF9F669_rdfs.comment_6372E349138FDD77> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP5FB62C9A71E12F10> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation." ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIPC8D13FA18A6F3C14> rdf:type up:Activity_Regulation_Annotation ;
  rdfs:comment "The M2 protein from most influenza A strains is inhibited by amantadine and rimantadine, resulting in viral uncoating incapacity. Emergence of amantadine-resistant variants is usually rapid." .
<#_81120904F123AC5D_rdfs.comment_5ED09A8425C9E0BB> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIPC8D13FA18A6F3C14> ;
  rdf:predicate rdfs:comment ;
  rdf:object "The M2 protein from most influenza A strains is inhibited by amantadine and rimantadine, resulting in viral uncoating incapacity. Emergence of amantadine-resistant variants is usually rapid." ;
  up:attribution <A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> .
<A0A221KMD8#SIP471798C392B1AD7B> rdf:type up:Subunit_Annotation ;
  rdfs:comment "Homotetramer; composed of two disulfide-linked dimers held together by non-covalent interactions. May interact with matrix protein 1." .
<#_C4F41DC14139DAC4_rdfs.comment_4DDE34CFC5C31106> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP471798C392B1AD7B> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Homotetramer; composed of two disulfide-linked dimers held together by non-covalent interactions. May interact with matrix protein 1." ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> ,
    <A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> .
<A0A221KMD8#SIP32F0BC45B31C5C87> rdf:type up:Subcellular_Location_Annotation ;
  rdfs:comment "Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion)." ;
  up:locatedIn <A0A221KMD8#SIP201D0F8B0DB3ED5C> ,
    <A0A221KMD8#SIP4B3B08F71C80DB8E> .
<#_B3FA4C03C8489E11_rdfs.comment_626F7C95724EE8BD> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP32F0BC45B31C5C87> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion)." ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP201D0F8B0DB3ED5C> up:cellularComponent location:275 .
<#_09CCBFC21E9C99E3_ECA11A063956BBD5_64F8C7C5EADACE63> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP201D0F8B0DB3ED5C> ;
  rdf:predicate up:cellularComponent ;
  rdf:object location:275 ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP4B3B08F71C80DB8E> up:cellularComponent location:372 ;
  up:topology location:9907 .
<#_BCE5806AFFCD84F0_ECA11A063956BBD5_ED35D530EAF8F111> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP4B3B08F71C80DB8E> ;
  rdf:predicate up:cellularComponent ;
  rdf:object location:372 ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_BCE5806AFFCD84F0_up.topology_8A01B222B2B6A3F9> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP4B3B08F71C80DB8E> ;
  rdf:predicate up:topology ;
  rdf:object location:9907 ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP6099C3B7A0F26F86> rdf:type up:Domain_Annotation ;
  rdfs:comment "Cytoplasmic tail plays an important role in virion assembly and morphogenesis." .
<#_A7B1D335FAA59441_rdfs.comment_89FD146357891E51> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP6099C3B7A0F26F86> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Cytoplasmic tail plays an important role in virion assembly and morphogenesis." ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> ,
    <A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> .
<A0A221KMD8#SIP56FD7E16888E8E14> rdf:type up:Annotation ;
  rdfs:comment "When the channel is activated, one or more imidazole moities of His-37 probably become bi-protonated." .
<#_869CBC657A806617_rdfs.comment_82B1B46B5DCFEE83> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP56FD7E16888E8E14> ;
  rdf:predicate rdfs:comment ;
  rdf:object "When the channel is activated, one or more imidazole moities of His-37 probably become bi-protonated." ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP3A26B3018204A9DB> rdf:type up:Similarity_Annotation ;
  rdfs:comment "Belongs to the influenza viruses matrix protein M2 family." .
<#_A488C8281C4ED677_rdfs.comment_49E2A1F8DCD95EC9> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP3A26B3018204A9DB> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Belongs to the influenza viruses matrix protein M2 family." ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> ,
    <A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> .
<A0A221KMD8#SIP7B3C65C3D846D8AC> rdf:type up:Caution_Annotation ;
  rdfs:comment "Lacks conserved residue(s) required for the propagation of feature annotation." .
<#_0904F3F3BA389196_rdfs.comment_1A62A2870263E30E> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8#SIP7B3C65C3D846D8AC> ;
  rdf:predicate rdfs:comment ;
  rdf:object "Lacks conserved residue(s) required for the propagation of feature annotation." ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP306245F4C453826A> rdf:type up:Topological_Domain_Annotation ;
  rdfs:comment "Virion surface" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt1tt22> .
<http://purl.uniprot.org/range/-9218578022581067730tt1tt22> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt1> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt22> .
<http://purl.uniprot.org/position/-9218578022581067730tt1> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 1 ;
  faldo:reference isoform:A0A221KMD8-1 .
<http://purl.uniprot.org/position/-9218578022581067730tt22> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 22 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_3F8EC68EF1ECE8B1> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIP306245F4C453826A> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP61FBA7C70E58DF76> rdf:type up:Transmembrane_Annotation ;
  rdfs:comment "Helical" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt28tt48> .
<http://purl.uniprot.org/range/-9218578022581067730tt28tt48> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt28> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt48> .
<http://purl.uniprot.org/position/-9218578022581067730tt28> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 28 ;
  faldo:reference isoform:A0A221KMD8-1 .
<http://purl.uniprot.org/position/-9218578022581067730tt48> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 48 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_296E88619AA6A5BB> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIP61FBA7C70E58DF76> ;
  up:attribution <A0A221KMD8#attribution-E81E3CD13273E6C639C0CE448CF71E78> .
<A0A221KMD8#SIPCEDB72E044171A37> rdf:type up:Topological_Domain_Annotation ;
  rdfs:comment "Intravirion" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt44tt97> .
<http://purl.uniprot.org/range/-9218578022581067730tt44tt97> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt44> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt97> .
<http://purl.uniprot.org/position/-9218578022581067730tt44> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 44 ;
  faldo:reference isoform:A0A221KMD8-1 .
<http://purl.uniprot.org/position/-9218578022581067730tt97> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 97 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_99998336D5C41413> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIPCEDB72E044171A37> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP37136496028F9F0B> rdf:type up:Region_Annotation ;
  rdfs:comment "Disordered" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt59tt88> .
<http://purl.uniprot.org/range/-9218578022581067730tt59tt88> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt59> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt88> .
<http://purl.uniprot.org/position/-9218578022581067730tt59> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 59 ;
  faldo:reference isoform:A0A221KMD8-1 .
<http://purl.uniprot.org/position/-9218578022581067730tt88> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 88 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_C3F87AEF7FBFE397> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIP37136496028F9F0B> ;
  up:attribution <A0A221KMD8#attribution-260F9275F08C92D1CF2D41553CB78263> .
<A0A221KMD8#SIPC53BA8369A8ED3F9> rdf:type up:Compositional_Bias_Annotation ;
  rdfs:comment "Basic and acidic residues" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt67tt88> .
<http://purl.uniprot.org/range/-9218578022581067730tt67tt88> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt67> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt88> .
<http://purl.uniprot.org/position/-9218578022581067730tt67> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 67 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_EA75D81819E82DE0> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIPC53BA8369A8ED3F9> ;
  up:attribution <A0A221KMD8#attribution-260F9275F08C92D1CF2D41553CB78263> .
<A0A221KMD8#SIP54F408E0BDA09DD9> rdf:type up:Site_Annotation ;
  rdfs:comment "Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt37tt37> .
<http://purl.uniprot.org/range/-9218578022581067730tt37tt37> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt37> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt37> .
<http://purl.uniprot.org/position/-9218578022581067730tt37> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 37 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_A81B624D4D47B07A> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIP54F408E0BDA09DD9> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP0EDBC825EF3318E8> rdf:type up:Site_Annotation ;
  rdfs:comment "Seems to be involved in pH gating" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt41tt41> .
<http://purl.uniprot.org/range/-9218578022581067730tt41tt41> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt41> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt41> .
<http://purl.uniprot.org/position/-9218578022581067730tt41> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 41 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_95FED7FD9CD9B970> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIP0EDBC825EF3318E8> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIPCA395F325904C5F7> rdf:type up:Modified_Residue_Annotation ;
  rdfs:comment "Phosphoserine; by host" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt64tt64> .
<http://purl.uniprot.org/range/-9218578022581067730tt64tt64> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt64> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt64> .
<http://purl.uniprot.org/position/-9218578022581067730tt64> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 64 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_BEEA77BFF22B8331> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIPCA395F325904C5F7> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIPF1750740405DDAF6> rdf:type up:Modified_Residue_Annotation ;
  rdfs:comment "Phosphoserine; by host" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt93tt93> .
<http://purl.uniprot.org/range/-9218578022581067730tt93tt93> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt93> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt93> .
<http://purl.uniprot.org/position/-9218578022581067730tt93> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 93 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_AB9AD5CD85DB481A> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIPF1750740405DDAF6> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP9D6E850A39DD3229> rdf:type up:Lipidation_Annotation ;
  rdfs:comment "S-palmitoyl cysteine; by host" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt50tt50> .
<http://purl.uniprot.org/range/-9218578022581067730tt50tt50> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt50> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt50> .
<http://purl.uniprot.org/position/-9218578022581067730tt50> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 50 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_275137F2BD3BC727> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIP9D6E850A39DD3229> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP4CAFFF132185FAAC> rdf:type up:Glycosylation_Annotation ;
  rdfs:comment "N-linked (GlcNAc...) asparagine; by host" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt20tt20> .
<http://purl.uniprot.org/range/-9218578022581067730tt20tt20> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt20> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt20> .
<http://purl.uniprot.org/position/-9218578022581067730tt20> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 20 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_B198B273D911A2FA> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIP4CAFFF132185FAAC> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP99E0CD5C47F23C66> rdf:type up:Disulfide_Bond_Annotation ;
  rdfs:comment "Interchain (with Cys-17)" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt17tt17> .
<http://purl.uniprot.org/range/-9218578022581067730tt17tt17> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt17> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt17> .
<http://purl.uniprot.org/position/-9218578022581067730tt17> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 17 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_E106E044F4AB8BCA> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIP99E0CD5C47F23C66> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<A0A221KMD8#SIP86BC08437FB68363> rdf:type up:Disulfide_Bond_Annotation ;
  rdfs:comment "Interchain (with Cys-19)" ;
  up:range <http://purl.uniprot.org/range/-9218578022581067730tt19tt19> .
<http://purl.uniprot.org/range/-9218578022581067730tt19tt19> rdf:type faldo:Region ;
  faldo:begin <http://purl.uniprot.org/position/-9218578022581067730tt19> ;
  faldo:end <http://purl.uniprot.org/position/-9218578022581067730tt19> .
<http://purl.uniprot.org/position/-9218578022581067730tt19> rdf:type faldo:Position ,
    faldo:ExactPosition ;
  faldo:position 19 ;
  faldo:reference isoform:A0A221KMD8-1 .
<#_kb.A0A221KMD8_up.annotation_68163FC064C8D0A6> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:annotation ;
  rdf:object <A0A221KMD8#SIP86BC08437FB68363> ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.classifiedWith_5ECB18F206C06C99> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:1015 ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.classifiedWith_6EC7159B1C90E4A6> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:325 ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.classifiedWith_F085EA3C52FC3482> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:1032 ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> ,
    <A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> .
<#_kb.A0A221KMD8_up.classifiedWith_46E016E0EBCF19B4> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:375 ;
  up:attribution <A0A221KMD8#attribution-85DC3F584DAB97A5D185E2BCED91C893> ,
    <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.classifiedWith_F10258C764662A85> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:1083 ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.classifiedWith_CECC727A75361D18> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:564 ;
  up:attribution <A0A221KMD8#attribution-E57DD1D8DBDB83C7A66A32FC16864DF1> ,
    <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.classifiedWith_933EE014DCF94B3A> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:597 ;
  up:attribution <A0A221KMD8#attribution-5BBC0B62EE6EC5E156144B6F61C637A9> ,
    <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.classifiedWith_41135A6F9CC8AB1D> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:735 ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> ,
    <A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> .
<#_kb.A0A221KMD8_up.classifiedWith_BC39FCD4575EC10A> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:1133 ;
  up:attribution <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> ,
    <A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> .
<#_kb.A0A221KMD8_up.classifiedWith_A790726439EE4C2B> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:1182 ;
  up:attribution <A0A221KMD8#attribution-AD40D0414E09A087388C0ADFF0E35A84> ,
    <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.classifiedWith_9E00215E4B7C8A19> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object keyword:946 ;
  up:attribution <A0A221KMD8#attribution-5001A9F5DD25D4C5E0ACF9676EAEAF81> ,
    <A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> .
<#_kb.A0A221KMD8_up.classifiedWith_obo.GO_0020002> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0020002 ;
  up:attribution <A0A221KMD8#attribution-0CACA73AD6FA5FC8FF131F2C26F5E326> .
<#_kb.A0A221KMD8_up.classifiedWith_obo.GO_0016020> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0016020 ;
  up:attribution <A0A221KMD8#attribution-8AEC0CC661531CFE2FAE4F290FCF9B78> .
<#_kb.A0A221KMD8_up.classifiedWith_obo.GO_0055036> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0055036 ;
  up:attribution <A0A221KMD8#attribution-0CACA73AD6FA5FC8FF131F2C26F5E326> .
<#_kb.A0A221KMD8_up.classifiedWith_obo.GO_0005216> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0005216 ;
  up:attribution <A0A221KMD8#attribution-8AEC0CC661531CFE2FAE4F290FCF9B78> .
<#_kb.A0A221KMD8_up.classifiedWith_obo.GO_0015078> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0015078 ;
  up:attribution <A0A221KMD8#attribution-8AEC0CC661531CFE2FAE4F290FCF9B78> .
<#_kb.A0A221KMD8_up.classifiedWith_obo.GO_0051259> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0051259 ;
  up:attribution <A0A221KMD8#attribution-8AEC0CC661531CFE2FAE4F290FCF9B78> .
<#_kb.A0A221KMD8_up.classifiedWith_obo.GO_0039521> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0039521 ;
  up:attribution <A0A221KMD8#attribution-8AEC0CC661531CFE2FAE4F290FCF9B78> .
<#_kb.A0A221KMD8_up.classifiedWith_obo.GO_0039707> rdf:type rdf:Statement ;
  rdf:subject <A0A221KMD8> ;
  rdf:predicate up:classifiedWith ;
  rdf:object go:0039707 ;
  up:attribution <A0A221KMD8#attribution-8AEC0CC661531CFE2FAE4F290FCF9B78> .
isoform:A0A221KMD8-1 rdf:type up:Simple_Sequence ;
  up:modified "2017-10-25"^^xsd:date ;
  up:version 1 ;
  up:mass 11205 ;
  up:md5Checksum "664e552ee665e4f7214675882d51c2c6" ;
  rdf:value "MSLLTEVETPIRNEWGCRCNDSSDPLVVAANIIGILHLILWILDRLFFKCIYRLFKHGLKRGPSTEGVPESMREEYRKEQQNAVDADDSHFVSIELE" .
<A0A221KMD8#attribution-0CACA73AD6FA5FC8FF131F2C26F5E326> dcterms:creator <http://purl.uniprot.org/goa-projects/UniProtKB-SubCell> ;
  up:evidence ECO:0007669 .
<A0A221KMD8#attribution-8AEC0CC661531CFE2FAE4F290FCF9B78> dcterms:creator <http://purl.uniprot.org/goa-projects/UniProtKB-UniRule> ;
  up:evidence ECO:0007669 .
<A0A221KMD8#attribution-5BBC0B62EE6EC5E156144B6F61C637A9> up:evidence ECO:0000256 ;
  up:source <http://purl.uniprot.org/arba/ARBA00022553> .
<A0A221KMD8#attribution-85DC3F584DAB97A5D185E2BCED91C893> up:evidence ECO:0000256 ;
  up:source <http://purl.uniprot.org/arba/ARBA00022781> .
<A0A221KMD8#attribution-5001A9F5DD25D4C5E0ACF9676EAEAF81> up:evidence ECO:0000256 ;
  up:source <http://purl.uniprot.org/arba/ARBA00022844> .
<A0A221KMD8#attribution-AD40D0414E09A087388C0ADFF0E35A84> up:evidence ECO:0000256 ;
  up:source <http://purl.uniprot.org/arba/ARBA00023039> .
<A0A221KMD8#attribution-E57DD1D8DBDB83C7A66A32FC16864DF1> up:evidence ECO:0000256 ;
  up:source <http://purl.uniprot.org/arba/ARBA00023139> .
<A0A221KMD8#attribution-3252376079F891D82290CC97AB394304> up:evidence ECO:0000256 ;
  up:source <http://purl.uniprot.org/hamap-rule/MF_04069> .
<A0A221KMD8#attribution-0F15563CA3E6811CE5381DC55DA4DCE7> up:evidence ECO:0000256 ;
  up:source <http://purl.uniprot.org/rulebase/RU361247> .
<A0A221KMD8#attribution-260F9275F08C92D1CF2D41553CB78263> up:evidence ECO:0000256 ;
  up:source <http://purl.uniprot.org/sam/MobiDB-lite> .
<A0A221KMD8#attribution-E81E3CD13273E6C639C0CE448CF71E78> up:evidence ECO:0000256 ;
  up:source <http://purl.uniprot.org/sam/Phobius> .
<A0A221KMD8#attribution-C6CCD48C8D266B9E80AAF5C54CBE2DDE> up:evidence ECO:0000313 ;
  up:source <http://purl.uniprot.org/embl-cds/ASM80232.1> .