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Entry version 16 (05 Jun 2019)
Sequence version 2 (20 Jun 2018)
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Protein

Clathrin heavy chain

Gene

cltca

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-190873 Gap junction degradation
R-DRE-196025 Formation of annular gap junctions
R-DRE-2132295 MHC class II antigen presentation
R-DRE-3928665 EPH-ephrin mediated repulsion of cells
R-DRE-432720 Lysosome Vesicle Biogenesis
R-DRE-432722 Golgi Associated Vesicle Biogenesis
R-DRE-437239 Recycling pathway of L1
R-DRE-5099900 WNT5A-dependent internalization of FZD4
R-DRE-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-DRE-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DRE-8856828 Clathrin-mediated endocytosis
R-DRE-8866427 VLDLR internalisation and degradation
R-DRE-8964038 LDL clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin heavy chainUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cltcaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-2299 cltca

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Coated pitUniRule annotation, Cytoplasmic vesicleUniRule annotation, Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A286YAZ4 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati537 – 683CHCRPROSITE-ProRule annotationAdd BLAST147
Repeati686 – 832CHCRPROSITE-ProRule annotationAdd BLAST147
Repeati837 – 976CHCRPROSITE-ProRule annotationAdd BLAST140
Repeati983 – 1128CHCRPROSITE-ProRule annotationAdd BLAST146
Repeati1132 – 1273CHCRPROSITE-ProRule annotationAdd BLAST142
Repeati1278 – 1424CHCRPROSITE-ProRule annotationAdd BLAST147
Repeati1427 – 1570CHCRPROSITE-ProRule annotationAdd BLAST144

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the clathrin heavy chain family.UniRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183166

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 4 hits
2.130.10.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00637 Clathrin, 7 hits
PF09268 Clathrin-link, 1 hit
PF01394 Clathrin_propel, 5 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002290 Clathrin_H_chain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00299 CLH, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50236 CHCR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A286YAZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICV REKVGEQAQV
60 70 80 90 100
VIIDMADPNT PIRRPISADS AIMNPASKVI ALKAAKTLQI FNIEMKSKMK
110 120 130 140 150
AHTMTDDVTF WKWISLNTVA LVTDNAVYHW SMEGDSQPVK VFDRHSSLAG
160 170 180 190 200
CQIINYRTDA KQKWLLLIGI SAQQNRVVGA MQLYSVDRKV SQPIEGHAAG
210 220 230 240 250
FGQFKMEGNT EESTLFCFAV RGQAGGKLHI IEVGTPPTGN QQFPKKAVDV
260 270 280 290 300
FFPPEAQNDF PVAMQISSKH DVVYLITKYG YIHLYDLETG TCIYMNRISG
310 320 330 340 350
ETIFVTAPHD ATAGIIGVNR KGQVLSVCVE EENIIQYITN VLQNPDLALR
360 370 380 390 400
MAVRNNLAGA EELFGRKFNN LFAGGNFAEA AKVAANAPKG ILRTPDTIRR
410 420 430 440 450
FQSVPAQPGQ TSPLLQYFGI LLDQGQLNKF ESLELCRPVL QQGRKQLLEK
460 470 480 490 500
WLKEDKLECS EELGDLVKSV DPTLALSVYL RANVPNKVIQ CFAETGQFPK
510 520 530 540 550
IVLYAKKVGY TPDWIFLLRN VMRISPDQGL QFAQMLVQDE EPLADITQIV
560 570 580 590 600
DVFMEYNLVQ QCTSFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL
610 620 630 640 650
GNQMFTNYDR AHIAQLCEKA GLLQRALEHY TDLYDIKRAV VHTHLLNPEW
660 670 680 690 700
LVNYFGSLSV EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLTE
710 720 730 740 750
LFESFKSFEG LFYFLGSIVN FSQDPEVHFK YIQAACKTGQ IKEVERICRE
760 770 780 790 800
SNCYNPERVK NFLKDLNQEA KLTDQLPLII VCDRFDFVHD LVLYLYRNNL
810 820 830 840 850
QKYIEIYVQK VNPSRLPVVI GGLLDVDCSE DVIKNLILVV RGQFSTDELV
860 870 880 890 900
AEVEKRNRLK LLLPWLESRI HEGCEEPATH NALAKIYIDS NNNPERFLRE
910 920 930 940 950
NPYYDSRVVG KYCEKRDPHL ACVAYERGTC DQELINVCNE NSLFKSLSRY
960 970 980 990 1000
LVRRRDPELW ASVLLETNPF RRPLIDQVVQ TALSETQDPE EVSVTVKAFM
1010 1020 1030 1040 1050
TADLPNELIE LLEKIVLDNS VFSEHRNLQN LLILTAIKAD RTRVMEYINR
1060 1070 1080 1090 1100
LDNYDAPDIA NIAISSELFE EAFAIFKKFD VNTSAVQVLI EHIGNLDRAY
1110 1120 1130 1140 1150
EFAERCNEPA VWSQLAKAQL QKGLVKESID SYIKADDPSA YMEVVQAADQ
1160 1170 1180 1190 1200
SGNWEDLVKF LQMARKKARE SYVETELIFA LAKTNRLAEL EEFINGPNNA
1210 1220 1230 1240 1250
HIQQVGDRCY DEKMYEAAKL LYNNVSNFGR LASTLVHLGE YQAAVDGARK
1260 1270 1280 1290 1300
ANSTRTWKEV CFACVDGKEF RLAQMCGLHI VVHADELEEL INYYQDRGYF
1310 1320 1330 1340 1350
EELITMLEAA LGLERAHMGM FTELAILYSK FKPQKMREHL ELFWSRVNIP
1360 1370 1380 1390 1400
KVLRAAEQAH LWAELVFLYD KYEEFDNAII TMMSHPTDAW KEGQFKDIIT
1410 1420 1430 1440 1450
KVANVELYYK AIQFYLEFRP LLLNDLLIVL SPRLDHSRAV NFFSKVKQLP
1460 1470 1480 1490 1500
LVKPYLRSVQ NHNNKSVNEA LNNLFISEED YQALRTSIDA YDNFDNISLA
1510 1520 1530 1540 1550
QRLEKHELIE FRRIAAYLFK GNNRWKQSVE LCKKDKLYKD AMQYASESKD
1560 1570 1580 1590 1600
TELAEELLQW FLDENKKECF AACLFTCYDL LRPDVVLETS WRNNIMDFAM
1610 1620 1630 1640 1650
PYFIQVMREY LSKVDKLETS ESLRKEEEQA TETQPIVYGT PQLMLTAGPS
1660 1670 1680
VPVPPQQGYG YGYTAAPGYP PQAPQAQPGF GYGM
Length:1,684
Mass (Da):192,290
Last modified:June 20, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EF904FEEA269979
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1R966F1R966_DANRE
Clathrin heavy chain
cltca
1,680Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QD79E9QD79_DANRE
Clathrin heavy chain
cltca
1,661Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8PXZ0A0A2R8PXZ0_DANRE
Clathrin heavy chain
cltca
1,666Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR392341 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_009303633.1, XM_009305358.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000179416; ENSDARP00000144157; ENSDARG00000043493

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
323579

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR392341 Genomic DNA No translation available.
RefSeqiXP_009303633.1, XM_009305358.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000179416; ENSDARP00000144157; ENSDARG00000043493
GeneIDi323579

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
323579
ZFINiZDB-GENE-030131-2299 cltca

Phylogenomic databases

GeneTreeiENSGT00950000183166

Enzyme and pathway databases

ReactomeiR-DRE-190873 Gap junction degradation
R-DRE-196025 Formation of annular gap junctions
R-DRE-2132295 MHC class II antigen presentation
R-DRE-3928665 EPH-ephrin mediated repulsion of cells
R-DRE-432720 Lysosome Vesicle Biogenesis
R-DRE-432722 Golgi Associated Vesicle Biogenesis
R-DRE-437239 Recycling pathway of L1
R-DRE-5099900 WNT5A-dependent internalization of FZD4
R-DRE-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-DRE-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DRE-8856828 Clathrin-mediated endocytosis
R-DRE-8866427 VLDLR internalisation and degradation
R-DRE-8964038 LDL clearance

Gene expression databases

ExpressionAtlasiA0A286YAZ4 baseline

Family and domain databases

Gene3Di1.25.40.10, 4 hits
2.130.10.110, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00637 Clathrin, 7 hits
PF09268 Clathrin-link, 1 hit
PF01394 Clathrin_propel, 5 hits
PIRSFiPIRSF002290 Clathrin_H_chain, 1 hit
SMARTiView protein in SMART
SM00299 CLH, 7 hits
SUPFAMiSSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A286YAZ4_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A286YAZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 22, 2017
Last sequence update: June 20, 2018
Last modified: June 5, 2019
This is version 16 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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