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Entry version 19 (13 Nov 2019)
Sequence version 1 (28 Mar 2018)
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Protein

Neuraminidase

Gene

NA

Organism
Influenza A virus
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.UniRule annotationSAAS annotation EC:3.2.1.18

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+UniRule annotationSAAS annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir (Tamiflu). These drugs interfere with the release of progeny virus from infected cells and are effective against all influenza strains. Resistance to neuraminidase inhibitors is quite rare.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei118SubstrateUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei151Proton donor/acceptorUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Binding sitei293SubstrateUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi294Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi298Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi324CalciumUniRule annotation1
Metal bindingi344Calcium; via carbonyl oxygenUniRule annotation1
Binding sitei368SubstrateUniRule annotation1
Active sitei402NucleophileUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NeuraminidaseUniRule annotationSAAS annotation (EC:3.2.1.18UniRule annotationSAAS annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAUniRule annotationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiInfluenza A virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11320 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaPolyploviricotinaInsthoviricetesArticulaviralesOrthomyxoviridaeAlphainfluenzavirus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 34HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host membrane, Membrane, VirionUniRule annotationSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi92 ↔ 417UniRule annotation
Disulfide bondi124 ↔ 129UniRule annotation
Disulfide bondi184 ↔ 231UniRule annotation
Disulfide bondi233 ↔ 238UniRule annotation
Disulfide bondi279 ↔ 292UniRule annotation
Disulfide bondi281 ↔ 290UniRule annotation
Disulfide bondi318 ↔ 335UniRule annotation
Disulfide bondi421 ↔ 446UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation, GlycoproteinUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

UniRule annotationSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni11 – 33Involved in apical transport and lipid raft associationUniRule annotationAdd BLAST23
Regioni91 – 469Head of neuraminidaseUniRule annotationAdd BLAST379
Regioni277 – 278Substrate bindingUniRule annotation2

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intact N-terminus is essential for virion morphogenesis. Possess two apical sorting signals, one in the ectodomain, which is likely to be a glycan, and the other in the transmembrane domain. The transmembrane domain also plays a role in lipid raft association.UniRule annotation

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 34 family.UniRule annotationSAAS annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15483 Influenza_NA, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_04071 INFV_NRAM, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001860 Glyco_hydro_34
IPR033654 Sialidase_Influenza_A/B
IPR036278 Sialidase_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00064 Neur, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50939 SSF50939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2I7ZLT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPNQKIITI GSICMTIGMA NLILQIGNII SIWVSHSIQI GNQSQIETCN
60 70 80 90 100
QSVITYENNT WVNQTYVNIS NTNFAARQSM ASVKLAGNSS LCPVSGWAIY
110 120 130 140 150
SKDNSVRIGS KGDVFVIREP FISCSPLECR TFFLTQGALL NDKHSNGTIK
160 170 180 190 200
DRSPYRTLMS CPIGEVPSPY NSRFESVAWS ASACHDGTNW LTIGISGPDS
210 220 230 240 250
GAVAVLKYNG IITDTIKSWR NNILRTQESE CACVNGSCFT IMTDGPSDGQ
260 270 280 290 300
ASYKIFRIEK GKIIKSVEMK APNYHYEECS CYPDSSEITC VCRDNWHGSN
310 320 330 340 350
RPWVSFNQNL EYQMGYICSG VFGDNPRPND KTGSCGPVSS NGANGVKGFS
360 370 380 390 400
FKYGNGVWIG RTKSISSRKG FEMIWDPNGW TGTDNKFSIK QDIVGINEWS
410 420 430 440 450
GYSGSFVQHP ELTGLDCIRP CFWVELIRGR PEENTIWTSG SSISFCGVDS
460
DTVGWSWPDG AELPFTIDK
Length:469
Mass (Da):51,711
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BCABA69F7EB410D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
MG830821 Viral cRNA Translation: AUS93553.1
MG978677 Viral cRNA Translation: AVH77531.1
MG978821 Viral cRNA Translation: AVH77729.1
MG978829 Viral cRNA Translation: AVH77740.1
MG978882 Viral cRNA Translation: AVH77812.1
MH083415 Viral cRNA Translation: AVP08508.1
MH083447 Viral cRNA Translation: AVP08552.1
MH083535 Viral cRNA Translation: AVP08673.1
MH083698 Viral cRNA Translation: AVP08898.1
MH084094 Viral cRNA Translation: AVP09442.1
MH125576 Viral cRNA Translation: AVR40525.1
MH125896 Viral cRNA Translation: AVR40966.1
MH126144 Viral cRNA Translation: AVR41307.1
MH126176 Viral cRNA Translation: AVR41351.1
MH183879 Viral cRNA Translation: AVX29176.1
MH246083 Viral cRNA Translation: AWC07032.1
MH156545 Viral cRNA Translation: AWH65969.1
MH305609 Viral cRNA Translation: AWI42207.1
MH305894 Viral cRNA Translation: AWI42600.1
MH446675 Viral cRNA Translation: AWR88893.1
MH446810 Viral cRNA Translation: AWR89079.1
MH446826 Viral cRNA Translation: AWR89101.1
MH540609 Viral cRNA Translation: AWX41622.1
MH600095 Viral cRNA Translation: AXB50931.1
MH601557 Viral cRNA Translation: AXB53052.1
MH601573 Viral cRNA Translation: AXB53075.1
MH601878 Viral cRNA Translation: AXB53520.1
MH669997 Viral cRNA Translation: AXF93591.1
MH670053 Viral cRNA Translation: AXF93668.1
MH670061 Viral cRNA Translation: AXF93679.1
MH726738 Viral cRNA Translation: AXK92885.1
MH797872 Viral cRNA Translation: AXR71589.1
MH797896 Viral cRNA Translation: AXR71624.1
MK265596 Viral cRNA Translation: AZJ60784.1
MK265626 Viral cRNA Translation: AZJ60824.1
MK363969 Viral cRNA Translation: AZS64658.1
MK364057 Viral cRNA Translation: AZS64777.1
MK364185 Viral cRNA Translation: AZS64953.1
MK364282 Viral cRNA Translation: AZS65089.1
MK364330 Viral cRNA Translation: AZS65155.1
MK364346 Viral cRNA Translation: AZS65177.1
MK364493 Viral cRNA Translation: AZS65381.1
MK364525 Viral cRNA Translation: AZS65425.1
MK364625 Viral cRNA Translation: AZS65563.1
MK380081 Viral cRNA Translation: AZY31713.1
MK380869 Viral cRNA Translation: AZY40010.1
MK382112 Viral cRNA Translation: AZY87968.1
MK382124 Viral cRNA Translation: AZY87980.1
MK398760 Viral cRNA Translation: QAB01930.1
MK398967 Viral cRNA Translation: QAB02215.1
MK398975 Viral cRNA Translation: QAB02226.1
MK400935 Viral cRNA Translation: QAB03486.1
MK400936 Viral cRNA Translation: QAB03487.1
MK445910 Viral cRNA Translation: QAU20770.1
MK445922 Viral cRNA Translation: QAU20787.1
MK475082 Viral cRNA Translation: QAY27615.1
MK475122 Viral cRNA Translation: QAY27672.1
MK475281 Viral cRNA Translation: QAY27890.1
MK475312 Viral cRNA Translation: QAY27932.1
MK475344 Viral cRNA Translation: QAY27977.1
MK502222 Viral cRNA Translation: QBA98173.1
MK502226 Viral cRNA Translation: QBA98177.1
MK502482 Viral cRNA Translation: QBA98554.1
MK502490 Viral cRNA Translation: QBA98565.1
MK502594 Viral cRNA Translation: QBA98716.1
MK502722 Viral cRNA Translation: QBA98902.1
MK502794 Viral cRNA Translation: QBA99008.1
MK556919 Viral cRNA Translation: QBF66085.1
MK556923 Viral cRNA Translation: QBF66091.1
MK556987 Viral cRNA Translation: QBF66179.1
MK557195 Viral cRNA Translation: QBF66465.1
MK557224 Viral cRNA Translation: QBF66504.1
MK557395 Viral cRNA Translation: QBF66740.1
MK557435 Viral cRNA Translation: QBF66795.1
MK557480 Viral cRNA Translation: QBF66856.1
MK557512 Viral cRNA Translation: QBF66900.1
MK576372 Viral cRNA Translation: QBH70582.1
MK576378 Viral cRNA Translation: QBH70588.1
MK576379 Viral cRNA Translation: QBH70589.1
MK576385 Viral cRNA Translation: QBH70595.1
MK576398 Viral cRNA Translation: QBH70608.1
MK576404 Viral cRNA Translation: QBH70614.1
MK576432 Viral cRNA Translation: QBH70642.1
MK576434 Viral cRNA Translation: QBH70644.1
MK576740 Viral cRNA Translation: QBH71099.1
MK576748 Viral cRNA Translation: QBH71110.1
MK576756 Viral cRNA Translation: QBH71121.1
MK577052 Viral cRNA Translation: QBH71539.1
MK577076 Viral cRNA Translation: QBH71572.1
MK577092 Viral cRNA Translation: QBH71595.1
MK577108 Viral cRNA Translation: QBH71617.1
MK577140 Viral cRNA Translation: QBH71662.1
MK577164 Viral cRNA Translation: QBH71696.1
MK623599 Viral cRNA Translation: QBL90711.1
MK623631 Viral cRNA Translation: QBL90755.1
MK623647 Viral cRNA Translation: QBL90777.1
MK623711 Viral cRNA Translation: QBL90865.1
MK626047 Viral cRNA Translation: QBL96312.1
MK626175 Viral cRNA Translation: QBL96488.1
MK626183 Viral cRNA Translation: QBL96499.1
MK626439 Viral cRNA Translation: QBL96850.1
MK630719 Viral cRNA Translation: QBM03075.1
MK630788 Viral cRNA Translation: QBM03170.1
MK630796 Viral cRNA Translation: QBM03181.1
MK630911 Viral cRNA Translation: QBM03340.1
MK630940 Viral cRNA Translation: QBM03379.1
MK631292 Viral cRNA Translation: QBM03863.1
MK631372 Viral cRNA Translation: QBM03973.1
MK631581 Viral cRNA Translation: QBM04261.1
MK631586 Viral cRNA Translation: QBM04267.1
MK631682 Viral cRNA Translation: QBM04399.1
MK631716 Viral cRNA Translation: QBM04446.1
MK633579 Viral cRNA Translation: QBM07333.1
MK635698 Viral cRNA Translation: QBM12110.1
MK635699 Viral cRNA Translation: QBM12111.1
MK635700 Viral cRNA Translation: QBM12112.1
MK635701 Viral cRNA Translation: QBM12113.1
MK635702 Viral cRNA Translation: QBM12114.1
MK635703 Viral cRNA Translation: QBM12115.1
MK635706 Viral cRNA Translation: QBM12118.1
MK635707 Viral cRNA Translation: QBM12119.1
MK635725 Viral cRNA Translation: QBM12137.1
MK635728 Viral cRNA Translation: QBM12140.1
MK635965 Viral cRNA Translation: QBM12484.1
MK635973 Viral cRNA Translation: QBM12495.1
MK636229 Viral cRNA Translation: QBM12866.1
MK636237 Viral cRNA Translation: QBM12878.1
MK636245 Viral cRNA Translation: QBM12889.1
MK676348 Viral cRNA Translation: QBP37556.1
MK676439 Viral cRNA Translation: QBP37681.1
MK676702 Viral cRNA Translation: QBP38042.1
MK676758 Viral cRNA Translation: QBP38119.1
MK743026 Viral cRNA Translation: QBS18539.1
MK743044 Viral cRNA Translation: QBS18557.1
MK743049 Viral cRNA Translation: QBS18562.1
MK743580 Viral cRNA Translation: QBS19338.1
MK743644 Viral cRNA Translation: QBS19426.1
MK743828 Viral cRNA Translation: QBS19691.1
MK763133 Viral cRNA Translation: QBX91473.1
MK763135 Viral cRNA Translation: QBX91475.1
MK763138 Viral cRNA Translation: QBX91478.1
MK763183 Viral cRNA Translation: QBX91523.1
MK763189 Viral cRNA Translation: QBX91529.1
MK763193 Viral cRNA Translation: QBX91533.1
MK763197 Viral cRNA Translation: QBX91537.1
MK763212 Viral cRNA Translation: QBX91552.1
MK763522 Viral cRNA Translation: QBX92016.1
MK763602 Viral cRNA Translation: QBX92133.1
MK763746 Viral cRNA Translation: QBX92339.1
MK763914 Viral cRNA Translation: QBX92587.1
MK773056 Viral cRNA Translation: QBY33927.1
MK773215 Viral cRNA Translation: QBY34145.1
MK785545 Viral cRNA Translation: QBZ79051.1
MK785550 Viral cRNA Translation: QBZ79056.1
MK785562 Viral cRNA Translation: QBZ79068.1
MK785563 Viral cRNA Translation: QBZ79069.1
MK785565 Viral cRNA Translation: QBZ79071.1
MK785580 Viral cRNA Translation: QBZ79086.1
MK785581 Viral cRNA Translation: QBZ79087.1
MK785582 Viral cRNA Translation: QBZ79088.1
MK786161 Viral cRNA Translation: QBZ79944.1
MK786577 Viral cRNA Translation: QBZ80548.1
MK839371 Viral cRNA Translation: QCF42681.1
MK840293 Viral cRNA Translation: QCF44012.1
MK840365 Viral cRNA Translation: QCF44116.1
MK855607 Viral cRNA Translation: QCG82644.1
MK855679 Viral cRNA Translation: QCG82743.1
MK855799 Viral cRNA Translation: QCG82908.1
MK868811 Viral cRNA Translation: QCH41672.1
MK868813 Viral cRNA Translation: QCH41674.1
MK868830 Viral cRNA Translation: QCH41691.1
MK869157 Viral cRNA Translation: QCH42168.1
MK898623 Viral cRNA Translation: QCO72112.1
MK912400 Viral cRNA Translation: QCP66589.1
MK912672 Viral cRNA Translation: QCP66985.1
MK912928 Viral cRNA Translation: QCP67355.1
MK912960 Viral cRNA Translation: QCP67402.1
MK913072 Viral cRNA Translation: QCP67567.1
MK913080 Viral cRNA Translation: QCP67578.1
MK913320 Viral cRNA Translation: QCP67932.1
MK927330 Viral cRNA Translation: QCQ18639.1
MK927335 Viral cRNA Translation: QCQ18644.1
MK927988 Viral cRNA Translation: QCQ19586.1
MK960212 Viral cRNA Translation: QCT08242.1
MK999452 Viral cRNA Translation: QCW11377.1
MK999532 Viral cRNA Translation: QCW11487.1
MK999844 Viral cRNA Translation: QCW11917.1
MN004492 Viral cRNA Translation: QCW18045.1
MN078637 Viral cRNA Translation: QDC27343.1
MN161042 Viral cRNA Translation: QDJ94852.1
MN169906 Viral cRNA Translation: QDK58155.1
MN230065 Viral cRNA Translation: QDR48456.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MG830821 Viral cRNA Translation: AUS93553.1
MG978677 Viral cRNA Translation: AVH77531.1
MG978821 Viral cRNA Translation: AVH77729.1
MG978829 Viral cRNA Translation: AVH77740.1
MG978882 Viral cRNA Translation: AVH77812.1
MH083415 Viral cRNA Translation: AVP08508.1
MH083447 Viral cRNA Translation: AVP08552.1
MH083535 Viral cRNA Translation: AVP08673.1
MH083698 Viral cRNA Translation: AVP08898.1
MH084094 Viral cRNA Translation: AVP09442.1
MH125576 Viral cRNA Translation: AVR40525.1
MH125896 Viral cRNA Translation: AVR40966.1
MH126144 Viral cRNA Translation: AVR41307.1
MH126176 Viral cRNA Translation: AVR41351.1
MH183879 Viral cRNA Translation: AVX29176.1
MH246083 Viral cRNA Translation: AWC07032.1
MH156545 Viral cRNA Translation: AWH65969.1
MH305609 Viral cRNA Translation: AWI42207.1
MH305894 Viral cRNA Translation: AWI42600.1
MH446675 Viral cRNA Translation: AWR88893.1
MH446810 Viral cRNA Translation: AWR89079.1
MH446826 Viral cRNA Translation: AWR89101.1
MH540609 Viral cRNA Translation: AWX41622.1
MH600095 Viral cRNA Translation: AXB50931.1
MH601557 Viral cRNA Translation: AXB53052.1
MH601573 Viral cRNA Translation: AXB53075.1
MH601878 Viral cRNA Translation: AXB53520.1
MH669997 Viral cRNA Translation: AXF93591.1
MH670053 Viral cRNA Translation: AXF93668.1
MH670061 Viral cRNA Translation: AXF93679.1
MH726738 Viral cRNA Translation: AXK92885.1
MH797872 Viral cRNA Translation: AXR71589.1
MH797896 Viral cRNA Translation: AXR71624.1
MK265596 Viral cRNA Translation: AZJ60784.1
MK265626 Viral cRNA Translation: AZJ60824.1
MK363969 Viral cRNA Translation: AZS64658.1
MK364057 Viral cRNA Translation: AZS64777.1
MK364185 Viral cRNA Translation: AZS64953.1
MK364282 Viral cRNA Translation: AZS65089.1
MK364330 Viral cRNA Translation: AZS65155.1
MK364346 Viral cRNA Translation: AZS65177.1
MK364493 Viral cRNA Translation: AZS65381.1
MK364525 Viral cRNA Translation: AZS65425.1
MK364625 Viral cRNA Translation: AZS65563.1
MK380081 Viral cRNA Translation: AZY31713.1
MK380869 Viral cRNA Translation: AZY40010.1
MK382112 Viral cRNA Translation: AZY87968.1
MK382124 Viral cRNA Translation: AZY87980.1
MK398760 Viral cRNA Translation: QAB01930.1
MK398967 Viral cRNA Translation: QAB02215.1
MK398975 Viral cRNA Translation: QAB02226.1
MK400935 Viral cRNA Translation: QAB03486.1
MK400936 Viral cRNA Translation: QAB03487.1
MK445910 Viral cRNA Translation: QAU20770.1
MK445922 Viral cRNA Translation: QAU20787.1
MK475082 Viral cRNA Translation: QAY27615.1
MK475122 Viral cRNA Translation: QAY27672.1
MK475281 Viral cRNA Translation: QAY27890.1
MK475312 Viral cRNA Translation: QAY27932.1
MK475344 Viral cRNA Translation: QAY27977.1
MK502222 Viral cRNA Translation: QBA98173.1
MK502226 Viral cRNA Translation: QBA98177.1
MK502482 Viral cRNA Translation: QBA98554.1
MK502490 Viral cRNA Translation: QBA98565.1
MK502594 Viral cRNA Translation: QBA98716.1
MK502722 Viral cRNA Translation: QBA98902.1
MK502794 Viral cRNA Translation: QBA99008.1
MK556919 Viral cRNA Translation: QBF66085.1
MK556923 Viral cRNA Translation: QBF66091.1
MK556987 Viral cRNA Translation: QBF66179.1
MK557195 Viral cRNA Translation: QBF66465.1
MK557224 Viral cRNA Translation: QBF66504.1
MK557395 Viral cRNA Translation: QBF66740.1
MK557435 Viral cRNA Translation: QBF66795.1
MK557480 Viral cRNA Translation: QBF66856.1
MK557512 Viral cRNA Translation: QBF66900.1
MK576372 Viral cRNA Translation: QBH70582.1
MK576378 Viral cRNA Translation: QBH70588.1
MK576379 Viral cRNA Translation: QBH70589.1
MK576385 Viral cRNA Translation: QBH70595.1
MK576398 Viral cRNA Translation: QBH70608.1
MK576404 Viral cRNA Translation: QBH70614.1
MK576432 Viral cRNA Translation: QBH70642.1
MK576434 Viral cRNA Translation: QBH70644.1
MK576740 Viral cRNA Translation: QBH71099.1
MK576748 Viral cRNA Translation: QBH71110.1
MK576756 Viral cRNA Translation: QBH71121.1
MK577052 Viral cRNA Translation: QBH71539.1
MK577076 Viral cRNA Translation: QBH71572.1
MK577092 Viral cRNA Translation: QBH71595.1
MK577108 Viral cRNA Translation: QBH71617.1
MK577140 Viral cRNA Translation: QBH71662.1
MK577164 Viral cRNA Translation: QBH71696.1
MK623599 Viral cRNA Translation: QBL90711.1
MK623631 Viral cRNA Translation: QBL90755.1
MK623647 Viral cRNA Translation: QBL90777.1
MK623711 Viral cRNA Translation: QBL90865.1
MK626047 Viral cRNA Translation: QBL96312.1
MK626175 Viral cRNA Translation: QBL96488.1
MK626183 Viral cRNA Translation: QBL96499.1
MK626439 Viral cRNA Translation: QBL96850.1
MK630719 Viral cRNA Translation: QBM03075.1
MK630788 Viral cRNA Translation: QBM03170.1
MK630796 Viral cRNA Translation: QBM03181.1
MK630911 Viral cRNA Translation: QBM03340.1
MK630940 Viral cRNA Translation: QBM03379.1
MK631292 Viral cRNA Translation: QBM03863.1
MK631372 Viral cRNA Translation: QBM03973.1
MK631581 Viral cRNA Translation: QBM04261.1
MK631586 Viral cRNA Translation: QBM04267.1
MK631682 Viral cRNA Translation: QBM04399.1
MK631716 Viral cRNA Translation: QBM04446.1
MK633579 Viral cRNA Translation: QBM07333.1
MK635698 Viral cRNA Translation: QBM12110.1
MK635699 Viral cRNA Translation: QBM12111.1
MK635700 Viral cRNA Translation: QBM12112.1
MK635701 Viral cRNA Translation: QBM12113.1
MK635702 Viral cRNA Translation: QBM12114.1
MK635703 Viral cRNA Translation: QBM12115.1
MK635706 Viral cRNA Translation: QBM12118.1
MK635707 Viral cRNA Translation: QBM12119.1
MK635725 Viral cRNA Translation: QBM12137.1
MK635728 Viral cRNA Translation: QBM12140.1
MK635965 Viral cRNA Translation: QBM12484.1
MK635973 Viral cRNA Translation: QBM12495.1
MK636229 Viral cRNA Translation: QBM12866.1
MK636237 Viral cRNA Translation: QBM12878.1
MK636245 Viral cRNA Translation: QBM12889.1
MK676348 Viral cRNA Translation: QBP37556.1
MK676439 Viral cRNA Translation: QBP37681.1
MK676702 Viral cRNA Translation: QBP38042.1
MK676758 Viral cRNA Translation: QBP38119.1
MK743026 Viral cRNA Translation: QBS18539.1
MK743044 Viral cRNA Translation: QBS18557.1
MK743049 Viral cRNA Translation: QBS18562.1
MK743580 Viral cRNA Translation: QBS19338.1
MK743644 Viral cRNA Translation: QBS19426.1
MK743828 Viral cRNA Translation: QBS19691.1
MK763133 Viral cRNA Translation: QBX91473.1
MK763135 Viral cRNA Translation: QBX91475.1
MK763138 Viral cRNA Translation: QBX91478.1
MK763183 Viral cRNA Translation: QBX91523.1
MK763189 Viral cRNA Translation: QBX91529.1
MK763193 Viral cRNA Translation: QBX91533.1
MK763197 Viral cRNA Translation: QBX91537.1
MK763212 Viral cRNA Translation: QBX91552.1
MK763522 Viral cRNA Translation: QBX92016.1
MK763602 Viral cRNA Translation: QBX92133.1
MK763746 Viral cRNA Translation: QBX92339.1
MK763914 Viral cRNA Translation: QBX92587.1
MK773056 Viral cRNA Translation: QBY33927.1
MK773215 Viral cRNA Translation: QBY34145.1
MK785545 Viral cRNA Translation: QBZ79051.1
MK785550 Viral cRNA Translation: QBZ79056.1
MK785562 Viral cRNA Translation: QBZ79068.1
MK785563 Viral cRNA Translation: QBZ79069.1
MK785565 Viral cRNA Translation: QBZ79071.1
MK785580 Viral cRNA Translation: QBZ79086.1
MK785581 Viral cRNA Translation: QBZ79087.1
MK785582 Viral cRNA Translation: QBZ79088.1
MK786161 Viral cRNA Translation: QBZ79944.1
MK786577 Viral cRNA Translation: QBZ80548.1
MK839371 Viral cRNA Translation: QCF42681.1
MK840293 Viral cRNA Translation: QCF44012.1
MK840365 Viral cRNA Translation: QCF44116.1
MK855607 Viral cRNA Translation: QCG82644.1
MK855679 Viral cRNA Translation: QCG82743.1
MK855799 Viral cRNA Translation: QCG82908.1
MK868811 Viral cRNA Translation: QCH41672.1
MK868813 Viral cRNA Translation: QCH41674.1
MK868830 Viral cRNA Translation: QCH41691.1
MK869157 Viral cRNA Translation: QCH42168.1
MK898623 Viral cRNA Translation: QCO72112.1
MK912400 Viral cRNA Translation: QCP66589.1
MK912672 Viral cRNA Translation: QCP66985.1
MK912928 Viral cRNA Translation: QCP67355.1
MK912960 Viral cRNA Translation: QCP67402.1
MK913072 Viral cRNA Translation: QCP67567.1
MK913080 Viral cRNA Translation: QCP67578.1
MK913320 Viral cRNA Translation: QCP67932.1
MK927330 Viral cRNA Translation: QCQ18639.1
MK927335 Viral cRNA Translation: QCQ18644.1
MK927988 Viral cRNA Translation: QCQ19586.1
MK960212 Viral cRNA Translation: QCT08242.1
MK999452 Viral cRNA Translation: QCW11377.1
MK999532 Viral cRNA Translation: QCW11487.1
MK999844 Viral cRNA Translation: QCW11917.1
MN004492 Viral cRNA Translation: QCW18045.1
MN078637 Viral cRNA Translation: QDC27343.1
MN161042 Viral cRNA Translation: QDJ94852.1
MN169906 Viral cRNA Translation: QDK58155.1
MN230065 Viral cRNA Translation: QDR48456.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Family and domain databases

CDDicd15483 Influenza_NA, 1 hit
HAMAPiMF_04071 INFV_NRAM, 1 hit
InterProiView protein in InterPro
IPR001860 Glyco_hydro_34
IPR033654 Sialidase_Influenza_A/B
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00064 Neur, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2I7ZLT1_9INFA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2I7ZLT1
Secondary accession number(s): A0A3Q9T5T4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: November 13, 2019
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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