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Entry version 5 (31 Jul 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

PPFIBP1 isoform 7

Gene

CR201_G0011421

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PPFIBP1 isoform 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CR201_G0011421Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini647 – 711SAMInterPro annotationAdd BLAST65
Domaini719 – 782SAMInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni371 – 391DisorderedSequence analysisAdd BLAST21
Regioni463 – 634DisorderedSequence analysisAdd BLAST172

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili99 – 126Sequence analysisAdd BLAST28
Coiled coili134 – 196Sequence analysisAdd BLAST63
Coiled coili207 – 227Sequence analysisAdd BLAST21
Coiled coili252 – 293Sequence analysisAdd BLAST42
Coiled coili305 – 339Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi472 – 491PolyampholyteSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 3 hits
1.20.5.1160, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042180 IF_rod_dom_coil1B
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454 SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2J8WBV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH
60 70 80 90 100
LVEDLRGLLE MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD
110 120 130 140 150
VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKLNA
160 170 180 190 200
TEEMLQQELL SRTSLETQKL DLMAEISNLK LKLTAVEKDR LDYEDKFRDT
210 220 230 240 250
EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS MKIKVGQMQY
260 270 280 290 300
EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD
310 320 330 340 350
RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQDKD
360 370 380 390 400
GEYEDLLNSS SISSLLDAQG FSDLEKSPSP TPVMGSPSRD PFNTSVPEEF
410 420 430 440 450
HTSILQVSIP SLLPATISME TSEKSKLTPK PETSFEENDG KIILGATVDT
460 470 480 490 500
QLCDKLLTSS LQKSSSLGNL KKETSDGEKE SIQKTSEDRA PAESRPFGTL
510 520 530 540 550
PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS APNLAETEKE
560 570 580 590 600
TAENLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ
610 620 630 640 650
STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE
660 670 680 690 700
QVCNWLMEQG LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK
710 720 730 740 750
LQLALQALGS EEETNHGKLD FNWVTRWLDD IGLPQYKTQF DEGRVDGRML
760 770 780 790 800
HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR INNFEPNCLR RRPSDENTIA
810 820 830 840 850
PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL EPRFNVETMA
860 870 880 890 900
QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV
910 920 930 940 950
KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL
960 970 980 990 1000
YEEDDLDRLE QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP
1010
SASITDEDSN V
Length:1,011
Mass (Da):114,112
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D4D2FB65C9B6DEF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
NDHI03003395 Genomic DNA Translation: PNJ67221.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NDHI03003395 Genomic DNA Translation: PNJ67221.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit
Gene3Di1.10.150.50, 3 hits
1.20.5.1160, 2 hits
InterProiView protein in InterPro
IPR042180 IF_rod_dom_coil1B
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2J8WBV4_PONAB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2J8WBV4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 31, 2019
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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