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Entry version 13 (31 Jul 2019)
Sequence version 1 (28 Mar 2018)
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Protein
Submitted name:

Uncharacterized protein

Gene

LCT

Organism
Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1273NucleophilePROSITE-ProRule annotation1
Active sitei1749NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LCTImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri61622 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeColobinaeRhinopithecus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233200 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Whole Genome Shotgun Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1884 – 1904HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501431877820 – 1928Sequence analysisAdd BLAST1909

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1220 – 1241DisorderedSequence analysisAdd BLAST22

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155324

KEGG Orthology (KO)

More...
KOi
K01229

Database of Orthologous Groups

More...
OrthoDBi
408001at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001360 Glyco_hydro_1
IPR018120 Glyco_hydro_1_AS
IPR033132 Glyco_hydro_1_N_CS
IPR017853 Glycoside_hydrolase_SF

The PANTHER Classification System

More...
PANTHERi
PTHR10353 PTHR10353, 6 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00232 Glyco_hydro_1, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00131 GLHYDRLASE1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00572 GLYCOSYL_HYDROL_F1_1, 2 hits
PS00653 GLYCOSYL_HYDROL_F1_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A2K6QCB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSWHAVFI ALLSVSSWGS DWESERNFIS TAGPLTNDLL HNLSGPLGDQ
60 70 80 90 100
SSNFVAGDKD LYVCHQPLPT FLPEYFSSLH ASQITHYKVF LSWAQLLPAG
110 120 130 140 150
STQNPDKKTV QCYRRLLEAL ETARLQPMVI LHHQTLPAST LQRTEVFADL
160 170 180 190 200
FADYATFAFH SFGDLVGIWF TFSDLEEVIK ELPHQESRAS RLQTLSDAHR
210 220 230 240 250
KAYEIYHENY ASPGGKLSVV LRVEDIPELL LEPPISALAQ DTVDFLSLDL
260 270 280 290 300
SYECQNEASL RQKLSKLQTI EPEVKVFIFN LKLPDCPSTT KSPARLLFSL
310 320 330 340 350
FEAVNKDQVL TIGSDINEFL SCSSSSEKSM SCSLTGSLAL QPEEQQDHEI
360 370 380 390 400
AGSSPASAYQ RVWEAFANQS RAERDAFLQD TFPEGFLWGA STGAFNVEGG
410 420 430 440 450
WAEGGRGASI WDPRRPLNTT EGQATPEVAS DSYHKVASDV TLLRGLRAQV
460 470 480 490 500
YKFSISWSRI FPTGHGSSPS LPGVAYYNKL IDRLRDAGIQ PMATLFHWDL
510 520 530 540 550
PQALQDHGGW QNESVVDAFL DYAAFCFSTF GDRVKLWVTF HEPWVMSYAG
560 570 580 590 600
YGTGQHPPGI SDPGVASFKV AHLVLKAHAR TWHYYNSHHR PQQQGHVGIV
610 620 630 640 650
LNSDWAEPLF PERPEDLRAS ERFLHFMLGW FAHPIFVDGD YPATLRTQIQ
660 670 680 690 700
QMNRQCPHPV AQLPKFTEAE KQLLKGSADF LGLSHYTSRL ISHAPRNTCI
710 720 730 740 750
PSYDTIGGFS QHVNHAWPQT SSSWIRVVPW GIRRLLQFVS LEYTRGKVPV
760 770 780 790 800
YLAGNGMPIG ESENLFDDSL RVDYFNQYIN EVLKAIKEDS VDVRSYIARS
810 820 830 840 850
LIDGFEGPSG YSQRFGLHHV NFNDSSKSRT PRKSAYFFTS IIEKNGFLTN
860 870 880 890 900
GTKRLPRPNT ANLPSKARAF AFPSEVPSKA KVVWEKFSSQ PKFERDLFYH
910 920 930 940 950
GTFRDDFLWG VSSSAYQIEG GWDADGKGPS IWDNFTHTPG SNVKDNATGD
960 970 980 990 1000
IACDSYHQLD ADLNMLRALK VKAYRFSISW SRIFPTGRNS SINSHGVDYY
1010 1020 1030 1040 1050
NRLIDGLMAS NIFPMVTLFH WDLPQALQDI GGWENPALIE LFDSYADFCF
1060 1070 1080 1090 1100
QTFGDRVKFW MTFNEPMYLA WLGYGSGEFP PGVKDPGWAP YRIAHAVIKA
1110 1120 1130 1140 1150
HARVYHTYDE KYRQQQKGVI SLSLSTHWAE PKSPGVPRDV EAADRMLQFS
1160 1170 1180 1190 1200
LGWFAHPIFR NGDYPDAMKW KVGNRSELQH LATSRLPGFT EEEKRFIRAT
1210 1220 1230 1240 1250
ADVFCLNTYS SRIVQYKTPR LNPPSYEDDQ EMAEEEDPSW PSTAVNRAAP
1260 1270 1280 1290 1300
WGMRRLLNWI KEEYGDIPIY ITENGVGLTD PNAEDTSRIF YHKTYINEAL
1310 1320 1330 1340 1350
KAYRLDGVDL RGYVAWSLMD NFEWLNGYTV KFGLYHVDFN NTNRPRTARA
1360 1370 1380 1390 1400
SARYYTEVIT NNGMPLARED EFLYGRFPEG FIWSAASAAY QIEGAWRADG
1410 1420 1430 1440 1450
KGLSIWDTFS HTPLKVENDA VADVACDSYH KIAEDLVTLQ NLGVSHYRFS
1460 1470 1480 1490 1500
ISWSRILPDG TTRYINEAGL NYYVRLIDAL LAASIQPQVT IYHWDLPQAL
1510 1520 1530 1540 1550
QDVGGWENET IVQRFKEYAD VLFQRLGDKV KFWITLNEPF VVAYQGYGYG
1560 1570 1580 1590 1600
TKAPGIFDRP GTAPYIVGHN LIKAHAEAWH LYNDVYRASQ GGVISITISS
1610 1620 1630 1640 1650
DWAEPRDPSN QEDVEAARRY VQFMGGWFAH PIFKNGDYNE VMKTRIRDRS
1660 1670 1680 1690 1700
LAAGLNKSRL PEFTESEKRR INGTYDFFGF NHYTTVLAYN LNYATAISSF
1710 1720 1730 1740 1750
DADRGVASIA DRSWPDSGSV WLKMTPFGFR RILNWFKEEY NDPPIYVTEN
1760 1770 1780 1790 1800
GVSQREETDL NDTARIYYLR TYINEALKAV QDKVDLRGYT VWSAMDNFEW
1810 1820 1830 1840 1850
STGFSERFGL HFVNYSDPSL PRIPKASAKF YASVVRCNGF PDPATGPHAC
1860 1870 1880 1890 1900
LHQPEDAGPT VSPVREEEVQ FLGLMLGTAE AQTALYVLFS LVLLGVCGLA
1910 1920
FLSYKYCKRS KQEKTQPSQQ ELSPVSSF
Length:1,928
Mass (Da):218,466
Last modified:March 28, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB5216BCC5D561601
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_010365578.1, XM_010367276.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRROT00000050676; ENSRROP00000026432; ENSRROG00000036958

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
104665436

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rro:104665436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_010365578.1, XM_010367276.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRROT00000050676; ENSRROP00000026432; ENSRROG00000036958
GeneIDi104665436
KEGGirro:104665436

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3938

Phylogenomic databases

GeneTreeiENSGT00940000155324
KOiK01229
OrthoDBi408001at2759

Family and domain databases

InterProiView protein in InterPro
IPR001360 Glyco_hydro_1
IPR018120 Glyco_hydro_1_AS
IPR033132 Glyco_hydro_1_N_CS
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10353 PTHR10353, 6 hits
PfamiView protein in Pfam
PF00232 Glyco_hydro_1, 4 hits
PRINTSiPR00131 GLHYDRLASE1
SUPFAMiSSF51445 SSF51445, 4 hits
PROSITEiView protein in PROSITE
PS00572 GLYCOSYL_HYDROL_F1_1, 2 hits
PS00653 GLYCOSYL_HYDROL_F1_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A2K6QCB6_RHIRO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A2K6QCB6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 28, 2018
Last sequence update: March 28, 2018
Last modified: July 31, 2019
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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