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Entry version 5 (05 Jun 2019)
Sequence version 1 (10 Oct 2018)
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Protein
Submitted name:

unconventional myosin-XVIIIa isoform X1

Gene

MYO18A

Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi510 – 517ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
unconventional myosin-XVIIIa isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYO18AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1706337 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiPhocoenidaeNeophocaena
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000252040 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini220 – 311PDZInterPro annotationAdd BLAST92
Domaini361 – 413Myosin N-terminal SH3-likeInterPro annotationAdd BLAST53
Domaini417 – 1197Myosin motorInterPro annotationAdd BLAST781
Domaini554 – 619RECA_3InterPro annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni140 – 167DisorderedSequence analysisAdd BLAST28
Regioni321 – 347DisorderedSequence analysisAdd BLAST27
Regioni735 – 754DisorderedSequence analysisAdd BLAST20
Regioni1462 – 1493DisorderedSequence analysisAdd BLAST32
Regioni1864 – 1913DisorderedSequence analysisAdd BLAST50
Regioni1971 – 2066DisorderedSequence analysisAdd BLAST96

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1261 – 1316Sequence analysisAdd BLAST56
Coiled coili1324 – 1358Sequence analysisAdd BLAST35
Coiled coili1521 – 1600Sequence analysisAdd BLAST80
Coiled coili1606 – 1654Sequence analysisAdd BLAST49
Coiled coili1670 – 1690Sequence analysisAdd BLAST21
Coiled coili1725 – 1822Sequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi140 – 164PolarSequence analysisAdd BLAST25
Compositional biasi322 – 336PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1971 – 1997PolyampholyteSequence analysisAdd BLAST27
Compositional biasi2011 – 2026PolarSequence analysisAdd BLAST16
Compositional biasi2028 – 2043PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2044 – 2066PolarSequence analysisAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01386 MYSc_Myo18, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR031244 MYO18A
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR002928 Myosin_tail
IPR036064 MYSc_Myo18
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR020587 RecA_monomer-monomer_interface

The PANTHER Classification System

More...
PANTHERi
PTHR45615:SF13 PTHR45615:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612 IQ, 1 hit
PF00063 Myosin_head, 2 hits
PF01576 Myosin_tail_1, 1 hit
PF00595 PDZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS50106 PDZ, 1 hit
PS50163 RECA_3, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A341AMK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNLMKKDKD KDGTRKEKKE KKEKKERMSA AELRSLEEMS LRRGFFNLNR
60 70 80 90 100
SSKRDSKTRL EISNPIPIKV ASSSDLHLTD IDSDSNRGSV ILDSGHLSTA
110 120 130 140 150
SSSDDLKGEE GSLRGSVLQR AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA
160 170 180 190 200
SETSTPSEHS AAPSPQVEVR TLEGQLMQHP GPGIPRPGPR SRAPELVTKR
210 220 230 240 250
FPADLRLPPV VPPLPPALRE LELQRRPTGD FGFSLRRTTV LDRGPEGQVY
260 270 280 290 300
RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GHNVESKSRD EIVEMIRQSG
310 320 330 340 350
DGVQLKVQPI PELSELSRSW LRSGEGPRRE PAHLDPEAAS PAHSQVKTEE
360 370 380 390 400
QIAAEEAWYE TEKVWLVHKD GFSLATQLKS EELSLPEGKV RVKLDHDGAI
410 420 430 440 450
LDVDEDDVEK ANAPSCDRLE DLASLVYLNE SSVLHTLRQR YGASLLHTYA
460 470 480 490 500
GPSLLVLSPR GAPAVYSEKV MHMFKGCRRE DMAPHIYAVA QTAYRAMVMS
510 520 530 540 550
RQDQSIVLLG SSGSGKTTSC QHLVQYLATI AGTSGNKVFS VDKWQALYTL
560 570 580 590 600
LEAFGNSPTI MNGNATRFSQ ILSLDFDQAG QVASASIQTM LLEKLRVARR
610 620 630 640 650
PAGEATFNIF YYLLACGDGT LRTELHLNHL AENNVFGIVP LAKPEEKQKA
660 670 680 690 700
AQQFSKLQTA MKVLGISPDE QKACWLILAA IYHLGAAGAT REAAEAGRRQ
710 720 730 740 750
FARHEWAQKA AYLLGCSLEE LSSAIFKHQH QGGTLQRSTS FRQGPEESSL
760 770 780 790 800
GDGTGPKLSA LECLEGMASG LYSELFTLLI SLVNRALKSS QHSLCSMMIV
810 820 830 840 850
DTPGFQNPEQ GGSARGASFE ELCHNYTQDR LQRLFHERTF VQELERYKEE
860 870 880 890 900
NIELAFDDLE PATGDSVAAV DQASHQSLVR SLAHTDEAKG LLWLLEEEVL
910 920 930 940 950
VPGATEDALL ERLFSYYGPQ EGDRKGQSPL LRSSKPHHFL LGHSHGTNWV
960 970 980 990 1000
EYNTAGWLSY TKQNPATQNA PRLLQDSQKK IISNLFLGRA GSATVLSGSI
1010 1020 1030 1040 1050
AGLEGGSQLA LRRATSMRKT FTTGMAAVKK KSLCIQIRLQ VDALIDTIKK
1060 1070 1080 1090 1100
SKLHFVHCFL PVAEGWAGEP RSAHSRRVSC SSELDLPPGD HCEAGLLQLD
1110 1120 1130 1140 1150
VPLLRAQLRG SRLLDAVRMY RQGYPDHMVF SEFRRRFDVL APHLTKKHGR
1160 1170 1180 1190 1200
NYIVVDEKRA VEELLESLDL EQSSCCMGLS RVFFRAGTLA RLEEQRDEQT
1210 1220 1230 1240 1250
SRNLTLFQAA CRGYLARQHF KKKKIQDLAI RCVQKNIKKN KGVKDWPWWK
1260 1270 1280 1290 1300
LFTTVRPLIE VQLSEEQIRN KDEEIQQLRS KLEKVEKERN ELRLSSDRLE
1310 1320 1330 1340 1350
TRISELTSEL TDERNTGESA SQLLDAETAE RLRAEKEMKE LQTQYDALKK
1360 1370 1380 1390 1400
KTEVMEMEVM EARLIRAAEI NGEVDDDDTG GEWRLKYERA VREVDFTKKR
1410 1420 1430 1440 1450
LQQEFEDKLE VEQQSKRQLE RRLGDLQADS DESQRALQQL KKKCQRLTAE
1460 1470 1480 1490 1500
LQDTKLHLEG QQVRNHELEK KQRRFDSELS QAHEEAQREK LQREKLQREK
1510 1520 1530 1540 1550
DMLLAEAFSL KQQMEEKDMD IAGFTQKVVS LEAELQDISS QESKDEASLA
1560 1570 1580 1590 1600
KVKKQLRDLE AKVKDQEEEL DEQAGTIQML EQAKLRLEME MERMRQTHSK
1610 1620 1630 1640 1650
EMESRDEEVE EARQSCQKKL KQMEVQLEEE YEDKQKVLRE KRELENKVAT
1660 1670 1680 1690 1700
LSDQVNQRDF ESEKRLRKDL KRTKALLADA QIMLDHLKNN APSKREIAQL
1710 1720 1730 1740 1750
KNQLEESEFT CAAAVKARKA MEVEIEDLHL QIDDIAKAKT ALEEQLSRLQ
1760 1770 1780 1790 1800
REKNEMQSRL EEDQEDMNEL MKKHKAAVAQ ASRDLAQMND LQAQLEEANK
1810 1820 1830 1840 1850
EKQELQEKLQ ALQSQVEFLE QSMVDRSLVS RQEAKIRELE TRLEFERTQV
1860 1870 1880 1890 1900
KRLESLAGRL KENMEKLTEE RDQRTAAENR EKEQNKRLQR QLRDTKEEMG
1910 1920 1930 1940 1950
ELARKEAEAS RKKHELEMDL ESLEAANQSL QADLKLAFKR IGDLQAAIED
1960 1970 1980 1990 2000
EMESDENEDL INSLQDMVTK YQKRKNKPEG DSDVDSELED RVDGVKSWLS
2010 2020 2030 2040 2050
KNKGPSKAAS DDGSLKSSSP TSYWKSLAPD RSDDEHDPLD STSRPRYSHN
2060
YLSDSDTEAK QTETNA
Length:2,066
Mass (Da):234,290
Last modified:October 10, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B6DB492FE65AF6E
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_024590377.1, XM_024734609.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_024590377.1, XM_024734609.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd01386 MYSc_Myo18, 1 hit
Gene3Di3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR031244 MYO18A
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR002928 Myosin_tail
IPR036064 MYSc_Myo18
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR020587 RecA_monomer-monomer_interface
PANTHERiPTHR45615:SF13 PTHR45615:SF13, 1 hit
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF00063 Myosin_head, 2 hits
PF01576 Myosin_tail_1, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS50106 PDZ, 1 hit
PS50163 RECA_3, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A341AMK6_9CETA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A341AMK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 10, 2018
Last sequence update: October 10, 2018
Last modified: June 5, 2019
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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