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Entry version 7 (31 Jul 2019)
Sequence version 1 (07 Nov 2018)
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Protein

Delta-like protein

Gene

JAG1

Organism
Ursus maritimus (Polar bear) (Thalarctos maritimus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:JAG1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiUrsus maritimus (Polar bear) (Thalarctos maritimus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29073 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeUrsus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000261680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1124 – 1149HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi243 ↔ 252PROSITE-ProRule annotation
Disulfide bondi256 ↔ 268PROSITE-ProRule annotation
Disulfide bondi276 ↔ 285PROSITE-ProRule annotation
Disulfide bondi309 ↔ 318PROSITE-ProRule annotation
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi418 ↔ 427PROSITE-ProRule annotation
Disulfide bondi456 ↔ 465PROSITE-ProRule annotation
Disulfide bondi494 ↔ 503PROSITE-ProRule annotation
Disulfide bondi510 ↔ 520PROSITE-ProRule annotation
Disulfide bondi531 ↔ 540PROSITE-ProRule annotation
Disulfide bondi569 ↔ 578PROSITE-ProRule annotation
Disulfide bondi607 ↔ 616PROSITE-ProRule annotation
Disulfide bondi673 ↔ 682PROSITE-ProRule annotation
Disulfide bondi711 ↔ 720PROSITE-ProRule annotation
Disulfide bondi749 ↔ 758PROSITE-ProRule annotation
Disulfide bondi787 ↔ 796PROSITE-ProRule annotation
Disulfide bondi826 ↔ 835PROSITE-ProRule annotation
Disulfide bondi864 ↔ 873PROSITE-ProRule annotation
Disulfide bondi902 ↔ 911PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini241 – 285DSLInterPro annotationAdd BLAST45
Domaini286 – 319EGF-likeInterPro annotationAdd BLAST34
Domaini352 – 390EGF-likeInterPro annotationAdd BLAST39
Domaini392 – 428EGF-likeInterPro annotationAdd BLAST37
Domaini430 – 466EGF-likeInterPro annotationAdd BLAST37
Domaini468 – 504EGF-likeInterPro annotationAdd BLAST37
Domaini506 – 541EGF-likeInterPro annotationAdd BLAST36
Domaini543 – 579EGF-likeInterPro annotationAdd BLAST37
Domaini581 – 617EGF-likeInterPro annotationAdd BLAST37
Domaini642 – 683EGF-likeInterPro annotationAdd BLAST42
Domaini685 – 721EGF-likeInterPro annotationAdd BLAST37
Domaini723 – 759EGF-likeInterPro annotationAdd BLAST37
Domaini761 – 797EGF-likeInterPro annotationAdd BLAST37
Domaini800 – 836EGF-likeInterPro annotationAdd BLAST37
Domaini838 – 874EGF-likeInterPro annotationAdd BLAST37
Domaini876 – 912EGF-likeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni1208 – 1274DisorderedSequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1208 – 1225PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1247 – 1265PolarSequence analysisAdd BLAST19

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K06052

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 11 hits
PF07645 EGF_CA, 1 hit
PF07657 MNNL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02059 JAGGEDFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A384D3M2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMRRSLPGS SLATQRAARR PPTGAIPALR PGQRDQDAPW TPAVERLERA
60 70 80 90 100
WEPSGGPLPG WVPALERLHL GWGSSGLPKC TLQVCGASGQ FELEILSMQN
110 120 130 140 150
VNGELQNGNC CGGVRNPGDR KCSHDECDTY FKVCLKEYQS RVTAGGPCSF
160 170 180 190 200
GSGSTPVIGG NTFNLKASRG NERNRIVLPF SFAWPRSYTL LVEAWDSSND
210 220 230 240 250
TLQPDSIIEK ASHSGMINPS RQWQTLKQNT GVAHFEYQIR VTCDDYYYGF
260 270 280 290 300
GCNKFCRPRD DFFGHYACDQ NGNKTCMEGW MGPECNRAIC RQGCSPKHGS
310 320 330 340 350
CKLPGDCRCQ YGWQGLYCDK CIPHPGCVHG TCNEPWQCLC ETNWGGQLCD
360 370 380 390 400
KDLNYCGTRQ PCLNGGTCSN TGPDKYQCSC PEGYSGSNCE IAEHACLSDP
410 420 430 440 450
CHNRGSCRET SLGFECECAP GWTGPTCSTN IDDCSPNNCS HGGTCQDLVN
460 470 480 490 500
GFKCVCPPQW TGKTCQLDAN ECEAKPCVNA KSCKNLIASY YCDCLPGWTG
510 520 530 540 550
QNCDININDC LGQCQNDASC RDLVNGYRCI CPPGYAGDHC ERDIDECASN
560 570 580 590 600
PCLNGGHCQN EINRFQCLCP TGFSGNLCQL DIDYCEPNPC QNGAQCYNRA
610 620 630 640 650
SDYFCKCPED YEGKNCSRLK DHCRTTPCEV IDSCTVAMAS NDTPEGVRYI
660 670 680 690 700
SSNVCGPHGK CKSQSGGKFT CDCNKGFTGT YCHENINDCE SNPCKNGGTC
710 720 730 740 750
IDGVNSYKCI CSDGWEGAYC ETNINDCSQN PCHNGGSCRD LVNDFYCDCK
760 770 780 790 800
NGWKGKTCHS RDSQCDEATC NNGGTCYDEG DAFKCMCPGG WEGTTCNIAR
810 820 830 840 850
NSSCLPNPCH NGGTCVVNGD SFTCVCKEGW EGPICTQNTN DCSPHPCYNS
860 870 880 890 900
GTCVDGDNWY RCECAPGFAG PDCRININEC QSSPCAFGAT CVDEINGYRC
910 920 930 940 950
ICPPGHSGAK CQEVSGRPCI TMGSVIPDGA KWDDDCNTCQ CLNGRIACSK
960 970 980 990 1000
VWCGPRPCLL HKGHSECPSG QSCIPILDDQ CFVRPCTGVG ECRSSSLQPV
1010 1020 1030 1040 1050
KTKCTSDPYY QENCANITFT FNKEMMSPGL TTEHICSELR NLNILKNVSA
1060 1070 1080 1090 1100
EYSIYIACEP SPSANNEIHV AISAEDIRDD GNPIKEITDK IIDLVSKRDG
1110 1120 1130 1140 1150
NSSLIAAVAE VRVQRRPLKN RTDFLVPLLS SVLTVAWICC LVTAFYWCVR
1160 1170 1180 1190 1200
KRRKPSSHAR SASEDNTTNN VREQLNQIKN PIEKHGANTV PIKDYENKNS
1210 1220 1230 1240 1250
KMSKIRTHNS EVEEDDMDKH QQKARFAKQP AYTLVDREEK PPNGTPAKHP
1260 1270
NWTNKQDNRD LESAQSLNRM EYIV
Length:1,274
Mass (Da):139,806
Last modified:November 7, 2018 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A8B1F8B2B167A87
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_008701672.1, XM_008703450.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103674543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
umr:103674543

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_008701672.1, XM_008703450.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi103674543
KEGGiumr:103674543

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
182

Phylogenomic databases

KOiK06052

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 11 hits
PF07645 EGF_CA, 1 hit
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A384D3M2_URSMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A384D3M2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 7, 2018
Last sequence update: November 7, 2018
Last modified: July 31, 2019
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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