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UniProtKB - A0A3Q7Q7P4 (A0A3Q7Q7P4_CALUR)

Entry version 4 (31 Jul 2019)
Sequence version 1 (10 Apr 2019)
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Protein
Submitted name:

dysferlin isoform X3

Gene

DYSF

Organism
Callorhinus ursinus (Northern fur seal)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
dysferlin isoform X3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DYSFImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallorhinus ursinus (Northern fur seal)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri34884 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Otariidae › Callorhinus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286641 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2080 – 2101HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 86C2InterPro annotationAdd BLAST86
Domaini255 – 336C2InterPro annotationAdd BLAST82
Domaini417 – 513C2InterPro annotationAdd BLAST97
Domaini1173 – 1278C2InterPro annotationAdd BLAST106
Domaini1599 – 1697C2InterPro annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni135 – 154DisorderedSequence analysisAdd BLAST20
Regioni178 – 249DisorderedSequence analysisAdd BLAST72
Regioni2029 – 2051DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi216 – 230Pro-richSequence analysisAdd BLAST15

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...CDDi		cd08373 C2A_Ferlin, 1 hit
cd04011 C2B_Ferlin, 1 hit
cd04018 C2C_Ferlin, 1 hit
cd04017 C2D_Ferlin, 1 hit
cd04037 C2E_Ferlin, 1 hit
cd08374 C2F_Ferlin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 6 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037726 C2A_Ferlin
IPR037720 C2B_Ferlin
IPR037722 C2C_Ferlin
IPR037723 C2D_Ferlin
IPR037724 C2E_Ferlin
IPR037725 C2F_Ferlin
IPR029998 Dysferlin
IPR012968 FerIin_dom
IPR037721 Ferlin
IPR012560 Ferlin_A-domain
IPR012561 Ferlin_B-domain
IPR032362 Ferlin_C
IPR006614 Peroxin/Ferlin

The PANTHER Classification System

More...PANTHERi		PTHR12546 PTHR12546, 1 hit
PTHR12546:SF44 PTHR12546:SF44, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168 C2, 7 hits
PF08165 FerA, 1 hit
PF08150 FerB, 1 hit
PF08151 FerI, 1 hit
PF16165 Ferlin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239 C2, 7 hits
SM00694 DysFC, 2 hits
SM00693 DysFN, 2 hits
SM01200 FerA, 1 hit
SM01201 FerB, 1 hit
SM01202 FerI, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004 C2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3Q7Q7P4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCCLLVRAS NLPSVKKDRR SDPVASLTFR GVKKRTKVIK NSVNPVWNEG 
        60         70         80         90        100
FEWDLKGIPL DQSSELHVVV KDHETMGRNR FLGEAQVPLR EVLATPSLSA 
       110        120        130        140        150
SFNAPLLDTK KQPTGASLVL QVSYTPLPGA APLFPPSASL EPSPTLPDVD 
       160        170        180        190        200
MVAGGGQSRA ETWSLLSDST VDTRYSGKKW LAPTDTGGEE DTEDQGLTGD 
       210        220        230        240        250
EAEPLLDQSS APGPGAPTTP RKPPPHPPTY HLGSKRKRSA PTARKLLSDK 
       260        270        280        290        300
PQDFQIRVQV IEGRQLPGMN IKPVVKVTAA GQTKRTRIHK GNSPLFNETL 
       310        320        330        340        350
FFNVFDSPSE LFDEPIFITV VDSRSLRTDA LIGEFRMDVG TIYREPRHAY 
       360        370        380        390        400
LRKWLLLSDP DDFSAGARGY LKASLCVLGP GDEAPLDRKD PSEDKEDIEN 
       410        420        430        440        450
NLLRPTGVAL RGAHFCLKVF RAEDLPQMDD AVMDNVKQIF GFDSNKKNLV 
       460        470        480        490        500
DPFMEVSFAG KMLCSKILEK TANPQWNQSI TLPAMFPSMC EKMRIRVMDW 
       510        520        530        540        550
DRLTHNDIVA TTYLSMSKIS APGGEIEEEP AGVAKPSPAM DLDDHLGFLP 
       560        570        580        590        600
TFGPCYVNLY GSPREFTGFP DPYAELNTGK GEGVAYRGRL LLSLETKLVE 
       610        620        630        640        650
HSEQKVEDLP ADDILRVEKY LRRRKYSLFA AFYSASMLQD VDDAIQFEVS 
       660        670        680        690        700
IGNYGNKFDT TCLPLASTTQ YSRAVFDGCH YYYLPWGNVK PVVVLSSYWE 
       710        720        730        740        750
DISHRVEAQN QLLRIADRLE AGLEQVHLAM KAQCNPEDVD SLVAQLMDEL 
       760        770        780        790        800
ISDCSQPLGN VHEIPSATHL DQYLYRLRSR HLSQITEAAL ALKLGHSGLP 
       810        820        830        840        850
AALEQAEDWL LRLRALAEEP QNSLPDIIIW MLQGDKRVAY QRLPAQEVLF 
       860        870        880        890        900
SRRGTSYCGK NCGKLQTIFL KYPMEGVPGA RMPVQIRVKL WFGLSVDEKE 
       910        920        930        940        950
FNQFAEGKLS VFAETYENQT KLALVGNWGT TGLTYPKFSD VTGKIKLPKD 
       960        970        980        990       1000
SFRPSAGWTW AGDWFVCPEK TLLHDTDAGH LSFVEEVFEN QTRLPGGQWI 
      1010       1020       1030       1040       1050
YMSDNYTDVN GEKVLPKDDI ECPLGWKWED EEWSTDLNRA VDEQGWEYSI 
      1060       1070       1080       1090       1100
TIPPDRKPKH WVPAEKMYYT HRRRRWVRLR RRDLSQMEAL KRHRQAEAEG 
      1110       1120       1130       1140       1150
EGWEYASLFG WKFHLEYRKT DAFRRRRWRR RMEPLEKTGP AAVFALEGAL 
      1160       1170       1180       1190       1200
GGVVDDRSED SMSVSTLNFG VNRPTISCIF DYGNRYHLRC YMYQARDLPS 
      1210       1220       1230       1240       1250
MDKDSFSDPY AIVSFLHQSQ KTVVVKNTLN PTWDQTLIFY EIEIFGEPAS 
      1260       1270       1280       1290       1300
IAEHPPSIVV ELYDHDTYGA DEFMGRCICQ PSLERMPRLA WFPLIRGSQL 
      1310       1320       1330       1340       1350
AGELLASFEL IQREKPAIHH IPGFEVQDTS GILDESEDTD LPYPPPQREA 
      1360       1370       1380       1390       1400
NIYVVPQNIK PVLQRTAIEI LAWGLRNMKS YQLASISSPS LVVECGGQTV 
      1410       1420       1430       1440       1450
QSCVIKNLRK NPNFDICTLF MEVMLPREEL YCPPIVIKVI DNRQFGRRPV 
      1460       1470       1480       1490       1500
VGQCTIRSLE RFMCDLYSEE SPSPQGGPDD VSLLSPGEDV LIDIDDKEPL 
      1510       1520       1530       1540       1550
IPVQEEEFID WWSKFFASTG EREKCGSYLE KGFDTLKVYD TQLENVEAFE 
      1560       1570       1580       1590       1600
GLSDFCNTFK LYRGKTQEET EDPSVIGEFK GLFKIYPLPE DPAVPMPPRQ 
      1610       1620       1630       1640       1650
FHQLAAQGPQ ECLVRIYIIR AFGLQPKDPN GKCDPYIKIS IGKKSMSDQD 
      1660       1670       1680       1690       1700
NYIPCTLEPV FGKMFELTCT LPLEKDLKIT LYDYDLLSKD EKIGETVIDL 
      1710       1720       1730       1740       1750
ENRLLSKFGA RCGLPQTYCV SGPNQWRDQL RPSQLLHLFC QQRGLKAPVY 
      1760       1770       1780       1790       1800
LTGRVLFQDK EYTIEEIESA SVLNPHLGPM EERLALHVLR QLGLVPEHVE 
      1810       1820       1830       1840       1850
SRPLYSPLQP DIEQGKLQMW IDLFPKALGR PGPPFNITPR KARRFFLRCI 
      1860       1870       1880       1890       1900
IWNTKDVTLD DLSITGEKMS DIYVKGWMVG FEEHKQKTDV HYRSLGGEGN 
      1910       1920       1930       1940       1950
FNWRFIFPFD YLPAEQVCTV SKKDAFWRLD KTESKIPARV VFQIWDNDKF 
      1960       1970       1980       1990       2000
SFDDFLGSLQ LDLNHMPKPA KTAEKCSLDQ LDDTLHLEWF VSLFEQKTVK 
      2010       2020       2030       2040       2050
GWWPCIAEEG EKKILAGKLE MTLEIVAESE HEERPAGQGR DEPNMNPKLE 
      2060       2070       2080       2090       2100
DPRRPDTSFL WFTSPYKTMK FILWRRFRCA IILFIILFIL LLFLGIFLYS 
      2110 
FPNYAAMKLV KPFS
Length:2,114
Mass (Da):240,571
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19AB69E97C4C0F22
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_025724211.1, XM_025868426.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_025724211.1, XM_025868426.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

CDDicd08373 C2A_Ferlin, 1 hit
cd04011 C2B_Ferlin, 1 hit
cd04018 C2C_Ferlin, 1 hit
cd04017 C2D_Ferlin, 1 hit
cd04037 C2E_Ferlin, 1 hit
cd08374 C2F_Ferlin, 1 hit
Gene3Di2.60.40.150, 6 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037726 C2A_Ferlin
IPR037720 C2B_Ferlin
IPR037722 C2C_Ferlin
IPR037723 C2D_Ferlin
IPR037724 C2E_Ferlin
IPR037725 C2F_Ferlin
IPR029998 Dysferlin
IPR012968 FerIin_dom
IPR037721 Ferlin
IPR012560 Ferlin_A-domain
IPR012561 Ferlin_B-domain
IPR032362 Ferlin_C
IPR006614 Peroxin/Ferlin
PANTHERiPTHR12546 PTHR12546, 1 hit
PTHR12546:SF44 PTHR12546:SF44, 1 hit
PfamiView protein in Pfam
PF00168 C2, 7 hits
PF08165 FerA, 1 hit
PF08150 FerB, 1 hit
PF08151 FerI, 1 hit
PF16165 Ferlin_C, 1 hit
SMARTiView protein in SMART
SM00239 C2, 7 hits
SM00694 DysFC, 2 hits
SM00693 DysFN, 2 hits
SM01200 FerA, 1 hit
SM01201 FerB, 1 hit
SM01202 FerI, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7Q7P4_CALUR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7Q7P4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: July 31, 2019
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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