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Entry version 3 (31 Jul 2019)
Sequence version 1 (05 Jun 2019)
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Protein
Submitted name:

Transcriptional regulator atrx isoform

Gene

LYPA_23C018693

Organism
Lynx pardinus (Iberian lynx) (Felis pardina)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-bindingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transcriptional regulator atrx isoformImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LYPA_23C018693Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLynx pardinus (Iberian lynx) (Felis pardina)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri191816 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeLynx

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini158 – 295PHD-typeInterPro annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 124DisorderedSequence analysisAdd BLAST103
Regioni425 – 1319DisorderedSequence analysisAdd BLAST895

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili283 – 303Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 61PolarSequence analysisAdd BLAST30
Compositional biasi69 – 83PolarSequence analysisAdd BLAST15
Compositional biasi108 – 123PolarSequence analysisAdd BLAST16
Compositional biasi425 – 472PolyampholyteSequence analysisAdd BLAST48
Compositional biasi486 – 505PolyampholyteSequence analysisAdd BLAST20
Compositional biasi533 – 576PolarSequence analysisAdd BLAST44
Compositional biasi627 – 658PolyampholyteSequence analysisAdd BLAST32
Compositional biasi662 – 678PolarSequence analysisAdd BLAST17
Compositional biasi679 – 705PolyampholyteSequence analysisAdd BLAST27
Compositional biasi706 – 723PolarSequence analysisAdd BLAST18
Compositional biasi754 – 798PolyampholyteSequence analysisAdd BLAST45
Compositional biasi811 – 829PolyampholyteSequence analysisAdd BLAST19
Compositional biasi838 – 863PolyampholyteSequence analysisAdd BLAST26
Compositional biasi873 – 912PolyampholyteSequence analysisAdd BLAST40
Compositional biasi929 – 948PolyampholyteSequence analysisAdd BLAST20
Compositional biasi965 – 1005PolyampholyteSequence analysisAdd BLAST41
Compositional biasi1017 – 1086PolyampholyteSequence analysisAdd BLAST70
Compositional biasi1093 – 1146PolyampholyteSequence analysisAdd BLAST54
Compositional biasi1154 – 1171PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1178 – 1195PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1196 – 1251PolarSequence analysisAdd BLAST56
Compositional biasi1267 – 1288PolyampholyteSequence analysisAdd BLAST22
Compositional biasi1295 – 1319PolyampholyteSequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025766 ADD
IPR041430 ADD_ATRX
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17981 ADD_ATRX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51533 ADD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A485P5U5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAQSLDESK LNTLVQKLHD FLAHSSEESE ETSSPPRLVM NQSTEKNSGS
60 70 80 90 100
GNNSDMMENS KEEGASSSEK SKSSGSSRSK RKPSIVTKYV ESDDEKPLDE
110 120 130 140 150
TVNEDASNEN SENDITMQSL PKGTVIVQPE PVLNEDKDDF KGPEFRSRSK
160 170 180 190 200
MKTENLKKRG EDGLHGIVSC TACGQQVNHF QKDSIYRHPS LQVLICKNCF
210 220 230 240 250
KYYMSDDISR DSDGMDEQCR WCAEGGNLIC CDFCHNAFCK KCILRNLGRK
260 270 280 290 300
ELSTIMDENN QWYCYICHPE PLLDLVTACN SVFENLEQLL QQNKKKIKVD
310 320 330 340 350
NEKSNKVYDH TPRFSPKKNN SNCNGEEKKL DESCSGTVTY SYSALIVPKE
360 370 380 390 400
MIKKAKKLIE TTANMNSSYV KFLKQAADNS EISSATKLRQ LKAFKSVLAD
410 420 430 440 450
IKKAHLALEE DLNSEIQALD AVNKEKNTKE HKVIDAKSET KVRKGEKPCA
460 470 480 490 500
LERKDFSKSE AKLSRKQVDS EHMDQSIVVQ EQRANKSASG EHKKSDKKEE
510 520 530 540 550
PQYEPTNTSD DLDMDIVSVP SSVPEDIFEN LETAMEVQSS ADNQGDGNSG
560 570 580 590 600
TEQELENSSV KLSITSKDNR GGIKSKTTAK VTKELYVKLT PVSLSNSPIK
610 620 630 640 650
GADCQEVPQD KDGYKSSSLN TKPENCGLGE EKNDNEHLFE SEVPLLSEES
660 670 680 690 700
DLRRSPRVKT TPLRRQTETN PATSNSDEEN NETVKEKQKL SVPMRKKDKR
710 720 730 740 750
NSSDSAVDNP KPNKLPKSKQ SEIVDQNSDS DEMLAILKEV SRMSHSSSSD
760 770 780 790 800
TDINETHTNH EKTLYDLKSQ TGKDDKGKRK RKSSTSGSDY DIKKGKSAKR
810 820 830 840 850
SIISKKKRQN QSESSNYDSE LEKEIKSMSK IGATKTTKKR VPNKEDYDSS
860 870 880 890 900
EDETHRKKGM DNQGQKSLKI AQEGSSDDAE RKQERENFSS AEGTVDKDKT
910 920 930 940 950
IMDLRDRMSK KQQSGVSSDG ARLPSGKEES FNSPEDKKVA ETKERSKHLK
960 970 980 990 1000
TKMGKRVQTG LLDITEKFPK KEQSDESSED DKKLSKKGTE VKEKKITDLK
1010 1020 1030 1040 1050
KNVIKMEQQY ESSSDSTEKL PEGEEISHFP KGIKQNKNDT TYGEKKRKQI
1060 1070 1080 1090 1100
KDKTSEKKDE LSDKAEKLQG KRDSCDSSED KKSKNGVSSR VKKRCNLPEK
1110 1120 1130 1140 1150
SSMKRRDCSS SDTEKYSMKE DGCDSSDKRL KRIELKERRN LNSKRNTKEV
1160 1170 1180 1190 1200
HSGSSSSDGE ESSEDNKKLK KQRTSAKKKA VSVKEKMRNS LRTSTKRKQA
1210 1220 1230 1240 1250
DISSSSSDIG DDQNSVGEGS SDEQKIKPVT ENLVLSSHTG FCQSSGDEAL
1260 1270 1280 1290 1300
SKSVPVTVDD DDDDNDPENR IAKKMLLEEI KANLSSDEDG SSDDEPEEGK
1310 1320 1330 1340
KRTGKHNEGN PGDEGELQRE VQDVIISLFD QFSLSRLSVC EIS
Length:1,343
Mass (Da):150,615
Last modified:June 5, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6D18DBD705720A3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CAAGRJ010027730 Genomic DNA Translation: VFV39708.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAGRJ010027730 Genomic DNA Translation: VFV39708.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR025766 ADD
IPR041430 ADD_ATRX
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF17981 ADD_ATRX, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51533 ADD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A485P5U5_LYNPA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A485P5U5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 5, 2019
Last sequence update: June 5, 2019
Last modified: July 31, 2019
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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