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Entry version 3 (13 Nov 2019)
Sequence version 1 (18 Sep 2019)
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Protein
Submitted name:

SH3 and multiple ankyrin repeat domains 3a

Gene
N/A
Organism
Lates calcarifer (Barramundi) (Holocentrus calcarifer)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SH3 and multiple ankyrin repeat domains 3aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLates calcarifer (Barramundi) (Holocentrus calcarifer)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8187 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangariaCarangaria incertae sedisCentropomidaeLates
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314980 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 119SH3InterPro annotationAdd BLAST60
Domaini160 – 254PDZInterPro annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 55DisorderedSequence analysisAdd BLAST55
Regioni258 – 278DisorderedSequence analysisAdd BLAST21
Regioni313 – 335DisorderedSequence analysisAdd BLAST23
Regioni389 – 465DisorderedSequence analysisAdd BLAST77
Regioni565 – 592DisorderedSequence analysisAdd BLAST28
Regioni720 – 827DisorderedSequence analysisAdd BLAST108
Regioni856 – 1126DisorderedSequence analysisAdd BLAST271
Regioni1145 – 1166DisorderedSequence analysisAdd BLAST22
Regioni1231 – 1268DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi411 – 448Pro-richSequence analysisAdd BLAST38
Compositional biasi722 – 740PolarSequence analysisAdd BLAST19
Compositional biasi786 – 807PolarSequence analysisAdd BLAST22
Compositional biasi810 – 827PolyampholyteSequence analysisAdd BLAST18
Compositional biasi856 – 923PolarSequence analysisAdd BLAST68
Compositional biasi963 – 998PolarSequence analysisAdd BLAST36
Compositional biasi999 – 1029Pro-richSequence analysisAdd BLAST31
Compositional biasi1045 – 1061PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1062 – 1094PolarSequence analysisAdd BLAST33

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17820 PDZ_6, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A4W6DP08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHEEDKPIPR RSHSHGYPHG HGPRGRLSPG SVQRDPSPPH HTPPALTGPR
60 70 80 90 100
GPKRKLYSAV PGRTFIVVKP YTPQGEGEIQ LNRGERVKVL SIGEGGFWEG
110 120 130 140 150
TVKGRTGWFP ADCVEEVQMR QYDPRLETRE DRTKRLFRHY TVGSYDNFTS
160 170 180 190 200
YSDYIIEEKN AVLQKKENEG FGFVLRGAKA ETPIEEFTPT PAFPALQYLE
210 220 230 240 250
SVDVEGVAWR AGLRTGDFLI EVNGVNVVKV GHKQVVSLIR QGGNRLLMKV
260 270 280 290 300
VSVTRKPESE EVVRKKAPPP PKRAPSTTLT LRSKSMTAEL EELASARRRR
310 320 330 340 350
GERLDEMLAS QESMLRAQPS EADYRAATVK QRPTSRRITP AEISSLFERQ
360 370 380 390 400
GMTLHGGLHP GIERGHIPLP KGMSRTKSFG ATEEDRLSAL AGEHRFPRSS
410 420 430 440 450
SMTDSLRDHS QPHPIPPPPQ TAPPPPPYYL DTGPPPAFCP PPPPSRTQSQ
460 470 480 490 500
GHEPGGRSSF KPSSLDLPYE AAQRQATHIE RQKKARSMII LQDSSHLPVE
510 520 530 540 550
PTEIPRPSAA TPPERIKRKG RVIDNPYANV GQFSIGLYTP TKPQRKKSPL
560 570 580 590 600
VKQLQVEDAQ EKASLALAAA HSRESSPSGR HPHPHGHTHT SRADYYQQQL
610 620 630 640 650
AAERERLRAQ GEMMFQGKGP FAAAIAGAVK DRERRLEERR KSTVFLSVGT
660 670 680 690 700
MEGASATSSD SPSLTQSHSI DERMLTRELG QLPPPALALS PSPSGTTFIH
710 720 730 740 750
PLTGKPLDPN SPLALALAAR ERALTSQSQS PTSSPEPRTK QERAGQGIIF
760 770 780 790 800
IDTQTKESPH EGAPTSPPFS PKSAKAAGYG VGSSPASVLV PQSTKPQWAS
810 820 830 840 850
SPSPVSFRQE MEARVEERKE EKRLEDKKSM LISIMDTSQQ KTAGLIMVHA
860 870 880 890 900
TSNGQAVGVG SELEQTPTPA SMEPSKSPSP RAKSPSPTVS QPQPQLQAQP
910 920 930 940 950
QTQRPASPAQ EKSLAQGSSE EDVDPYTVTL PPVMLSSSDE ETREELRKIG
960 970 980 990 1000
VVPPPDEFAN GLLAQAQETQ VSPPKPATSP TATTTPTPQT LSTPTTPIVT
1010 1020 1030 1040 1050
PTQPQPPQPP PPPSAAAVSG KPSDPLEPPP VGESGSAADS GVEEADTRSS
1060 1070 1080 1090 1100
SERERDHHLE TTSTVSTVSS MSTLSSESGE PADTHTTHTS YADGQTFVLD
1110 1120 1130 1140 1150
KPPVPPKPRL KSQIGGSKGP VTFRDPLLKQ SSDSELLSQQ QAAALAAAAA
1160 1170 1180 1190 1200
GGAGLPSGGS ASVTGLAPTK PRYLFQRRSK LWGDPVEPRG PGVGLGIGSL
1210 1220 1230 1240 1250
GNLGGLGLGL GADEGAKPSV MGELSSRLQQ LNKDTRSLGE EPLGASLDPG
1260
RKSPVAGARC EDTEESKP
Length:1,268
Mass (Da):136,494
Last modified:September 18, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22C4133A77F314DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A4W6DP96A0A4W6DP96_LATCA
SH3 and multiple ankyrin repeat dom...
1,484Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4W6DMU1A0A4W6DMU1_LATCA
SH3 and multiple ankyrin repeat dom...
1,448Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4W6DPJ8A0A4W6DPJ8_LATCA
SH3 and multiple ankyrin repeat dom...
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLCAT00010027247; ENSLCAP00010026679; ENSLCAG00010012445

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSLCAT00010027247; ENSLCAP00010026679; ENSLCAG00010012445

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF17820 PDZ_6, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4W6DP08_LATCA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4W6DP08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2019
Last sequence update: September 18, 2019
Last modified: November 13, 2019
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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