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Entry version 2 (11 Dec 2019)
Sequence version 1 (13 Nov 2019)
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Protein
Submitted name:

Neural cell adhesion molecule L1

Gene

D4764_08G0006130

Organism
Takifugu flavidus (sansaifugu)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neural cell adhesion molecule L1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:D4764_08G0006130Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTakifugu flavidus (sansaifugu)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri433684 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000324091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1126 – 1147HelicalSequence analysisAdd BLAST22

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

    Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502277216234 – 1264Sequence analysisAdd BLAST1231

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 134Ig-likeInterPro annotationAdd BLAST90
    Domaini144 – 235Ig-likeInterPro annotationAdd BLAST92
    Domaini250 – 338Ig-likeInterPro annotationAdd BLAST89
    Domaini343 – 431Ig-likeInterPro annotationAdd BLAST89
    Domaini437 – 522Ig-likeInterPro annotationAdd BLAST86
    Domaini526 – 617Ig-likeInterPro annotationAdd BLAST92
    Domaini624 – 719Fibronectin type-IIIInterPro annotationAdd BLAST96
    Domaini724 – 818Fibronectin type-IIIInterPro annotationAdd BLAST95
    Domaini823 – 925Fibronectin type-IIIInterPro annotationAdd BLAST103
    Domaini929 – 1024Fibronectin type-IIIInterPro annotationAdd BLAST96
    Domaini1026 – 1120Fibronectin type-IIIInterPro annotationAdd BLAST95

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni703 – 735DisorderedSequence analysisAdd BLAST33
    Regioni1154 – 1202DisorderedSequence analysisAdd BLAST49
    Regioni1219 – 1264DisorderedSequence analysisAdd BLAST46

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1154 – 1192PolyampholyteSequence analysisAdd BLAST39
    Compositional biasi1250 – 1264PolarSequence analysisAdd BLAST15

    Keywords - Domaini

    RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00063 FN3, 5 hits

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.10, 11 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003961 FN3_dom
    IPR036116 FN3_sf
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR013098 Ig_I-set
    IPR003599 Ig_sub
    IPR003598 Ig_sub2
    IPR026966 Neurofascin/L1/NrCAM_C

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13882 Bravo_FIGEY, 1 hit
    PF00041 fn3, 5 hits
    PF07679 I-set, 2 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00060 FN3, 5 hits
    SM00409 IG, 6 hits
    SM00408 IGc2, 5 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48726 SSF48726, 6 hits
    SSF49265 SSF49265, 3 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50853 FN3, 5 hits
    PS50835 IG_LIKE, 6 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A5C6MN97-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAHTQRQQGG SRGQWSRCLL LLLLPLAAQP GRAAIQIPSS FKIPPAITTQ
    60 70 80 90 100
    PESVTVFSVE DLVMRCEASG NPSPTFHWTK DGEEFDPGSD PEMKVTEEAG
    110 120 130 140 150
    SSVFYTLSNT MDTLKQYQGK YICYASNELG TAVSNAAVLM IDAPPVQQKE
    160 170 180 190 200
    KKVTEKGEVG HSIALSCNPP QSSMQPIIHW MDNRLRHIRL SDRVMVGKDG
    210 220 230 240 250
    NLYFANLLTE DSRNDYTCNI QYLATRTILA KVPITLTVNP SNLVPRNRRP
    260 270 280 290 300
    QMMRPTGSHS TYHALRGQTL ELECIVQGLP TPKVSWLRKD GEMSESRISK
    310 320 330 340 350
    DMFDRRLSFT NISESDGGEY QCIAENVQGR TFHTYTVTVE ASPYWTNAPV
    360 370 380 390 400
    SQLYAPGETV KLDCQADGIP SPTITWTVNG VPLSATSLEP RRSLTESRSL
    410 420 430 440 450
    ILKDVIFGDT AIYQCQASNK HGTILANANV YVIELPPQIL TGNGSTYTFV
    460 470 480 490 500
    EGQKALLECE TFGSPKPKVT WESSSISLLV ADPRVNLLTN GGLEIANVSH
    510 520 530 540 550
    DDEGIYTCLV QGSNISVNAE VEVLNRTVIL SPPQALRLQP GKTAIFTCLY
    560 570 580 590 600
    VTDPKLSSPL LQWRKNDQKI FESHSDKKYT FDGPGLMISN VEPGDEGVYT
    610 620 630 640 650
    CQIITKLDMV EASSTLTLCD RPDPPVHLQV TNAKHRVVTL NWTPGDDNNS
    660 670 680 690 700
    PILEYVVEFE DQDMKENGWE ELKRVAADKK HVNLPLWPYM SYRFRVIAIN
    710 720 730 740 750
    DQGKSDPSKP SDLYKTPADA PDSNPEDVRS ESTDPDTLVI TWEEMDKRNF
    760 770 780 790 800
    NGPDFKYRVM WRRVVGSGPD WHEKYTIAPP FIVTDVQNFS AFEIKVQAVN
    810 820 830 840 850
    KKGLGPEPDP VIGYSGEDVP LEAPLNLGVL LENSTTIRVT WAAVDKETVR
    860 870 880 890 900
    GHLLGYKIYL TWGHHRNSRA QEPENIVVVQ TGANEEKKSI TNLRPYCHYD
    910 920 930 940 950
    LAISAFNSKG EGPLSEKTSF MTPEGVPGPP MSMQMTSPSE SEITLHWTPP
    960 970 980 990 1000
    SKPNGILLGY SLQYRKMQSD DNPLQVVDIA SPEITHLTLK GLDRHSHYQF
    1010 1020 1030 1040 1050
    LLMARTAAGK GLSIEILGAT TLEGLPPANI SLSAEERSVN LSWEARKRHR
    1060 1070 1080 1090 1100
    TVGFQIHYFS KNDGGKWKKT EMVNSSLQFY QLQGLTPGSH YRLLFTYKNN
    1110 1120 1130 1140 1150
    TFWETEIQTK GTSVTEVQPS FATQGWFIGV VSAVVLLLLV LLILCFIKRS
    1160 1170 1180 1190 1200
    KGGKYSVKDK EDGPMDSEAR PMKDETFGEY SDLEEKRTAS QPSLGEDSKL
    1210 1220 1230 1240 1250
    CSEDNLDFNG SSAVTTELNM DESLASQFSR HSEGPEPFHG VPDNSPLNPA
    1260
    ANPPATNGAP SFLN
    Length:1,264
    Mass (Da):140,342
    Last modified:November 13, 2019 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF39EC32B21D59E68
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    RHFK02000021 Genomic DNA Translation: TWW56626.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    RHFK02000021 Genomic DNA Translation: TWW56626.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Family and domain databases

    CDDicd00063 FN3, 5 hits
    Gene3Di2.60.40.10, 11 hits
    InterProiView protein in InterPro
    IPR003961 FN3_dom
    IPR036116 FN3_sf
    IPR007110 Ig-like_dom
    IPR036179 Ig-like_dom_sf
    IPR013783 Ig-like_fold
    IPR013098 Ig_I-set
    IPR003599 Ig_sub
    IPR003598 Ig_sub2
    IPR026966 Neurofascin/L1/NrCAM_C
    PfamiView protein in Pfam
    PF13882 Bravo_FIGEY, 1 hit
    PF00041 fn3, 5 hits
    PF07679 I-set, 2 hits
    SMARTiView protein in SMART
    SM00060 FN3, 5 hits
    SM00409 IG, 6 hits
    SM00408 IGc2, 5 hits
    SUPFAMiSSF48726 SSF48726, 6 hits
    SSF49265 SSF49265, 3 hits
    PROSITEiView protein in PROSITE
    PS50853 FN3, 5 hits
    PS50835 IG_LIKE, 6 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5C6MN97_9TELE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5C6MN97
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2019
    Last sequence update: November 13, 2019
    Last modified: December 11, 2019
    This is version 2 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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