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Entry version 65 (08 May 2019)
Sequence version 1 (23 Jan 2007)
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Protein

CLIP-associating protein 1

Gene

clasp1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules during anaphase. Plays a crucial role in chromatin-induced microtubule formation. May also act at microtubule minus ends. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-XTR-2467813 Separation of Sister Chromatids
R-XTR-2500257 Resolution of Sister Chromatid Cohesion
R-XTR-2565942 Regulation of PLK1 Activity at G2/M Transition
R-XTR-380259 Loss of Nlp from mitotic centrosomes
R-XTR-380270 Recruitment of mitotic centrosome proteins and complexes
R-XTR-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-XTR-380320 Recruitment of NuMA to mitotic centrosomes
R-XTR-5620912 Anchoring of the basal body to the plasma membrane
R-XTR-5663220 RHO GTPases Activate Formins
R-XTR-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CLIP-associating protein 1By similarity
Alternative name(s):
Cytoplasmic linker-associated protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clasp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6049805 clasp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Kinetochore, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003979211 – 1452CLIP-associating protein 1Add BLAST1452

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1A5G0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with clip1/clip-170, and cenpe.

1 Publication

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati68 – 87HEAT 1Sequence analysisAdd BLAST20
Repeati88 – 124HEAT 2Sequence analysisAdd BLAST37
Repeati163 – 200HEAT 3Sequence analysisAdd BLAST38
Repeati407 – 442HEAT 4Sequence analysisAdd BLAST36
Repeati443 – 479HEAT 5Sequence analysisAdd BLAST37
Repeati926 – 963HEAT 6Sequence analysisAdd BLAST38
Repeati1256 – 1293HEAT 7Sequence analysisAdd BLAST38
Repeati1374 – 1411HEAT 8Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi532 – 724Ser-richSequence analysisAdd BLAST193

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLASP family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1A5G0

KEGG Orthology (KO)

More...
KOi
K16578

Database of Orthologous Groups

More...
OrthoDBi
66632at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG

The PANTHER Classification System

More...
PANTHERi
PTHR21567:SF28 PTHR21567:SF28, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12348 CLASP_N, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349 TOG, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A1A5G0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQGMDYWLG QIQQKDVGKR LQVGPDLMEY LSDRQKSIDL EQDQTVLDRM
60 70 80 90 100
VDGLATSWVN SSNYKVALLG MDILSALVTR LQDRFRSQIG TVLPSLMDRL
110 120 130 140 150
GDAKDSVREQ DQNLLIKIME QASNPQYVWE RMFSGFKHKN FRTREGVCLC
160 170 180 190 200
LIATLNVYGA HSLTLSKIVP HICNLLGDPN SQVRDAAINC LVEIYRHVGE
210 220 230 240 250
RVRADLSKKG LPQSRLNVIF TKFDEVQKSG TMILSSADKN FDDEDSVDGN
260 270 280 290 300
RPSSASSSAS SKAPQAARRG VSLGTARRPG TSSAAPKPGG TAKEGAGGVD
310 320 330 340 350
EEDFIRGFED VPTVQIYSSR DLEESLNKIR EILSDDKHDW EQRISALKKI
360 370 380 390 400
RSLLLAGAAE YDTFFPQLRL LDGAFKLSAK DLRSQVVREA CITLGHLSSV
410 420 430 440 450
LGNKFDHGAE AIMPTVFNLV PNSAKIMATS GVVAIRLIIR QTHVPRLIPI
460 470 480 490 500
ITSNCTSKSV AVRRRCYEFL DLLLQEWQTH SLERHVSVLA ETIKKGIHDA
510 520 530 540 550
DSEARIVARK CYWGFHSHFS KEAEQLFHTL ESSYQKALQS HLKNSDSIVS
560 570 580 590 600
LPQSDRSSSS SQESLNRPLS AKRSPTGSTV SRASTATSKS TPGSLQRSRS
610 620 630 640 650
DIDVNAATCA KSKATSGASA APFSSVAALP PGSYASLGRI RTRRQSSGST
660 670 680 690 700
TSTASTPADT RGRSRAKVVS QSQPGSRSSS PGKLLGSGYG GIASGPQRVP
710 720 730 740 750
QMPSSEKRSK IPRSQGCSRE TSPSRIGLDR FGISQPGRIP SAMRVLSSST
760 770 780 790 800
DLEAAVADAL KKPVRRRYEP YGMYSDDDAN SDASSACSER SYSSKNGGIP
810 820 830 840 850
HYLRQTEDVA EVLNHCASSN WSERKEGLIG LQNLLKSQRT LSRVELKRLC
860 870 880 890 900
EIFTRMFADP HSKRVFSMFL ETLVDFVIIH KDDLQDWLFI LLTQLLKKMG
910 920 930 940 950
ADLLGSVQAK VQKALDVTRD SFPFDQQFNI LMRFIVDQTQ TPNLKVKVAI
960 970 980 990 1000
LKYIESLARQ MDPTDFVNSS ETRLAVSRII TWTTEPKSSD VRKAAQVVLI
1010 1020 1030 1040 1050
SLFELNTPEF TMLLGALPKT FQDGATKLLH NHLKNSSNSS MGSPSNTIGR
1060 1070 1080 1090 1100
TPSRHSSSRA SPLTSPTNCS HGGLSPSMLD YDTENLNSDE IYSSLRGVTE
1110 1120 1130 1140 1150
AIEKFSFRSQ VDLNEPVRRE GKKESELGSC DVGIASPASD LRGGTDMVEG
1160 1170 1180 1190 1200
GRMALDNKTS LLNTQPPRAF TGPRGREYNP YAYSDSINSY DKTALKEAVF
1210 1220 1230 1240 1250
DDDMDQLRDV PIDHSDLVAD LLKELSNHNE RVEERKGALC ELLKITREDS
1260 1270 1280 1290 1300
LAVWEEHFKT ILLLLLETLG DKDHAIRALA LRVLREILRN QPARFKNYAE
1310 1320 1330 1340 1350
LTIMKTLEAH KDSHKEVVRA AEEAASTLAG SIHPEQCIKV LCPIIQTADY
1360 1370 1380 1390 1400
PINLAAIKMQ TKVIERISKE SLHQILPDII PGLLQGYDNT ESSVRKASVF
1410 1420 1430 1440 1450
CLVAIYSVIG EELKPYLAQL TGGKMKLLNL YIKRAQTTNS NSSSSSDVST

HS
Length:1,452
Mass (Da):160,245
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67AB39EC81F41C3C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6PN01F6PN01_XENTR
CLIP-associating protein 1
clasp1
1,472Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6T2J9F6T2J9_XENTR
CLIP-associating protein 1
clasp1
1,204Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC128634 mRNA Translation: AAI28635.1

NCBI Reference Sequences

More...
RefSeqi
NP_001090708.1, NM_001097239.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100036688

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100036688

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128634 mRNA Translation: AAI28635.1
RefSeqiNP_001090708.1, NM_001097239.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA1A5G0

Genome annotation databases

GeneIDi100036688
KEGGixtr:100036688

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23332
XenbaseiXB-GENE-6049805 clasp1

Phylogenomic databases

InParanoidiA1A5G0
KOiK16578
OrthoDBi66632at2759

Enzyme and pathway databases

ReactomeiR-XTR-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-XTR-2467813 Separation of Sister Chromatids
R-XTR-2500257 Resolution of Sister Chromatid Cohesion
R-XTR-2565942 Regulation of PLK1 Activity at G2/M Transition
R-XTR-380259 Loss of Nlp from mitotic centrosomes
R-XTR-380270 Recruitment of mitotic centrosome proteins and complexes
R-XTR-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-XTR-380320 Recruitment of NuMA to mitotic centrosomes
R-XTR-5620912 Anchoring of the basal body to the plasma membrane
R-XTR-5663220 RHO GTPases Activate Formins
R-XTR-8854518 AURKA Activation by TPX2

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG
PANTHERiPTHR21567:SF28 PTHR21567:SF28, 3 hits
PfamiView protein in Pfam
PF12348 CLASP_N, 2 hits
SMARTiView protein in SMART
SM01349 TOG, 4 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLAP1_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1A5G0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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