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Entry version 55 (08 May 2019)
Sequence version 1 (23 Jan 2007)
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Protein

CLIP-associating protein 1-B

Gene

clasp1b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules during anaphase. Plays a crucial role in chromatin-induced microtubule formation. May also act at microtubule minus ends. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CLIP-associating protein 1-BBy similarity
Alternative name(s):
Cytoplasmic linker-associated protein 1-BImported
Protein Orbit homolog
Short name:
Xorbit
Short name:
Xorbit/CLASP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clasp1bImported
Synonyms:clasp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6049836 clasp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Kinetochore, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003979201 – 1456CLIP-associating protein 1-BAdd BLAST1456

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A1A5K2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with clip1/clip-170, and cenpe.

1 Publication

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati68 – 87HEAT 1Sequence analysisAdd BLAST20
Repeati88 – 124HEAT 2Sequence analysisAdd BLAST37
Repeati163 – 200HEAT 3Sequence analysisAdd BLAST38
Repeati442 – 479HEAT 4Sequence analysisAdd BLAST38
Repeati930 – 967HEAT 5Sequence analysisAdd BLAST38
Repeati1260 – 1297HEAT 6Sequence analysisAdd BLAST38
Repeati1378 – 1415HEAT 7Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi532 – 685Ser-richSequence analysisAdd BLAST154

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CLASP family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16578

Database of Orthologous Groups

More...
OrthoDBi
66632at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG

The PANTHER Classification System

More...
PANTHERi
PTHR21567:SF28 PTHR21567:SF28, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12348 CLASP_N, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349 TOG, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1A5K2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQGMDYWLG QIQQKDVGKR LQVGPDLIEY LLDRQKSIDL EQDQTLLDRM
60 70 80 90 100
VDGLATSWVN SSNYKVALLG MDILSALVTR LQDRFRTQIG TVLPSLMDRL
110 120 130 140 150
GDAKDSVRDQ DQNLLIKIME QASNPQYMWE RMFSGFKHKN FRTREGVCLC
160 170 180 190 200
LIATLNVYGA NSLTLSKIVP HICNLLGDPN SQVRDAAINC LVEIYRHVGE
210 220 230 240 250
RVRADLSKKG LPQSRLNVIF TKFDEVQKSG TMILSTTDKN FDDEDSVDGN
260 270 280 290 300
RPSSASSSAS SKAPQTARRG VSLGTGRRPG TSSAAPKTGG TAKEGAGALD
310 320 330 340 350
EEDFIRAFED APTVQIYSSR DLEESLNKIR EILSDDKHDW EQRISALKKI
360 370 380 390 400
RSLLLAGAAE YDNFFQQLRL LDGAFKLSAK DLRSQVVREA CITLGHLSSV
410 420 430 440 450
LGNKFDHGAE AVMPTVFNLV PNSTKIMATS GVVTIRLIIR HTHVPRLIPI
460 470 480 490 500
ITSNCTSKSV AVRRRCYEFL DLLLQEWQTH SLERHVSVLA ETIKKGIHDA
510 520 530 540 550
DSEARIVARK CYWGFHGHFS KEAEQLFHAL ESSYQKALQS HLKNSDSIVS
560 570 580 590 600
LPQSDRSSSS SQESLNRPLS AKRSPTGSTV SRATSKSTTG SLQRSRSDID
610 620 630 640 650
VNAAATSKTK AASGASTAPF SSVAALPPGS YASLGRIRTR RQSSGSTTST
660 670 680 690 700
ASTPADTRGR SRAKVVSQSQ PGSRSSSPGK LLGSSYGGIA TGPQRVPQMP
710 720 730 740 750
SEKRSKIPRS QGCSRETSPS RTVLDRFGIS QPGRIPSAMR VLSSSTDLEA
760 770 780 790 800
AVADALLLGD SRNKMKPVRR RYEPYGMYSD DDANSDASSA CSERSYSSKN
810 820 830 840 850
GGIPHYLRQT EDVAEVLNHC ASSNWSERKE GLVGLQNLLK SQRLLSRVEL
860 870 880 890 900
KRLCEIFTRM FADPHSKRVF SMFLETLVDF VIIHKDDLQD WLFILLTQLL
910 920 930 940 950
KKMGADLLGS VQAKVQKALD VTRDSFPFDQ QFNILMRFIV DQTQTPNLKV
960 970 980 990 1000
KVAILKYIES LARQMDPTDF VNSSETRLAV SRIITWTTEP KSSDVRKAAQ
1010 1020 1030 1040 1050
VVLISLFELN TPEFTMLLGA LPKTFQDGAT KLLHNHLKNS SNSSMGSPSN
1060 1070 1080 1090 1100
TIGRTPSRHS SSRASPLTSP TNCSHGGLSP SMLDYDTENL NSDEIYSSLR
1110 1120 1130 1140 1150
GVTEAIEKFS FRSQVDLNEP VRRDGKKESE MGSCDAGMAS PASDLRGGTD
1160 1170 1180 1190 1200
MVEGGRMALD NKTSLLNTQP PRAFTGPRGR EYNPYAYSDS INSYDKTALK
1210 1220 1230 1240 1250
EAVFDDDMDQ LRDVPIDHSD LVADLLKELS NHNERVEERK GALCELLKIT
1260 1270 1280 1290 1300
REDNLAVWEE HFKTILLLLL ETLGDKDHAI RALALRVLRE ILRNQPARFK
1310 1320 1330 1340 1350
NYAELTIMKT LEAHKDSHKE VVRAAEEAAS TLAGSIHPEQ CIKVLCPIIQ
1360 1370 1380 1390 1400
TADYPINLAA IKMQTKVIER ISKESLHQIL PDIIPGLLQG YDNTESSVRK
1410 1420 1430 1440 1450
ASVFCLVAVY SVIGEELKPY LAQLTGSKMK LLNLYIKRAQ TTNSNSSSSS

DVSTHS
Length:1,456
Mass (Da):161,045
Last modified:January 23, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64111A33A930310C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC128690 mRNA Translation: AAI28691.1

NCBI Reference Sequences

More...
RefSeqi
NP_001128506.1, NM_001135034.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
445862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:445862

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128690 mRNA Translation: AAI28691.1
RefSeqiNP_001128506.1, NM_001135034.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA1A5K2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi445862
KEGGixla:445862

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
445862
XenbaseiXB-GENE-6049836 clasp1

Phylogenomic databases

KOiK16578
OrthoDBi66632at2759

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG
PANTHERiPTHR21567:SF28 PTHR21567:SF28, 3 hits
PfamiView protein in Pfam
PF12348 CLASP_N, 2 hits
SMARTiView protein in SMART
SM01349 TOG, 4 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLA1B_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1A5K2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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