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Entry version 92 (08 May 2019)
Sequence version 1 (06 Feb 2007)
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Protein
Submitted name:

TNR protein

Gene

TNR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TNR proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36642

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A1L306

PRoteomics IDEntifications database

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PRIDEi
A1L306

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A1L306 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A1L306, 7 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini227 – 319Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini320 – 404Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini405 – 494Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini495 – 586Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini587 – 676Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini677 – 764Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini765 – 854Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini855 – 941Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini942 – 1029Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1028 – 1243Fibrinogen C-terminalInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili26 – 53Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1225 Eukaryota
KOG2579 Eukaryota
ENOG410ZYS4 LUCA

KEGG Orthology (KO)

More...
KOi
K06252

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 9 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033079 TNR

The PANTHER Classification System

More...
PANTHERi
PTHR19143:SF254 PTHR19143:SF254, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 1 hit
PF18720 EGF_Tenascin, 2 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 4 hits
SM00186 FBG, 1 hit
SM00060 FN3, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 5 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A1L306-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQTSDHESQ VTFTHRINFP KKACPCASSA QVLQELLSRI EMLEREVSVL
60 70 80 90 100
RDQCNANCCQ ESAATGQLDY IPHCSGHGNF SFESCGCICN EGWFGKNCSE
110 120 130 140 150
PYCPLGCSSR GVCVDGQCIC DSEYSGDDCS ELRCPTDCSS RGLCVDGECV
160 170 180 190 200
CEEPYTGEDC RELRCPGDCS GKGRCANGTC LCEEGYVGED CGQRQCLNAC
210 220 230 240 250
SGRGQCEEGL CVCEEGYQGP DCSAVAPPED LRVAGISDRS IELEWDGPMA
260 270 280 290 300
VTEYVISYQP TALGGLQLQQ RVPGDWSGVT ITELEPGLTY NISVYAVISN
310 320 330 340 350
ILSLPITAKV ATHLSTPQGL QFKTITETTV EVQWEPFSFS FDGWEISFIP
360 370 380 390 400
KNNEGGVIAQ VPSDVTSFNQ TGLKPGEEYI VNVVALKEQA RSPPTSASVS
410 420 430 440 450
TVIDGPTQIL VRDVSDTVAF VEWIPPRAKV DFILLKYGLV GGEGGRTTFR
460 470 480 490 500
LQPPLSQYSV QALRPGSRYE VSVSAVRGTN ESDSATTQFT TEIDAPKNLR
510 520 530 540 550
VGSRTATSLD LEWDNSEAEV QEYKVVYSTL AGEQYHEVLV PRGIGPTTRA
560 570 580 590 600
TLTDLVPGTE YGVGISAVMN SQQSVPATMN ARTELDSPRD LMVTASSETS
610 620 630 640 650
ISLIWTKASG PIDHYRITFT PSSGIASEVT VPKDRTSYTL TDLEPGAEYI
660 670 680 690 700
ISVTAERGRQ QSLESTVDAF TGFRPISHLH FSHVTSSSVN ITWSDPSPPA
710 720 730 740 750
DRLILNYSPR DEEEEMMEVS LDATKRHAVL MGLQPATEYI VNLVAVHGTV
760 770 780 790 800
TSEPIVGSIT TGIDPPKDIT ISNVTKDSVM VSWSPPVASF DYYRVSYRPT
810 820 830 840 850
QVGRLDSSVV PNTVTEFTIT RLNPATEYEI SLNSVRGREE SERICTLVHT
860 870 880 890 900
AMDNPVDLIA TNITPTEALL QWKAPVGEVE NYVIVLTHFA VAGETILVDG
910 920 930 940 950
VSEEFRLVDL LPSTHYTATM YATNGPLTSG TISTNFSTLL DPPANLTASE
960 970 980 990 1000
VTRQSALISW QPPRAEIENY VLTYKSTDGS RKELIVDAED TWIRLEGLLE
1010 1020 1030 1040 1050
NTDYTVLLQA AQDTTWSSIT STAFTTGGRV FPHPQDCAQH LMNGDTLSGV
1060 1070 1080 1090 1100
YPIFLNGELS QKLQVYCDMT TDGGGWIVFQ RRQNGQTDFF RKWADYRVGF
1110 1120 1130 1140 1150
GNVEDEFWLG LDNIHRITSQ GRYELRVDMR DGQEAAFASY DRFSVEDSRN
1160 1170 1180 1190 1200
LYKLRIGSYN GTAGDSLSYH QGRPFSTEDR DNDVAVTNCA MSYKGAWWYK
1210 1220 1230 1240 1250
NCHRTNLNGK YGESRHSQGI NWYHWKGHEF SIPFVEMKMR PYNHRLMAGR

KRQSLQF
Length:1,257
Mass (Da):138,577
Last modified:February 6, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC91D34380A00E43F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC129830 mRNA Translation: AAI29831.1

NCBI Reference Sequences

More...
RefSeqi
NP_003276.3, NM_003285.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7143

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7143

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC129830 mRNA Translation: AAI29831.1
RefSeqiNP_003276.3, NM_003285.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA1L306, 7 interactors

Proteomic databases

PeptideAtlasiA1L306
PRIDEiA1L306

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7143
KEGGihsa:7143

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7143
PharmGKBiPA36642

Phylogenomic databases

eggNOGiKOG1225 Eukaryota
KOG2579 Eukaryota
ENOG410ZYS4 LUCA
KOiK06252

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNR human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7143

Gene expression databases

GenevisibleiA1L306 HS

Family and domain databases

CDDicd00063 FN3, 9 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033079 TNR
PANTHERiPTHR19143:SF254 PTHR19143:SF254, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 1 hit
PF18720 EGF_Tenascin, 2 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 9 hits
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00186 FBG, 1 hit
SM00060 FN3, 9 hits
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA1L306_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L306
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 8, 2019
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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