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Entry version 101 (18 Sep 2019)
Sequence version 3 (05 Apr 2011)
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Protein

Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Gene

SSC5D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processImmunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000471 Scavenging by Class B Receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
Alternative name(s):
Soluble scavenger protein with 5 SRCR domains
Short name:
SSc5D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSC5D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26641 SSC5D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618194 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A1L4H1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000179954

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SSC5D

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033298517 – 1573Soluble scavenger receptor cysteine-rich domain-containing protein SSC5DAdd BLAST1557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 109PROSITE-ProRule annotation
Disulfide bondi58 ↔ 119PROSITE-ProRule annotation
Disulfide bondi89 ↔ 99PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi223 ↔ 287PROSITE-ProRule annotation
Disulfide bondi236 ↔ 297PROSITE-ProRule annotation
Disulfide bondi267 ↔ 277PROSITE-ProRule annotation
Disulfide bondi329 ↔ 393PROSITE-ProRule annotation
Disulfide bondi342 ↔ 403PROSITE-ProRule annotation
Disulfide bondi373 ↔ 383PROSITE-ProRule annotation
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi492 ↔ 557PROSITE-ProRule annotation
Disulfide bondi505 ↔ 567PROSITE-ProRule annotation
Disulfide bondi537 ↔ 547PROSITE-ProRule annotation
Disulfide bondi797 ↔ 861PROSITE-ProRule annotation
Disulfide bondi810 ↔ 871PROSITE-ProRule annotation
Disulfide bondi841 ↔ 851PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A1L4H1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
A1L4H1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A1L4H1

PRoteomics IDEntifications database

More...
PRIDEi
A1L4H1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
150 [A1L4H1-1]
151 [A1L4H1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A1L4H1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A1L4H1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in monocytes/macrophages and T-lymphocytes. Highly expressed in placenta and spleen, and also detected at lower levels in colon, and more weakly in lung, heart and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179954 Expressed in 188 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A1L4H1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A1L4H1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042008

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LGALS1 and laminin.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129821, 13 interactors

Protein interaction database and analysis system

More...
IntActi
A1L4H1, 20 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374274

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 120SRCR 1PROSITE-ProRule annotationAdd BLAST101
Domaini198 – 298SRCR 2PROSITE-ProRule annotationAdd BLAST101
Domaini304 – 404SRCR 3PROSITE-ProRule annotationAdd BLAST101
Domaini467 – 568SRCR 4PROSITE-ProRule annotationAdd BLAST102
Domaini772 – 872SRCR 5PROSITE-ProRule annotationAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi616 – 729Thr-richAdd BLAST114
Compositional biasi970 – 1488Pro-richAdd BLAST519
Compositional biasi1089 – 1382Thr-richAdd BLAST294
Compositional biasi1558 – 1561Poly-Thr4
Compositional biasi1563 – 1566Poly-Glu4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHBC Eukaryota
ENOG410XQVR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162592

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154412

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A1L4H1

Identification of Orthologs from Complete Genome Data

More...
OMAi
WTWDTPS

Database of Orthologous Groups

More...
OrthoDBi
158600at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A1L4H1

TreeFam database of animal gene trees

More...
TreeFami
TF329295

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.250.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00530 SRCR, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00258 SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00202 SR, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56487 SSF56487, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00420 SRCR_1, 5 hits
PS50287 SRCR_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A1L4H1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVLACLLAA LVGIQAVERL RLADGPHGCA GRLEVWHGGR WGTVCDDGWD
60 70 80 90 100
LRDAAVACRQ LGCGGALAAP GGAFFGEGAG PVWLSELACR GNEGQLGLCH
110 120 130 140 150
HRGWKAHICS HEEDAGVVCA GQRVANSRDD STSPLDGAPW PGLLLELSPS
160 170 180 190 200
TEEPLVTHAP RPAGNPQNAS RKKSPRPKQA KSTRAPLLTT GAPRQERLRL
210 220 230 240 250
VSGPHRCAGR LEVWHGGRWG TVCDDGWDLR DAAVACRELG CGGALAAPGG
260 270 280 290 300
ARFGPGAGPV WMDDVGCGGG EQALRDCPRS PWGRSNCDHS EDAGLVCTGP
310 320 330 340 350
APRLRLADGP HGCAGRLEVW HGGRWGSVCD DAWDLRDAAV ACRELGCGGA
360 370 380 390 400
LAAPGGAFFG EGSGPIILDD LRCRGNETAL RFCPARPWGQ HDCHHREDAG
410 420 430 440 450
AVCDGMPLGY VPPTAPTDSN NSTPREAASR PPSTMTSQAP GTAGVSPPPA
460 470 480 490 500
SPTVLWEPGP EAGSPQLRLV AGPSKCSGRL EVWHDQRWGT VCDDSWDMRD
510 520 530 540 550
SAVVCRELGC GGPQQPDPAA GRFGWGAGPI WLDDVGCVGT EASLSDCPAA
560 570 580 590 600
PWGKHNCAHN EDVGVTCTGP PGLDSISDPF SWSWIPGLGR DRDAWLPGEL
610 620 630 640 650
ATKPSASVTA SVLEKTTTKA PGKMPKSTKK WVTKNAKRPT TQPPVMPTTK
660 670 680 690 700
HSRAQSPPDL TSQTTAALTT EASRRPTSEF TRRPTTEAPQ RWTSHTTATL
710 720 730 740 750
TPQAPRERTT KTMAMLTTQG PQEMTSESTI KSIPQASLEP SAEIPEGSPE
760 770 780 790 800
SPKDPAPSPS VSTTGESGLF RVRLADGPNR CAGRLEVWHA GRWGTVCDDN
810 820 830 840 850
WDLRDATVAC WELGCGKVRP RVGKTHYGPG TGPIWLDDMG CKGSEASLSD
860 870 880 890 900
CPSGAWGKHN CDHEEDVGLT CTGYTDYDDY PPWTWDPTSR EDLAKGTTTA
910 920 930 940 950
GVPGHTLPWR TTRRPGSSSP AIRRLPDTGS KDGYKLPWTW DTPSGRGLAE
960 970 980 990 1000
GTPTAGKLGP TLGAGTTRSP GSPPTLRVHG DTGSPRKPWP ERRPPRPAAT
1010 1020 1030 1040 1050
RTAPPTPSPG PSASPGPPGP ALTSDSSREL TPHSALTSEA TSDAPDTSPP
1060 1070 1080 1090 1100
TPDPASRTNP DLILTSPDFA LSTPDSSVVP ALTPEPSPTP LPTLPKELTS
1110 1120 1130 1140 1150
DPSTPSEVTS LSPTSEQVPE SDTTPDLDTT PYSSTVSEYS RSPDPSPSPH
1160 1170 1180 1190 1200
PTTTPDPTMA PDPITTLNPT VTPHFPTTPH PTTTPHPTTI THSTMIPDPT
1210 1220 1230 1240 1250
TTPQPFTTIT HSTMIPDPTT TPQPFTTMQP TTTPHSTTPH PTTTPHPTTI
1260 1270 1280 1290 1300
THSTMIPDPT TTPQPFTTMQ PTTMPHPTTT PHPTTTPHPT TTPHPTTTPH
1310 1320 1330 1340 1350
PTMTPDPTTT PYPTTTPDPT TTPHPTTPDP SSTPVITTVS LPTSLGTELS
1360 1370 1380 1390 1400
SPTLAPTVKP SLHPQLTFTA PAPHTSTSQI PTLEPSPALE SSPSRSSTAT
1410 1420 1430 1440 1450
SMDPLSTEDF KPPRSQSPNL TPPPTHTPHS ASDLTVSPDP LLSPTAHPLD
1460 1470 1480 1490 1500
HPPLDPLTLG PTPGQSPGPH GPCVAPTPPV RVMACEPPAL VELVAAVRDV
1510 1520 1530 1540 1550
GGQLQRLTQV VEQERQERQA LLLGLTQLVE AARGLGQLGE AVKRLAEMAW
1560 1570
TTSMPAPTTT TPEEEERPLR GDV
Length:1,573
Mass (Da):165,743
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9151F14B58BD1A0D
GO
Isoform 2 (identifier: A1L4H1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     929-953: GSKDGYKLPWTWDTPSGRGLAEGTP → EPEAGAPRGDAPRSRTARVAAPP
     954-1573: Missing.

Show »
Length:951
Mass (Da):100,561
Checksum:iDE1008BB0541B78C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZ17M0QZ17_HUMAN
Soluble scavenger receptor cysteine...
SSC5D
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPL3K7EPL3_HUMAN
Soluble scavenger receptor cysteine...
SSC5D
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI30539 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI30541 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence ACJ02752 differs from that shown. Reason: Frameshift at position 934.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti976L → P in ACJ02751 (PubMed:19535143).Curated1
Sequence conflicti1274M → I in ACJ02751 (PubMed:19535143).Curated1
Sequence conflicti1456P → S in ACJ02751 (PubMed:19535143).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040792929 – 953GSKDG…AEGTP → EPEAGAPRGDAPRSRTARVA APP in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_040793954 – 1573Missing in isoform 2. 1 PublicationAdd BLAST620

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU699476 mRNA Translation: ACJ02751.1
EU699477 mRNA Translation: ACJ02752.1 Frameshift.
AC008735 Genomic DNA No translation available.
BC130538 mRNA Translation: AAI30539.1 Different initiation.
BC130540 mRNA Translation: AAI30541.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS46196.1 [A1L4H1-1]
CCDS59424.1 [A1L4H1-2]

NCBI Reference Sequences

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RefSeqi
NP_001138422.1, NM_001144950.1 [A1L4H1-1]
NP_001182196.1, NM_001195267.1 [A1L4H1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000389623; ENSP00000374274; ENSG00000179954 [A1L4H1-1]
ENST00000587166; ENSP00000467252; ENSG00000179954 [A1L4H1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
284297

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:284297

UCSC genome browser

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UCSCi
uc002qlg.5 human [A1L4H1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU699476 mRNA Translation: ACJ02751.1
EU699477 mRNA Translation: ACJ02752.1 Frameshift.
AC008735 Genomic DNA No translation available.
BC130538 mRNA Translation: AAI30539.1 Different initiation.
BC130540 mRNA Translation: AAI30541.1 Different initiation.
CCDSiCCDS46196.1 [A1L4H1-1]
CCDS59424.1 [A1L4H1-2]
RefSeqiNP_001138422.1, NM_001144950.1 [A1L4H1-1]
NP_001182196.1, NM_001195267.1 [A1L4H1-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi129821, 13 interactors
IntActiA1L4H1, 20 interactors
STRINGi9606.ENSP00000374274

PTM databases

iPTMnetiA1L4H1
PhosphoSitePlusiA1L4H1

Polymorphism and mutation databases

BioMutaiSSC5D

Proteomic databases

jPOSTiA1L4H1
MassIVEiA1L4H1
PaxDbiA1L4H1
PRIDEiA1L4H1
ProteomicsDBi150 [A1L4H1-1]
151 [A1L4H1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389623; ENSP00000374274; ENSG00000179954 [A1L4H1-1]
ENST00000587166; ENSP00000467252; ENSG00000179954 [A1L4H1-2]
GeneIDi284297
KEGGihsa:284297
UCSCiuc002qlg.5 human [A1L4H1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
284297

GeneCards: human genes, protein and diseases

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GeneCardsi
SSC5D
HGNCiHGNC:26641 SSC5D
HPAiHPA042008
MIMi618194 gene
neXtProtiNX_A1L4H1
OpenTargetsiENSG00000179954

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHBC Eukaryota
ENOG410XQVR LUCA
GeneTreeiENSGT00940000162592
HOGENOMiHOG000154412
InParanoidiA1L4H1
OMAiWTWDTPS
OrthoDBi158600at2759
PhylomeDBiA1L4H1
TreeFamiTF329295

Enzyme and pathway databases

ReactomeiR-HSA-3000471 Scavenging by Class B Receptors

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
284297

Pharos

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Pharosi
A1L4H1

Protein Ontology

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PROi
PR:A1L4H1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179954 Expressed in 188 organ(s), highest expression level in tendon
ExpressionAtlasiA1L4H1 baseline and differential
GenevisibleiA1L4H1 HS

Family and domain databases

Gene3Di3.10.250.10, 5 hits
InterProiView protein in InterPro
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
PfamiView protein in Pfam
PF00530 SRCR, 5 hits
PRINTSiPR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00202 SR, 5 hits
SUPFAMiSSF56487 SSF56487, 5 hits
PROSITEiView protein in PROSITE
PS00420 SRCR_1, 5 hits
PS50287 SRCR_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRCRL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A1L4H1
Secondary accession number(s): B5MDQ5
, C7S7T9, C7S7U0, K7EP70
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 5, 2011
Last modified: September 18, 2019
This is version 101 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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