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Entry version 115 (31 Jul 2019)
Sequence version 2 (23 Sep 2008)
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Protein

PH and SEC7 domain-containing protein 1

Gene

PSD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 1
Alternative name(s):
Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6
Short name:
Exchange factor for ARF6
Exchange factor for ARF6 A
Pleckstrin homology and SEC7 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSD
Synonyms:EFA6, EFA6A1 Publication, KIAA2011, PSD1, TYL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9507 PSD

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602327 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A5PKW4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi621E → K: Loss of GEF activity, loss of ARF6 localization to the cleavage furrow and, later in cytokinesis, to the midbody ring. 1 Publication1
Mutagenesisi765 – 766RK → EE: Loss of localization to the plasma membrane during interphase and to the cleavage furrow during cytokinesis. No effect on ARF6 localization to the cleavage furrow and, later in cytokinesis, to the midbody ring. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
5662

Open Targets

More...
OpenTargetsi
ENSG00000059915

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33854

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PSD

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003182981 – 1024PH and SEC7 domain-containing protein 1Add BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei126PhosphoserineBy similarity1
Modified residuei156PhosphoserineBy similarity1
Modified residuei720PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A5PKW4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A5PKW4

PRoteomics IDEntifications database

More...
PRIDEi
A5PKW4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
723 [A5PKW4-1]
724 [A5PKW4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A5PKW4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A5PKW4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000059915 Expressed in 137 organ(s), highest expression level in right frontal lobe

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A5PKW4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A5PKW4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059237

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ACTN1.

Interacts (ARF6-bound form) with KCNK1; does not interact with KCNK1 in the absence of ARF6 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Usp9xP703983EBI-719999,EBI-2214043From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111641, 3 interactors

Protein interaction database and analysis system

More...
IntActi
A5PKW4, 12 interactors

Molecular INTeraction database

More...
MINTi
A5PKW4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000020673

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A5PKW4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini512 – 706SEC7PROSITE-ProRule annotationAdd BLAST195
Domaini756 – 869PHPROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili898 – 924Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 181Pro-richAdd BLAST164
Compositional biasi432 – 466Pro-richAdd BLAST35
Compositional biasi483 – 488Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PSD family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0932 Eukaryota
COG5307 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060162

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A5PKW4

KEGG Orthology (KO)

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KOi
K12494

Identification of Orthologs from Complete Genome Data

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OMAi
DAPWTER

Database of Orthologous Groups

More...
OrthoDBi
301851at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A5PKW4

TreeFam database of animal gene trees

More...
TreeFami
TF319755

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171 Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15410 PH_9, 1 hit
PF01369 Sec7, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00683 SPECTRINPH

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48425 SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms may exist.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A5PKW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQGAMRFCS EGDCAISPPR CPRRWLPEGP VPQSPPASMY GSTGSLLRRV
60 70 80 90 100
AGPGPRGREL GRVTAPCTPL RGPPSPRVAP SPWAPSSPTG QPPPGAQSSV
110 120 130 140 150
VIFRFVEKAS VRPLNGLPAP GGLSRSWDLG GVSPPRPTPA LGPGSNRKLR
160 170 180 190 200
LEASTSDPLP ARGGSALPGS RNLVHGPPAP PQVGADGLYS SLPNGLGGPP
210 220 230 240 250
ERLATLFGGP ADTGFLNQGD TWSSPREVSS HAQRIARAKW EFFYGSLDPP
260 270 280 290 300
SSGAKPPEQA PPSPPGVGSR QGSGVAVGRA AKYSETDLDT VPLRCYRETD
310 320 330 340 350
IDEVLAEREE ADSAIESQPS SEGPPGTAYP PAPRPGPLPG PHPSLGSGNE
360 370 380 390 400
DEDDDEAGGE EDVDDEVFEA SEGARPGSRM PLKSPVPFLP GTSPSADGPD
410 420 430 440 450
SFSCVFEAIL ESHRAKGTSY TSLASLEALA SPGPTQSPFF TFELPPQPPA
460 470 480 490 500
PRPDPPAPAP LAPLEPDSGT SSAADGPWTQ RGEEEEAEAR AKLAPGREPP
510 520 530 540 550
SPCHSEDSLG LGAAPLGSEP PLSQLVSDSD SELDSTERLA LGSTDTLSNG
560 570 580 590 600
QKADLEAAQR LAKRLYRLDG FRKADVARHL GKNNDFSKLV AGEYLKFFVF
610 620 630 640 650
TGMTLDQALR VFLKELALMG ETQERERVLA HFSQRYFQCN PEALSSEDGA
660 670 680 690 700
HTLTCALMLL NTDLHGHNIG KRMTCGDFIG NLEGLNDGGD FPRELLKALY
710 720 730 740 750
SSIKNEKLQW AIDEEELRRS LSELADPNPK VIKRISGGSG SGSSPFLDLT
760 770 780 790 800
PEPGAAVYKH GALVRKVHAD PDCRKTPRGK RGWKSFHGIL KGMILYLQKE
810 820 830 840 850
EYKPGKALSE TELKNAISIH HALATRASDY SKRPHVFYLR TADWRVFLFQ
860 870 880 890 900
APSLEQMQSW ITRINVVAAM FSAPPFPAAV SSQKKFSRPL LPSAATRLSQ
910 920 930 940 950
EEQVRTHEAK LKAMASELRE HRAAQLGKKG RGKEAEEQRQ KEAYLEFEKS
960 970 980 990 1000
RYSTYAALLR VKLKAGSEEL DAVEAALAQA GSTEDGLPPS HSSPSLQPKP
1010 1020
SSQPRAQRHS SEPRPGAGSG RRKP
Length:1,024
Mass (Da):109,543
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74583FEAAB0E4E01
GO
Isoform 2 (identifier: A5PKW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-379: Missing.

Show »
Length:645
Mass (Da):70,393
Checksum:i547D22FAB7C0D087
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUT6A0A1B0GUT6_HUMAN
PH and SEC7 domain-containing prote...
PSD
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC23107 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109A → T in CAA68002 (PubMed:9417912).Curated1
Sequence conflicti109A → T in AAI42690 (PubMed:15489334).Curated1
Sequence conflicti462A → T in CAA68002 (PubMed:9417912).Curated1
Sequence conflicti537E → D in CAA68002 (PubMed:9417912).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0311861 – 379Missing in isoform 2. 1 PublicationAdd BLAST379

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X99688 mRNA Translation: CAA68002.1
AB095931 mRNA Translation: BAC23107.1 Different initiation.
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49693.1
CH471066 Genomic DNA Translation: EAW49694.1
BC142643 mRNA Translation: AAI42644.1
BC142689 mRNA Translation: AAI42690.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31272.1 [A5PKW4-1]
CCDS73187.1 [A5PKW4-2]

Protein sequence database of the Protein Information Resource

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PIRi
G01205

NCBI Reference Sequences

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RefSeqi
NP_001257894.1, NM_001270965.1 [A5PKW4-1]
NP_001257895.1, NM_001270966.1 [A5PKW4-2]
NP_002770.3, NM_002779.4 [A5PKW4-1]
XP_011538270.1, XM_011539968.1 [A5PKW4-1]
XP_011538271.1, XM_011539969.2 [A5PKW4-1]
XP_016871922.1, XM_017016433.1 [A5PKW4-1]
XP_016871923.1, XM_017016434.1 [A5PKW4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000020673; ENSP00000020673; ENSG00000059915 [A5PKW4-1]
ENST00000406432; ENSP00000384830; ENSG00000059915 [A5PKW4-1]
ENST00000611678; ENSP00000481250; ENSG00000059915 [A5PKW4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5662

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5662

UCSC genome browser

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UCSCi
uc001kvg.3 human [A5PKW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99688 mRNA Translation: CAA68002.1
AB095931 mRNA Translation: BAC23107.1 Different initiation.
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49693.1
CH471066 Genomic DNA Translation: EAW49694.1
BC142643 mRNA Translation: AAI42644.1
BC142689 mRNA Translation: AAI42690.1
CCDSiCCDS31272.1 [A5PKW4-1]
CCDS73187.1 [A5PKW4-2]
PIRiG01205
RefSeqiNP_001257894.1, NM_001270965.1 [A5PKW4-1]
NP_001257895.1, NM_001270966.1 [A5PKW4-2]
NP_002770.3, NM_002779.4 [A5PKW4-1]
XP_011538270.1, XM_011539968.1 [A5PKW4-1]
XP_011538271.1, XM_011539969.2 [A5PKW4-1]
XP_016871922.1, XM_017016433.1 [A5PKW4-1]
XP_016871923.1, XM_017016434.1 [A5PKW4-1]

3D structure databases

SMRiA5PKW4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111641, 3 interactors
IntActiA5PKW4, 12 interactors
MINTiA5PKW4
STRINGi9606.ENSP00000020673

PTM databases

iPTMnetiA5PKW4
PhosphoSitePlusiA5PKW4

Polymorphism and mutation databases

BioMutaiPSD

Proteomic databases

jPOSTiA5PKW4
PaxDbiA5PKW4
PRIDEiA5PKW4
ProteomicsDBi723 [A5PKW4-1]
724 [A5PKW4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000020673; ENSP00000020673; ENSG00000059915 [A5PKW4-1]
ENST00000406432; ENSP00000384830; ENSG00000059915 [A5PKW4-1]
ENST00000611678; ENSP00000481250; ENSG00000059915 [A5PKW4-2]
GeneIDi5662
KEGGihsa:5662
UCSCiuc001kvg.3 human [A5PKW4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5662
DisGeNETi5662

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PSD
HGNCiHGNC:9507 PSD
HPAiHPA059237
MIMi602327 gene
neXtProtiNX_A5PKW4
OpenTargetsiENSG00000059915
PharmGKBiPA33854

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0932 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00940000155061
HOGENOMiHOG000060162
InParanoidiA5PKW4
KOiK12494
OMAiDAPWTER
OrthoDBi301851at2759
PhylomeDBiA5PKW4
TreeFamiTF319755

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PSD human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5662

Protein Ontology

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PROi
PR:A5PKW4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000059915 Expressed in 137 organ(s), highest expression level in right frontal lobe
ExpressionAtlasiA5PKW4 baseline and differential
GenevisibleiA5PKW4 HS

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PfamiView protein in Pfam
PF15410 PH_9, 1 hit
PF01369 Sec7, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A5PKW4
Secondary accession number(s): B1AKX7
, D3DR87, Q15673, Q8IVG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 23, 2008
Last modified: July 31, 2019
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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