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Entry version 93 (31 Jul 2019)
Sequence version 1 (23 Sep 2008)
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Protein
Submitted name:

cDNA FLJ58078, highly similar to Tyrosine-protein phosphatase non-receptortype 23

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1266Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation, ReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA FLJ58078, highly similar to Tyrosine-protein phosphatase non-receptortype 23Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B4DST5

PeptideAtlas

More...
PeptideAtlasi
B4DST5

PRoteomics IDEntifications database

More...
PRIDEi
B4DST5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
5051

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 268BRO1InterPro annotationAdd BLAST268
Domaini1094 – 1326Tyrosine-protein phosphataseInterPro annotationAdd BLAST233
Domaini1239 – 1317TYR_PHOSPHATASE_2InterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni575 – 686DisorderedSequence analysisAdd BLAST112
Regioni762 – 1025DisorderedSequence analysisAdd BLAST264
Regioni1387 – 1510DisorderedSequence analysisAdd BLAST124

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili430 – 457Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi578 – 592PolyampholyteSequence analysisAdd BLAST15
Compositional biasi599 – 615PolyampholyteSequence analysisAdd BLAST17
Compositional biasi768 – 800Pro-richSequence analysisAdd BLAST33
Compositional biasi822 – 893Pro-richSequence analysisAdd BLAST72
Compositional biasi906 – 929Pro-richSequence analysisAdd BLAST24
Compositional biasi957 – 982Pro-richSequence analysisAdd BLAST26
Compositional biasi994 – 1013PolarSequence analysisAdd BLAST20
Compositional biasi1394 – 1444Pro-richSequence analysisAdd BLAST51
Compositional biasi1445 – 1488PolarSequence analysisAdd BLAST44

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0789 Eukaryota
KOG2220 Eukaryota
ENOG410XQX6 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000012993

Database of Orthologous Groups

More...
OrthoDBi
550620at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.280, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025304 ALIX_V_dom
IPR004328 BRO1_dom
IPR038499 BRO1_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13949 ALIX_LYPXL_bnd, 1 hit
PF03097 BRO1, 1 hit
PF00102 Y_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01041 BRO1, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51180 BRO1, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B4DST5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGAMDKRVS EEGMKVSCTH FQCAAGAFAY LREHFPQAYS VDMSRQILTL
60 70 80 90 100
NVNLMLGQAQ ECLLEKSMLD NRKSFLVARI SAQVVDYYKE ACRALENPDT
110 120 130 140 150
ASLLGRIQKD WKKLVQMKIY YFAAVAHLHM GKQAEEQQKF GERVAYFQSA
160 170 180 190 200
LDKLNEAIKL AKGQPDTVQD ALRFTMDVIG GKYNSAKKDN DFIYHEAVPA
210 220 230 240 250
LDTLQPVKGA PLVKPLPVNP TDPAVTGPDI FAKLVPMAAH EASSLYSEEK
260 270 280 290 300
AKLLREMMAK IEDKNEVLDQ FMDSMQLDPE TVDNLDAYSH IPPQLMEKCA
310 320 330 340 350
ALSVRPDTVR NLVQSMQVLS GVFTDVEASL KDIRDLLEED ELLEQKFQEA
360 370 380 390 400
VGQAGAISIT SKAELAEVRR EWAKYMEVHE KASFTNSELH RAMNLHVGNL
410 420 430 440 450
RLLSGPLDQV RAALPTPALS PEDKAVLQNL KRILAKVQEM RDQRVSLEQQ
460 470 480 490 500
LRELIQKDDI TASLVTTDHS EMKKLFEEQL KKYDQLKVYL EQNLAAQDRV
510 520 530 540 550
LCALTEANVQ YAAVRRVLSD LDQKWNSTLQ TLVASYEAYE DLMKKSQEGR
560 570 580 590 600
DFYADLESKV AALLERTQST CQAREAARQQ LLDRELKKKP PPRPTAPKPL
610 620 630 640 650
LPRREESEAV EAGDPPEELR SLPPDMVAGP RLPDTFLGSA TPLHFPPSPF
660 670 680 690 700
PSSTGPGPHY LSGPLPPGTY SGPTQLIQPR APGPHAMPVA PGPALYPAPA
710 720 730 740 750
YTPELGLVPR SSPQHGVVSS PYVGVGPAPP VAGLPSAPPP QFSGPELAMA
760 770 780 790 800
VRPATTTVDS IQAPIPSHTA PRPNPTPAPP PPCFPVPPPQ PLPTPYTYPA
810 820 830 840 850
GAKQPIPAQH HFSSGIPAGF PAPRIGPQPQ PHPQPHPSQA FGPQPPQQPL
860 870 880 890 900
PLQHPHLFPP QAPGLLPPQS PYPYAPQPGV LGQPPPPLHT QLYPGPAQDP
910 920 930 940 950
LPAHSGALPF PSPGPPQPPH PPLAYGPAPS TRPMGPQAAP LTIRGPSSAG
960 970 980 990 1000
QSTPSPHLVP SPAPSPGPGP VPPRPPAAEP PPCLRRGAAA ADLLSSSPES
1010 1020 1030 1040 1050
QHGGTQSPGG GQPLLQPTKV DAAEGRRPQA LRLIERDPYE HPERLRQLQQ
1060 1070 1080 1090 1100
ELEAFRGQLG DVGALDTVWR ELQDAQEHDA RGRSIAIARC YSLKNRHQDV
1110 1120 1130 1140 1150
MPYDSNRVVL RSGKDDYINA SCVEGLSPYC PPLVATQAPL PGTAADFWLM
1160 1170 1180 1190 1200
VHEQKVSVIV MLVSEAEMEK QKVARYFPTE RGQPMVHGAL SLALSSVRST
1210 1220 1230 1240 1250
ETHVERVLSL QFRDQSLKRS LVHLHFPTWP ELGLPDSPSN LLRFIQEVHA
1260 1270 1280 1290 1300
HYLHQRPLHT PIIVHCSSGV GRTGAFALLY AAVQEVEAGN GIPELPQLVR
1310 1320 1330 1340 1350
RMRQQRKHML QEKLHLRFCY EAVVRHVEQV LQRHGVPPPC KPLASASISQ
1360 1370 1380 1390 1400
KNHLPQDSQD LVLGGDVPIS SIQATIAKLS IRPPGGLESP VASLPGPAEP
1410 1420 1430 1440 1450
PGLPPASLPE STPIPSSSPP PLSSPLPEAP QPKEEPPVPE APSSGPPSSS
1460 1470 1480 1490 1500
LELLASLTPE AFSLDSSLRG KQRMSKHNFL QAHNGQGLRA TRPSDDPLSL
1510
LDPLWTLNKT
Length:1,510
Mass (Da):164,567
Last modified:September 23, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FF204F75DEBA060
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK299906 mRNA Translation: BAG61747.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291411.1, NM_001304482.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25930

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299906 mRNA Translation: BAG61747.1
RefSeqiNP_001291411.1, NM_001304482.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiB4DST5
PeptideAtlasiB4DST5
PRIDEiB4DST5
ProteomicsDBi5051

Genome annotation databases

GeneIDi25930

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25930

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
KOG2220 Eukaryota
ENOG410XQX6 LUCA
HOGENOMiHOG000012993
OrthoDBi550620at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25930

Family and domain databases

Gene3Di1.25.40.280, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR025304 ALIX_V_dom
IPR004328 BRO1_dom
IPR038499 BRO1_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF13949 ALIX_LYPXL_bnd, 1 hit
PF03097 BRO1, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01041 BRO1, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51180 BRO1, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB4DST5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B4DST5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 31, 2019
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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