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Entry version 60 (16 Oct 2019)
Sequence version 3 (10 Apr 2019)
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Protein
Submitted name:

Centrosomal protein 131

Gene

CEP131

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-BTA-380259 Loss of Nlp from mitotic centrosomes
R-BTA-380270 Recruitment of mitotic centrosome proteins and complexes
R-BTA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-BTA-380320 Recruitment of NuMA to mitotic centrosomes
R-BTA-5620912 Anchoring of the basal body to the plasma membrane
R-BTA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Centrosomal protein 131Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP131Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:27192 CEP131

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E1BH47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000000875 Expressed in 9 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000001166

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 134DisorderedSequence analysisAdd BLAST134
Regioni193 – 212DisorderedSequence analysisAdd BLAST20
Regioni222 – 256DisorderedSequence analysisAdd BLAST35
Regioni307 – 452DisorderedSequence analysisAdd BLAST146
Regioni535 – 562DisorderedSequence analysisAdd BLAST28
Regioni780 – 809DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili568 – 595Sequence analysisAdd BLAST28
Coiled coili629 – 649Sequence analysisAdd BLAST21
Coiled coili658 – 685Sequence analysisAdd BLAST28
Coiled coili856 – 951Sequence analysisAdd BLAST96
Coiled coili960 – 1005Sequence analysisAdd BLAST46
Coiled coili1014 – 1041Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 49PolarSequence analysisAdd BLAST23
Compositional biasi69 – 90PolarSequence analysisAdd BLAST22
Compositional biasi233 – 254PolarSequence analysisAdd BLAST22
Compositional biasi321 – 341PolyampholyteSequence analysisAdd BLAST21
Compositional biasi378 – 402PolarSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEUN Eukaryota
ENOG410YVPU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001758

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E1BH47

Database of Orthologous Groups

More...
OrthoDBi
918776at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328914

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030465 CEP131

The PANTHER Classification System

More...
PANTHERi
PTHR31540 PTHR31540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E1BH47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGSRALSGP EGSLEGVDLS LTGLPPPMNR RPNSASATKP ITRSISVVTG
60 70 80 90 100
NEPRRKLLEN PGPGGSRAIN NLRRSNSATQ VNQPQANQAW PSPLRPAEPP
110 120 130 140 150
DFLTLFEGSP SGRKRPASLS KASSEKGATW NVLDDRPRAF TLPSDAQSPG
160 170 180 190 200
ALDVPVGPRR RECTVPLAPN FTANNRSNKG AVGNCVTTMV HNHYTPSERV
210 220 230 240 250
PPPPKSSNRT APSLNNIIKA ATDEGEGSSL GKPQKNVARS NHVVQNNSGG
260 270 280 290 300
TTGLLRRKEV TEEEAERFIH QVNQAAVTIQ RWYRHQVQRR RAGAARLERL
310 320 330 340 350
LASKREGQRQ RLGEGSLLDQ HQQREAARRK AREEKARQAR RAAIQELQQK
360 370 380 390 400
RAQKSGNADL GLLKGMGETE KPQPTQEPAM RPGSTTQQTR KANNTGASFH
410 420 430 440 450
TAGSEDAGQP ALGSSPEPRQ LSEDKPQDAS LQDVPGEGLE GMGRAGSRAK
460 470 480 490 500
SKATLDELLD TLKLLEQEPE PLPCPRAYHK DKYAWTDEED DASSLTADNL
510 520 530 540 550
EKFGKLSAAA GPPEDGTLLS EAKLQSIMNF LDEMEKSGQG RPASAPQGPM
560 570 580 590 600
PEEGLGRLEP TSEVSTSVMR LQLEVEEKKQ AMVLLQRALA QQRDLTFRRV
610 620 630 640 650
KETERELGRQ LRQQKEHYEA TIRRHLSFID QLIEDKKALG EKCEALVAEL
660 670 680 690 700
KLGDQRRKDR EAQLQEQHEL EIKKLKELMS ATEKVRREKW INEKTRKIKE
710 720 730 740 750
ITVKGLEPEI QKLIAKHKQE VKKLKGLHAT ELLQAEERAA QHYGRQAEEL
760 770 780 790 800
REHLEREKEA LGRQEWERAQ QRQRAELDEL RRQLEESSSA GGRALRAEFE
810 820 830 840 850
KGKEEQERRH QMELKALKDQ LEVERQMWEA NSAKKEEAWL LNRERELKEE
860 870 880 890 900
IRKGRDKEIE LVIHRLEADM TQAREESERA AENRVKRLRD KYEAELSELE
910 920 930 940 950
QSERKLQERC AELKGRLGEA EGENVRLQGL VRQKEKELAD VKAVNEQLTG
960 970 980 990 1000
ERSSLAQVLR QEFADRLATS EEENRQTKAE LAELRARQRL ELEQLTREKQ
1010 1020 1030 1040 1050
AELEEVHGRV KMALAKKEEA VSSLRKQHQA AMKRAEHLEE LLEQCRRPFP

SAK
Length:1,053
Mass (Da):118,853
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FE45A886619F5C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1M407A0A3Q1M407_BOVIN
Centrosomal protein 131
CEP131
1,154Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1M3D3A0A3Q1M3D3_BOVIN
Centrosomal protein 131
CEP131
1,089Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q1MHK6A0A3Q1MHK6_BOVIN
Centrosomal protein 131
CEP131
1,115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000001166; ENSBTAP00000001166; ENSBTAG00000000875

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001166

Proteomic databases

PaxDbiE1BH47

Genome annotation databases

EnsembliENSBTAT00000001166; ENSBTAP00000001166; ENSBTAG00000000875

Organism-specific databases

VGNCiVGNC:27192 CEP131

Phylogenomic databases

eggNOGiENOG410IEUN Eukaryota
ENOG410YVPU LUCA
GeneTreeiENSGT00390000001758
InParanoidiE1BH47
OrthoDBi918776at2759
TreeFamiTF328914

Enzyme and pathway databases

ReactomeiR-BTA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-BTA-380259 Loss of Nlp from mitotic centrosomes
R-BTA-380270 Recruitment of mitotic centrosome proteins and complexes
R-BTA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-BTA-380320 Recruitment of NuMA to mitotic centrosomes
R-BTA-5620912 Anchoring of the basal body to the plasma membrane
R-BTA-8854518 AURKA Activation by TPX2

Gene expression databases

BgeeiENSBTAG00000000875 Expressed in 9 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR030465 CEP131
PANTHERiPTHR31540 PTHR31540, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE1BH47_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1BH47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: April 10, 2019
Last modified: October 16, 2019
This is version 60 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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