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Entry version 60 (16 Oct 2019)
Sequence version 2 (26 Jun 2013)
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Protein

Down syndrome cell adhesion molecule-like protein 1 homolog

Gene

DSCAML1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (PubMed:18216854).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Neurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Down syndrome cell adhesion molecule-like protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSCAML1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 24

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 1592ExtracellularCuratedAdd BLAST1575
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1593 – 1613HelicalSequence analysisAdd BLAST21
Topological domaini1614 – 2042CytoplasmicCuratedAdd BLAST429

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043454418 – 2042Down syndrome cell adhesion molecule-like protein 1 homologSequence analysisAdd BLAST2025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi46 ↔ 102PROSITE-ProRule annotation
Glycosylationi78N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi145 ↔ 197PROSITE-ProRule annotation
Disulfide bondi248 ↔ 295PROSITE-ProRule annotation
Disulfide bondi337 ↔ 387PROSITE-ProRule annotation
Glycosylationi369N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi430 ↔ 486PROSITE-ProRule annotation
Glycosylationi472N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi514N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi527 ↔ 576PROSITE-ProRule annotation
Glycosylationi557N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi618 ↔ 670PROSITE-ProRule annotation
Glycosylationi667N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi711N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi712 ↔ 768PROSITE-ProRule annotation
Glycosylationi750N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi797N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi810N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi811 ↔ 868PROSITE-ProRule annotation
Glycosylationi927N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1083N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1145N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1163N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1276N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1312 ↔ 1364PROSITE-ProRule annotation
Glycosylationi1346N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1493N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1532N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1562N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

SDK1, SDK2, DSCAM and DSCAML1 are expressed in non-overlapping subsets of interneurons and retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae (PubMed:18216854).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000007314 Expressed in 3 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E1C8P7 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000011821

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E1C8P7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 107Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST71
Domaini114 – 216Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST103
Domaini227 – 311Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST85
Domaini315 – 403Ig-like C2-type 4PROSITE-ProRule annotationAdd BLAST89
Domaini409 – 502Ig-like C2-type 5PROSITE-ProRule annotationAdd BLAST94
Domaini507 – 587Ig-like C2-type 6PROSITE-ProRule annotationAdd BLAST81
Domaini597 – 686Ig-like C2-type 7PROSITE-ProRule annotationAdd BLAST90
Domaini691 – 785Ig-like C2-type 8PROSITE-ProRule annotationAdd BLAST95
Domaini789 – 886Ig-like C2-type 9PROSITE-ProRule annotationAdd BLAST98
Domaini888 – 985Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini990 – 1089Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini1094 – 1190Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini1194 – 1289Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini1279 – 1368Ig-like C2-type 10PROSITE-ProRule annotationAdd BLAST90
Domaini1384 – 1478Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST95
Domaini1479 – 1579Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1915 – 1996Pro-richPROSITE-ProRule annotationAdd BLAST82
Compositional biasi1960 – 1965Poly-SerSequence analysis6
Compositional biasi1999 – 2005Poly-ThrSequence analysis7

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155354

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRSNQYT

Database of Orthologous Groups

More...
OrthoDBi
14047at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 16 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033029 DSCAML1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

The PANTHER Classification System

More...
PANTHERi
PTHR13817:SF54 PTHR13817:SF54, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

E1C8P7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLVTFFLLY SLRKAHTEDV GTSLYFVNDS IQQVTFSSTV GVVIPCPAAG
60 70 80 90 100
SPSAVLRWYL ATGDDIYDVP HIRHVHANGT LQLYPFSPSA FNSFIHDNDY
110 120 130 140 150
FCTAENSAGK IRSPNIRVKA VFREPYTVRV EDQRSMRGNV AVFKCLIPSS
160 170 180 190 200
VQEYVSVVSW EKDTVSIIPE NRFFITSYGG LYISDVQKED ALSTYRCITK
210 220 230 240 250
HKYSGETRQS NGARLSVSDA DPAESIPTML DSFQSREVRA GRLVELPCIA
260 270 280 290 300
SGYPNPAIRW LKDGRPLPAD GRWAKRITGL SIADLRVEDS GTYICEVTNT
310 320 330 340 350
FGSAEVTGTL TVIDPLRVTL TPKKLKTGIG STVILSCALS GSPEYVIRWY
360 370 380 390 400
RNTDLVVVDD FISIRGISNE TLLITAAQKS HSGAYQCFAT RKSQTAQDFS
410 420 430 440 450
IITLEDGTPR IVSSFSEKVV NPGEQFSLMC AAKGAPPPTV TWALDDEPIP
460 470 480 490 500
RDNGHRTNQY TMSDGTTVSH MNVTSPQIKD GGVYRCTARN SVGSAEYQAR
510 520 530 540 550
INVRGPPSIR AMKNITAVAG RDTFINCRVI GYPYYSIKWY KDSLLLPDNH
560 570 580 590 600
RQVVFENGTL KLMDVQKGMD EGEYLCSVLI QPQLSISQSV HVTVKVPPLI
610 620 630 640 650
QPFEFPPASI GQLLYIPCVV SSGDMPIHIT WRKDGHVILS GSGVTIESKE
660 670 680 690 700
FMSSLQISSV SLKHNGNYTC IASNAAATVS RERQLIVRVP PRFVVQPNNQ
710 720 730 740 750
DGIYGKAGVL NCSVDGYPPP KVMWKHAKGS GNPQQYHPIP LTGRIQILPN
760 770 780 790 800
SSLLIRHVLE EDIGYYLCQA SNGVGTDISK SMFLTVKIPA MITSHPNTTI
810 820 830 840 850
AIKGQSKELN CTARGERPII IRWEKGDTVI DPDRNMRYAI ATKDNGDEVI
860 870 880 890 900
STLKLKPADR GDSVFFSCHA INSYGEDRGL IQLTVQEPPD PPELEIREVK
910 920 930 940 950
ARSMNLRWTQ RFDGNSIITG FDIEYKNKSD SWDFKQSTRN ISPTINQANI
960 970 980 990 1000
VDLHPASVYS IRMYSFNKIG RSEPSKELTI STEEAAPDGP PMDVTLQPMT
1010 1020 1030 1040 1050
SQSIQVTWKA PKKELQNGVI RGYQIGYREN SPGSNGQYSI VEMKATGDSE
1060 1070 1080 1090 1100
VYTLDNLKKF AQYGVVVQAF NRAGTGPSSS EINATTLEDV PSQPPENVRA
1110 1120 1130 1140 1150
ISITSDVAVI SWSEPPRSTL NGVLKGYRVI FWSLYMDGEW GEMQNITTTR
1160 1170 1180 1190 1200
ERVELRGMEK FTNYSVQVLA YTQAGDGVRS SVLYIQTKED IPGPPAGIKA
1210 1220 1230 1240 1250
VPSSASSVVV SWLPPAKPNG IIRKYTIFCS SPGSGQPAPS EYETSPDQLF
1260 1270 1280 1290 1300
YRIAHLNRGQ QYMLWVAAVT SAGRGNISEK VTIEPAGKAP AKIISFGGTV
1310 1320 1330 1340 1350
TTPWMKDVRL PCNSVGEPVP AIKWTKDSED SAIPVTVDGH RLIQANGTLV
1360 1370 1380 1390 1400
LRSVKAEDSG YYTCTATNTW GFDTIIINLL VQVPPDQPRL TVSKTSASSI
1410 1420 1430 1440 1450
TLAWIPGDNG GSSIRGFVLQ YSVDNSEEWK DVFISSSERS FKLESLKCGT
1460 1470 1480 1490 1500
WYKVKLAAKN SVGAGRISEI IEAKTHGREP SFSKDQHLFT HINSTHARLN
1510 1520 1530 1540 1550
LQGWSSGGCP ITAIVLEYRP KGNWGWQSLR TNSSGEVFLT ELREATWYEL
1560 1570 1580 1590 1600
RMKACNSAGC GNESTQFATL DYDGSTIPPI KSAQGEGDDV KKLFTIACPI
1610 1620 1630 1640 1650
ILATLGVALL FIIRKKRKEK RLKRLRDAKS LAEMLISKNN RSFDTPVKGP
1660 1670 1680 1690 1700
PQGPRLHIDI PRVQLLIEDK EGIKQLGDDK ATIPVTDTEF SQAVNPQSFC
1710 1720 1730 1740 1750
TGVSLHHPAL IQNTGPLIDM SDIRPGTNPV SRKSVKSAHS TRNRYSSQWT
1760 1770 1780 1790 1800
LTKCQASTPA RTLTSDWRTV GSQHGITVTE SDSYSASLSQ DTDKGRNSMV
1810 1820 1830 1840 1850
STESASSTYE ELARAYEHAK LEEQLQHAKF EITECFISDS SSDQMTTGTT
1860 1870 1880 1890 1900
DNADSMTSMS TPSEPGICRF TASPPKPQDS ERGKSVAVPI PHRASKSDYC
1910 1920 1930 1940 1950
NLPLYVKSDA FFRKPDSHEP CPVVPPREAS IRSLARGYHP PARHLTLDPA
1960 1970 1980 1990 2000
AKPPGLPPPS SSSSSTTLPQ RTLPMPTAAS TAPAPAPAPA APAEPPANTT
2010 2020 2030 2040
TTTTTHSKVG GSRDSLLEMS TSGAGRAQKQ GAGAYSKSYT LV
Length:2,042
Mass (Da):223,884
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i580169E8CE770408
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN03008271 Genomic DNA No translation available.
AADN03008296 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000011835; ENSGALP00000011821; ENSGALG00000007314

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03008271 Genomic DNA No translation available.
AADN03008296 Genomic DNA No translation available.

3D structure databases

SMRiE1C8P7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011821

Genome annotation databases

EnsembliENSGALT00000011835; ENSGALP00000011821; ENSGALG00000007314

Phylogenomic databases

GeneTreeiENSGT00940000155354
OMAiHRSNQYT
OrthoDBi14047at2759

Gene expression databases

BgeeiENSGALG00000007314 Expressed in 3 organ(s), highest expression level in brain
ExpressionAtlasiE1C8P7 baseline

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 16 hits
InterProiView protein in InterPro
IPR033029 DSCAML1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PANTHERiPTHR13817:SF54 PTHR13817:SF54, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSCL1_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E1C8P7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2015
Last sequence update: June 26, 2013
Last modified: October 16, 2019
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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