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Entry version 82 (16 Oct 2019)
Sequence version 1 (08 Feb 2011)
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Protein
Submitted name:

Peptidyl-prolyl cis-trans isomerase D

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomeraseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Peptidyl-prolyl cis-trans isomerase DImported
Submitted name:
Testicular tissue protein Li 147Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171497 Expressed in 233 organ(s), highest expression level in frontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM27P143733EBI-10176944,EBI-719493

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
E5KN55, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 183PPIase cyclophilin-typeInterPro annotationAdd BLAST165
Domaini223 – 256TPR_REGIONInterPro annotationAdd BLAST34
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati223 – 256TPRPROSITE-ProRule annotationAdd BLAST34
Domaini273 – 340TPR_REGIONInterPro annotationAdd BLAST68
Repeati273 – 306TPRPROSITE-ProRule annotationAdd BLAST34
Repeati307 – 340TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0546 Eukaryota
COG0652 LUCA

KEGG Orthology (KO)

More...
KOi
K05864

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKDFGNK

Database of Orthologous Groups

More...
OrthoDBi
1403619at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
2.40.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF13176 TPR_7, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00153 CSAPPISMRASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF50891 SSF50891, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E5KN55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA
60 70 80 90 100
LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG
110 120 130 140 150
EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG
160 170 180 190 200
QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD
210 220 230 240 250
SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL
260 270 280 290 300
RYVDSSKAVI ETADRAKLQP IALSCVLNIG ACKLKMSNWQ GAIDSCLEAL
310 320 330 340 350
ELDPSNTKAL YRRAQGWQGL KEYDQALADL KKAQGIAPED KAIQAELLKV
360 370
KQKIKAQKDK EKAVYAKMFA
Length:370
Mass (Da):40,764
Last modified:February 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39D4100748B35D48
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ205146 Genomic DNA Translation: ADP90614.1
HQ205147 Genomic DNA Translation: ADP90615.1
HQ205148 Genomic DNA Translation: ADP90616.1
HQ205149 Genomic DNA Translation: ADP90617.1
HQ205151 Genomic DNA Translation: ADP90619.1
HQ205152 Genomic DNA Translation: ADP90620.1
HQ205153 Genomic DNA Translation: ADP90621.1
HQ205154 Genomic DNA Translation: ADP90622.1
HQ205155 Genomic DNA Translation: ADP90623.1
HQ205156 Genomic DNA Translation: ADP90624.1
HQ205157 Genomic DNA Translation: ADP90625.1
HQ205158 Genomic DNA Translation: ADP90626.1
HQ205159 Genomic DNA Translation: ADP90627.1
HQ205160 Genomic DNA Translation: ADP90628.1
HQ205161 Genomic DNA Translation: ADP90629.1
HQ205162 Genomic DNA Translation: ADP90630.1
HQ205163 Genomic DNA Translation: ADP90631.1
HQ205165 Genomic DNA Translation: ADP90633.1
HQ205166 Genomic DNA Translation: ADP90634.1
HQ205168 Genomic DNA Translation: ADP90636.1
HQ205169 Genomic DNA Translation: ADP90637.1
HQ205170 Genomic DNA Translation: ADP90638.1
HQ205171 Genomic DNA Translation: ADP90639.1
HQ205172 Genomic DNA Translation: ADP90640.1
HQ205173 Genomic DNA Translation: ADP90641.1
HQ205174 Genomic DNA Translation: ADP90642.1
HQ205175 Genomic DNA Translation: ADP90643.1
HQ205176 Genomic DNA Translation: ADP90644.1
HQ205177 Genomic DNA Translation: ADP90645.1
HQ205178 Genomic DNA Translation: ADP90646.1
HQ205179 Genomic DNA Translation: ADP90647.1
HQ205180 Genomic DNA Translation: ADP90648.1
HQ205181 Genomic DNA Translation: ADP90649.1
HQ205182 Genomic DNA Translation: ADP90650.1
HQ205183 Genomic DNA Translation: ADP90651.1
HQ205184 Genomic DNA Translation: ADP90652.1
HQ205185 Genomic DNA Translation: ADP90653.1
HM005460 mRNA Translation: AEE61058.1

NCBI Reference Sequences

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RefSeqi
NP_005029.1, NM_005038.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
5481

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5481

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ205146 Genomic DNA Translation: ADP90614.1
HQ205147 Genomic DNA Translation: ADP90615.1
HQ205148 Genomic DNA Translation: ADP90616.1
HQ205149 Genomic DNA Translation: ADP90617.1
HQ205151 Genomic DNA Translation: ADP90619.1
HQ205152 Genomic DNA Translation: ADP90620.1
HQ205153 Genomic DNA Translation: ADP90621.1
HQ205154 Genomic DNA Translation: ADP90622.1
HQ205155 Genomic DNA Translation: ADP90623.1
HQ205156 Genomic DNA Translation: ADP90624.1
HQ205157 Genomic DNA Translation: ADP90625.1
HQ205158 Genomic DNA Translation: ADP90626.1
HQ205159 Genomic DNA Translation: ADP90627.1
HQ205160 Genomic DNA Translation: ADP90628.1
HQ205161 Genomic DNA Translation: ADP90629.1
HQ205162 Genomic DNA Translation: ADP90630.1
HQ205163 Genomic DNA Translation: ADP90631.1
HQ205165 Genomic DNA Translation: ADP90633.1
HQ205166 Genomic DNA Translation: ADP90634.1
HQ205168 Genomic DNA Translation: ADP90636.1
HQ205169 Genomic DNA Translation: ADP90637.1
HQ205170 Genomic DNA Translation: ADP90638.1
HQ205171 Genomic DNA Translation: ADP90639.1
HQ205172 Genomic DNA Translation: ADP90640.1
HQ205173 Genomic DNA Translation: ADP90641.1
HQ205174 Genomic DNA Translation: ADP90642.1
HQ205175 Genomic DNA Translation: ADP90643.1
HQ205176 Genomic DNA Translation: ADP90644.1
HQ205177 Genomic DNA Translation: ADP90645.1
HQ205178 Genomic DNA Translation: ADP90646.1
HQ205179 Genomic DNA Translation: ADP90647.1
HQ205180 Genomic DNA Translation: ADP90648.1
HQ205181 Genomic DNA Translation: ADP90649.1
HQ205182 Genomic DNA Translation: ADP90650.1
HQ205183 Genomic DNA Translation: ADP90651.1
HQ205184 Genomic DNA Translation: ADP90652.1
HQ205185 Genomic DNA Translation: ADP90653.1
HM005460 mRNA Translation: AEE61058.1
RefSeqiNP_005029.1, NM_005038.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiE5KN55, 1 interactor

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5481

Genome annotation databases

GeneIDi5481
KEGGihsa:5481

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5481

Phylogenomic databases

eggNOGiKOG0546 Eukaryota
COG0652 LUCA
KOiK05864
OMAiCKDFGNK
OrthoDBi1403619at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5481

Gene expression databases

BgeeiENSG00000171497 Expressed in 233 organ(s), highest expression level in frontal cortex

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF13176 TPR_7, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE5KN55_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E5KN55
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 8, 2011
Last sequence update: February 8, 2011
Last modified: October 16, 2019
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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