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Entry version 62 (16 Oct 2019)
Sequence version 2 (16 Nov 2011)
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Protein
Submitted name:

IQ motif containing GTPase activating protein 1

Gene

IQGAP1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-373753 Nephrin family interactions
R-BTA-5626467 RHO GTPases activate IQGAPs
R-BTA-5674135 MAP2K and MAPK activation
R-BTA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
IQ motif containing GTPase activating protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQGAP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:30258 IQGAP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1MC48

PRoteomics IDEntifications database

More...
PRIDEi
F1MC48

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000013060 Expressed in 9 organ(s), highest expression level in lung

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000017366

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1MC48

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 116Calponin-homology (CH)InterPro annotationAdd BLAST116
Domaini630 – 663WWInterPro annotationAdd BLAST34
Domaini955 – 1188Ras-GAPInterPro annotationAdd BLAST234

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili125 – 152Sequence analysisAdd BLAST28
Coiled coili229 – 249Sequence analysisAdd BLAST21
Coiled coili320 – 340Sequence analysisAdd BLAST21
Coiled coili439 – 466Sequence analysisAdd BLAST28
Coiled coili528 – 548Sequence analysisAdd BLAST21
Coiled coili840 – 860Sequence analysisAdd BLAST21
Coiled coili1445 – 1465Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2128 Eukaryota
COG5261 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183076

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1MC48

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEWVKHW

TreeFam database of animal gene trees

More...
TreeFami
TF313078

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
IPR000593 RasGAP_C
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001202 WW_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF00612 IQ, 4 hits
PF00616 RasGAP, 1 hit
PF03836 RasGAP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 4 hits
SM00323 RasGAP, 1 hit
SM00456 WW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF48350 SSF48350, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS50096 IQ, 4 hits
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1MC48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYSEVFPQW MEACLGEDLP PTTELEEGLR NGVYLAKLGN FFSPKVVSLK
60 70 80 90 100
KIYDREQTRY KATGLHFRHT DNVIQWLNAM GEIGLPKIFY PETTDIYDRK
110 120 130 140 150
NMPRCIYCIH ALSLYLFKLG LAPQIQDLYG KVDFTEEEIN NMKIELEKYG
160 170 180 190 200
IQMPAFSKIG GILANELSVD EAALHAAVIA INEAIDHRIP ADTFTALKNP
210 220 230 240 250
NAMLVNLEEC LASTYQDILY QAKQDKMANA KNRRERDVYE ELLTQAEIQG
260 270 280 290 300
NINKVNLLAA LTNIDLALEQ GSAPALFKIL QSPALGLRGL QQQNSDWYLK
310 320 330 340 350
QLLSDRQQKR QGGQAEPLQK EELQSGVDAA NTAAQEYQRR LAAVAAINAA
360 370 380 390 400
IQKGVAEKTV LELMNPEAQL PQVYPFAADL YQKELATLQQ QSPEHSLTHP
410 420 430 440 450
ELSVAVEMLS SVALINRALE SGDMNTVWKQ LSSSVTGLTN IEEENCQRYL
460 470 480 490 500
DELMKLKAQA RAENNEFITW NDIQASVDHV NRVVQEEHER ILAIGLINEA
510 520 530 540 550
LDEGDAQKTL QALQIPAAKL EGVLSEVAQH YQDTLIRAKR EKAQETQDES
560 570 580 590 600
AVLWLDEIQG GIWQSNKDTQ EAQRFALGIF AINEAVEKGD VGKTLSALRS
610 620 630 640 650
PDVGLYGVIP ECGETYQSDL AEAKKKKLAA DNNSKWVKHW VKGGYHYYHN
660 670 680 690 700
LETQEGGWDE PSDFVQNSMQ LSREEIQSSI SGVTAAYNRE QLWLANEGLI
710 720 730 740 750
TKLQACCRGY LVRQEFRSRM NFLKKQIPAI TCIQSQWRGY KQKKAYQDRL
760 770 780 790 800
AYLRSHKDEV IKIQSLARMH QARKRYRERL QYFRDHINDI IKIQAFIRAN
810 820 830 840 850
KARDDYKTLI NAEDPPMIVV RKFVHLLDQS DQDFQEELDL MKMREEVITL
860 870 880 890 900
IRSNQQLEND LNLMDIKIGL LVKNKITLQD VVSHSKKLTK KNKEQLSDMM
910 920 930 940 950
MLNKQKGGLK ALSKEKREKL EAYQHLFYLL QTNPTYLAKL IFQMPQNKST
960 970 980 990 1000
KFMDSVIFTL YNYASNQREE YLLLRLFKTA LQEEIKSKVD QIQEIVTGNP
1010 1020 1030 1040 1050
TVIKMVVSFN RGARGQNALR QILAPVVKEI MDDKTLNIKT DPVDIYKSWV
1060 1070 1080 1090 1100
NQMESQTGEA SKLPYDVTPE QALSHEEVRT RLDNSIRNMR AVTDKFLAAI
1110 1120 1130 1140 1150
ISSVDKIPYG MRFIAKVLKD SLHEKFPDAG EDELLKIIGN LLYYRYMNPA
1160 1170 1180 1190 1200
IVAPDAFDII DLSAGGQLTT DQRRNLGSIA KMLQHAASNK MFLGDNAHLS
1210 1220 1230 1240 1250
IINEYLSQSY QKFRRFFQTA CDVPELQDKF NVDEYSDLVT LTKPVIYISI
1260 1270 1280 1290 1300
GEIINTHTLL LDHQDAIAPE HNDPIHELLD DLGEVPTIES LIGAGNLNDP
1310 1320 1330 1340 1350
NKEALAKTEV SLTLTNKFDV PGDENAEMDA RTILLNTKRL IVDVIRFQPG
1360 1370 1380 1390 1400
ETLTEILETP ATSEQEAEHQ RAMQRRAIRD AKTPDKMKKS KTIKEDSSLS
1410 1420 1430 1440 1450
LQEKKEKIQS GLKKLTELGT VDPKNRYQEL INDIARDIRN QRRYRQRRKA
1460 1470 1480 1490 1500
ELVKLQQTYA ALNSKATFYG EQVDYYKSYI KTCLDNLASK GKEMKGKKSK
1510 1520 1530 1540 1550
KISLKYTAAR LHEKGVLLEI EDLQVNQFKN VIFEISPTEE VGDFEVKAKF
1560 1570 1580 1590 1600
MGVQMETFML HYQDLLQLQY EGVAVMKLFD RAKVNVNLLI FLLNKKFYEK
Length:1,600
Mass (Da):182,782
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2812220549981181
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q1MIB0A0A3Q1MIB0_BOVIN
IQ motif containing GTPase activati...
IQGAP1
1,583Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000017366; ENSBTAP00000017366; ENSBTAG00000013060

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiF1MC48
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017366

Proteomic databases

PaxDbiF1MC48
PRIDEiF1MC48

Genome annotation databases

EnsembliENSBTAT00000017366; ENSBTAP00000017366; ENSBTAG00000013060

Organism-specific databases

VGNCiVGNC:30258 IQGAP1

Phylogenomic databases

eggNOGiKOG2128 Eukaryota
COG5261 LUCA
GeneTreeiENSGT00950000183076
InParanoidiF1MC48
OMAiSEWVKHW
TreeFamiTF313078

Enzyme and pathway databases

ReactomeiR-BTA-373753 Nephrin family interactions
R-BTA-5626467 RHO GTPases activate IQGAPs
R-BTA-5674135 MAP2K and MAPK activation
R-BTA-6798695 Neutrophil degranulation

Gene expression databases

BgeeiENSBTAG00000013060 Expressed in 9 organ(s), highest expression level in lung

Family and domain databases

CDDicd00014 CH, 1 hit
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
IPR000593 RasGAP_C
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001202 WW_dom
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00612 IQ, 4 hits
PF00616 RasGAP, 1 hit
PF03836 RasGAP_C, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 4 hits
SM00323 RasGAP, 1 hit
SM00456 WW, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48350 SSF48350, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS50096 IQ, 4 hits
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1MC48_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1MC48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 16, 2011
Last modified: October 16, 2019
This is version 62 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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