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Entry version 68 (11 Dec 2019)
Sequence version 2 (26 Jun 2013)
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Protein

Apoptotic protease-activating factor 1

Gene

APAF1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-6798695 Neutrophil degranulation
R-GGA-9627069 Regulation of the apoptosome activity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apoptotic protease-activating factor 1UniRule annotation
Short name:
APAF-1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APAF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1P1P3

PRoteomics IDEntifications database

More...
PRIDEi
F1P1P3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGALG00000011531 Expressed in 10 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Oligomerizes upon binding of cytochrome c and dATP.

UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000037437

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 90CARDInterPro annotationAdd BLAST90
Domaini609 – 1214WD_REPEATS_REGIONInterPro annotationAdd BLAST606
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati609 – 650WDPROSITE-ProRule annotationAdd BLAST42
Repeati651 – 692WDPROSITE-ProRule annotationAdd BLAST42
Repeati693 – 736WDPROSITE-ProRule annotationAdd BLAST44
Repeati737 – 778WDPROSITE-ProRule annotationAdd BLAST42
Repeati876 – 908WDPROSITE-ProRule annotationAdd BLAST33
Repeati1000 – 1032WDPROSITE-ProRule annotationAdd BLAST33
Repeati1041 – 1081WDPROSITE-ProRule annotationAdd BLAST41
Repeati1082 – 1123WDPROSITE-ProRule annotationAdd BLAST42
Repeati1124 – 1165WDPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4155 Eukaryota
KOG4658 Eukaryota
ENOG410XP3K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157710

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVWNITT

Database of Orthologous Groups

More...
OrthoDBi
62693at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08323 CARD_APAF1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017251 Apaf-1
IPR041452 APAF1_C
IPR037963 APAF1_CARD_dom
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR020472 G-protein_beta_WD-40_rep
IPR002182 NB-ARC
IPR027417 P-loop_NTPase
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR036388 WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17908 APAF1_C, 1 hit
PF00619 CARD, 1 hit
PF00931 NB-ARC, 1 hit
PF00400 WD40, 8 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037646 Apop_pept_activating-1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00114 CARD, 1 hit
SM00320 WD40, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit
SSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209 CARD, 1 hit
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 9 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1P1P3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDENSRMCLI TNRQALEKDI KTSYIMDHMV ADQVLTLQEE EKVKQQNTQK
60 70 80 90 100
ERAAMLINTL LTKDNNAYRS FYNALLHEGY RDLAALLQDG IPAFSSKNGK
110 120 130 140 150
NAMDERTSYV KTALCEGGVP QRPVVFVSRP KLVDDIKQKL RSLGSDPGWV
160 170 180 190 200
TVYGMAGCGK TVLTAEALRD HQLLRGCFPG GVHWISVGKQ DKAGLLIKLQ
210 220 230 240 250
NLCSRLEHDS TLPQRPPLNI EEAKDRLRLL MLRKYQRSLL VLDDIWDSWV
260 270 280 290 300
LKAFDNQCQV LITSRDRSVT DAVSGNKYEI HVESGLTHEK GLEVLALFVN
310 320 330 340 350
MKISELPEQA SCIVTECKGS PLVISLIGAL LRDFPSRWEY YLKQLQNKQF
360 370 380 390 400
KRIRKSSSYD YEALDEAMSI SVEQLSNDLK EYYKDLSILP KDVKVPTKVL
410 420 430 440 450
CILWDMETEE VEDILQEFVN KSLLFCDRNG NSFHYYLHDL QLDFLTEKNC
460 470 480 490 500
NQLQELHKNI VNQYKRYYKL HVPVLSQEDC MYWYNFLAYH MAGANMQKEL
510 520 530 540 550
RDLMFSLDWI KAKTELVGPA HLIHEYVEYS SVLDEKDSII RENFQEFLSL
560 570 580 590 600
NGHLLGRQPF PDITQLGLCQ PETSEVYQQA KLRAQRETGT FYLEWINKKS
610 620 630 640 650
LKNLSRLVVR PHRDAVYHAC FSRDRQRIAS CGADKTLQVF KAESGERLLE
660 670 680 690 700
ISAHDDEILC CTFSADDKYV ATCSADKKVK IWNSRTGKCL YVYEEHTEQV
710 720 730 740 750
NCCQFNNRRG QYLLATCSDD TYIKLWDLKD KYCRNTMFGH VNAVSHCRFS
760 770 780 790 800
PNDDYIASCS TDGTVKLWNV HSANELRTIE IKDFFRNADE QQDDVEVLVK
810 820 830 840 850
CCSWSRSSDT ILVVAKNKLL LFDVTTSNLL TQVIISHHST IQYCDFCAGD
860 870 880 890 900
ELVAVALSHC SIELWNIKSL SKVADCRGHT SWVHCVTFSS DGSLFLTSSE
910 920 930 940 950
DQTIRIWETN KVCKSSDAVL KSELDVVFHN GEVMILAIYN QKHIQLINGN
960 970 980 990 1000
TDSIIMQTEP QESLICCCCL SEDLKFAAFG QENGAIKVLR LLDGRVLTSR
1010 1020 1030 1040 1050
EAYRTSVQHC RFTTDCQTLI SSAHDAVIQV WNWQLNECVF LKGHKEAIKD
1060 1070 1080 1090 1100
FAFLENSKLL SWSFDGTVKV WNITTGKTEK DFACHRGAVL SCAVSPDGSR
1110 1120 1130 1140 1150
FSSTSADKTA KIWSFESSSV LHELKGHEAC VRCSAFSPSN KLLATGDDKG
1160 1170 1180 1190 1200
DIRIWDILTG ELLHFCSSVT VDEEEPTHGG WVTDLSFSPD SKMLVSSGGY
1210 1220 1230 1240
LKWWDVTTGE SLQTFYTNGT NLKSIHVSPN FDVYVTVDNL GILYVLRKL
Length:1,249
Mass (Da):142,293
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F1DA882CA6CCC3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000523 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_416167.3, XM_416167.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000038231; ENSGALP00000037437; ENSGALG00000011531

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
417926

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000523 Genomic DNA No translation available.
RefSeqiXP_416167.3, XM_416167.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037437

Proteomic databases

PaxDbiF1P1P3
PRIDEiF1P1P3

Genome annotation databases

EnsembliENSGALT00000038231; ENSGALP00000037437; ENSGALG00000011531
GeneIDi417926

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
317

Phylogenomic databases

eggNOGiKOG4155 Eukaryota
KOG4658 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00940000157710
OMAiKVWNITT
OrthoDBi62693at2759

Enzyme and pathway databases

ReactomeiR-GGA-6798695 Neutrophil degranulation
R-GGA-9627069 Regulation of the apoptosome activity

Gene expression databases

BgeeiENSGALG00000011531 Expressed in 10 organ(s), highest expression level in colon

Family and domain databases

CDDicd08323 CARD_APAF1, 1 hit
Gene3Di1.10.10.10, 1 hit
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR017251 Apaf-1
IPR041452 APAF1_C
IPR037963 APAF1_CARD_dom
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR020472 G-protein_beta_WD-40_rep
IPR002182 NB-ARC
IPR027417 P-loop_NTPase
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF17908 APAF1_C, 1 hit
PF00619 CARD, 1 hit
PF00931 NB-ARC, 1 hit
PF00400 WD40, 8 hits
PIRSFiPIRSF037646 Apop_pept_activating-1, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00114 CARD, 1 hit
SM00320 WD40, 12 hits
SUPFAMiSSF47986 SSF47986, 1 hit
SSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 9 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1P1P3_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1P1P3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: June 26, 2013
Last modified: December 11, 2019
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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