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Entry version 60 (31 Jul 2019)
Sequence version 1 (03 May 2011)
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Protein
Submitted name:

Apolipoprotein B

Gene

APOB

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-202733 Cell surface interactions at the vascular wall
R-CFA-3000471 Scavenging by Class B Receptors
R-CFA-3000480 Scavenging by Class A Receptors
R-CFA-3000497 Scavenging by Class H Receptors
R-CFA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-CFA-432142 Platelet sensitization by LDL
R-CFA-5686938 Regulation of TLR by endogenous ligand
R-CFA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-CFA-8856828 Clathrin-mediated endocytosis
R-CFA-8866423 VLDL assembly
R-CFA-8957275 Post-translational protein phosphorylation
R-CFA-8963888 Chylomicron assembly
R-CFA-8964038 LDL clearance
R-CFA-8964046 VLDL clearance
R-CFA-975634 Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Apolipoprotein BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:37994 APOB

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1P8Z5

PRoteomics IDEntifications database

More...
PRIDEi
F1P8Z5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000003887 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000005806

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1P8Z5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 646VitellogeninInterPro annotationAdd BLAST627

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2410 – 2430Sequence analysisAdd BLAST21
Coiled coili4156 – 4180Sequence analysisAdd BLAST25
Coiled coili4220 – 4247Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4338 Eukaryota
ENOG411104F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00590000083139

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1P8Z5

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALIQCGQ

TreeFam database of animal gene trees

More...
TreeFami
TF331316

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.20, 1 hit
2.30.230.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022176 ApoB100_C
IPR016024 ARM-type_fold
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR009454 Lipid_transpt_open_b-sht
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12491 ApoB100_C, 1 hit
PF06448 DUF1081, 1 hit
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51211 VITELLOGENIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1P8Z5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AEDEVPESAS PGCAKGATRF KHLRKYVYNY EAESSSSIPG TTDSRSATRI
60 70 80 90 100
NCKVELEVPQ LCNFIVRTSQ CTLKEGNGFN PKGRPSLHKT KNSEEFAAAM
110 120 130 140 150
SKYELRLAIP EGKQVLLYPE KEEPTHILNI KRGLISALLV PPETEADKQV
160 170 180 190 200
LFLDTVYGNC SSDLTVNARK ANVATEISIE RNLEKCDHFK PISTGVSPLA
210 220 230 240 250
LIKGMVRPLS TLISSNQSCQ YTLDPKKKHV SEAICKEQHL FLPFSYENKY
260 270 280 290 300
GIMTQVTQTL KLEDTPKINS RFFDEGAKEV GLAFESTKST SPPKQAEAIV
310 320 330 340 350
KTIQELQTLH VSEQNAQRAN LFNKLVTELR GLNNEALTTL LPKLMEVSSP
360 370 380 390 400
ITLQALIQCG QSQCYTHILQ WLRSEKANPL LIDVVTYLVA LTPEPSAERL
410 420 430 440 450
QEIFSTAQEQ QSRATLYALS HVVNNYHKAN PVVTQDLLNI ADYLLEQLQD
460 470 480 490 500
SCTGNEDHTY LILRVIGNMG RTMETVAPRL TSSILKCIQS TEPSLLIQKA
510 520 530 540 550
AIQALRKMEL KDEVREVLLQ VFLDDASPGE KRLAAYLMLM RSPSQSDINQ
560 570 580 590 600
ITQLLPREQN EQVKNFVASH IANILNSEEL YIKDLKKLVE GALKGSQLPT
610 620 630 640 650
IMDFSKFSRN YHLSKSVSLP SLDPISGKIE GNLIFDPNNY LPKESMLKTT
660 670 680 690 700
LTVFGLAPAD LFEIGLEGKG FEPTLEALFG KQGFFPDSVN KALYWVDDQV
710 720 730 740 750
PDHVSKVLVD HFGYTKDGKR EQDMVNGIML NVERLIKDLK SKEFPEARAY
760 770 780 790 800
LHILGEELGF VRLHDLQLLG KMLLNGVHTL AGIPQMIGEA IRKGLKNDLF
810 820 830 840 850
LHYIFMDNAF ELPTGLGLQL QVSSSGVITP GMKAGMKVEM ANLLTELVAK
860 870 880 890 900
PSVSMEFVTN MGIIIPDFSK TGIQMNTNFF HETGLEMQIA FKAGRLKFVI
910 920 930 940 950
PSPTRPVKLF SGSNTLHLVS TTKTEEVAPL NESRKSWSTC KPLFTGLDYC
960 970 980 990 1000
SSGAYSTANS PESASYYPLS RDTRFELELK PTGEVEQYSA SVSYELQREG
1010 1020 1030 1040 1050
GASVDTLTFI TQTEGLKQTE AAMMFKYNRQ STTLSSEIQI PDFDVDLGTI
1060 1070 1080 1090 1100
LRVSDESAME KKSYRLTLDI QNKKITEVTL TGHVSYDKRE EGKIKGVISI
1110 1120 1130 1140 1150
PRLQAEARSE ILTQWSPTKL LVHMDSSATA YGLTISKKLG WRYDEEKIEF
1160 1170 1180 1190 1200
EWNTGTNVDT KKAASNFPMD FSDYPKSLHM YANSLLDHRV PQTDMTFRHV
1210 1220 1230 1240 1250
GSKLMVATDT WLQKASRSLP YAQNLQDHLS GLKELYLQKM GLPDFHVPEN
1260 1270 1280 1290 1300
IFLKSDGRVK YTLNKNSVKI EIPLPFGGKS SKELKMSETI QTPDLNFKSI
1310 1320 1330 1340 1350
GFYLPSREFQ VPTFTIPKLY QLQVPLLGVL DLSANIYNNL YNWSASYTGG
1360 1370 1380 1390 1400
NTTNNHWSLQ AQYHMKADSV VDLLSYSVQG SGETTYDHRN TFTLSCDGYL
1410 1420 1430 1440 1450
HHKLLDSNMK FSHVEKIRNN PASKSVLTFN TSTAWGPQMS ASLHLDSKKK
1460 1470 1480 1490 1500
HHLYVKEAKI DGQFTVSSFY AKGIYDLSYQ RDSTTGQLRG ESNLRFNSSY
1510 1520 1530 1540 1550
LQGTNQITGR YEDGTVSLTS TSDLQDGIIK NTAFLRYENY ELTLKSDTSG
1560 1570 1580 1590 1600
KHEDFATYNK VDMTFSKQNA LVRSEYQADY KSLRLFTLLS GSLNSHGLEL
1610 1620 1630 1640 1650
NADVLGTDKI NSGAHKATLR IAQDGMSTSA TTNLKYNPLV LENELNAALG
1660 1670 1680 1690 1700
LSGASVRLTT NGRFREHNAK FSLDGKATLT EVSLGSAYQA MILGFDSKNV
1710 1720 1730 1740 1750
FNFKISREGL KLSNDMMGSY AEMKLDYTNN LNIAGLSLDF SSKLDNIYSS
1760 1770 1780 1790 1800
DKFYKQNFNV QLQPYSLVTT LSNDLQFNAL DLTNSGKLRL EPLKLNVGGN
1810 1820 1830 1840 1850
IKGVYQNNEI KHIYTISYAD LSASYKTDTV AKVQGTEFSH RLNTNIAGLA
1860 1870 1880 1890 1900
SAIDISTSYN SDSLHFSNIV HSAMAPFTMT IDALTNSNGK LSFWGEHTGQ
1910 1920 1930 1940 1950
LYSKFLLKAE PLALTFSHDY KGSTSHHLPL KSSITTGLDH KVSALLTPAE
1960 1970 1980 1990 2000
QTGTWKVKTQ LNENEYSQDF DAYNDKDKVG VELRGRALAE PTMIDFSIPV
2010 2020 2030 2040 2050
PFLLSEYINI IDVLGMRDAV AQPQEFSVVA SVKYDKNQNV HTINLPFFES
2060 2070 2080 2090 2100
LPEYFEEKRM VIITALETIQ RELKLINIDQ FVKKYRTALD KLPQQTYGYL
2110 2120 2130 2140 2150
NSLNWERQVS SAKEKLITLI ENYRITENDV QIALNNTKIS LNDKLSQLKT
2160 2170 2180 2190 2200
YVIQFDQYIK DNYDLRDFKI AVAKIIDQII EKLKILDEHY HIHVNLVKTI
2210 2220 2230 2240 2250
HDVCLFIEKT DFNRIGNSTA FWIQNVDTKY QIKIQIQEKL QQLKTHIQNI
2260 2270 2280 2290 2300
DIQHLADQLK QQVEALDVRV LLDKLRITIP FQRIKEIIEH VRNYVVNLMK
2310 2320 2330 2340 2350
DFEVAEKINM FGTMSHKLIK MYGIDRHIQV LMDKLVQLAH QYKLKETVQK
2360 2370 2380 2390 2400
LSSVLQQVKI KDHFEKLVKC IDDAIKQLKA FSFKKIIEGV NRFLDMLVKK
2410 2420 2430 2440 2450
LRSFDYHQFV DEANNKIHEV TQRLNGEIQA LELPQKAKAL RLFIEDIKAT
2460 2470 2480 2490 2500
VSVHLENLKG TQISLFFDWL QEPLNSTSLT HIKEKFQETL EDIRERVYQM
2510 2520 2530 2540 2550
DIQREVKRYL SLVGQVYSTL VTYISDWWSL AAKNLTDFAE QYSIQYWAEN
2560 2570 2580 2590 2600
LKALVEQGFT VPEIQTTFGT MPAFEVSLRA LQEATFQTPD FIVPLTDLKV
2610 2620 2630 2640 2650
PSVQINFKKL KDIEIPPKFT TPEFTILNTF HVPSFTIDLV ELKAKIIRTI
2660 2670 2680 2690 2700
DQMLSSELQW PVPEMYLRDL EGVDTILASI TLPDFCLPEI TIPEFIIPNF
2710 2720 2730 2740 2750
DFKDYQVPDL HIPEFQLPRM PHTVEVPTFG KLHSILKIQS PLFTLDANAD
2760 2770 2780 2790 2800
IQNVTTSGNK AEIAASITAR GESKLEVLSF DFQANAQLSD PKISPLVMKQ
2810 2820 2830 2840 2850
SVRFSSKYLK TEHESEVLFF GNAIEGKSNT VAGLHTEKNT LELSNGVLVT
2860 2870 2880 2890 2900
INNQLTLDSS TKYFHKLNIP KLDFSSQAEL RNEIKTLLES GHITWTSSGL
2910 2920 2930 2940 2950
GSWKWACNTS SDEGAHESQV SFTMKEAMAS FGLSNKISSK HLKLSQNLVF
2960 2970 2980 2990 3000
ESSFPDFSKF EIQSQVESQH VGHSVLAAKG TALLGERKAE ITGNHNAHLN
3010 3020 3030 3040 3050
GKIIGTLKNS LFFTAQPFEL TASTNNEGNL KVSFPLKLIG KVDFLNNYIL
3060 3070 3080 3090 3100
LLSPSTQQAG WQASARFNQY KYHHNFSAGN NENSVEAHIG INGEANLDFL
3110 3120 3130 3140 3150
NIPLTIPEMT LPYTTLTTPH VKDFSLWEKT GLKEFLKTTR QSFDLSVKSQ
3160 3170 3180 3190 3200
YKKNKDKHII PIHFYMKDFQ VLSTPGDIFI PAMGNITYDF SFKSGLITLN
3210 3220 3230 3240 3250
TNVGLYNQSD IVAHFLTSSS SVIDGLQYKL EGTSSLTRKR GLKLATALSL
3260 3270 3280 3290 3300
SNKFVEGNHD STISLTKKNM EASVTTSAKV QIPILRMNFK QELNGNTKSK
3310 3320 3330 3340 3350
PTVSSSIELI YDLNSPKLYS TATGRVNHKL SLESLTSYFS IESSTKGDVK
3360 3370 3380 3390 3400
GSVLSREYSG SIAGEASTYL NSKSTRTSVK LQGASKVDGI WNLDVKENFA
3410 3420 3430 3440 3450
GETTLQRIYA IWEHNMKNSL QLEDLFSSSG EHTSKATLEL SPWKMSALVR
3460 3470 3480 3490 3500
VHASQPNSFL EINYLDQEMS LNANTENQKV SWKSEVQVHS EFFQNNIQLF
3510 3520 3530 3540 3550
NDQEEARLDV GSSLKVSLWF LKDIILPIYD KSLWDLLKLD VTTSIDKRQY
3560 3570 3580 3590 3600
LHAATALVYT KNPKGYHFSV PVQELADKFI IPRLKLSDLN SSFVIPTFQV
3610 3620 3630 3640 3650
PFTDLQVPSY TIDFSEIKLY KKLSTLPFSL NIPMLPKVKF PKIDVLTKYS
3660 3670 3680 3690 3700
EPEDSSVPFF EIIVPASQLT VSQFTLLQSS SGDSAVEYLN EVASKFADFE
3710 3720 3730 3740 3750
LPAITIPEQT IEIPSIKFSV PAGIFIPSFG ALTAHFGVVS PLYNATWSAG
3760 3770 3780 3790 3800
LKNKVEYVET FLNSTCSSTI QFLEYDLNVV GTHKIEDGML VCRTKGTFAH
3810 3820 3830 3840 3850
RDISAEYKED NRYRGLQDWK KEIRLDITSP TFTDAHLHYQ LNKNYLSYLV
3860 3870 3880 3890 3900
ASPAVGTVAF DMEDNNRTLK LNLYYRPQSS LDKKLNIFKT EWRYRESDEK
3910 3920 3930 3940 3950
NQIKVSWEEE AVSKLLTSLK DNVPKATGAL YDYANKYHQE HTGLDLTDAS
3960 3970 3980 3990 4000
SKLRRSLQNS ADWAYHSVLE KIDKADLGFQ SIAKGTTRTY QQWKDKAQDL
4010 4020 4030 4040 4050
YQEMLLAHRD QGDFQGLQKD MFDRLMGVTQ EYKVTVSHQI DSLIDFLKFT
4060 4070 4080 4090 4100
KFQLPGKPGT YTKDELCTMV MKEVGQVLSQ VYSKIYSGFE ILFSYFQDLM
4110 4120 4130 4140 4150
EKSELIKDLE IKIPFDSKSY KLIDVILEFG RVLKSLSQKP QDAFNNLQSI
4160 4170 4180 4190 4200
NTTEMLSDLQ RYLQRAFQKI EEEIQRLKEK KFSYLINHIQ HKINIIFNKY
4210 4220 4230 4240 4250
IPYVFEFLKR NLYLNFGKFN ELVQNQLQEA SQQLQQLHQI IKDLRKEYVD
4260 4270 4280 4290 4300
SNVVSWTLRY YELEEEIISL IKNLVDVLKD FHSKYTVSTA DLVSQLSSKV
4310 4320 4330 4340 4350
EQFVQKDIQE YLSILIDADG KGKEKIAELS TSTQEIIKSW ANAMKEIISD
4360 4370 4380 4390 4400
YHQQFRYKLQ DFLDQLSDYY EKFITESKRL IDLSIQNYHM FLRYITELLK
4410 4420
ELQSATVNNM IPYIKVSPGE FTITL
Length:4,425
Mass (Da):501,535
Last modified:May 3, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF71F40C0EEEA77CB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03010768 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000006266; ENSCAFP00000005806; ENSCAFG00000003887

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03010768 Genomic DNA No translation available.

3D structure databases

SMRiF1P8Z5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000005806

Proteomic databases

PaxDbiF1P8Z5
PRIDEiF1P8Z5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000006266; ENSCAFP00000005806; ENSCAFG00000003887

Organism-specific databases

VGNCiVGNC:37994 APOB

Phylogenomic databases

eggNOGiKOG4338 Eukaryota
ENOG411104F LUCA
GeneTreeiENSGT00590000083139
InParanoidiF1P8Z5
OMAiALIQCGQ
TreeFamiTF331316

Enzyme and pathway databases

ReactomeiR-CFA-202733 Cell surface interactions at the vascular wall
R-CFA-3000471 Scavenging by Class B Receptors
R-CFA-3000480 Scavenging by Class A Receptors
R-CFA-3000497 Scavenging by Class H Receptors
R-CFA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-CFA-432142 Platelet sensitization by LDL
R-CFA-5686938 Regulation of TLR by endogenous ligand
R-CFA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-CFA-8856828 Clathrin-mediated endocytosis
R-CFA-8866423 VLDL assembly
R-CFA-8957275 Post-translational protein phosphorylation
R-CFA-8963888 Chylomicron assembly
R-CFA-8964038 LDL clearance
R-CFA-8964046 VLDL clearance
R-CFA-975634 Retinoid metabolism and transport

Gene expression databases

BgeeiENSCAFG00000003887 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR022176 ApoB100_C
IPR016024 ARM-type_fold
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR009454 Lipid_transpt_open_b-sht
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
PfamiView protein in Pfam
PF12491 ApoB100_C, 1 hit
PF06448 DUF1081, 1 hit
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
SMARTiView protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1P8Z5_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1P8Z5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 31, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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