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Entry version 61 (16 Oct 2019)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Collagen type VI alpha 1 chain

Gene

COL6A1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-1442490 Collagen degradation
R-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-186797 Signaling by PDGF
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-216083 Integrin cell surface interactions
R-CFA-3000178 ECM proteoglycans
R-CFA-419037 NCAM1 interactions
R-CFA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type VI alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL6A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 31

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:39480 COL6A1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500327143519 – 1026Sequence analysisAdd BLAST1008

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1PFM6

PRoteomics IDEntifications database

More...
PRIDEi
F1PFM6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000011911 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000017530

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 234VWFAInterPro annotationAdd BLAST199
Domaini614 – 803VWFAInterPro annotationAdd BLAST190
Domaini827 – 1019VWFAInterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 589DisorderedSequence analysisAdd BLAST339

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi302 – 330PolyampholyteSequence analysisAdd BLAST29

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IS79 Eukaryota
ENOG410ZQTS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162889

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1PFM6

KEGG Orthology (KO)

More...
KOi
K06238

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITAQICI

Database of Orthologous Groups

More...
OrthoDBi
140989at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331207

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 3 hits
PF00092 VWA, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00327 VWA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234 VWFA, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1PFM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPGRALLPL LLACWAAAQD APGSARAVAF QDCPVDLFFV LDTSESVALR
60 70 80 90 100
LKPYGALVDK VKAFTKRFID NLRDRYYRCD RNLVWNAGAL HYSDEVEIIS
110 120 130 140 150
PLTPMPADRD ALKAKVDAVK YFGKGTYTDC AIKKGLEELL VGGSHLKENK
160 170 180 190 200
YLIVVTDGHP LEGYKEPCGG LEDAVNEAKH LGVKVFSVAI TPDHLEPRLS
210 220 230 240 250
IIATDHTYRR NFTAADWGQS RDAEEIITQT IDTIVDMIKN NVEQVCCSFE
260 270 280 290 300
CQPARGPPGP RGDPGYEGER GKPGLPGEKG EAGEPGRPGD LGPIGYQGMK
310 320 330 340 350
GEKGSRGEKG SRGSKGYKGE KGKRGIDGVD GMKGEMGYPG LPGCKGSPGF
360 370 380 390 400
DGAQGPPGPK GDAGAFGRKG EKGAPGADGE PGRPGNTGPP GDEGEPGLPG
410 420 430 440 450
PPGEKGEAGD EGNPGPDGAP GERGGPGERG PRGTPGVRGP RGDPGEAGPQ
460 470 480 490 500
GDQGREGPVG IPGDPGEAGP AGPKGYRGDE GPPGPEGSRG APGPAGPPGD
510 520 530 540 550
PGLMGERGED GPPGNGTEGF PGFPGYPGSR GPPGINGTKG YPGLKGDEGE
560 570 580 590 600
AGDPGDDNND ISPPGVKGAK GYRGPEGPQG PPGHTGPPGP DECEILDIIM
610 620 630 640 650
KMCSCCECKC GPIDILFVLD SSESIGLQNF EIAKDFVVKV IDRLSRDELV
660 670 680 690 700
KFEPGQSHVG VVQYSHNQMQ EHVDLRDPNI RSVQELKEAI KKLRWMAGGT
710 720 730 740 750
FTGEALQYTR NQLLPPTQNN RIALVITDGR SDTQRDTTPL SVLCGPDIQV
760 770 780 790 800
VSVGIKDMFG YVAGSDQLNV ISCQGLGPQG RPGISLVKEN YAELLEDNFL
810 820 830 840 850
KNVTTQICID KKCPDYTCPI MFSSPADITI LLDGSASVGS HNFDTTKRFA
860 870 880 890 900
KRLAERFLTA GRTDPAHDVR VAVVQYSGPG QQRPGRGALR FLQNYTVLAS
910 920 930 940 950
TVDGMDFFND ATDVNDALGY VTRFYREAST RDAKKRLLLF SDGNSQGATA
960 970 980 990 1000
AAIEKAVQEA QRADIEIFVV VVGRQVNEPH VRVLVTGKTA EYDVAFGERH
1010 1020
LFRVPSYQAL LRGVFYQTVS RKVALG
Length:1,026
Mass (Da):108,578
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F0887F82E1993FA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03016661 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_003434049.2, XM_003434001.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000018918; ENSCAFP00000017530; ENSCAFG00000011911

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
403668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cfa:403668

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03016661 Genomic DNA No translation available.
RefSeqiXP_003434049.2, XM_003434001.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000017530

Proteomic databases

PaxDbiF1PFM6
PRIDEiF1PFM6

Genome annotation databases

EnsembliENSCAFT00000018918; ENSCAFP00000017530; ENSCAFG00000011911
GeneIDi403668
KEGGicfa:403668

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1291
VGNCiVGNC:39480 COL6A1

Phylogenomic databases

eggNOGiENOG410IS79 Eukaryota
ENOG410ZQTS LUCA
GeneTreeiENSGT00940000162889
InParanoidiF1PFM6
KOiK06238
OMAiITAQICI
OrthoDBi140989at2759
TreeFamiTF331207

Enzyme and pathway databases

ReactomeiR-CFA-1442490 Collagen degradation
R-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-186797 Signaling by PDGF
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-216083 Integrin cell surface interactions
R-CFA-3000178 ECM proteoglycans
R-CFA-419037 NCAM1 interactions
R-CFA-8948216 Collagen chain trimerization

Gene expression databases

BgeeiENSCAFG00000011911 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR008160 Collagen
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 3 hits
PF00092 VWA, 3 hits
SMARTiView protein in SMART
SM00327 VWA, 3 hits
SUPFAMiSSF53300 SSF53300, 3 hits
PROSITEiView protein in PROSITE
PS50234 VWFA, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1PFM6_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1PFM6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: October 16, 2019
This is version 61 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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