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Entry version 64 (16 Oct 2019)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Collagen type IV alpha 1 chain

Gene

COL4A1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-1442490 Collagen degradation
R-CFA-1474244 Extracellular matrix organization
R-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-186797 Signaling by PDGF
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-216083 Integrin cell surface interactions
R-CFA-2243919 Crosslinking of collagen fibrils
R-CFA-3000157 Laminin interactions
R-CFA-3000171 Non-integrin membrane-ECM interactions
R-CFA-419037 NCAM1 interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type IV alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL4A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:39473 COL4A1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1Q133

PRoteomics IDEntifications database

More...
PRIDEi
F1Q133

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000006062 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000009106

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F1Q133

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1399 – 1623Collagen IV NC1InterPro annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 343DisorderedSequence analysisAdd BLAST343
Regioni388 – 1399DisorderedSequence analysisAdd BLAST1012

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi62 – 76Pro-richSequence analysisAdd BLAST15
Compositional biasi87 – 107Pro-richSequence analysisAdd BLAST21
Compositional biasi133 – 168Pro-richSequence analysisAdd BLAST36
Compositional biasi236 – 254PolyampholyteSequence analysisAdd BLAST19
Compositional biasi743 – 771Pro-richSequence analysisAdd BLAST29
Compositional biasi1295 – 1309Pro-richSequence analysisAdd BLAST15
Compositional biasi1369 – 1388Pro-richSequence analysisAdd BLAST20

Keywords - Domaini

CollagenSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157678

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1Q133

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMQGHEG

TreeFam database of animal gene trees

More...
TreeFami
TF316865

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 17 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00111 C4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51403 NC1_IV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1Q133-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QGERGLPGLQ GVIGFPGMQG PEGPQGPPGQ KGDTGEPGLP GTKGTRGPPG
60 70 80 90 100
ASGYPGNPGL PGIPGQDGPP GPPGIPGCNG TKGEPGPLGP PGLPGFAGNP
110 120 130 140 150
GPPGLPGMKG DPGEIIGHVP GTLLKGERGF PGPPGTPGSP GLPGLQGPVG
160 170 180 190 200
PPGFTGPPGP PGPPGPPGEK GQMGLSFQGP KGDKQQGDQG VSGPPGVPGQ
210 220 230 240 250
AQVQEKGDFA TKGEKGQKGE PGFQGMPGVG EKGEPGKPGP RGKPGKDGEK
260 270 280 290 300
GEKGSPGFPG DSGYPGLPGR EGFKGDKGEA GPPGPPGIAI GPGPLGEKGE
310 320 330 340 350
RGYPGAPGLR GEPGPKGFPG LQGQPGPPEV RGRAQGQSMG AGGIQGWAWP
360 370 380 390 400
LGWPSVLLGH SSRTASGPPS GQERLGRSCR TSYGIVECQP GPPGDQGPPG
410 420 430 440 450
IPGQPGLTGE VGEKGQKGDS CLVCDMAGLR GPPGPQGPPG EIGFPGQPGA
460 470 480 490 500
KGDRGLPGRD GLEGLPGPQG VPGLMGQPGA KGEPGEIYFD ARLKGDKGDP
510 520 530 540 550
GFPGQPGMPG RAGSPGRDGH PGLPGPKGSP GSVGLKGERG PPGGVGFPGS
560 570 580 590 600
RGDIGPPGPP GFGPIGPVGD KGQAGFPGIP GSPGQPGPKG EAGKVVPLPG
610 620 630 640 650
PPGAQGLPGS PGFQGPQGDR GFPGTPGRPG LPGEKGAIGQ PGIGFPGPPG
660 670 680 690 700
PKGVDGLPGD VGPPGSPGRP GFNGLPGNPG VPGQKGEPGI GLPGLKGLPG
710 720 730 740 750
LPGIPGTPGE KGNIGGPGVP GEHGAIGPPG LQGIRGDPGP PGLQGPKGAP
760 770 780 790 800
GVPGIGPPGA VGPPGGQGPP GSSGPPGVKG EKGFPGFPGL DMPGPKGDKG
810 820 830 840 850
SQGLPGLTGQ SGLPGLPGQQ GTPGVPGFPG PKGEMGVMGT PGQPGSPGPA
860 870 880 890 900
GLPGLPGEKG DHGFPGSSGP RGDPGFKGDK GDVGLPGKPG SMDKVDMGSM
910 920 930 940 950
KGQKGDQGEK GQIGPTGDKG SRGDPGTPGV PGKDGQAGHP GQPGPKGDPG
960 970 980 990 1000
IGGTPGAPGL PGPKGSVGGM GLPGTPGEKG VPGIPGPQGV PGLPGEKGAK
1010 1020 1030 1040 1050
GEKGQAGLPG IGIPGRPGDK GEQGISGFPG SPGEKGEKGS AGVPGIPGSP
1060 1070 1080 1090 1100
GPKGLPGTVG YPGSPGLPGE KGDKGLPGSD GIPGIKGEAG LPGQPGPTGP
1110 1120 1130 1140 1150
AGQKGEPGSD GIPGSVGEKG EPGLPGRGFP GFPGAKGEKG SKGDVGFPGQ
1160 1170 1180 1190 1200
AGSPGIPGSK GEPGFLGPPG PQGQPGLPGA PGHAVEGPKG DRGPQGQPGL
1210 1220 1230 1240 1250
PGLPGPVGPP GLPGLDGLKG DKGNPGWPGA PGAPGPKGEP GFQGLPGIGG
1260 1270 1280 1290 1300
SPGITGSKGD MGPPGVPGFQ GQKGLPGLQG AKGDQGDQGF PGSKGLPGPP
1310 1320 1330 1340 1350
GPPGPYDIVK GDPGLPGPEG PAGLKGLPGP PGPKGQQGVT GSVGLPGPPG
1360 1370 1380 1390 1400
IPGFDGAPGQ KGETGPFGPP GPRGFPGPPG PDGLPGSMGP PGTPSVDHGF
1410 1420 1430 1440 1450
LVTRHSQTTD DPQCPPGTKI LYHGYSLLYV QGNERAHGQD LGTAGSCLRK
1460 1470 1480 1490 1500
FSTMPFLFCN INNVCNFASR NDYSYWLSTP EPMPMSMAPI AGDNIRPFIS
1510 1520 1530 1540 1550
RCAVCEAPAM VMAVHSQTIQ IPQCPSGWSS LWIGYSFVMH TSAGAEGSGQ
1560 1570 1580 1590 1600
ALASPGSCLE EFRSAPFIEC HGRGTCNYYA NAYSFWLATI ERSEMFKKPT
1610 1620
PSTLKAGELR THVSRCQVCM RRT
Length:1,623
Mass (Da):156,198
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D910AA80EDF388C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9P8Y4J9P8Y4_CANLF
Collagen type IV alpha 1 chain
COL4A1
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03013382 Genomic DNA No translation available.
AAEX03013383 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000009808; ENSCAFP00000009106; ENSCAFG00000006062

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03013382 Genomic DNA No translation available.
AAEX03013383 Genomic DNA No translation available.

3D structure databases

SMRiF1Q133
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000009106

Proteomic databases

PaxDbiF1Q133
PRIDEiF1Q133

Genome annotation databases

EnsembliENSCAFT00000009808; ENSCAFP00000009106; ENSCAFG00000006062

Organism-specific databases

VGNCiVGNC:39473 COL4A1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000157678
InParanoidiF1Q133
OMAiGMQGHEG
TreeFamiTF316865

Enzyme and pathway databases

ReactomeiR-CFA-1442490 Collagen degradation
R-CFA-1474244 Extracellular matrix organization
R-CFA-1650814 Collagen biosynthesis and modifying enzymes
R-CFA-186797 Signaling by PDGF
R-CFA-2022090 Assembly of collagen fibrils and other multimeric structures
R-CFA-216083 Integrin cell surface interactions
R-CFA-2243919 Crosslinking of collagen fibrils
R-CFA-3000157 Laminin interactions
R-CFA-3000171 Non-integrin membrane-ECM interactions
R-CFA-419037 NCAM1 interactions

Gene expression databases

BgeeiENSCAFG00000006062 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 17 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1Q133_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1Q133
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: October 31, 2012
Last modified: October 16, 2019
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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