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Entry version 64 (16 Oct 2019)
Sequence version 2 (21 Sep 2011)
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Protein
Submitted name:

Si:dkey-32n7.4

Gene

si:dkey-32n7.4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-DRE-202733 Cell surface interactions at the vascular wall
R-DRE-216083 Integrin cell surface interactions
R-DRE-3000178 ECM proteoglycans
R-DRE-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:dkey-32n7.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:si:dkey-32n7.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-110411-175 si:dkey-32n7.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1094 – 1113HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F1QSJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000002956 Expressed in 15 organ(s), highest expression level in head kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit.

SAAS annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000129555

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati85 – 145FG-GAPPROSITE-ProRule annotationAdd BLAST61
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini159 – 335VWFAInterPro annotationAdd BLAST177
Repeati345 – 392FG-GAPPROSITE-ProRule annotationAdd BLAST48
Repeati393 – 445FG-GAPPROSITE-ProRule annotationAdd BLAST53
Repeati446 – 506FG-GAPPROSITE-ProRule annotationAdd BLAST61
Repeati520 – 566FG-GAPPROSITE-ProRule annotationAdd BLAST47
Repeati570 – 631FG-GAPPROSITE-ProRule annotationAdd BLAST62

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPBA Eukaryota
ENOG410ZFBE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154838

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1QSJ9

KEGG Orthology (KO)

More...
KOi
K06462

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKTITMY

Database of Orthologous Groups

More...
OrthoDBi
73876at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105391

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.130, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00191 Int_alpha, 3 hits
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 6 hits
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F1QSJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDWYSYISL CIFCVPQSVM TFNVDHAAWK TFTAPLTNNV AFGYKVIQED
60 70 80 90 100
MTRLTVSDPL IQINRDERGQ IYSCDVNRGT CSSLNIYGRV PSEAVNMSLG
110 120 130 140 150
LSMVKDPGSS KLVVCGPTIP KNCPGVSTYN GMCFVNEHRR SFTGPIPSSL
160 170 180 190 200
RECPKSQIDI AFLLDGSGSV DPVDFNKMKA FVVEMIKSFI DRDTQFAIAQ
210 220 230 240 250
FSTECVIHYK FQQVKNPAWW QRAVNGIQQT HGWTFTATAI RLLVESLFVS
260 270 280 290 300
SGGARQSASK ILVVITDGES NDKFLTEAVQ QAQEKSITRY AIGVGNAFNK
310 320 330 340 350
YSARNELTVI ASIPTDKHVF KVTDFDALES IREILKENII AIEGTQTSGD
360 370 380 390 400
SSRMEFAQDG FSAALTSDTD LIMTAVGAFQ WKGGYQLFKL NDQTSVFQAG
410 420 430 440 450
SEHNSYLGYS LAIATVYNTK YAVMGAPRHK HEGLVTVTRI DRMSDQIQLD
460 470 480 490 500
PPKTQIGSYF GAEVCVVDLN SDSNTDLLLV SAPTYTESER EGKVFVYSYT
510 520 530 540 550
RRPFFSFSDV VLVGMAGQRG RFGSSLASPA DLNGDGFKDV LVGAPLEEDG
560 570 580 590 600
KGSIYIFNGR DGGIISSYSQ RIAGSSVQSG LQYFGVSLSQ SSPDQTADSL
610 620 630 640 650
PDIAVGSKGA VLLLRSRPIM LLETKVSYNP SKISTGHTDC KNQLQTTLIV
660 670 680 690 700
CFTMKGYRHH KRDLNAKITY NITLDAKRQN HRAFFSAKDN LLSNVIDIGN
710 720 730 740 750
TEVCKNHDFL IEACPEDALN PLSNQLKFTF EGLPSSQMQN LRPILLPEIK
760 770 780 790 800
TTSDHDLDFE RECGKDNVCV DNLRVDFNFS GSTNIEVGIM QEINVTVFVE
810 820 830 840 850
NRGENSYNTH FTLNYPYGFS YRRITSKQGR VECSSLDGEQ GVRLGETECA
860 870 880 890 900
ISKPILKDNT KIVFEITYSI NKEVTLGQNV IFSASVKSGN DKHSESSELS
910 920 930 940 950
KKKSIDVKYG IYVALIRHEN STIHINFTSG KKDLSKPVQQ TIKIENDLRP
960 970 980 990 1000
LAFTAFIRVP LKLGDTDIWK ESTLQVSDCV KNKTEKPSVT NYMDDIKKHH
1010 1020 1030 1040 1050
VLNCSVAVCA VFICDVNLIK NERKLYNITG NVSSAWIEQT GLKSAVFELV
1060 1070 1080 1090 1100
STTTMDYDMS TYVFFSSDSR NTAPSLQIST QVEVYEEVDL TKEIIGGVIG
1110 1120 1130
GLVLLALITA ALYKAGFFKS QYKQMMEEAQ GEEAPQ
Length:1,136
Mass (Da):125,898
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4CE53F15F5EFEA5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL954132 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005156064.1, XM_005156007.3
XP_009304682.1, XM_009306407.2
XP_009304683.1, XM_009306408.2
XP_009304684.1, XM_009306409.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000025912; ENSDARP00000014655; ENSDARG00000002956
ENSDART00000153699; ENSDARP00000129555; ENSDARG00000002956

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101882585

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:101882585

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954132 Genomic DNA No translation available.
RefSeqiXP_005156064.1, XM_005156007.3
XP_009304682.1, XM_009306407.2
XP_009304683.1, XM_009306408.2
XP_009304684.1, XM_009306409.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000129555

Proteomic databases

PRIDEiF1QSJ9

Genome annotation databases

EnsembliENSDART00000025912; ENSDARP00000014655; ENSDARG00000002956
ENSDART00000153699; ENSDARP00000129555; ENSDARG00000002956
GeneIDi101882585
KEGGidre:101882585

Organism-specific databases

ZFINiZDB-GENE-110411-175 si:dkey-32n7.4

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
GeneTreeiENSGT00940000154838
InParanoidiF1QSJ9
KOiK06462
OMAiCKTITMY
OrthoDBi73876at2759
TreeFamiTF105391

Enzyme and pathway databases

ReactomeiR-DRE-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-DRE-202733 Cell surface interactions at the vascular wall
R-DRE-216083 Integrin cell surface interactions
R-DRE-3000178 ECM proteoglycans
R-DRE-6798695 Neutrophil degranulation

Gene expression databases

BgeeiENSDARG00000002956 Expressed in 15 organ(s), highest expression level in head kidney

Family and domain databases

Gene3Di2.130.10.130, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 3 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 2 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 6 hits
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1QSJ9_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1QSJ9
Secondary accession number(s): X1WH45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: September 21, 2011
Last modified: October 16, 2019
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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