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Entry version 67 (11 Dec 2019)
Sequence version 3 (22 Nov 2017)
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Protein

Cubilin

Gene

CUBN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi980Calcium 1By similarity1
Metal bindingi988Calcium 1By similarity1
Metal bindingi1027Calcium 1By similarity1
Metal bindingi1029Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi1030Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi1097Calcium 2By similarity1
Metal bindingi1107Calcium 2By similarity1
Metal bindingi1148Calcium 2By similarity1
Metal bindingi1215Calcium 3By similarity1
Metal bindingi1223Calcium 3By similarity1
Metal bindingi1264Calcium 3By similarity1
Metal bindingi1266Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi1267Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi1330Calcium 4By similarity1
Metal bindingi1338Calcium 4By similarity1
Metal bindingi1375Calcium 4By similarity1
Metal bindingi1377Calcium 4; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Protein transport, Steroid metabolism, Sterol metabolism, Transport
LigandCalcium, Cobalamin, Cobalt, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cubilin
Alternative name(s):
Intrinsic factor-cobalamin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUBN
Synonyms:IFCR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Endosome, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000044766921 – 36Removed in mature formBy similarityAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501276813037 – 3625CubilinSequence analysisAdd BLAST3589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi137 ↔ 148PROSITE-ProRule annotation
Disulfide bondi142 ↔ 157PROSITE-ProRule annotation
Disulfide bondi159 ↔ 168PROSITE-ProRule annotation
Disulfide bondi175 ↔ 191PROSITE-ProRule annotation
Disulfide bondi185 ↔ 200PROSITE-ProRule annotation
Disulfide bondi202 ↔ 211PROSITE-ProRule annotation
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi268 ↔ 281PROSITE-ProRule annotation
Disulfide bondi275 ↔ 290PROSITE-ProRule annotation
Disulfide bondi293 ↔ 304PROSITE-ProRule annotation
Disulfide bondi310 ↔ 325PROSITE-ProRule annotation
Disulfide bondi317 ↔ 334PROSITE-ProRule annotation
Disulfide bondi337 ↔ 348PROSITE-ProRule annotation
Disulfide bondi354 ↔ 367PROSITE-ProRule annotation
Disulfide bondi361 ↔ 377PROSITE-ProRule annotation
Disulfide bondi379 ↔ 393PROSITE-ProRule annotation
Disulfide bondi400 ↔ 410PROSITE-ProRule annotation
Disulfide bondi405 ↔ 419PROSITE-ProRule annotation
Disulfide bondi421 ↔ 430PROSITE-ProRule annotation
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi437 ↔ 448PROSITE-ProRule annotation
Disulfide bondi442 ↔ 457PROSITE-ProRule annotation
Disulfide bondi459 ↔ 468PROSITE-ProRule annotation
Disulfide bondi475 ↔ 501PROSITE-ProRule annotation
Disulfide bondi528 ↔ 550PROSITE-ProRule annotation
Disulfide bondi591 ↔ 617PROSITE-ProRule annotation
Disulfide bondi644 ↔ 666PROSITE-ProRule annotation
Disulfide bondi709 ↔ 734PROSITE-ProRule annotation
Glycosylationi712N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi761 ↔ 779PROSITE-ProRule annotation
Glycosylationi781N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi817 ↔ 842PROSITE-ProRule annotation
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi869 ↔ 891PROSITE-ProRule annotation
Disulfide bondi932 ↔ 958PROSITE-ProRule annotation
Glycosylationi957N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi984N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi985 ↔ 1005PROSITE-ProRule annotation
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1104 ↔ 1126PROSITE-ProRule annotation
Disulfide bondi1167 ↔ 1193PROSITE-ProRule annotation
Glycosylationi1170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1219N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1220 ↔ 1242PROSITE-ProRule annotation
Disulfide bondi1280 ↔ 1308PROSITE-ProRule annotation
Glycosylationi1287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1334N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1335 ↔ 1353PROSITE-ProRule annotation
Disulfide bondi1393 ↔ 1419PROSITE-ProRule annotation
Disulfide bondi1446 ↔ 1468PROSITE-ProRule annotation
Glycosylationi1502N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1512 ↔ 1538PROSITE-ProRule annotation
Glycosylationi1553N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1565 ↔ 1583PROSITE-ProRule annotation
Disulfide bondi1622 ↔ 1649PROSITE-ProRule annotation
Glycosylationi1648N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1677 ↔ 1699PROSITE-ProRule annotation
Disulfide bondi1740 ↔ 1766PROSITE-ProRule annotation
Disulfide bondi1793 ↔ 1814PROSITE-ProRule annotation
Glycosylationi1804N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1821N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1887N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1907 ↔ 1929PROSITE-ProRule annotation
Disulfide bondi1980 ↔ 2008PROSITE-ProRule annotation
Disulfide bondi2034 ↔ 2056PROSITE-ProRule annotation
Glycosylationi2087N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2094 ↔ 2120PROSITE-ProRule annotation
Glycosylationi2119N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2219 ↔ 2249PROSITE-ProRule annotation
Glycosylationi2276N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2277 ↔ 2299PROSITE-ProRule annotation
Disulfide bondi2338 ↔ 2365PROSITE-ProRule annotation
Glycosylationi2388N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2392 ↔ 2413PROSITE-ProRule annotation
Glycosylationi2402N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2454 ↔ 2480PROSITE-ProRule annotation
Disulfide bondi2507 ↔ 2529PROSITE-ProRule annotation
Glycosylationi2533N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2572 ↔ 2601PROSITE-ProRule annotation
Glycosylationi2583N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2594N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2612N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2630 ↔ 2651PROSITE-ProRule annotation
Disulfide bondi2691 ↔ 2717PROSITE-ProRule annotation
Disulfide bondi2744 ↔ 2766PROSITE-ProRule annotation
Disulfide bondi2807 ↔ 2833PROSITE-ProRule annotation
Disulfide bondi2862 ↔ 2885PROSITE-ProRule annotation
Glycosylationi2887N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2922 ↔ 2948PROSITE-ProRule annotation
Glycosylationi2925N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2928N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2947N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2979 ↔ 3001PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3010PhosphothreonineBy similarity1
Disulfide bondi3039 ↔ 3066PROSITE-ProRule annotation
Glycosylationi3044N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3093 ↔ 3115PROSITE-ProRule annotation
Glycosylationi3105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3159 ↔ 3187PROSITE-ProRule annotation
Disulfide bondi3217 ↔ 3239PROSITE-ProRule annotation
Glycosylationi3270N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3280 ↔ 3308PROSITE-ProRule annotation
Glycosylationi3285N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3334 ↔ 3356PROSITE-ProRule annotation
Glycosylationi3359N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3397 ↔ 3423PROSITE-ProRule annotation
Glycosylationi3432N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3450 ↔ 3472PROSITE-ProRule annotation
Glycosylationi3459N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3513 ↔ 3539PROSITE-ProRule annotation
Glycosylationi3535N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3566 ↔ 3588PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide.By similarity
N-glycosylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei36 – 37Cleavage; by furinSequence analysis2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1RWC3

PeptideAtlas

More...
PeptideAtlasi
F1RWC3

PRoteomics IDEntifications database

More...
PRIDEi
F1RWC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in kidney cortex (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000011030 Expressed in 5 organ(s), highest expression level in kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AMN.

Component of the cubam complex composed of one CUBN trimer and one AMN chain (PubMed:30523278). The cubam complex can dimerize (PubMed:30523278).

Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner.

Found in a complex with PID1/PCLI1, LRP1 and CUBNI.

Interacts with LRP1 and PID1/PCLI1 (By similarity).

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000026326

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini133 – 169EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini171 – 212EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini264 – 305EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini306 – 349EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini350 – 394EGF-like 5PROSITE-ProRule annotationAdd BLAST45
Domaini396 – 431EGF-like 6PROSITE-ProRule annotationAdd BLAST36
Domaini433 – 469EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini475 – 587CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini591 – 703CUB 2PROSITE-ProRule annotationAdd BLAST113
Domaini709 – 816CUB 3PROSITE-ProRule annotationAdd BLAST108
Domaini817 – 928CUB 4PROSITE-ProRule annotationAdd BLAST112
Domaini932 – 1042CUB 5PROSITE-ProRule annotationAdd BLAST111
Domaini1045 – 1163CUB 6PROSITE-ProRule annotationAdd BLAST119
Domaini1167 – 1279CUB 7PROSITE-ProRule annotationAdd BLAST113
Domaini1280 – 1391CUB 8PROSITE-ProRule annotationAdd BLAST112
Domaini1393 – 1508CUB 9PROSITE-ProRule annotationAdd BLAST116
Domaini1512 – 1621CUB 10PROSITE-ProRule annotationAdd BLAST110
Domaini1622 – 1736CUB 11PROSITE-ProRule annotationAdd BLAST115
Domaini1740 – 1852CUB 12PROSITE-ProRule annotationAdd BLAST113
Domaini1854 – 1965CUB 13PROSITE-ProRule annotationAdd BLAST112
Domaini1980 – 2093CUB 14PROSITE-ProRule annotationAdd BLAST114
Domaini2094 – 2215CUB 15PROSITE-ProRule annotationAdd BLAST122
Domaini2219 – 2336CUB 16PROSITE-ProRule annotationAdd BLAST118
Domaini2338 – 2450CUB 17PROSITE-ProRule annotationAdd BLAST113
Domaini2454 – 2567CUB 18PROSITE-ProRule annotationAdd BLAST114
Domaini2572 – 2689CUB 19PROSITE-ProRule annotationAdd BLAST118
Domaini2691 – 2803CUB 20PROSITE-ProRule annotationAdd BLAST113
Domaini2807 – 2921CUB 21PROSITE-ProRule annotationAdd BLAST115
Domaini2922 – 3037CUB 22PROSITE-ProRule annotationAdd BLAST116
Domaini3039 – 3152CUB 23PROSITE-ProRule annotationAdd BLAST114
Domaini3159 – 3276CUB 24PROSITE-ProRule annotationAdd BLAST118
Domaini3280 – 3397CUB 25PROSITE-ProRule annotationAdd BLAST118
Domaini3397 – 3509CUB 26PROSITE-ProRule annotationAdd BLAST113
Domaini3513 – 3625CUB 27PROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni43 – 50Interaction with AMNBy similarity8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CUB domains 5 to 8 mediate binding to CBLIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2.By similarity
The cubam complex is composed of a 400 Angstrom long stem and a globular crown region. The stem region is probably formed by AMN and the CUBN N-terminal region, including the EGF-like domains. The crown is probably formed by the CUBN CUB domains.1 Publication

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3714 Eukaryota
ENOG410ZPX7 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1RWC3

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHLEYHP

TreeFam database of animal gene trees

More...
TreeFami
TF316506

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 27 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 27 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR035914 Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 27 hits
PF00008 EGF, 2 hits
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042 CUB, 27 hits
SM00181 EGF, 8 hits
SM00179 EGF_CA, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 27 hits
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01180 CUB, 27 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 7 hits
PS01187 EGF_CA, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

F1RWC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNNMSLLFL WSLVIFLTFA ESYGEAGGPE LQRHKRNTEL QQPRMAAERG
60 70 80 90 100
NLVFFTGLAQ NIEFRTGSQG KIKLNDEDVG ECLRQIQKNK FDIMNLKRGI
110 120 130 140 150
IGLPQNVSSQ IHQLESKLVD LERRFQSLQL TVDGKVCSSN PCQNGATCLN
160 170 180 190 200
LHDSFFCICP SQWKGPLCSD DVNECEIYSG TPLGCQNGAT CINTPGSYSC
210 220 230 240 250
LCSPETHGPQ CASKYDDCEG GSEMRCVHGI CEDLTRVQAG EPRFRCICHA
260 270 280 290 300
GWTSPSNSTA CTLDRDECSS WPAPCSALVP CFNTLGSFYC GACPTGWQGN
310 320 330 340 350
GYICEDINEC EINNGGCSVA PPVECVNTPG SYYCPSCPPG YQGDGRMCTL
360 370 380 390 400
IDLCSVNNGG CHPHAACSLI LGSLPLCTCL PGYTGNGYGL HGCVPLSNVC
410 420 430 440 450
LTRPCLHGQC METASGYVCN CDSGWAGMNC TENINECLSN PCLNGGTCVD
460 470 480 490 500
GINAFSCECT RFWTGSLCHL PQQVCGGTMS DVSGSFSYMS PDVGYVHDVD
510 520 530 540 550
CFWVLRTEEG KVLRITFTFF QLESVDNCPH EFLQIHDGDS PAAFPLGRFC
560 570 580 590 600
GSSPPHELLS SDNALYFHFF SEHLRNERGF TIRWETRQPE CGGVLTGTYG
610 620 630 640 650
SLKSPGYPGK YPPGRDCVWK VIASPDLLIT FTFGTLSLEH HDDCRKDYLE
660 670 680 690 700
IRDGPLHQDP VLGKFCTSLS VPPLQTTGPF ARIHFHSDNQ INDQGFHITY
710 720 730 740 750
LTTPSDLHCG GNFTDPEGLL SPDLSGPFTH SRQCIYVITQ PLGEQIQVNF
760 770 780 790 800
THVELEGQSG CSQSYIEVRD DQTLLGKVCG NETPSHIKSI TNSIWIRLKI
810 820 830 840 850
DASVVRASFG AAYQVACGGE LTGEGVIRSP FYPNVYPGER ICRWTIHQPQ
860 870 880 890 900
SQVVLLNFTA FEMGSSAHCD TDYIEIGSSP VLGSPENKKY CGTDIPSFIT
910 920 930 940 950
SVYNSLHVVF VKSSSTENHG FMAKFSTEAL ACGEILTESS GIIQSPGHPN
960 970 980 990 1000
IYPHGVNCTW HILVQPGHLI HLEIRQFHLE FHYNCTRDYL EIYDTVSDTS
1010 1020 1030 1040 1050
LGRYCGKSIP PSLTSNTNSL KLIFVADADL AYEGFVINYE ATDASAGNTT
1060 1070 1080 1090 1100
ALLYRRIWIF TSPNFPSNYP NNMECIYRIT VETSQQIALH FTDFSLEEPI
1110 1120 1130 1140 1150
GGACAADYVE ITNGGYASSP PLGKYCGSNP PPRIISHSNK LWLKFKSDFF
1160 1170 1180 1190 1200
GSGPGFSAYW DGSLTGCGGN LTTPTGTFTS PNYPMPYYHS SECFWWLKSS
1210 1220 1230 1240 1250
HGSPFELEFN DFHLEYHPNC TLDYLDVYDG LSTSSHLLTR LCGNEKPPLI
1260 1270 1280 1290 1300
RSTGDSMSLK LRTDEGQQGG GFLVKYQQTC DNVVIVNRTY GILESIHYPK
1310 1320 1330 1340 1350
PYSVNQRCNW TIQATAGNTV NYTFLAFELE SHANCSTDYL ELYDGPQRMG
1360 1370 1380 1390 1400
RFCGAVIPPS GSTTGSRLQV LFHTDGVGQG ERGFQMQWLV HGCGGELSGD
1410 1420 1430 1440 1450
TGTFSSPGYP VGYPANKECI WYIHSSPGSS IQLTIHDFDV EYHATCNFDV
1460 1470 1480 1490 1500
LEIYGGPDFH SPRIAQLCVQ RSAENPMQVS STGNELALRF KTDSSVNGRG
1510 1520 1530 1540 1550
FNVSWRAVPG GCGGIFQAPS GEIHSPNYPS PYRSNTECTW LIQVEKNHRV
1560 1570 1580 1590 1600
LLNFTDFDLE PQDSCIMAFD GLSSATARLV GVCGRQQLSN PIISTGSSLF
1610 1620 1630 1640 1650
VRFQSGPSRQ SRGFRAQFRQ ACGGHILTDS FDTISSPRFP ASYPNNQNCS
1660 1670 1680 1690 1700
WIIQAQPPFN HITLSFSHFG LESSSTCTRD FVEILDGSHS DAPLRGRYCG
1710 1720 1730 1740 1750
SSMPHPITSF GNALMLRFVS DSSVNFDGFH ATYVASTSAC GGIFHMAEGI
1760 1770 1780 1790 1800
FNSPGYPEVY PSNVECVWNI ASSPGNQLQL SFITFQLEDS RDCSRDFVEI
1810 1820 1830 1840 1850
REGNATGRLV GRYCGNVLPL NYSSIIGHDL WIKFVSDGSG SGVGFQAAFN
1860 1870 1880 1890 1900
NIFGNDHIVG THGKVASPLW PRNYPHNSNY QWIVNVNESQ VIHGRILEMD
1910 1920 1930 1940 1950
VEGTFNCYYD KLRIYDGADI HSRLIGTYCG AQTESFSSTG SSLTFQFSSD
1960 1970 1980 1990 2000
SSISGRGFLL EWFAMDASDG PLPTIATGAC GGFLRTGDAP VFLYSPGWPG
2010 2020 2030 2040 2050
SYSNGADCMW LIQAPDSTVE LNILSLDIES HRTCDYDKLV IRDGDNNMAQ
2060 2070 2080 2090 2100
ELAVLCGREI PGPIRSTGEY MTIRFTSDFS VTRAGFNASF HKSCGGYLHA
2110 2120 2130 2140 2150
DRGIITSPGY PEAYTSNLNC SWHVQVQQGL SIAVHFEQPF QVSNRDAFCN
2160 2170 2180 2190 2200
QGDYLVLKNG PDIYSPPLGP HGGNGRFCGS RPSSTLFTSD NELFVQFISD
2210 2220 2230 2240 2250
NSNEGQGFKI TYEAKSLACG GNIYIHDADS SGYVASPNHP DNYPQHADCI
2260 2270 2280 2290 2300
WVIAAPSGRP IRLEFEDQFS IEITPNCTSS YLELRDGADS NAPVLAKFCG
2310 2320 2330 2340 2350
TSLPPSQLSS GEVMYLRFRS DNSPTHAGFK AKYSIAQCGG TVTGQSGVIE
2360 2370 2380 2390 2400
SSGYPALPYA NNLFCEWRLQ GLSGHYLTIH FEDFNLQNSS GCERDFVEIW
2410 2420 2430 2440 2450
ENHTSGNLLG RYCGNTVPDS IDTSGNVALV RFVTDGFLTA SGFRLRFDSS
2460 2470 2480 2490 2500
MEGCGGDLQG PTGTFTAPNY LNPNPHGWMC EWRITVQEGR RVTLTLNDLR
2510 2520 2530 2540 2550
LEAHPFCNSE HVAVFNGIRS NSPQLEKRCS SVNGSNEIRS SGNTMKVVYF
2560 2570 2580 2590 2600
TDGSRPYGGF TASYTSSEDA VCGGSLTNSP EGNFTSPGYD GTRNYSRNLN
2610 2620 2630 2640 2650
CEWTLSNSNQ GNSSIYIDFE DFYLESHQDC QFDVLEFRVD NADGLLIWRL
2660 2670 2680 2690 2700
CGSSKPTMPL VIPYPQVWIH FVTNERVEHI GFRARYSFTD CGGIQIGDHG
2710 2720 2730 2740 2750
VISSPNYPAS YDSLTHCSWL LEAPQGHTIT LTFSDFDIEA HASCAWDSVT
2760 2770 2780 2790 2800
VRNGGSPGSP IIGHYCGSSN PRTIQSGSNQ LVVIFNTDSS VQNGGFYATW
2810 2820 2830 2840 2850
NTETSGCGGI LHSDTGTIRS PHWPQNFPEN SRCSWTVITH PSKHLEISFD
2860 2870 2880 2890 2900
NNFLIPSGDS QCLNSFVKVW AGTQEADKDL LATSCGNVSP GRIITPRNAF
2910 2920 2930 2940 2950
TAVFQSQETP AQGFSASFLS RCGRNFTNPS GYIVSPNYPK QYDNNMNCTY
2960 2970 2980 2990 3000
IIEASPLSVI LLKVVSFHLE ARSTVSGSCD SDGVHIIRGH SLSSTPLVTL
3010 3020 3030 3040 3050
CGDEALSPVT ISGPVLLNFY SNAHTTDFGF KFSYRITPCG GTFNLSFGII
3060 3070 3080 3090 3100
KSPSYSYSNY PNDMHCLYTV TVRDDRVIQL KFNDFDLVPS TFCSQDYLEI
3110 3120 3130 3140 3150
YDGSNISDPL LGKFCGSTLP PNVKSSNNTM FLVFKTDSVH TARGWKISFR
3160 3170 3180 3190 3200
ETLGPQQGCG GYLTGSTHTF GSPDSDSNGR YDKNLNCIWF ITAPVNKLIK
3210 3220 3230 3240 3250
LTFSTFALEA ATSLQRCIYD YVKLYDGDSE NANLAGTFCG STVPAPFISS
3260 3270 3280 3290 3300
GNFLTVQFVS DSSLEREGFN ATYTLLDMPC GGTYNATWTS QSIWSPSSSD
3310 3320 3330 3340 3350
PDVPLTTCTW VIEAPLHQQV EITVWTFQLH SQDCDQNYLE FRDPPERNGN
3360 3370 3380 3390 3400
PGIRFCGRNA SAVPTFYSSL STAIIIFKSE VFNTDSRVGF TYRIAGCSRE
3410 3420 3430 3440 3450
YQKAFGRLRS PGWPAGYASD ADCAVVLRAP QNHTISLFFH AFGLEDSGGC
3460 3470 3480 3490 3500
TRDFLEVRNG SESTSPLLGK YCGTLLPNPI FSQSRDLYLR FKSDSATSGR
3510 3520 3530 3540 3550
GYEIIWTSSP SGCGGTLYGD SGLVTSPGYP GTYPNHTHCE WVIIAPGGRP
3560 3570 3580 3590 3600
VTVSFSFISI DDPGECVQNY LMLYDGPDAN SPSSGPYCGA DTDVAPFAAS
3610 3620
SHRVFIRFHA EAAARPSALR LTWAS
Length:3,625
Mass (Da):397,366
Last modified:November 22, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB7BC4184199CC28
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AEMK02000074 Genomic DNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000074 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000026326

Proteomic databases

PaxDbiF1RWC3
PeptideAtlasiF1RWC3
PRIDEiF1RWC3

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
InParanoidiF1RWC3
OMAiFHLEYHP
TreeFamiTF316506

Gene expression databases

BgeeiENSSSCG00000011030 Expressed in 5 organ(s), highest expression level in kidney

Family and domain databases

CDDicd00041 CUB, 27 hits
Gene3Di2.60.120.290, 27 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 27 hits
PF00008 EGF, 2 hits
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 3 hits
SMARTiView protein in SMART
SM00042 CUB, 27 hits
SM00181 EGF, 8 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF49854 SSF49854, 27 hits
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01180 CUB, 27 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 7 hits
PS01187 EGF_CA, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUBN_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1RWC3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 31, 2019
Last sequence update: November 22, 2017
Last modified: December 11, 2019
This is version 67 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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