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Entry version 60 (16 Oct 2019)
Sequence version 3 (22 Nov 2017)
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Protein
Submitted name:

GRIP and coiled-coil domain-containing protein 2

Gene

GCC2

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-6811440 Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GRIP and coiled-coil domain-containing protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCC2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F1SU27

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000008138 Expressed in 6 organ(s), highest expression level in kidney

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000008689

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1609 – 1659GRIPInterPro annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni678 – 698DisorderedSequence analysisAdd BLAST21
Regioni1478 – 1543DisorderedSequence analysisAdd BLAST66

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili34 – 61Sequence analysisAdd BLAST28
Coiled coili69 – 142Sequence analysisAdd BLAST74
Coiled coili147 – 167Sequence analysisAdd BLAST21
Coiled coili225 – 252Sequence analysisAdd BLAST28
Coiled coili257 – 288Sequence analysisAdd BLAST32
Coiled coili324 – 351Sequence analysisAdd BLAST28
Coiled coili416 – 440Sequence analysisAdd BLAST25
Coiled coili449 – 490Sequence analysisAdd BLAST42
Coiled coili499 – 547Sequence analysisAdd BLAST49
Coiled coili551 – 571Sequence analysisAdd BLAST21
Coiled coili579 – 599Sequence analysisAdd BLAST21
Coiled coili715 – 742Sequence analysisAdd BLAST28
Coiled coili799 – 886Sequence analysisAdd BLAST88
Coiled coili902 – 932Sequence analysisAdd BLAST31
Coiled coili946 – 1001Sequence analysisAdd BLAST56
Coiled coili1016 – 1088Sequence analysisAdd BLAST73
Coiled coili1117 – 1231Sequence analysisAdd BLAST115
Coiled coili1253 – 1273Sequence analysisAdd BLAST21
Coiled coili1285 – 1319Sequence analysisAdd BLAST35
Coiled coili1332 – 1399Sequence analysisAdd BLAST68
Coiled coili1451 – 1478Sequence analysisAdd BLAST28
Coiled coili1579 – 1613Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1521 – 1540PolarSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0864 Eukaryota
COG5171 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183078

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F1SU27

KEGG Orthology (KO)

More...
KOi
K20282

Database of Orthologous Groups

More...
OrthoDBi
200498at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332907

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00755 Grip, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50913 GRIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F1SU27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDPAHDGVA SPATPGTGRY KLETLPKEDL IKFAKKQMML IQKAKSRCTE
60 70 80 90 100
LEKEIEELRS KSGGTDNITK ALTERLDAIL LEKAETEQQC VSLKKENIKM
110 120 130 140 150
KQEVEDSVTK LEDMHKEFEQ SQRNYMKEME NLKNELMAVH SKHSNDKAGW
160 170 180 190 200
QKELEEAAKK QLELSKQLKF HNDSEEIVKK LQEEIQKIKP AFEEQILYLQ
210 220 230 240 250
QQLEAATNEK EQEITHLQGV IEANSQQYQK DINSLQEELL RLKSTHQEEV
260 270 280 290 300
KELMCQIEAS AIEHEAEVNN LNQLKENLVR QCEGEEKNIQ QKYECELENL
310 320 330 340 350
GKTSNANQEN QMCSLLLKEN TLVEQGENEK VKHLEDALKE LESQHTILKD
360 370 380 390 400
ELTYMNNLKL KLEIDAQHIK DEFFHEREDL EFKINELLLA KEEQGCVIEK
410 420 430 440 450
LKCELEDSDK QFRCIVEQHN KEVKSLKEQH QKEISELNEA FLSGSEKEKL
460 470 480 490 500
TLMFEIQGLK EQCENLQQEK QEAILNYESL REIMEILQTE LGESAGKISQ
510 520 530 540 550
EFESMKQQQA SDVNELQQKL RTAFNEKDAL LETVNRLQTE NEKLLSQQEF
560 570 580 590 600
VPELENTIKT LQEKNEEYLV SLSQRDTMAQ ELEAKISHLI EEKDDLISKM
610 620 630 640 650
KSSHEEMNDL HKKCERENKL IVELREKVEQ TTRYNSELEQ KVNELTAGLE
660 670 680 690 700
ETLKEKDQNN QQLEKLLAQL QTLSGEQEAM SSEAQSLYEE NSRLTSEKDQ
710 720 730 740 750
LSRDLEALLS QKEGEFLLKE QLSELEKKLQ LALEERDHLN KLFDSEQDQK
760 770 780 790 800
LLVKTQLCNF LKQMESKVSE ESEDQDIVNV LQAVSESLAK INEEKHSLFF
810 820 830 840 850
QYNARVAELE KEIKFLQEEN EIQCEKLRSS LRDHEQEKVT LRKELEETLS
860 870 880 890 900
KKEALEHDLL EMKNANEQTR LENQNLLIQV EEVSQKLCSR NENHNEKEKS
910 920 930 940 950
FIKELEHLKP LLEEKESELQ DLRAELVSLK DSLEKSPSVE SDQPSVKEFE
960 970 980 990 1000
EKIGYLEKES KEKEEKINKL KLVAVKAKKE LDSSRKETQI LREELESVRS
1010 1020 1030 1040 1050
EKDQLSTSMR DLIQGAESYK NLLLEYDKQS EQLDKEKERA NNFEHHVEDL
1060 1070 1080 1090 1100
TRQLKNTTFQ CEKLNSDNED LLARIETLQS NTRLLEVQIL EAHKAKAVAD
1110 1120 1130 1140 1150
RELEAEKLQK EQKIKEHASS ICELEELQLQ LQKEKKQLQK TMQELELVRK
1160 1170 1180 1190 1200
DAQQTTLMNM EIADYERLMK ELNQKLANKN SKIEDLEQEI KIQKQKQETL
1210 1220 1230 1240 1250
QEEMTSLQAS VQQYEEKNTK IKQLLVKTKK ELADSKQAEN DHLLLQASLK
1260 1270 1280 1290 1300
GELEASQQQI EGFKIQLAEV TAEKHKAHEH LKASAEQQQR TLGTYQQRVA
1310 1320 1330 1340 1350
ALQEECRAAK AEQAAVTSEF ESYKVRVHNV LKQQKNKSVS QTENEGAKQE
1360 1370 1380 1390 1400
REHLEMLIDQ LKIKLQDTQN NLQVHVSELQ ALQSEHDALL ERNSRLLQET
1410 1420 1430 1440 1450
VSKEAELREK LCSVQAENTA LRTEQAQMAA QLAAQGEALR GGFRDQVRQL
1460 1470 1480 1490 1500
QEEHRGTVET LQQQLSQLEA QLFQLRSEPA TRGPASSHQP LKNLRERRNT
1510 1520 1530 1540 1550
DLPLLDVQAV TREEGEGMET TEAESSSSAS IHTPSLEQLL SSPEARLEPP
1560 1570 1580 1590 1600
SWHAEFTKEE LVQKLSSTTK SADHLNSLLR ETEATNAILL EQIKLLKSEI
1610 1620 1630 1640 1650
RRLERNQERE KSAANLEYLK NVLLQFILLK PGSERARLLP VVGTMLQLSP
1660 1670 1680
EEKARLAAAA QGEEENASRS SGWASYLHSW SGLR
Length:1,684
Mass (Da):195,059
Last modified:November 22, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3EF51623020DCD1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A287B5U7A0A287B5U7_PIG
GRIP domain-containing protein
GCC2
1,594Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AEMK02000020 Genomic DNA No translation available.
DQIR01199907 Transcribed RNA Translation: HDB55384.1

NCBI Reference Sequences

More...
RefSeqi
XP_003124901.3, XM_003124853.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000008915; ENSSSCP00000008689; ENSSSCG00000008138

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100512405

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:100512405

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000020 Genomic DNA No translation available.
DQIR01199907 Transcribed RNA Translation: HDB55384.1
RefSeqiXP_003124901.3, XM_003124853.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008689

Proteomic databases

PaxDbiF1SU27

Genome annotation databases

EnsembliENSSSCT00000008915; ENSSSCP00000008689; ENSSSCG00000008138
GeneIDi100512405
KEGGissc:100512405

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9648

Phylogenomic databases

eggNOGiKOG0864 Eukaryota
COG5171 LUCA
GeneTreeiENSGT00950000183078
InParanoidiF1SU27
KOiK20282
OrthoDBi200498at2759
TreeFamiTF332907

Enzyme and pathway databases

ReactomeiR-SSC-6811440 Retrograde transport at the Trans-Golgi-Network

Gene expression databases

BgeeiENSSSCG00000008138 Expressed in 6 organ(s), highest expression level in kidney

Family and domain databases

InterProiView protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF1SU27_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F1SU27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 3, 2011
Last sequence update: November 22, 2017
Last modified: October 16, 2019
This is version 60 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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