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Entry version 44 (11 Dec 2019)
Sequence version 2 (11 Dec 2019)
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Protein

Nuclear factor 1

Gene

nfib

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processDNA replicationUniRule annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear factor 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nfibImported
Synonyms:med13lImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-486376 nfib

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6T394

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000000835 Expressed in 12 organ(s), highest expression level in heart

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a homodimer.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000001859

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CTF/NF-I family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3663 Eukaryota
ENOG410Y16G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013680

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6T394

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLNPQET

TreeFam database of animal gene trees

More...
TreeFami
TF313889

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000647 CTF/NFI
IPR020604 CTF/NFI_DNA-bd-dom
IPR019739 CTF/NFI_DNA-bd_CS
IPR019548 CTF/NFI_DNA-bd_N
IPR003619 MAD_homology1_Dwarfin-type

The PANTHER Classification System

More...
PANTHERi
PTHR11492 PTHR11492, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00859 CTF_NFI, 1 hit
PF03165 MH1, 1 hit
PF10524 NfI_DNAbd_pre-N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00523 DWA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00349 CTF_NFI_1, 1 hit
PS51080 CTF_NFI_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6T394-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAAANWAAN GASLEDCHSN LFSLAELTGI KWRRYRYQGP GECGPVISAP
60 70 80 90 100
AQDDPILLSF IRCLQANLLC VWRREVKPDR KELWIFWWGD EPNLGDVIHH
110 120 130 140 150
ELHMDEEGLW ENGLSYECRT LLFKAIHNLL ERCLLDKNFV RIGKWFVKPC
160 170 180 190 200
EKEEKSLSKS ENLSCSFTFF LHGESNVCTS VEIAQHQPVY LINQQHLHLA
210 220 230 240 250
QTSHAPCQVI LSPYGLSGTL TGHGYKTSDP TTRKLLEEWR PFYPTVLRVR
260 270 280 290 300
QDQQEELQYN DDFPAAVEVI VGGVRLVYPS AFVLIAQSDL PLSSSVGGAG
310 320 330 340 350
HSSTGGQQCT AVTKDPSPCR MPLTPPTSPE QIAPGDGKEN PSSINSHSTE
360 370 380 390 400
DGVSNPKQSS KCGEKSCHRL SSYMAQRVWK ECIVNRCQPK LTVSSQQEGE
410 420 430 440 450
IQISKAPWDF VDPTHRATCS CSRHKYSKQR SAPSGSRPSS VTQPNMGGIP
460 470 480 490 500
TSCSSSLPPP ASSKHKPTDR QEKAEKLQKK TTTPFHHRAL PIQNEQCLTQ
510 520 530 540 550
EMAIQQRQGA EAATSTPPNR QYQSMPSAGE LDQLLTSQPS DSPHSPASPM
560 570 580 590 600
PPTLSPQPPQ QEVAIPDPEV QPCNSTLYPN GLEMQPLDDR TMMAAGLGLP
610 620 630 640 650
LMAELSETSI YCSSLSQSQQ TENSWQEYML PSTGNEDFRP PNIPVEWHES
660 670 680 690 700
IQETGEDSTA LERLLAQPNK RFKVLDENRP ILSDNRTYLD QPPMYLEQLG
710 720 730 740 750
DNLDPYTFED GEIKYSFTAT KKCKMGAERD LSRKLKADEG FEKNASPTEQ
760 770 780 790 800
PASVTDPGKN VMSIFSPASK PDPRQDRGIA ASLTQVKDLA PSLNDLDNLF
810 820 830 840 850
DNSEDEDLAG SPGTRAMKAP SVGSEDRALG KDARTAVAYS ATDLQRMFPT
860 870 880 890 900
PPSLEQHPAF SPIMIYKDGV SSETTATLAM MESPMVNLAS MHHLEFKMEV
910 920 930 940 950
EEGLCSPKPE EIRDFSYVHR VASSQPFVGT SMFAPLKSLP SQCLLSLKIP
960 970 980 990 1000
DACVYRPSWA APPKMQHLPL PPATSFNRDG YMNVPSVGSL TDPDYLQLNT
1010 1020 1030 1040 1050
PQTNTPLAPC STAPASNSGT GGVLPSPATP RFSVPTPRTP RTPRTPRGGG
1060 1070 1080 1090 1100
GASGQGSAKY DSTDLCSPAS TPSTTRPLSS VEPASSHPAP EAHSLYVTLL
1110 1120 1130 1140 1150
LSDSVLNIFK DRNFDSCCIC ACNLNIKGAD VGIYIPDSSN EDQYRCTCGF
1160 1170 1180 1190 1200
SAIVNRRLGY NSGLFIEDEM DIFGRSSDLG QAVERRLNIR VTERLGQEQP
1210 1220 1230 1240 1250
PPGLLLLLQR QCTRPFNNCS STWELSYCQG VSLLDRPSWN YDRVRAESSD
1260 1270 1280 1290 1300
AWPECLNALE QGRQYVDNPT GGRVDEALVK SATFHLWPHS NVLDVSMLPS
1310 1320 1330 1340 1350
QDVVRMLLSL QPFLQDAIQK KRTGRTWENI QHVQGPLTWQ QFHKMAGRGS
1360 1370 1380 1390 1400
YGSEESPEPL PIPNLLVGYD KDFLTIAPFS LPFWERLLLE PYGGQRDVGY
1410 1420 1430 1440 1450
LVLCPENSAL LDGAKAFFRD LSAVYEMCRL GEHRPICKVL SDGIMKISQP
1460 1470 1480 1490 1500
AGDSEETSCE EMDNQARLQL FAQTCRQHLA PYLSTLQLDS SLLLPPKNQP
1510 1520 1530 1540 1550
PTVQTSSSPA VPSCPTGVLF NTTPNGTSTT PLPPPPLSSS TSLPAGNSTV
1560 1570 1580 1590 1600
PTGFNNCPSQ NTSSIVERPL GNQTTGDPEP SQQSMQQETP ENATEREKIG
1610 1620 1630 1640 1650
IPTEPEPAGA LSSCPTVVIY MVDPFTYTVD EDCHPGNYWM LGLIRCFTDM
1660 1670 1680 1690 1700
LESLPEPLRS ACILQVVPCH SLLQTVNDEV VSYIQHLKSL AFSVYCQCRR
1710 1720 1730 1740 1750
PIATQIPIKP LTGFGPAAAL NAILRNQEQP SPGQMYSPPF LLSPTKDKQT
1760 1770 1780 1790 1800
ELGETFGEAG QKYNVLFVGY CLSHDQRWLL ASCTDLQGEL LETCVVNIHV
1810 1820 1830 1840 1850
PNRFRRSKVS ARKIGLQKLW EWCVEIIQTT SLPWRVVIGR LGRLGHGELK
1860 1870 1880 1890 1900
DWSILLGECS LQTISRQLKE TCKMCGISAA DSPSILSACL VAMEPQGSFT
1910 1920 1930 1940 1950
VMPDMLDLPF LDDMDNDIGI LITGNLHSPP NSSPGSPTGA GPHFQHSRSQ
1960 1970 1980 1990 2000
VERLLSRETP EELKQQPLAL GYYVSTAKAE NLPEWFWSSC PHAQNQCPLF
2010 2020 2030 2040 2050
LKASLHHHIS VSHNDDLVPA RTSQRVPHPL DSKTTSDVLR FVLEQYNALS
2060 2070 2080
WLTCNPATQD RTSCLPVHFT VLTQMYNMVM DFL
Length:2,083
Mass (Da):229,926
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFBEBBE3B3A3B9EF
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000002013; ENSXETP00000001859; ENSXETG00000006347

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000001859

Proteomic databases

PaxDbiF6T394

Genome annotation databases

EnsembliENSXETT00000002013; ENSXETP00000001859; ENSXETG00000006347

Organism-specific databases

XenbaseiXB-GENE-486376 nfib

Phylogenomic databases

eggNOGiKOG3663 Eukaryota
ENOG410Y16G LUCA
GeneTreeiENSGT00390000013680
InParanoidiF6T394
OMAiHLNPQET
TreeFamiTF313889

Gene expression databases

BgeeiENSXETG00000000835 Expressed in 12 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR000647 CTF/NFI
IPR020604 CTF/NFI_DNA-bd-dom
IPR019739 CTF/NFI_DNA-bd_CS
IPR019548 CTF/NFI_DNA-bd_N
IPR003619 MAD_homology1_Dwarfin-type
PANTHERiPTHR11492 PTHR11492, 1 hit
PfamiView protein in Pfam
PF00859 CTF_NFI, 1 hit
PF03165 MH1, 1 hit
PF10524 NfI_DNAbd_pre-N, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
PROSITEiView protein in PROSITE
PS00349 CTF_NFI_1, 1 hit
PS51080 CTF_NFI_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6T394_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6T394
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: December 11, 2019
This is version 44 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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