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Entry version 53 (16 Oct 2019)
Sequence version 1 (27 Jul 2011)
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Protein
Submitted name:

Otolin 1

Gene

otol1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-1442490 Collagen degradation
R-XTR-1474244 Extracellular matrix organization
R-XTR-1650814 Collagen biosynthesis and modifying enzymes
R-XTR-2022090 Assembly of collagen fibrils and other multimeric structures
R-XTR-204005 COPII-mediated vesicle transport
R-XTR-216083 Integrin cell surface interactions
R-XTR-2214320 Anchoring fibril formation
R-XTR-5694530 Cargo concentration in the ER
R-XTR-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Otolin 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:otol1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-950285 otol1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6TWI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000016183 Expressed in 9 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000035280

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 129DisorderedSequence analysisAdd BLAST129
Regioni141 – 478DisorderedSequence analysisAdd BLAST338
Regioni497 – 1390DisorderedSequence analysisAdd BLAST894

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 50Pro-richSequence analysisAdd BLAST15
Compositional biasi155 – 169Pro-richSequence analysisAdd BLAST15
Compositional biasi601 – 630PolyampholyteSequence analysisAdd BLAST30
Compositional biasi641 – 655Pro-richSequence analysisAdd BLAST15
Compositional biasi770 – 789PolyampholyteSequence analysisAdd BLAST20
Compositional biasi845 – 881PolyampholyteSequence analysisAdd BLAST37
Compositional biasi943 – 965Pro-richSequence analysisAdd BLAST23
Compositional biasi1178 – 1192PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1240 – 1271PolyampholyteSequence analysisAdd BLAST32
Compositional biasi1318 – 1353PolyampholyteSequence analysisAdd BLAST36

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410Z1XK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154865

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6TWI0

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTQGEPI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6TWI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CKRQFKCNVL GEKGQKGELG SAGRPGATGP PGEAGRNGIP GPPGPVGPRG
60 70 80 90 100
PPGEGTASRG QKGETGDPGT DGIPGSPGRP GNPGTPASPF GERGSPGPSG
110 120 130 140 150
PKGEKGVPGE PGEVINGGGG IPGRKGEPGI PVSIVDSYYL SNGIPGQPGT
160 170 180 190 200
PGQRGIPGTP GPPGPEGPSG SSGLPGQSVK PFQGEKGERG ERGLPGSVDG
210 220 230 240 250
AGGKGEPGSP GSPGAQGQAG PRGPTGLSGQ KGEKGEAGEG FPGAAGRTGD
260 270 280 290 300
PGDRVRHSEE GPRGPPGEQG TKGDRGAPGQ DGERGEKGER GPPGFQGLKG
310 320 330 340 350
PSGGLGPRGD KGPYTPLSAW IEQGDQGAPG EPGKSGSQGP AGPEGPKGSR
360 370 380 390 400
GDSDQGPPGF GIPGQPGAKG DQGERGNVGL AGKTGQKGEP GEPGQNGEPG
410 420 430 440 450
KSGPPGQIGL RGKEGDRGEK GDEGTPGESG IPGKNGERGL RGTQGPQGPQ
460 470 480 490 500
GKPGDAGDPG EHGMKGAKGE AGANGLPGER GCLYDTYITV WTGYPGLEGL
510 520 530 540 550
RGPPGPRGET GDRGTPGEKG ERGPPGVDGR NGLDGKPGQP GSPGQRGDAG
560 570 580 590 600
KQGDPGRDGL PGLRGEQGPP GLIGPVGPPG IPGKQGEDGK PGFNGKNGED
610 620 630 640 650
GTPGEDGRKV RTGDKGDVGP AGRDGRDGQK GTQGEPGSVG PAGPPGVPGN
660 670 680 690 700
PGPIGPPGQG DRGEQGAKGE QGRPGEMGAR GEPGSTAQMK IKGEPGVPGE
710 720 730 740 750
KGAPGREGTM GFPGERGQKG ERGDLGPAGP QGPPGRAIGE RGPEGPSGQT
760 770 780 790 800
GDPGKPGIPG IPGKAGEPGE QGKAGDKGER GERGERGGSK QQEGATPLPT
810 820 830 840 850
LYQSQGKDGA RGPVGPPGPK GEVVEIIATG LPGERGLTGP RGIKHILKCK
860 870 880 890 900
GDPGADGEKG AKGDKGVDGQ KGDRGDSGEK GRDGSPGSVG ERGLAGPEGK
910 920 930 940 950
PSIPHQGEKG NSGLPGPSGN PGEPGQQGPP GPTGIKGSPG EPGPSIRGPP
960 970 980 990 1000
GPQGIAGPPG LPGPPGLMGE SGKPGVPGRD GSPGKDGELG LPGKMGMPGP
1010 1020 1030 1040 1050
PGLVGTRGEA GEPGTPGEFV AGPSGPKGEK AAGIPGEAGQ KGDRGLPGAR
1060 1070 1080 1090 1100
GEKGSKGPPG PRGEKGQAGV GLPGPAGQIG PPGLKGDVGL PGPPGPPGLQ
1110 1120 1130 1140 1150
GIAGIPGQPG LRGEVGQLGP PGQQGERGLQ GFAGREGNVG PQGQSGAPGA
1160 1170 1180 1190 1200
MGPAGPPGVK GDKGDSGIGQ LGPRGERGDP GSRGEDGRPG LEGDRGPPGL
1210 1220 1230 1240 1250
PGNRGERGDK GDPGPIGLKG DKGETLTIEG PPGPRGNKGE MGERGIKGSE
1260 1270 1280 1290 1300
GEKGDKGDQG LHGEKGVKGE QGDKGATGFV GARGPGGQKG ETGAFGEPGE
1310 1320 1330 1340 1350
PGLSGKDGVP GMRGEKGEPG IHGLKGIKGD RGMKGLCGQD GEKGDKGKHG
1360 1370 1380 1390
ERGPAGESTI GPRGIPGIPG ERGEQGMIGV DGTKGDKGSP
Length:1,390
Mass (Da):133,946
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44B37976E6A67957
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAMC01018892 Genomic DNA No translation available.
AAMC01018893 Genomic DNA No translation available.
AAMC01018894 Genomic DNA No translation available.
AAMC01018895 Genomic DNA No translation available.
AAMC01018896 Genomic DNA No translation available.
AAMC01018897 Genomic DNA No translation available.
AAMC01018898 Genomic DNA No translation available.
AAMC01018899 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000035280; ENSXETP00000035280; ENSXETG00000016183

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01018892 Genomic DNA No translation available.
AAMC01018893 Genomic DNA No translation available.
AAMC01018894 Genomic DNA No translation available.
AAMC01018895 Genomic DNA No translation available.
AAMC01018896 Genomic DNA No translation available.
AAMC01018897 Genomic DNA No translation available.
AAMC01018898 Genomic DNA No translation available.
AAMC01018899 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000035280

Proteomic databases

PaxDbiF6TWI0

Genome annotation databases

EnsembliENSXETT00000035280; ENSXETP00000035280; ENSXETG00000016183

Organism-specific databases

XenbaseiXB-GENE-950285 otol1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410Z1XK LUCA
GeneTreeiENSGT00940000154865
InParanoidiF6TWI0
OMAiHTQGEPI

Enzyme and pathway databases

ReactomeiR-XTR-1442490 Collagen degradation
R-XTR-1474244 Extracellular matrix organization
R-XTR-1650814 Collagen biosynthesis and modifying enzymes
R-XTR-2022090 Assembly of collagen fibrils and other multimeric structures
R-XTR-204005 COPII-mediated vesicle transport
R-XTR-216083 Integrin cell surface interactions
R-XTR-2214320 Anchoring fibril formation
R-XTR-5694530 Cargo concentration in the ER
R-XTR-8948216 Collagen chain trimerization

Gene expression databases

BgeeiENSXETG00000016183 Expressed in 9 organ(s), highest expression level in embryo

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
PfamiView protein in Pfam
PF01391 Collagen, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6TWI0_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6TWI0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 53 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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