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Entry version 68 (16 Oct 2019)
Sequence version 1 (27 Jul 2011)
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Protein
Submitted name:

Heparan sulfate proteoglycan 2

Gene

hspg2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-1474228 Degradation of the extracellular matrix
R-XTR-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-XTR-2022928 HS-GAG biosynthesis
R-XTR-2024096 HS-GAG degradation
R-XTR-216083 Integrin cell surface interactions
R-XTR-3000157 Laminin interactions
R-XTR-3000171 Non-integrin membrane-ECM interactions
R-XTR-3000178 ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Heparan sulfate proteoglycan 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hspg2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6465357 hspg2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi118 ↔ 130PROSITE-ProRule annotation
Disulfide bondi125 ↔ 143PROSITE-ProRule annotation
Disulfide bondi137 ↔ 152PROSITE-ProRule annotation
Disulfide bondi202 ↔ 214PROSITE-ProRule annotation
Disulfide bondi209 ↔ 227PROSITE-ProRule annotation
Disulfide bondi221 ↔ 236PROSITE-ProRule annotation
Disulfide bondi242 ↔ 254PROSITE-ProRule annotation
Disulfide bondi249 ↔ 267PROSITE-ProRule annotation
Disulfide bondi261 ↔ 276PROSITE-ProRule annotation
Disulfide bondi305 ↔ 320PROSITE-ProRule annotation
Disulfide bondi701 ↔ 710PROSITE-ProRule annotation
Disulfide bondi760 ↔ 769PROSITE-ProRule annotation
Disulfide bondi809 ↔ 818PROSITE-ProRule annotation
Disulfide bondi1141 ↔ 1150PROSITE-ProRule annotation
Disulfide bondi1153 ↔ 1167PROSITE-ProRule annotation
Disulfide bondi1175 ↔ 1187PROSITE-ProRule annotation
Disulfide bondi1195 ↔ 1204PROSITE-ProRule annotation
Disulfide bondi1482 ↔ 1491PROSITE-ProRule annotation
Disulfide bondi1541 ↔ 1550PROSITE-ProRule annotation
Disulfide bondi3897 ↔ 3906PROSITE-ProRule annotation
Disulfide bondi3932 ↔ 3941PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F7CCA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000017911 Expressed in 11 organ(s), highest expression level in skeletal muscle tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000038816

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 110SEAInterPro annotationAdd BLAST110
Domaini323 – 400Ig-likeInterPro annotationAdd BLAST78
Domaini462 – 647Laminin IV type AInterPro annotationAdd BLAST186
Domaini682 – 731Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini732 – 789Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini794 – 838Laminin EGF-likeInterPro annotationAdd BLAST45
Domaini867 – 1044Laminin IV type AInterPro annotationAdd BLAST178
Domaini1128 – 1169Laminin EGF-likeInterPro annotationAdd BLAST42
Domaini1175 – 1224Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini1251 – 1429Laminin IV type AInterPro annotationAdd BLAST179
Domaini1463 – 1512Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini1513 – 1570Laminin EGF-likeInterPro annotationAdd BLAST58
Domaini1570 – 1664Ig-likeInterPro annotationAdd BLAST95
Domaini1670 – 1756Ig-likeInterPro annotationAdd BLAST87
Domaini1766 – 1854Ig-likeInterPro annotationAdd BLAST89
Domaini1861 – 1944Ig-likeInterPro annotationAdd BLAST84
Domaini1956 – 2038Ig-likeInterPro annotationAdd BLAST83
Domaini2055 – 2175Ig-likeInterPro annotationAdd BLAST121
Domaini2190 – 2272Ig-likeInterPro annotationAdd BLAST83
Domaini2285 – 2367Ig-likeInterPro annotationAdd BLAST83
Domaini2384 – 2466Ig-likeInterPro annotationAdd BLAST83
Domaini2478 – 2561Ig-likeInterPro annotationAdd BLAST84
Domaini2575 – 2661Ig-likeInterPro annotationAdd BLAST87
Domaini2681 – 2768Ig-likeInterPro annotationAdd BLAST88
Domaini2779 – 2861Ig-likeInterPro annotationAdd BLAST83
Domaini2877 – 2960Ig-likeInterPro annotationAdd BLAST84
Domaini2967 – 3055Ig-likeInterPro annotationAdd BLAST89
Domaini3066 – 3148Ig-likeInterPro annotationAdd BLAST83
Domaini3153 – 3237Ig-likeInterPro annotationAdd BLAST85
Domaini3251 – 3334Ig-likeInterPro annotationAdd BLAST84
Domaini3339 – 3423Ig-likeInterPro annotationAdd BLAST85
Domaini3428 – 3504Ig-likeInterPro annotationAdd BLAST77
Domaini3516 – 3692LAM_G_DOMAINInterPro annotationAdd BLAST177
Domaini3688 – 3868LAM_G_DOMAINInterPro annotationAdd BLAST181
Domaini3870 – 3907EGF-likeInterPro annotationAdd BLAST38
Domaini3909 – 3942EGF-likeInterPro annotationAdd BLAST34
Domaini3967 – 4155LAM_G_DOMAINInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni154 – 197DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi167 – 181Pro-richSequence analysisAdd BLAST15

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Laminin EGF-like domainPROSITE-ProRule annotation, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3509 Eukaryota
ENOG410XTD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156670

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F7CCA0

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDERGSM

TreeFam database of animal gene trees

More...
TreeFami
TF326548

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 20 hits
4.10.400.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR000082 SEA_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 1 hit
PF07679 I-set, 9 hits
PF00052 Laminin_B, 3 hits
PF00053 Laminin_EGF, 7 hits
PF00054 Laminin_G_1, 2 hits
PF02210 Laminin_G_2, 1 hit
PF00057 Ldl_recept_a, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00179 EGF_CA, 2 hits
SM00180 EGF_Lam, 8 hits
SM00409 IG, 21 hits
SM00408 IGc2, 21 hits
SM00406 IGv, 8 hits
SM00281 LamB, 3 hits
SM00282 LamG, 3 hits
SM00192 LDLa, 4 hits
SM00200 SEA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 21 hits
SSF49899 SSF49899, 3 hits
SSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 7 hits
PS50835 IG_LIKE, 21 hits
PS50025 LAM_G_DOMAIN, 3 hits
PS51115 LAMININ_IVA, 3 hits
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 4 hits
PS50024 SEA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F7CCA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VYYRALVNFT QSIEYSPELD NVSSPEFIDL SEAVVDTLES EYHKIPGEQM
60 70 80 90 100
VSVVYVKVID GDTFVELDVG SEGYSNDAEI RQVLFSVIDS RSIASYITSA
110 120 130 140 150
QGFQFRRLGS VTPSLRPCRD DEFTCTSGDC VPAEYRCDHR HDCRDMSDEL
160 170 180 190 200
ECATPGPNLG PVSTARPATT PPRPFTRPPV IATTPYKPFT HKPPPDLETR
210 220 230 240 250
QCRRDEARCP NGQCIPRDYL CDGEKDCKDG SDEMHCGTPS PCEPNEFKCK
260 270 280 290 300
NGRCALKLWR CDGDNDCGDG SDELNCPTKG PSDTCAPDQF VCVQARTCIP
310 320 330 340 350
ASYQCDDEAD CPDRSDEVGC NPPQVITPPE ESIMASRGDT VRFTCVAIGV
360 370 380 390 400
PTPIITWRLN WGHIPTSSRV SMTSENGHGT LIIRDVKEAD QGAYTCEAIN
410 420 430 440 450
AKGMVFGIPD GVLILKPHRG PCPEGSFYVE NSARCIPCFC FGVTKVCQQT
460 470 480 490 500
GRYRNQIRLR FDVPEDFKGV NFTVPSHVGI PPLSSNQLQI DTSVEEFQLV
510 520 530 540 550
DLSRRFLSID SFWTLPGQFL GNKVDSYGGS LSFKVRYGLT RGQSEPVRKP
560 570 580 590 600
DVILVGNGRK LIYRVQTSTQ PSIVNQRKIQ FTEENWQHES GASVTREDLL
610 620 630 640 650
MTLQNLEAIM IQTVYDNKMA SVGISDIVMD TTSVEYTQLG PAVGVEECRR
660 670 680 690 700
CPGGYAGPSC EVCAAQFERV PGGPFLGTCS GCNCNGHASS CDPVSGYCLN
710 720 730 740 750
CQHNTEGPQC NKCKAGFFGD PTRGVSDACR PCPCPHTDPR RRFSDTCFMD
760 770 780 790 800
VDGQPTCDSC APGYTGRRCE RCAEGYDGRP MQPGGRCEPV GNVCDVKGAL
810 820 830 840 850
STGDGSCVCK SHVEGNFCNE CKSGTFYLSE KNPDGCLKCF CMGITRQCSS
860 870 880 890 900
SFWNRDQQQV SSTYDSQDRV PFTISNAGST RTLSESIRVT GQSELTFSNF
910 920 930 940 950
LNVPQDVYFW VLPDRFKGDK VTSYGGELRY TITFEAPAGS QPLFGQPDVV
960 970 980 990 1000
LQGNGIFLEH SANTRTAPGF PITITVPFRE RAWRRADGQD ATREHLLMAL
1010 1020 1030 1040 1050
ADIDLLMIRA SYAERMVETR ISNIHMDVAV PYPTDRQRAV EVEHCVCPPG
1060 1070 1080 1090 1100
YSGPSCQVCA PLALLFFASK TGLRAIAFCS INRGAVGDPG QARPPHPTPP
1110 1120 1130 1140 1150
GKFILYQSWH GVITVGLPTA LGQYFGTCFL DRDGHPTCDS CPVGYAGRQC
1160 1170 1180 1190 1200
ERCAPGYRGD PARGQPCTAD GGSSCPCDLR GSVSDRCDSR RQCECKPNVE
1210 1220 1230 1240 1250
GASCGTCRPH HFYLSTENPD GCLPCFCMGV TQQCTSSTYH RELISTPFLP
1260 1270 1280 1290 1300
GNFQNFALVN RQRSSRITSG FTVEMSRHGP QLTHSSFDQL GQESYYWQLP
1310 1320 1330 1340 1350
EGYQGDKVAS YGGKLRYTLT YNAGIRGSAL PDADVQITGN DITLVAYQHD
1360 1370 1380 1390 1400
LRPRESKSFE IVFRESSWKR PDGQPATREH LMMALADLDE ILVRASYSTD
1410 1420 1430 1440 1450
MLSSSITGVS METAGPSYTN LPQALEVEEC RCPPGYQGLS CQDCAPGYTR
1460 1470 1480 1490 1500
TGGGLYLGHC EPCYCNGHSE SCHPETGACS NCLHNTVGES CDQCAPGFYG
1510 1520 1530 1540 1550
DASAGTPEDC QPCACPLTNP DNQFSKTCEI LGTSGYRCTA CQPGYTGQYC
1560 1570 1580 1590 1600
ERCAPGYTGN PNIPGQKCVP EDSRSKLIVR IHPQKATLSP GGEVTLRCHV
1610 1620 1630 1640 1650
SGNPPYYFYW TREDGRPIPP SAKAVGEGEN LHFSRVQPTD SGVYICTCRS
1660 1670 1680 1690 1700
PESVNTSKAE IVVSAAPSKP ITVTVEEQRV QTVRPGSDVT FICTAKSKSP
1710 1720 1730 1740 1750
AYTLVWTRQH NRKLPDRAMD FNGILTIRRV QPEDAGIYVC TGSNMYDMDE
1760 1770 1780 1790 1800
GNATLYVQGA GTATSPNAAA EPRQLTVQRG QTAEFRCTAT GTPTPAVEWT
1810 1820 1830 1840 1850
ELLSLAGPNG GLSPRAVVQG GVLRFHSVEP SDEGQYTCRV HNSAGQHFAR
1860 1870 1880 1890 1900
VDLRVHSGSL PEVQVSPERT EVREGDTVRL YCRAGGTPAA TISWRKEGGS
1910 1920 1930 1940 1950
LPPQARTERT DISTLVIPSI SAADGGTYLC VGTSSAGSAQ ARIEVIVIGE
1960 1970 1980 1990 2000
APIHGPTLRI EPSSDTVIEG QLVELNCVSA NPYATVTWHR GGGRPLSPNH
2010 2020 2030 2040 2050
QAYGSKLRIL QASTADSGEY ICRVTNGAAT QQASIIITIT RSSGPQQLPA
2060 2070 2080 2090 2100
SGNVPALRIE PSSDTLVEGQ TLELNCLFPS YPNAVVTWHR SGQPLSPNHQ
2110 2120 2130 2140 2150
VSDGEGQVEG GACSTSFHWP VVPGFWFPIT AVYWLNWQVS GPRLRILQAS
2160 2170 2180 2190 2200
VADSGEYICR VTTGPVTQKA SILVTITRAS GPSIPLGNGP AVRIETSSGS
2210 2220 2230 2240 2250
VVEGQTLELN CVVAGQPDAV VTWHRAGRLL SPNHQVLGSR LRITQASVAD
2260 2270 2280 2290 2300
SGEYICRTTT GTTTRQGSIM VTITHSTSSA SLITPTINIE SAPDSVAEGQ
2310 2320 2330 2340 2350
TVVLNCVIEG RPHQEVTWYR PDQPLAPNHQ VSGSRLRITH ASPRDSGEYI
2360 2370 2380 2390 2400
CRIQSGAGVQ MASIMVSIEG SSLSEYQDTG LGSPIRIESS SETVELGQTI
2410 2420 2430 2440 2450
ELNCLAEGHP GAVVTWHRSG GLPLPSNHQV SGSRMRILQA SPADSGIYIC
2460 2470 2480 2490 2500
RVSSASGSQE ASVTINVHSS AQVPNQFPYP ILIEKSADTV SEGQTLDLNC
2510 2520 2530 2540 2550
VVVGQPQAPV SWHRPGASFS SNHQISGSRL RIVQASTADS GQYVCRHDTG
2560 2570 2580 2590 2600
AGIQQASISV SILSGAASSY RLQSPVISID PHSATVQRGQ NATFKCRIHD
2610 2620 2630 2640 2650
GAQPIRVTWQ MRHNQPMEDN VHISPNGSII TIVGATHKNQ GSYRCMASNA
2660 2670 2680 2690 2700
YGMVHSSVNL VVQGKWHQLP PVLTQPPLGN PPLVIPHGKI RVKEGEPINV
2710 2720 2730 2740 2750
ECMGIGDPRP IVSWRRTGAR ENLKQHRLAP LDGTAVLQIP SAKPADSGSY
2760 2770 2780 2790 2800
TCVAHNPHGS TQVHVEVHVE GHVISPGAPL VLADKPVHVV VTGGQATLSC
2810 2820 2830 2840 2850
SASGNPTPTI TWSKLRAPLP WQHQVVNNTL IIPNVAQQDS GQYICNASNA
2860 2870 2880 2890 2900
DGHAEVYVTL DVESTCSAGT GFNPTAPAYA TTLPHEASVS PGEPIQIQCL
2910 2920 2930 2940 2950
AHGTPPIKFQ WSRVDGTLPG QASIQDGVLH IDQASASDSG TYRCVASNKV
2960 2970 2980 2990 3000
GSSEAFAQMS LVLPGRPTAS IIPRGPVRVK VGSPIYLECM GQGDPRPVVS
3010 3020 3030 3040 3050
WRRTGDRQNL KPQQLVPLDS HAVLQILSAR PEDSGSYTCT AQNPSGSTQV
3060 3070 3080 3090 3100
QVEVHVEGRV ITPGVPKVTA EQPLHVVVAG DRASLSCTAV GNPAPKITWS
3110 3120 3130 3140 3150
KLRAPLPWQH EIVNDTLIIP KAALQDSGQY ICNASNAEGY SEVFVTLDVE
3160 3170 3180 3190 3200
TPPYATTLPD EVSVSVGEVI QIQCLAHGTS PLKFQWSKVN GSLPDRATVR
3210 3220 3230 3240 3250
DSTLHINLAK AADAGTYRCV VGNKVGSSKT FAQLIVTMVP LTQYLSLRSA
3260 3270 3280 3290 3300
PFAVRVSPLI DTKAVSGTAE FTCTVVGDPR ARIQWSKEGG QLPAGHQVQG
3310 3320 3330 3340 3350
GVLRIPNLES GNEGTYTCRV SSRFGQAQES VRLVLQALPK VRINIRTSVQ
3360 3370 3380 3390 3400
TVLAGNSVEF ECLALGDPRA KVTWSKVGSR LPADAVISGG TLRIEQVKQS
3410 3420 3430 3440 3450
DAGQYRCTAA NDVGEVQSHV ILHVQSVPQI AAQPEMKEIT AGSTAVFPCL
3460 3470 3480 3490 3500
ASGFPVPDIT WSKLEGDLPS DHQIDNNVLT ILSVKPEDAG TYVCTAANRQ
3510 3520 3530 3540 3550
GRVTAFSMLK VRERVVPYFT GQPQSYLSLP SIKDAHKKLE IKITFRPDTA
3560 3570 3580 3590 3600
DGMLVYSGQK KSNGADFVSF GLVGGRPEFR FDAGSGMATI RYPTAISLGE
3610 3620 3630 3640 3650
FHTVTLYRNL TQGSLVVDRH VPVNGTSQGK FQGLDLNEEL FLGGYSHYDS
3660 3670 3680 3690 3700
ISKTGLNSGF VGCVRQLIIQ GEEVIFKDLD LSANGVSNCP TCRDRPCKVP
3710 3720 3730 3740 3750
LQKVASVDSR ETWQQLCNMV TVGQDGDSRA RWRQYKMGRR KKKGVQVGRV
3760 3770 3780 3790 3800
TNEGVNGPLV VPTGLAILRS LEPVTLGQWH KVSAERVNKD GTLIVDGTDP
3810 3820 3830 3840 3850
VKRSAPGKSQ GLNLKTLMYL GGVDGSVELP SAANISRHFQ GCIGEVSING
3860 3870 3880 3890 3900
KKVDISYSFT ESSAIGQCYD NSPCDRMPCL HGGRCQPTGE YEYQCLCLDG
3910 3920 3930 3940 3950
FKGDRCETHE DQCQIHNPCL NGATCKDNRC HCPSGYSGTI CEHGRTAGAE
3960 3970 3980 3990 4000
DRDWPVEGSG GNDAPGLYGS FFSDDSYIAL PKHVFPRSRP EAPETIELEI
4010 4020 4030 4040 4050
RTSSSEGVIL WQGMEENEQG KGKDFISLGL KDGHLVFSYQ LGSGEANIRS
4060 4070 4080 4090 4100
EDPVNDGEWH RIVAVREGKL GSIQIDGEDS VSGASPGRNI MVNTKGSVYL
4110 4120 4130 4140 4150
GGAPNVKTLT GGKFSSGING CIKNLVILNA RPSQQPHQPI DLKHHAEAGH

NTKECPS
Length:4,157
Mass (Da):448,807
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1957F8729E14D77
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AAMC01127504 Genomic DNA No translation available.
AAMC01127505 Genomic DNA No translation available.
AAMC01127506 Genomic DNA No translation available.
AAMC01127507 Genomic DNA No translation available.
AAMC01127508 Genomic DNA No translation available.
AAMC01127509 Genomic DNA No translation available.
AAMC01127510 Genomic DNA No translation available.
AAMC01127511 Genomic DNA No translation available.
AAMC01127512 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSXETT00000038816; ENSXETP00000038816; ENSXETG00000017911

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01127504 Genomic DNA No translation available.
AAMC01127505 Genomic DNA No translation available.
AAMC01127506 Genomic DNA No translation available.
AAMC01127507 Genomic DNA No translation available.
AAMC01127508 Genomic DNA No translation available.
AAMC01127509 Genomic DNA No translation available.
AAMC01127510 Genomic DNA No translation available.
AAMC01127511 Genomic DNA No translation available.
AAMC01127512 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000038816

Proteomic databases

PaxDbiF7CCA0

Genome annotation databases

EnsembliENSXETT00000038816; ENSXETP00000038816; ENSXETG00000017911

Organism-specific databases

XenbaseiXB-GENE-6465357 hspg2

Phylogenomic databases

eggNOGiKOG3509 Eukaryota
ENOG410XTD2 LUCA
GeneTreeiENSGT00940000156670
InParanoidiF7CCA0
OMAiCDERGSM
TreeFamiTF326548

Enzyme and pathway databases

ReactomeiR-XTR-1474228 Degradation of the extracellular matrix
R-XTR-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-XTR-2022928 HS-GAG biosynthesis
R-XTR-2024096 HS-GAG degradation
R-XTR-216083 Integrin cell surface interactions
R-XTR-3000157 Laminin interactions
R-XTR-3000171 Non-integrin membrane-ECM interactions
R-XTR-3000178 ECM proteoglycans

Gene expression databases

BgeeiENSXETG00000017911 Expressed in 11 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

CDDicd00112 LDLa, 4 hits
Gene3Di2.60.40.10, 20 hits
4.10.400.10, 4 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR000082 SEA_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07679 I-set, 9 hits
PF00052 Laminin_B, 3 hits
PF00053 Laminin_EGF, 7 hits
PF00054 Laminin_G_1, 2 hits
PF02210 Laminin_G_2, 1 hit
PF00057 Ldl_recept_a, 4 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00179 EGF_CA, 2 hits
SM00180 EGF_Lam, 8 hits
SM00409 IG, 21 hits
SM00408 IGc2, 21 hits
SM00406 IGv, 8 hits
SM00281 LamB, 3 hits
SM00282 LamG, 3 hits
SM00192 LDLa, 4 hits
SM00200 SEA, 1 hit
SUPFAMiSSF48726 SSF48726, 21 hits
SSF49899 SSF49899, 3 hits
SSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 4 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 5 hits
PS50027 EGF_LAM_2, 7 hits
PS50835 IG_LIKE, 21 hits
PS50025 LAM_G_DOMAIN, 3 hits
PS51115 LAMININ_IVA, 3 hits
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 4 hits
PS50024 SEA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF7CCA0_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F7CCA0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 16, 2019
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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