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Entry version 64 (13 Nov 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Collagen type V alpha 1 chain

Gene

COL5A1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-1442490 Collagen degradation
R-BTA-1650814 Collagen biosynthesis and modifying enzymes
R-BTA-186797 Signaling by PDGF
R-BTA-2022090 Assembly of collagen fibrils and other multimeric structures
R-BTA-216083 Integrin cell surface interactions
R-BTA-3000171 Non-integrin membrane-ECM interactions
R-BTA-3000178 ECM proteoglycans
R-BTA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type V alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL5A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:58369 COL5A1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 41Sequence analysisAdd BLAST41
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501879212642 – 1847Sequence analysisAdd BLAST1806

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G3MZI7

PRoteomics IDEntifications database

More...
PRIDEi
G3MZI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000047998 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3300 Collagen type V trimer variant 1
CPX-4 Collagen type V trimer variant 2
CPX-5 Collagen type V trimer variant 3

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000054985

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1618 – 1846Fibrillar collagen NC1InterPro annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni247 – 279DisorderedSequence analysisAdd BLAST33
Regioni306 – 526DisorderedSequence analysisAdd BLAST221
Regioni568 – 1583DisorderedSequence analysisAdd BLAST1016

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi385 – 399PolarSequence analysisAdd BLAST15
Compositional biasi478 – 492Pro-richSequence analysisAdd BLAST15
Compositional biasi691 – 709Pro-richSequence analysisAdd BLAST19
Compositional biasi811 – 825PolyampholyteSequence analysisAdd BLAST15
Compositional biasi955 – 982Pro-richSequence analysisAdd BLAST28
Compositional biasi1165 – 1179PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1330 – 1366Pro-richSequence analysisAdd BLAST37
Compositional biasi1390 – 1405Pro-richSequence analysisAdd BLAST16
Compositional biasi1463 – 1477Pro-richSequence analysisAdd BLAST15
Compositional biasi1534 – 1549Pro-richSequence analysisAdd BLAST16
Compositional biasi1565 – 1582Pro-richSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159211

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3MZI7

Database of Orthologous Groups

More...
OrthoDBi
1233761at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323987

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3MZI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVHTRWKAR SPLRPGAPLL SPPPLLLLLL LLLWAPPPSR AAQPADLLKV
60 70 80 90 100
LDFHNLPDGI TKTTGFCAAR RSSKGPDVAY RVTKDAQLSA PTKQLYPASA
110 120 130 140 150
FPEDFSILTT VKAKKGSQAF LVSIYNEQGI QQIGLEMGRS PVFLYEDHTG
160 170 180 190 200
KPGPEDYPLF RGINLSDGKW HRIALSVHKK NVTLILDCKK KTTKFLDRSE
210 220 230 240 250
HPVIDVNGIV VFGTRILDEE VFEGDIQQLL LVSDHRAAYD YCEHYSPDCD
260 270 280 290 300
TAVPDKPQSQ DPNPDEYYPD GDNEGDTYYY EYPYYEDTDD TGKDPITTKT
310 320 330 340 350
PVEAARETTE VAEELTQPPT EAPSAPSTTE GPGKEEDPGI GDYDYVPSED
360 370 380 390 400
YYTPPPYEDF GYGEGIENPD ENPDQLPDQG ARAEVPTSTV LTSNDSNPAP
410 420 430 440 450
PPEEGIDDLE EEFTEETIKN LDESYYDPYY DPTISPSEIG PGMPANQDTI
460 470 480 490 500
YEGMGGPRGE KGQKGEPAII EPGMLLEGPP GPEGPAGLPG PPGTMGPTGQ
510 520 530 540 550
VGDPGERGPP GRPGLPGADG LPGPPGTMLM LPFRFGGGGD AGSKGPMVSA
560 570 580 590 600
QESQAQAILQ QARLALRGPA GPMGLTGRPG PMGPPGSGGL KGEPGDMGPQ
610 620 630 640 650
GPRGVQGPPG PAGKPGRRGR AGSDGARGMP GQTGPKGDRG FDGLAGLPGE
660 670 680 690 700
KGHRGDPGPS GPPGPPGEDG ERGDDGEVGP RGLPGEPGPR GLLGPKGPPG
710 720 730 740 750
PPGPPGVTGM DGQPGPKGNV GPQGEPGPPG QQGNPGAQGL PGPQGAIGPP
760 770 780 790 800
GEKGPLGKPG LPGMPGADGP PGHPGKEGPP GEKGGQGPPG PQGPIGYPGP
810 820 830 840 850
RGVKGADGIR GLKGTKGEKG EDGFPGFKGD MGIKGDRGEI GPPGPRGEDG
860 870 880 890 900
PEGPKGRGGP NGDPGPLGPP GEKGKLGVPG LPGYPGRQGP KGSIGFPGFP
910 920 930 940 950
GANGEKGGRG TPGKPGPRGQ RGPTGPRGER GPRGITGKPG PKGNSGGDGP
960 970 980 990 1000
AGPPGERGPN GPQGPTGFPG PKGPPGPPGK DGLPGHPGQR GETGFQGKTG
1010 1020 1030 1040 1050
PPGPPGVVGP QGPTGETGPM GERGHPGPPG PPGEQGLPGL AGKEGTKGDP
1060 1070 1080 1090 1100
GPAGLPGKDG PPGLRGFPGD RGLPGPVGAL GLKGSEGPPG PPGPAGSPGE
1110 1120 1130 1140 1150
RGPAGAAGPI GIPGRPGPQG PPGPAGEKGA PGEKGPQGPA GRDGLQGPVG
1160 1170 1180 1190 1200
LPGPAGPVGP PGEDGDKGEI GEPGQKGSKG DKGEQGPPGP TGPQGPIGQP
1210 1220 1230 1240 1250
GPSGADGEPG PRGQQGLFGQ KGDEGPRGFP GPPGPVGLQG LPGPPGEKGE
1260 1270 1280 1290 1300
TGDVGQMGPP GPPGPRGPSG APGADGPQGP PGGIGNPGAV GEKGEPGEAG
1310 1320 1330 1340 1350
EPGLPGEGGP PGPKGERGEK GESGPSGAAG PPGPKGPPGD DGPKGSPGPV
1360 1370 1380 1390 1400
GFPGDPGPPG EPGPAGQDGP PGDKGDDGEP GQTGSPGPTG EPGPSGPPGK
1410 1420 1430 1440 1450
RGPPGPAGPE GRQGEKGAKG EAGLEGPPGK TGPIGPQGAP GKPGPDGLRG
1460 1470 1480 1490 1500
IPGPVGEQGL PGAPGPDGPP GPMGPPGLPG LKGDSGPKGE KGHPGLIGLI
1510 1520 1530 1540 1550
GPPGEQGEKG DRGVPGPQGS SGPKGEQGIT GPSGPIGPPG PPGLPGPPGP
1560 1570 1580 1590 1600
KGAKGSSGPT GPKGEAGQPG PPGPPGPPGE VIQPLPIQAS RTRRNIDASQ
1610 1620 1630 1640 1650
LMDDAEGEQY MDYADGMEEI FGSLNSLKLE IEQMKRPLGT PQNPARTCKD
1660 1670 1680 1690 1700
LQLCHPDFPD GEYWVDPNQG CSRDSFKVYC NFTAGGSTCV FPDKKSEGAR
1710 1720 1730 1740 1750
ITSWPKENPG SWFSEFKRGK LLSYVDAEGN PVGVVQMTFL RLLSASAHQN
1760 1770 1780 1790 1800
ITYNCYQSVA WQDAATGSYD KAMRFLGSND EEMSYDNSPY IRALVDGCAT
1810 1820 1830 1840
KKGYQKTVLE IDTPKVEQVP IVDIMFNDFG EASQKFGFEV GPACFLG
Length:1,847
Mass (Da):184,867
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC6C269EA2623CFC
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000063052; ENSBTAP00000054985; ENSBTAG00000047998

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-3300 Collagen type V trimer variant 1
CPX-4 Collagen type V trimer variant 2
CPX-5 Collagen type V trimer variant 3
STRINGi9913.ENSBTAP00000054985

Proteomic databases

PaxDbiG3MZI7
PRIDEiG3MZI7

Genome annotation databases

EnsembliENSBTAT00000063052; ENSBTAP00000054985; ENSBTAG00000047998

Organism-specific databases

VGNCiVGNC:58369 COL5A1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000159211
InParanoidiG3MZI7
OrthoDBi1233761at2759
TreeFamiTF323987

Enzyme and pathway databases

ReactomeiR-BTA-1442490 Collagen degradation
R-BTA-1650814 Collagen biosynthesis and modifying enzymes
R-BTA-186797 Signaling by PDGF
R-BTA-2022090 Assembly of collagen fibrils and other multimeric structures
R-BTA-216083 Integrin cell surface interactions
R-BTA-3000171 Non-integrin membrane-ECM interactions
R-BTA-3000178 ECM proteoglycans
R-BTA-8948216 Collagen chain trimerization

Gene expression databases

BgeeiENSBTAG00000047998 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 4 hits
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3MZI7_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3MZI7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: April 10, 2019
Last modified: November 13, 2019
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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