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Entry version 42 (31 Jul 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

DNA topoisomerase 2-beta

Gene

GW7_15047

Organism
Heterocephalus glaber (Naked mole rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomeraseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DNA topoisomerase 2-betaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:GW7_15047Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHeterocephalus glaber (Naked mole rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10181 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaBathyergidaeHeterocephalus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006813 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10181.XP_004857952.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini443 – 643MAGEInterPro annotationAdd BLAST201
Domaini797 – 914ToprimInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1431 – 1461DisorderedSequence analysisAdd BLAST31
Regioni1592 – 1896DisorderedSequence analysisAdd BLAST305

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1480 – 1500Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1431 – 1450PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1625 – 1669PolyampholyteSequence analysisAdd BLAST45
Compositional biasi1670 – 1687AcidicSequence analysisAdd BLAST18
Compositional biasi1715 – 1734PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1761 – 1778PolarSequence analysisAdd BLAST18
Compositional biasi1794 – 1814PolyampholyteSequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5BF97

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00187 TOP4c, 1 hit
cd03365 TOPRIM_TopoIIA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
1.10.268.10, 1 hit
3.30.230.10, 2 hits
3.30.565.10, 1 hit
3.40.50.670, 1 hit
3.90.199.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012542 DTHCT
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR041898 MAGE_WH1
IPR041899 MAGE_WH2
IPR002190 MHD_dom
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR001241 Topo_IIA
IPR013760 Topo_IIA-like_dom_sf
IPR002205 Topo_IIA_A/C
IPR013758 Topo_IIA_A/C_ab
IPR013757 Topo_IIA_A_a_sf
IPR013759 Topo_IIA_B_C
IPR013506 Topo_IIA_bsu_dom2
IPR018522 TopoIIA_CS
IPR031660 TOPRIM_C
IPR006171 TOPRIM_domain
IPR034157 TOPRIM_TopoII

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00204 DNA_gyraseB, 1 hit
PF00521 DNA_topoisoIV, 1 hit
PF08070 DTHCT, 1 hit
PF02518 HATPase_c, 1 hit
PF01454 MAGE, 1 hit
PF01751 Toprim, 1 hit
PF16898 TOPRIM_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01373 MAGE, 1 hit
SM00433 TOP2c, 1 hit
SM00434 TOP4c, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54211 SSF54211, 2 hits
SSF55874 SSF55874, 1 hit
SSF56719 SSF56719, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50838 MAGE, 1 hit
PS00177 TOPOISOMERASE_II, 1 hit
PS50880 TOPRIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5BF97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAGKPLPVD QEQWDCGSEA PISGLEAAEL STVVCWSGVL CVFVVWNQTL
60 70 80 90 100
FDQNNAAKKE ELEAANKNDS SKKLSVERVY QKKTQLEHIL LRPDTYIGSV
110 120 130 140 150
EPLTQLMWVY DEDVGMNCRE VTFVPGLYKI FDEILVNAAD NKQRDKNMTC
160 170 180 190 200
IKISIDPESN IISIWNNGKG IPVVEHKVEK VYVPALIFGQ LLTSSNYDDD
210 220 230 240 250
EKKVTGGRNG YGAKLCNIFS TKFTVETACK EYKHSFKQTW MNNMMKTSEA
260 270 280 290 300
KIKHFDGEDY TCITFQPDLS KFKMEKLDKD IVALMTRRAY DLAGSCKGVK
310 320 330 340 350
VMFNGKKLPV NGFRSYVDLY VKDKLDETGV ALKVIHELAN ERWDVCLTLS
360 370 380 390 400
EKGFQQISFV NSIATTKWRI LSCDFSKSGF GFLEKLNCYC LSTLFSSTGD
410 420 430 440 450
LEASDPQQVL AVLMASSQRS QSCEGSSSSQ DAHFSHTLQN VLLNAKLCKL
460 470 480 490 500
VSFLLKYQKK EQVTMKEMMH VVSHDYRNNF PLNFWELCES MYLGFGIKIR
510 520 530 540 550
KVNYSGNTYE LVPILGLTYS GILDGDDERI ILKIDIIIFV LSLIFIEGNC
560 570 580 590 600
ISEEDLTEKV KRWDMLAQSE RIHFEEAWKF ITENLVWEEY LMYRQIPSSD
610 620 630 640 650
PAHYEFLWGP RAHAETSKMK LLVHMAHLNG TDPKSYPELY EEALEAKLGI
660 670 680 690 700
EPGFLRNGIL HKGGGRHVDY VVDQVVGKLI EVVKKKNKAG VSVKPFQVKN
710 720 730 740 750
HIWVFINCLI ENPTFDSQTK ENMTLQPKSF GSKCQLSEKF FKAASNCGIV
760 770 780 790 800
ESILNWVKFK AQTQLNKKCS SVKYSKIKGI PKLDDANDAG GKHSLECTLI
810 820 830 840 850
LTEGDSAKSL AVSGLGVIGR DRYGVFPLRG KILNVREASH KQIMENAEIN
860 870 880 890 900
NIIKIVGLQY KKSYDDAESL KTLRYGKIMI MTDQDQDGSH IKGLLINFIH
910 920 930 940 950
HNWPSLLKHG FLEEFITPIV KASKNKQELS FYSIPEFDEW KKHIENQKAW
960 970 980 990 1000
KIKYYKGLGT STAKEAKEYF ADMERHRILF RYAGPEDDAA ITLAFSKKKI
1010 1020 1030 1040 1050
DDRKEWLTNF MEDRRQRRLH GLPEQFLYGT ATKHLTYNDF INKELILFSN
1060 1070 1080 1090 1100
SDNERSIPSL VDGFKPGQRK VLFTCFKRND KREVKVAQLA GSVAEMSAYH
1110 1120 1130 1140 1150
HGEQALMMTI VNLAQNFVGS NNINLLQPIG QFGTRLHGGK DAASPRYIFT
1160 1170 1180 1190 1200
MLSSLARLLF PAVDDNLLKF LYDDNQRVEP EWYIPIIPMV LINGAEGIGT
1210 1220 1230 1240 1250
GWACKLPNYD AREIVNNVRR MLEGLDPHPM LPNYKNFKGT IQELGQNQYA
1260 1270 1280 1290 1300
VSGEIFVVDR NTVEITELPV RTWTQVYKEQ VLEPMLNGTD KTPALISDYK
1310 1320 1330 1340 1350
EYHTDTTVKF VVKMTEEKLA QAEAAGLHKV FKLQTTLTCN SMVLFDHMGC
1360 1370 1380 1390 1400
LKKYETVQDI LKEFFDLRLS YYGLRKEWLV GMLGAESTKL NNQARFILEK
1410 1420 1430 1440 1450
IQGKITIENR SKKDLIQMLV QRGYESDPVK AWKEAQEKAA EEEETQNQHD
1460 1470 1480 1490 1500
DSSSDSGTPS GPDFNYILNM SLWSLTKEKV EELIKQRDAK GREVNDLKRK
1510 1520 1530 1540 1550
SPSDLWKEDL AAFVEELDKV EAQEREDILA GMSGKAIKGK VGKPKVKKLQ
1560 1570 1580 1590 1600
LEETMPSPYG RRVVPEITAM KADASKKLLK KKKGDLDTTV VKVEFDEEFS
1610 1620 1630 1640 1650
GTPAEGTRVR KTPTASGKPS AKKVKKRNPW SDDESKSESD LEETEPVVIP
1660 1670 1680 1690 1700
RDSLLRRAAA ERPKYTFDFS EEEDDDADDD DDDNNDLEEL QVKASPIIND
1710 1720 1730 1740 1750
GEDEFIPSDG LDKDEYTFSP SKSTPEKSLH DKKNQDFGNL FSFPSYSQKS
1760 1770 1780 1790 1800
EDDSAKFDSN EEDTASVFSP SFGLKQTDKV PSKTVAAKKG KPPLDTASKS
1810 1820 1830 1840 1850
KRAPKQKKVV ETINSDSDSE FGVPKKTATP KGKGRGAKKR KASSSENEGD
1860 1870 1880 1890 1900
YNPGRKSSKT TSKKPKKTSF DQDSDVDIFP SDFTSDPPSL PRTGRARKEV
1910
KYFAESDEED VDFAMFN
Length:1,917
Mass (Da):217,322
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB05C26B00EDE3C48
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JH169917 Genomic DNA Translation: EHB07958.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH169917 Genomic DNA Translation: EHB07958.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10181.XP_004857952.1

Phylogenomic databases

InParanoidiG5BF97

Family and domain databases

CDDicd00187 TOP4c, 1 hit
cd03365 TOPRIM_TopoIIA, 1 hit
Gene3Di1.10.10.1200, 1 hit
1.10.10.1210, 1 hit
1.10.268.10, 1 hit
3.30.230.10, 2 hits
3.30.565.10, 1 hit
3.40.50.670, 1 hit
3.90.199.10, 1 hit
InterProiView protein in InterPro
IPR012542 DTHCT
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR041898 MAGE_WH1
IPR041899 MAGE_WH2
IPR002190 MHD_dom
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR001241 Topo_IIA
IPR013760 Topo_IIA-like_dom_sf
IPR002205 Topo_IIA_A/C
IPR013758 Topo_IIA_A/C_ab
IPR013757 Topo_IIA_A_a_sf
IPR013759 Topo_IIA_B_C
IPR013506 Topo_IIA_bsu_dom2
IPR018522 TopoIIA_CS
IPR031660 TOPRIM_C
IPR006171 TOPRIM_domain
IPR034157 TOPRIM_TopoII
PfamiView protein in Pfam
PF00204 DNA_gyraseB, 1 hit
PF00521 DNA_topoisoIV, 1 hit
PF08070 DTHCT, 1 hit
PF02518 HATPase_c, 1 hit
PF01454 MAGE, 1 hit
PF01751 Toprim, 1 hit
PF16898 TOPRIM_C, 1 hit
SMARTiView protein in SMART
SM01373 MAGE, 1 hit
SM00433 TOP2c, 1 hit
SM00434 TOP4c, 1 hit
SUPFAMiSSF54211 SSF54211, 2 hits
SSF55874 SSF55874, 1 hit
SSF56719 SSF56719, 1 hit
PROSITEiView protein in PROSITE
PS50838 MAGE, 1 hit
PS00177 TOPOISOMERASE_II, 1 hit
PS50880 TOPRIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5BF97_HETGA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5BF97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 31, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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