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Entry version 61 (16 Oct 2019)
Sequence version 1 (14 Dec 2011)
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Protein
Submitted name:

SF3b1 domain-containing protein

Gene

sftb-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-72163 mRNA Splicing - Major Pathway
R-CEL-72165 mRNA Splicing - Minor Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SF3b1 domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sftb-1Imported
ORF Names:CELE_T08A11.2Imported, T08A11.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
T08A11.2 ; CE03641 ; WBGene00011605 ; sftb-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
G5EEQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G5EEQ8

PeptideAtlas

More...
PeptideAtlasi
G5EEQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00011605 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.T08A11.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G5EEQ8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini313 – 458SF3b1InterPro annotationAdd BLAST146

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 90DisorderedSequence analysisAdd BLAST90
Regioni120 – 337DisorderedSequence analysisAdd BLAST218

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili865 – 892Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi120 – 137PolyampholyteSequence analysisAdd BLAST18
Compositional biasi152 – 198PolyampholyteSequence analysisAdd BLAST47
Compositional biasi201 – 222PolarSequence analysisAdd BLAST22
Compositional biasi257 – 273PolarSequence analysisAdd BLAST17
Compositional biasi303 – 318PolyampholyteSequence analysisAdd BLAST16
Compositional biasi319 – 337PolarSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0213 Eukaryota
COG5181 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018393

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G5EEQ8

KEGG Orthology (KO)

More...
KOi
K12828

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSRWDAT

Database of Orthologous Groups

More...
OrthoDBi
245208at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G5EEQ8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015016 SF3b_su1
IPR038737 SF3b_su1-like

The PANTHER Classification System

More...
PANTHERi
PTHR12097 PTHR12097, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08920 SF3b1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G5EEQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRSGEAYAQ ELNRKRVANQ RAAAAEDNDE NKGNGNKVAF GAAGNFDTDV
60 70 80 90 100
YGSVRGENRD SYLDSIGTGE EDDVDEDSMP SVQKKSTNYA QPHKFIEEVA
110 120 130 140 150
AASEDTDPFA DTRTKTIAER QSKYHERAMR RQISPDRADA FVDQTPDNRN
160 170 180 190 200
RGYAEVMRDQ MYHEEKGRVE RELADRAKAG ELHVTGQPEK KKGRWDAEAP
210 220 230 240 250
STDASSDNLG AASATPSQGS APRKRLGFSK ISADAATPRA ARWDETPAHS
260 270 280 290 300
TGAADATPSV DKWSTTPAAQ TPRRNRWDET PKENLNDGSM TPGWGMETPA
310 320 330 340 350
RGGSDDVKIE DTPSASKRRS RWDLTPSQTP NVAAATPLHS GLQTPSFTPS
360 370 380 390 400
HPSQTPIGAM TPGGATPIGT AAMGMKTPAP HMIPMTPEQM QIYRWEKEID
410 420 430 440 450
DRNRPLTDEE LDSLFPPGYK VLVPPMNYIP LRTPSRKLMA TPTPMGGAAG
460 470 480 490 500
GGFFMPGTPD RDGIGEKGVG GLVDTQPKNA ELPPLKPDDM QYFDKLLMDV
510 520 530 540 550
DESQLTKEEK NEREIMEHLL KIKNGTPPMR KSGLRKITEN ARKYGAGPLF
560 570 580 590 600
NQILPLLMSP SLEDQERHLM VKVIDRILYK LDDLVRPYVH KILVVIEPLL
610 620 630 640 650
IDEDYYARVE GREIISNLAK AAGLATMIST MRPDIDNVDE YVRNTTARAF
660 670 680 690 700
AVVASALGIP ALLPFLKAVC KSKKSWQARH TGIKIVQQMA ILMGCAVLPH
710 720 730 740 750
LKALVDIVES GLDDEQQKVR TITALCLAAL AEASSPYGIE AFDSVLKPLW
760 770 780 790 800
KGIRMHRGKG LAAFLKAIGY LIPLMDAEYA SYYTREVMLI LIREFASPDE
810 820 830 840 850
EMKKIVLKVV KQCCATDGVE ASYIRDEVLP SFFKAFWNQR MAMDRRNYRQ
860 870 880 890 900
LVDTTVEIAQ KVGCVEMIAR IVDDLKDENE QYRKMVMETI ENIVALQGAT
910 920 930 940 950
DIDARLEEQL IDGLLYAFQE QTQEDSVMLD GFGTICSSLG RRAKAYIPQI
960 970 980 990 1000
CGTILWRLNN KSAKVRQQAA DLIARIAPVM HMCEEEKMMG HMGVVLYEYL
1010 1020 1030 1040 1050
GEEYPEVLGS ILGALKAICN VIGMTKMTPP IKDLLPRLTP ILKNRHEKVQ
1060 1070 1080 1090 1100
ENCIDLVGAI ADRGSEFVSA REWMRICFEL LELLKAHKKS IRRAAINTFG
1110 1120 1130 1140 1150
FIAKAIGPHD VLATLLNNLK VQERQLRVCT TVAIAIVSET CAPFTVLPAI
1160 1170 1180 1190 1200
MNEYRVPEIN VQNGVLKALS FMFEYIGEMA KDYIYAVVPL LIDALMERDQ
1210 1220 1230 1240 1250
VHRQIAVDAV AHLAIGVYGF GCEDALIHLL NYVWPNMLEN SPHLIQRWVF
1260 1270 1280 1290 1300
ACEGMRVSLG PIKVLQYCLQ ALWHPARKVR EPVWKVFNNL ILGSADALIA
1310 1320
AYPRIENTPT NQYVRYELDY NL
Length:1,322
Mass (Da):147,324
Last modified:December 14, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A4EE3FD675CDE84
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA90777.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T24140

NCBI Reference Sequences

More...
RefSeqi
NP_497853.1, NM_065452.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T08A11.2.1; T08A11.2.1; WBGene00011605

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T08A11.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAA90777.1
PIRiT24140
RefSeqiNP_497853.1, NM_065452.4

3D structure databases

SMRiG5EEQ8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.T08A11.2

Proteomic databases

EPDiG5EEQ8
PaxDbiG5EEQ8
PeptideAtlasiG5EEQ8

Genome annotation databases

EnsemblMetazoaiT08A11.2.1; T08A11.2.1; WBGene00011605
GeneIDi175549
KEGGicel:CELE_T08A11.2

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175549
WormBaseiT08A11.2 ; CE03641 ; WBGene00011605 ; sftb-1

Phylogenomic databases

eggNOGiKOG0213 Eukaryota
COG5181 LUCA
GeneTreeiENSGT00390000018393
InParanoidiG5EEQ8
KOiK12828
OMAiRSRWDAT
OrthoDBi245208at2759
PhylomeDBiG5EEQ8

Enzyme and pathway databases

ReactomeiR-CEL-72163 mRNA Splicing - Major Pathway
R-CEL-72165 mRNA Splicing - Minor Pathway

Gene expression databases

BgeeiWBGene00011605 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015016 SF3b_su1
IPR038737 SF3b_su1-like
PANTHERiPTHR12097 PTHR12097, 1 hit
PfamiView protein in Pfam
PF08920 SF3b1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG5EEQ8_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G5EEQ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 16, 2019
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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