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Entry version 43 (31 Jul 2019)
Sequence version 1 (25 Jan 2012)
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Protein

Delta-like protein

Gene

EGK_02669

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EGK_02669Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1040 – 1065HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi159 ↔ 168PROSITE-ProRule annotation
Disulfide bondi172 ↔ 184PROSITE-ProRule annotation
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
Disulfide bondi225 ↔ 234PROSITE-ProRule annotation
Disulfide bondi296 ↔ 305PROSITE-ProRule annotation
Disulfide bondi334 ↔ 343PROSITE-ProRule annotation
Disulfide bondi372 ↔ 381PROSITE-ProRule annotation
Disulfide bondi410 ↔ 419PROSITE-ProRule annotation
Disulfide bondi426 ↔ 436PROSITE-ProRule annotation
Disulfide bondi447 ↔ 456PROSITE-ProRule annotation
Disulfide bondi485 ↔ 494PROSITE-ProRule annotation
Disulfide bondi523 ↔ 532PROSITE-ProRule annotation
Disulfide bondi589 ↔ 598PROSITE-ProRule annotation
Disulfide bondi627 ↔ 636PROSITE-ProRule annotation
Disulfide bondi665 ↔ 674PROSITE-ProRule annotation
Disulfide bondi703 ↔ 712PROSITE-ProRule annotation
Disulfide bondi742 ↔ 751PROSITE-ProRule annotation
Disulfide bondi780 ↔ 789PROSITE-ProRule annotation
Disulfide bondi818 ↔ 827PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini157 – 201DSLInterPro annotationAdd BLAST45
Domaini202 – 235EGF-likeInterPro annotationAdd BLAST34
Domaini268 – 306EGF-likeInterPro annotationAdd BLAST39
Domaini308 – 344EGF-likeInterPro annotationAdd BLAST37
Domaini346 – 382EGF-likeInterPro annotationAdd BLAST37
Domaini384 – 420EGF-likeInterPro annotationAdd BLAST37
Domaini422 – 457EGF-likeInterPro annotationAdd BLAST36
Domaini459 – 495EGF-likeInterPro annotationAdd BLAST37
Domaini497 – 533EGF-likeInterPro annotationAdd BLAST37
Domaini558 – 599EGF-likeInterPro annotationAdd BLAST42
Domaini601 – 637EGF-likeInterPro annotationAdd BLAST37
Domaini639 – 675EGF-likeInterPro annotationAdd BLAST37
Domaini677 – 713EGF-likeInterPro annotationAdd BLAST37
Domaini716 – 752EGF-likeInterPro annotationAdd BLAST37
Domaini754 – 790EGF-likeInterPro annotationAdd BLAST37
Domaini792 – 828EGF-likeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1124 – 1190DisorderedSequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1124 – 1141PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1162 – 1181PolarSequence analysisAdd BLAST20

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410XP6K LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 10 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 1 hit
PF07657 MNNL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02059 JAGGEDFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

G7N2Z1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CGASGQFELE ILSMQNVNGE LQNGNCCGGA RNPGDRKCTR DECDTYFKVC
60 70 80 90 100
LKEYQSRVTA GGPCSFGSGS TPVIGGNTFN LKASRGNDRN RIVLPFSFAW
110 120 130 140 150
PRSYTLLVEA WDSSNDTVQP DSIIEKASHS GMINPSRQWQ TLKQNTGVAH
160 170 180 190 200
FEYQIRVTCD DYYYGFGCNK FCRPRDDFFG HYACDQNGNK TCMEGWMGPE
210 220 230 240 250
CNRAICRQGC SPKHGSCKLP GDCRCQYGWQ GLYCDKCIPH PGCVHGICNE
260 270 280 290 300
PWQCLCETNW GGQLCDKDLN YCGTHQPCLN GGTCSNTGPD KYQCSCPEGY
310 320 330 340 350
SGPNCEIAEH ACLSDPCHNR GSCKETSLGF ECECSPGWTG PTCSTNIDDC
360 370 380 390 400
SPNNCSHGGT CQDLVNGFKC VCPPQWTGKT CQLDANECEA KPCVNAKSCK
410 420 430 440 450
NLIASYYCDC LPGWMGQNCD ININDCLGQC QNDASCRDLV NGYRCICPPG
460 470 480 490 500
YAGDHCERDI DECASNPCLN GGHCQNEINR FQCLCPTGFS GNLCQLDIDY
510 520 530 540 550
CEPNPCQNGA QCYNRASDYF CKCPEDYEGK NCSHLKDHCR TTPCEVIDSC
560 570 580 590 600
TVAMASNDTP EGVRYISSNV CGPHGKCKSQ SGGKFTCDCN KGFTGTYCHE
610 620 630 640 650
NINDCESNPC RNGGTCIDGV NSYKCICSDG WEGAYCETNI NDCSQNPCHN
660 670 680 690 700
GGTCRDLVND FYCDCKNGWK GKTCHSRDSQ CDEATCNNGG TCYDEGDAFK
710 720 730 740 750
CMCPGGWEGT TCNIARNSSC LPNPCHNGGT CVVNGESFTC VCKEGWEGPI
760 770 780 790 800
CAQNTNDCSP HPCYNSGTCV DGDNWYRCEC APGFAGPDCR ININECQSSP
810 820 830 840 850
CAFGATCVDE INGYRCVCPP GHSGAKCQEV SGRPCITMGS VIPDGAKWDD
860 870 880 890 900
DCNTCQCLNG RIACSKVWCG PRPCLLHKGH SECPSGQSCI PILDDQCFVH
910 920 930 940 950
PCTGVGECRS SSLQPVKTKC TSDSYYQDNC ANITFTFNKE MMSPGLTTEH
960 970 980 990 1000
ICSELRNLNI LKNVSAEYSI YIACEPSPSA NNEIHVAISA EDIRDDGNPI
1010 1020 1030 1040 1050
KEITDKIIDL VSKRDGNSSL IAAVAEVRVQ RRPLKNRTDF LVPLLSSVLT
1060 1070 1080 1090 1100
VAWICCLVTA FYWCLRKRRK PGSHTHSASE DNTTNNVREQ LNQIKNPIEK
1110 1120 1130 1140 1150
HGANTVPIKD YENKNSKMSK IRTHNSEVEE DDMDKHQQKA RFAKQPAYTL
1160 1170 1180 1190
VDREEKPPNG TPTKHPNWTN KQDNRDLESA QSLNRMEYIV
Length:1,190
Mass (Da):130,724
Last modified:January 25, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8992D9FA7C90D0C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1190Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM001262 Genomic DNA Translation: EHH19923.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001262 Genomic DNA Translation: EHH19923.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 10 hits
PF07645 EGF_CA, 1 hit
PF12661 hEGF, 1 hit
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00214 VWC, 1 hit
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 11 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG7N2Z1_MACMU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G7N2Z1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 25, 2012
Last sequence update: January 25, 2012
Last modified: July 31, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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