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Entry version 47 (31 Jul 2019)
Sequence version 2 (09 Jan 2013)
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Protein
Submitted name:

DS cell adhesion molecule like 1

Gene

DSCAML1

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DS cell adhesion molecule like 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSCAML1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001595 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9601.ENSPPYP00000004485

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 165Ig-likeInterPro annotationAdd BLAST90
Domaini173 – 272Ig-likeInterPro annotationAdd BLAST100
Domaini281 – 361Ig-likeInterPro annotationAdd BLAST81
Domaini369 – 457Ig-likeInterPro annotationAdd BLAST89
Domaini463 – 556Ig-likeInterPro annotationAdd BLAST94
Domaini561 – 641Ig-likeInterPro annotationAdd BLAST81
Domaini651 – 740Ig-likeInterPro annotationAdd BLAST90
Domaini745 – 839Ig-likeInterPro annotationAdd BLAST95
Domaini843 – 941Ig-likeInterPro annotationAdd BLAST99
Domaini942 – 1039Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini1044 – 1143Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini1148 – 1244Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini1248 – 1343Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1333 – 1432Ig-likeInterPro annotationAdd BLAST100
Domaini1438 – 1532Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1533 – 1633Fibronectin type-IIIInterPro annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 59DisorderedSequence analysisAdd BLAST59
Regioni1835 – 1856DisorderedSequence analysisAdd BLAST22
Regioni1895 – 1939DisorderedSequence analysisAdd BLAST45
Regioni1994 – 2108DisorderedSequence analysisAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1669 – 1689Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1895 – 1921PolarSequence analysisAdd BLAST27
Compositional biasi2034 – 2066Pro-richSequence analysisAdd BLAST33
Compositional biasi2080 – 2101PolarSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQJM Eukaryota
ENOG410XQX7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155354

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H2NFF1

TreeFam database of animal gene trees

More...
TreeFami
TF316846

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 16 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033029 DSCAML1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

The PANTHER Classification System

More...
PANTHERi
PTHR13817:SF54 PTHR13817:SF54, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H2NFF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGAGELRRE EPPPQPSAGL RSRESGARSA GGWERAERGR GAAARPTTGP
60 70 80 90 100
PXXXXXXXXX XXANQVSPLA SPAARPEDVG TSLYFVNDSL QQVTFSSSVG
110 120 130 140 150
VVVPCPAAGS PSAALRWYLA TGDDIYDVPH IRHVHANGTL QLYPFSPSAF
160 170 180 190 200
NSFIHDNDYF CTAENAAGKI RSPNIRVKAV FREPYTVRVE DQRSMRGNVA
210 220 230 240 250
VFKCLIPSSV QEYVSVVSWE KDTVSIIPGE RAGPGGLYIS DVQKEDALST
260 270 280 290 300
YRCITKHKYS GETRQSNGAR LSVTDPAESI PTILDGFHSQ EVWAGHTVEL
310 320 330 340 350
PCTASGYPIP AIRWLKDGRP LPADSRWTKR ITGLTISDLR TEDSGTYICE
360 370 380 390 400
VTNTFGSAEA TGILMVIDPL HVALTPKKLK TGIGSTVILS CALTGSPEFT
410 420 430 440 450
IRWYRNTELV LPDEAISIRG LSNETLLITS AQKSHSGAYQ CFATRKAQTA
460 470 480 490 500
QDFAIIALED GTPRIVSSFS EKVVNPGEQF SLMCAAKGAP PPTVTWALDD
510 520 530 540 550
EPIVRDGSHR TNQYTMSDGT TISHMNVTGP QIRDGGVYRC TARNSVGSAE
560 570 580 590 600
YQARINVRGP PSIRAMRNIT AVAGRDTLIN CRVIGYPYYS IKWYKDALLL
610 620 630 640 650
PDNHRQVVFE NGTLKLTDVQ KGMDEGEYLC SVLIQPQLSI SQSVHVAVKV
660 670 680 690 700
PPLIQPFEFP PASIGQLLYI PCVVSSGDMP IRITWRKDGQ VIISGSGVTI
710 720 730 740 750
ESKEFMSSLQ ISSVSLKHNG NYTCIASNAA ATVSRERQLI VRVPPRFVVQ
760 770 780 790 800
PNNQDGIYGK AGVLNCSVDG YPPPKVMWKH AKGSGNPQQY HPVPLTGRIQ
810 820 830 840 850
ILPNSSLLIR HVLEEDIGYY LCQASNGVGT DISKSMFLTV KIPAMITSHP
860 870 880 890 900
NTTIAIKGHA KELNCTARGE RPIIIRWEKG DTVIDPDRVM RYTITTKDNG
910 920 930 940 950
DEVISTLKLK PADRGDSVFF SCHAINSYGE DRGLIHSLTL EPPDPPELEI
960 970 980 990 1000
REVKARSMNL RWTQRFDGNS IITGFDIEYK NKSDSWDFKQ STRNISPTIN
1010 1020 1030 1040 1050
QANIVDLHPA SVYSIRMYSF NKIGRSEPSK ELTISTEEAA PDGPPMDVTL
1060 1070 1080 1090 1100
QPVTSQSIQV TWKAPKKELQ NGVIRGYQIG YRENSPGSNG QYSIVEMKAT
1110 1120 1130 1140 1150
GDSEVYTLDN LKKFAQYGVV VQAFNRAGTG PSSSEINATT LEDVPSQPPE
1160 1170 1180 1190 1200
NVRALSITSD VAVISWSEPP RSTLNGVLKG YRVIFWSLYV DGEWGEMQNI
1210 1220 1230 1240 1250
TTTRERVELR GMEKFTNYSV QVLAYTQAGD GVRSSVLYIQ TKEDVPGPPA
1260 1270 1280 1290 1300
GIKAVPSSAS SVVVSWLPPT KPNGVIRKYT IFCSSPGSGQ PAPSEYETSP
1310 1320 1330 1340 1350
EQLFYRIAHL NRGQQYLLWV AAVTSAGRGN SSEKVTIEPA GKAPAKIISF
1360 1370 1380 1390 1400
GGTVTTPWMK DVRLPCNSVG DPAPAVKWTK DSEDSAIPVS MDGHRIIHTN
1410 1420 1430 1440 1450
GTLLLRAVKA EDSGYYTCTA TNTGGFDTII VNLLVQVPPD QPRLTVSKTS
1460 1470 1480 1490 1500
ASSITLTWIP GDNGGSSIRG FMLQYSVDNS EEWKDVFISS SERSFKLDSL
1510 1520 1530 1540 1550
KCGTWYKVKL AAKNSVGSGR ISEIIEAKTH GREPSFSKDQ HLFTHINSTH
1560 1570 1580 1590 1600
ARLNLQGWNN GGCPITAIVL EYRPKGTWAW QGLRANSSGE VFLTELREAT
1610 1620 1630 1640 1650
WYELRMRACN SAGCGNETAQ FATLDYDGST IPPIKSAQGE GDDVKKLFTI
1660 1670 1680 1690 1700
GCPVILATLG VALLFIVRKK RKEKRLKRLR DAKSLAEMLI SKNNRSFDTP
1710 1720 1730 1740 1750
VKGPPQGPRL HIDIPRVQLL IEDKEGIKQL GDDKATIPVT DAEFSQAVNP
1760 1770 1780 1790 1800
QSFCTGVSLH HPALIQSTGP LIDMSDIRPG TNPVSRKNVK SAHSTRNRYS
1810 1820 1830 1840 1850
SQWTLTKCQA STPARTLTSD WRTVGSQHGV TVTESDSYSA SLSQDTDKGR
1860 1870 1880 1890 1900
NSMVSTESAS STYEELARAY EHAKLEEQLQ HAKFEITECF ISDSSSDQMT
1910 1920 1930 1940 1950
TGTNENADSM TSMSTPSEPG ICRFTASPPK PQDADRGKNV AVPIPHRANK
1960 1970 1980 1990 2000
SDYCNLPLYA KSEAFFRKAD GREPCPVVPP REASIRNLAR TYHTQARHLT
2010 2020 2030 2040 2050
LDPASKPLGL PHPGAPAAAS TATLPQRTLA MPAPPAGTAP PAPGPTPAEP
2060 2070 2080 2090 2100
PTAPSAAPPA PSTEPPRAGG PHTKMGGSRD SLLEMSTSRV GRSQKQGAGP
2110
TPNPTPLVXX XXALFIFN
Length:2,118
Mass (Da):230,681
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD01D6F0891E37432
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABGA01008156 Genomic DNA No translation available.
ABGA01008157 Genomic DNA No translation available.
ABGA01008158 Genomic DNA No translation available.
ABGA01008159 Genomic DNA No translation available.
ABGA01008160 Genomic DNA No translation available.
ABGA01008161 Genomic DNA No translation available.
ABGA01008162 Genomic DNA No translation available.
ABGA01008163 Genomic DNA No translation available.
ABGA01008164 Genomic DNA No translation available.
ABGA01008165 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPPYT00000004661; ENSPPYP00000004485; ENSPPYG00000003915

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABGA01008156 Genomic DNA No translation available.
ABGA01008157 Genomic DNA No translation available.
ABGA01008158 Genomic DNA No translation available.
ABGA01008159 Genomic DNA No translation available.
ABGA01008160 Genomic DNA No translation available.
ABGA01008161 Genomic DNA No translation available.
ABGA01008162 Genomic DNA No translation available.
ABGA01008163 Genomic DNA No translation available.
ABGA01008164 Genomic DNA No translation available.
ABGA01008165 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi9601.ENSPPYP00000004485

Genome annotation databases

EnsembliENSPPYT00000004661; ENSPPYP00000004485; ENSPPYG00000003915

Phylogenomic databases

eggNOGiENOG410IQJM Eukaryota
ENOG410XQX7 LUCA
GeneTreeiENSGT00940000155354
InParanoidiH2NFF1
TreeFamiTF316846

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 16 hits
InterProiView protein in InterPro
IPR033029 DSCAML1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PANTHERiPTHR13817:SF54 PTHR13817:SF54, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 4 hits
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 10 hits
SM00408 IGc2, 9 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 10 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH2NFF1_PONAB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H2NFF1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 21, 2012
Last sequence update: January 9, 2013
Last modified: July 31, 2019
This is version 47 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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